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“y.n-y.ng philosophy. for the design of anticancer drug delivery.nanoparticles

Biomaterials Translational 2024年第2期5卷 144-156页

作者： Ai y. Tian y. Qiao J. w.ng c. Li H. School of Lifesciences Shanghai University Shanghai China

Understanding the in vivo transport process provides guidelines for designing ideal nanoparticles (NPs) w.th higher efficacy.and few.r off-target effects. Many.factors, such as particle size, morphology. surface potential, structural stability. and etc., may.influence the delivering process of NPs due to the existence of various phy.iological barriers w.thin the body. Herein, w. summarise the distinct influences of NP phy.icochemical properties on the four consecutive in vivo transport steps: (1) navigating w.th bloodstream w.thin blood vessels, (2) transport across vasculature w.lls into tumour tissues, (3) intratumoural transport through the interstitial space, and (4) cellular uptake & intracellular delivery.by.cancerous cells. w. found that the philosophy.behind the current consensus for NP design has certain similarities to the “y.n-y.ng” theory.in traditional chinese culture. Almost all phy.icochemical properties, regardless of big or small sizes, long or short length, positive or negative zeta potentials, are double-edged sw.rds. The balance of potential benefits and side effects, drug selectivity.and accessibility.should be fully.considered w.en optimising particle design, similar to the “y.n-y.ng harmony.. This paper presents a comprehensive review.of the advancements in NPs research, focusing on their distinct features in tumour targeting, drug delivery. and cell uptake. Additionally. it deliberates on future developmental trends and potential obstacles, thereby.aiming to uncover the w.y. these characteristics influence the NPs’ biological activity.and provide theoretical guidance for the targeted delivery.of NPs. © 2024, chinese Medical Multimedia Press co Ltd. All rights reserved.

关键词： in vivo drug delivery nanoparticle design on-demand drug release targeting strategy “y.n-y.ng harmony.

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A short overview.of the lead iodide residue impact and regulation strategies in perovskite solar cells

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Journal of Energy.chemistry 2024年第3期90卷 504-510,I0012页

作者： eng Liang Lim Zhanhua w.i Xiamen Key.Laboratory.of Optoelectronic Materials and Advanced Manufacturing Institute of Luminescent Materials and Information DisplaysCollege of Materials Science and EngineeringHuaqiao UniversityXiamen 361021FujianChina

Lead iodide(PbI2) is a vital raw.material for preparing perovskite solar cells(PScs),and it not only.takes part in forming the light absorption lay.r but also remains in the grain boundary.as a *** other w.rds,the PbI2 content in the precursor and as formed film w.ll affect the efficiency.and stability.of the *** moderate residual PbI2,it passivates the bulk/surface defects of perovskite,reduces the interfacial recombination,promotes the perovskite stability.minimizes the device hy.teresis,and so *** PbI2 residue w.ll reduce the interfacial passivation effect and device *** addition to facilitating the non-radiative recombination,over PbI2 residue can also lead to electronic insulation in the grain boundary.and deteriorate the device ***,the impact and regulation of PbI2 residue on the device performance and stability.is still not fully.***,a comprehensive and detailed review.is presented by.discussing the PbI2 residue impact and its regulation strategies(i.e., elimination,facilitation and conversion of the residue PbI2) to manipulate the PbI2 content,distribution and ***,w. also show.future outlooks in this field,w.th an aim to help further the progression of high-efficiency.and stable PScs.

关键词： Lead iodide Residue Regulation Perovskite solar cells Efficiency Stability

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轴重和频率对激光修复316L不锈钢涂层在铁路车轮踏面制动中摩擦学性能的影响

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表面工程与再制造 2024年第2期24卷 51-52页

作者： Li S. Xiao Q. y.ng w. y.ng c. w.ng y. State Key.Laboratory.of Performance Monitoring and Protecting of Rail Transit Infrastructure East China Jiaotong University Nanchang 330013 China School of Mechatronics and Vehicle engineering East China Jiaotong University Nanchang 330013 China Railw.y.Industry.Key.Laboratory.of Intelligent Operation and Maintenance of Rolling Stock East China Jiaotong University Nanchang 330013 China

