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on cal.ul.ting gl.cial.is.s.atic adjus.ment

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Geodes.0}and Geody.amics 2024年第5期15卷 441-452页

作者： l.M.Cathl.s Cornel. Univers.ty IthacaNY 14853USA

Model.ng the earth's.fl.id and el.s.ic res.ons. to the mel.ing of the gl.ciers.of the l.s. ice age is.the mos. direct w.y.to infer the earth's.radial.vis.os.ty.***,w. compare tw. methods.for cal.ul.ting the vis.oel.s.ic res.ons. to s.rface *** one,the el.s.ic equation of motion is.converted to a vis.oel.s.ic equation us.ng the Corres.ondence *** the other,el.s.ic deformation is.added to the vis.ous.fl.w.as.is.s.atic adjus.ment *** tw. model.ng methods.predict adjus.ment his.ories.that are different enough to potential.y.impact the interpretation of the obs.rved gl.cial.is.s.atic adjus.ment(GIA).The differences.aris. from buoy.ncy.and w.ether fl.id dis.l.cements.are s.bjected to hy.ros.atic *** methods.agree if they.us. the s.me equations.and boundary.*** origin of the differences.is.determined by.vary.ng the boundary.conditions.and pre-s.res. appl.cation.

关键词： Gl.cial.is.s.atic adjus.ment Vis.oel.s.ic normal.modes Hy.ros.atic pre-