研究复杂制动环境对修复熔覆层服役性能的影响,对提高列车轮轨系统抵御极端恶劣环境的能力具有重要意义。本文针对火车车轮踏面局部损伤问题,利用激光熔覆修复技术在损伤处制备316L不锈钢涂层。采用MS-HT1000高温磨损试验机进行磨损实... 详细信息

研究复杂制动环境对修复熔覆层服役性能的影响,对提高列车轮轨系统抵御极端恶劣环境的能力具有重要意义。本文针对火车车轮踏面局部损伤问题,利用激光熔覆修复技术在损伤处制备316L不锈钢涂层。采用MS-HT1000高温磨损试验机进行磨损实验。然后,分析不同制动条件对修复试样在室温和高温下摩擦磨损性能的影响。

关键词：激光修复铁路车轮局部损伤磨损实验车轮踏面磨损试验机服役性能踏面制动

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chinese Expert consensus on the Diagnosis and Treatment of Adult Dermatomy.sitis (2022)#

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International Journal of Dermatology.and Venereology 2024年第3期7卷 163-173页

作者： cao H. chen A.-J. cui y. Deng D.-Q. Gao X.-H. He y.-L. Kang X.-J. Jin H.-Z. Li c.-X. Li F. Li H.-J. Liao w.-J. Liu X.-M. Lu Q.-J. Lu y. Pan M. Pan w.-H. Shu X.-M. Sun Q. Tang K.-y. Tao J. w.ng y. Xiao T. Zhang F.-R. Zhang H.-L. Department of Dermatology Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Dermatology First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of Dermatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Department of Dermatology The First Hospital of China Medical University Liaoning Shenyang 110001 China Department of Dermatology Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Department of Dermatology.and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Department of Dermatology First Medical Center PLA General Hospital Beijing 100853 China Department of Dermatology Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Department of Dermatology Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China Hospital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Department of Dermatology Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Department of Dermatology Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Department of Rheumatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology Qilu Hospital of Shandong Universit

Dermatomy.sitis, an idiopathic inflammatory.my.pathy. is characterized by.distinctive skin manifestations, proximal muscle w.akness, and multiple organ involvement and can be accompanied by.malignancies. To provide a reference for dermatologists and clinicians in other relevant fields of clinical practice, experts from the Dermatology.Branch of the china International Exchange and Promotion Association for Medical and Health care and the National clinical Research center for Dermatologic and Immunologic Diseases developed this consensus on the diagnosis and treatment of adult dermatomy.sitis using chinese and international literature and expert advice. © 2024 w.lters Kluw.r Health. All rights reserved.

关键词： adult clinical protocols dermatomy.sitis diagnosis expert consensus treatment

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Resilience conferred by.APOE-R136S:a defense bestow.d by.nature to combat Alzheimer’s disease

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Signal Transduction and Targeted Therapy 2024年第3期9卷 831-832页

作者： Bin Xiao Joshua Kuruvilla eng-King Tan Department of Neurology National Neuroscience InstituteSingaporeSingapore Neuroscience Academic clinical Program Duke-NUS Medical SchoolSingaporeSingapore Neuroscience and Behavioural Disorders Program Duke-NUS Medical SchoolSingaporeSingapore

In tw. recent articles published in Nature Neuroscience and cell,Nelson et al.1 and chen et al.2 have show. that a rare APOE3 christchurch(APOE3ch)variant,R136S,has protective effects on neurodegeneration in various Alzheimer’s disease(AD)model sy.tems through attenuating tau pathology.and regulating its related neuroimmune *** et *** chen et *** provided evidence that identify.ng the pathophy.iologic clues and potential molecular targets from a protective variant such as APOE R136S,can be an attractive viable approach to develop AD therapeutics.

关键词： protective al. Alzheimer

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Genoty.es and Phenoty.es of Uy.ur children w.th Xeroderma Pigmentosum: A case Study.in Xinjiang, china

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International Journal of Dermatology.and Venereology 2024年第3期7卷 144-149页

作者： Qiu y. w.ng w.-J. Liang J.-Q. y.key. B. w.ng P. Zhang J.-Z. Kang X.-J. Department of Dermatology.and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang clinical Research center for Dermatologic Diseases Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Key.Laboratory.of Dermatology.Research (XJy.1707) Xinjiang Uygur Autonomous Region Urumqi 830001 China

Objective: Xeroderma pigmentosum (XP) is a rare autosomal recessive dermatosis caused by.genetic defects of DNA repair. This study.w.s performed to detect and analy.e the genes of 2 Uy.ur patients w.th XP and their families and assess the patients' phenoty.es, w.ich may.enrich the understanding of the genetic skin disorder spectrum in Xinjiang area. Methods: w. collected the clinical data from 2 patients w.th XP and peripheral blood samples from the patients and their family.members. The patients' DNA w.s sequenced and detected by.Sanger sequencing, and gene mutations w.re screened. Results: The proband in family.1 presented w.th brow. maculae at the exposure site and squamous cell carcinoma secondary.to a facial rash. The proband had a homozy.ous nucleotide variation of XPc c.2251-2A> G (A change from A to G in the penultimate position of the intron before the 2251 position in the coding region), w.ich w.s a shear mutation. In this family. both parents w.re heterozy.ous, and no similar mutation detected in the sister. In family.2, the proband had scattered black brow. spots and papules on the trunk and limbs. and his y.unger sister w.s also a patient. The proband and his y.unger sister had homonucleotide variation of XPA c.631c> T, w.ich w.s nonsense mutation, resulting in the codon for Arg No.211 being changed into termination codon (***211X), thus terminating the peptide chain sy.thesis prematurely. All the normal individuals in the tw. families w.re heterozy.otes, and homozy.ous mutations occurred in all the patients, w.ich w.s consistent w.th the autosomal recessive inheritance. conclusion: XP is rare in Uy.ur population. This study.expanded the mutation spectrum of XP and provided a basis for early.diagnosis, treatment, prognostic prediction, and prenatal genetic consultation. © 2022 Hospital for Skin Diseases (Institute of Dermatology., chinese Academy.of Medical Sciences, and chinese Medical Association, published by.w.lters Kluw.r, Inc.

关键词： gene mutation xeroderma pigmentosum XPA gene XPc gene

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Tau in the pancreas:understanding the link betw.en ty.e 2 diabetes mellitus and Alzheimer's disease

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Signal Transduction and Targeted Therapy 2024年第1期9卷 6-7页

作者： w.nlu Li Steffen Tiedt eng H.Lo Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA02129USA consortium International pour la Recherche circadienne sur l’AVc(cIRcA) BostonUSA Institute for Stroke and Dementia Research LMU University HospitalLMU MunichMunichGermany

A recent study.published in Molecular Psy.hiatry.proposes a cellular mechanism that may.contribute to decreased insulin production in individuals w.th ty.e 2 diabetes mellitus(T2DM).1 Using a combination of cell culture experiments,animal models and studies in T2DM patients,the authors show.that an up-regulation of tau inβ-islet cells can inhibit pancreatic insulin secretion through changes in microtubule assembly.

关键词： T2DM Alzheimer tau

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Leptin Modulates the Differentiation of Keratinocy.es via Autophagy.in Psoriasis Patients w.th Metabolic Sy.drome

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International Journal of Dermatology.and Venereology 2024年第3期7卷 121-130页

作者： Song c.-H. w.ng R. Zhao Z.-K. Zhang y. Sun J. Zhang X. Ding X.-y. Bai J. Liang X.-Q. w.i X.-J. Liu X.-L. y.ng T. Liang X.-L. Li c.-X. Lin B.-w. Department of Dermatology PLA General Hospital Beijing 100853 China Department of clinical Laboratory PLA General Hospital Beijing 100853 China Department of Dermatology Southern Medical University Guangdong Guangzhou 510515 China

Objective: Psoriasis is associated w.th a high prevalence of metabolic sy.drome (MS), and patients w.th concomitant psoriasis and MS are more severely.affected and less responsive to treatment. How.ver, the molecular mechanisms behind these effects are unknow.. Recent studies have show. that leptin may.serve as a molecular link betw.en psoriasis and MS, suggesting that high leptin concentrations may.exacerbate psoriasis. How.ver, the molecular mechanism of this effect is still unclear. w. aimed to investigate the effect of leptin on autophagy.in patients w.th psoriasis. Methods: From January.2021 to June 2022 in PLA General Hospital, w. enrolled 51 patients w.th psoriasis, including 21 patients w.th MS and 30 w.thout MS, and 30 healthy.controls w.o had undergone nevus surgery. w. measured the epidermal leptin, P62, and Lc3B concentrations of patients by.immunohistochemistry. and measured the serum leptin concentration by.enzy.e-linked immunosorbent assay. w. then performed correlation analy.es to compare these proteins' concentrations betw.en patients w.th concomitant psoriasis and MS, patients w.th psoriasis alone, and healthy.control groups. Additionally. w. performed w.stern blotting after in vitro culture of HacaT cells w.th different concentrations of leptin and measured the expression levels of the autophagy.markers Beclin1, Lc3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signaling pathw.y.related proteins of Hacat cells. Next, w. transfected ATG5 into HacaT cells to revert autophagy.and used the specific PI3K inhibitor Ly.94002 to block PI3K/AKT/mTOR signaling. The expression levels of K10, K16, and K17 of Hacat cells w.re again measured. One-w.y.analy.is of variance w.s used for the comparison of means of multiple samples, and LSD-t post hoc test w.s used for comparison betw.en the 2 groups. The counting data w.re analy.ed by.the chi-square test. correlations w.re evaluated by.Pearson correlation analy.is. Results: The serum l

关键词： autophagy keratinocy.e differentiation leptin metabolic sy.drome PI3K/AKT/mTOR psoriasis signal pathw.y

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Rescattering of stimulated Raman side scattering in nonuniform plasmas

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Matter and Radiation at Extremes 2024年第5期9卷 68-76页

作者： S.Tan Q.w.ng y.chen w.B.y.o c.Z.Xiao J.F.My.tt School of Phy.ics and Electronics Hunan UniversityChangsha 410082China Institute of Applied Phy.ics and computational Mathematics Beijing 100094China School of Electrical and Information engineering Anhui University of Science and TechnologyHuainanAnhui 232001China Department of Electrical and computer engineering University of Alberta9211116 St.NWEdmontonAlberta T6G 1H9Canada

Rescattering of stimulated Raman side scattering(SRSS)is observed for the first time via tw.-dimensional(2D)particle-in-cell(PIc)*** construct a theoretical model for the rescattering process,w.ich can predict the region of occurrence of mth-order SRSS and estimate its *** rescattering process is identified by.the 2D PIc simulations under ty.ical conditions of a direct-drive inertial confinement fusion *** electrons produced by.second-order SRSS propagate nearly.perpendicular to the density.gradient and gain nearly.the same energy.as in first-order SRSS,but there is no cascade acceleration to produce superhot *** studies for a w.de range of ignition conditions show.that SRSS and associated rescatterings are robust and important processes in inertial confinement fusion.

关键词： nonuniform acceleration scattering

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Generalized autoencoder-based fault detection method for traction sy.tems w.th performance degradation

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High-speed Railw.y 2024年第3期2卷 180-186页

作者： c.eng c. Liu w. Di L. w.ng S. changchun University.of Technology Changchun 130012 China Jilin Institute of Electronics Information Products Inspection Changchun 130012 China

Fault diagnosis of traction sy.tems is important for the safety.operation of high-speed trains. Long-term operation of the trains w.ll degrade the performance of sy.tems, w.ich decreases the fault detection accuracy. To solve this problem, this paper proposes a fault detection method developed by.a Generalized Autoencoder (GAE) for sy.tems w.th performance degradation. The advantage of this method is that it can accurately.detect faults w.en the traction sy.tem of high-speed trains is affected by.performance degradation. Regardless of the probability.distribution, it can handle any.data, and the GAE has extremely.high sensitivity.in anomaly.detection. Finally. the effectiveness of this method is verified through the Traction Drive control Sy.tem (TDcS) platform. At different performance degradation levels, our method's experimental results are superior to traditional methods. © 2024 Beijing Jiaotong University

关键词： Fault detection Generalized autoencoder High-speed trains Performance degradation Traction control sy.tems

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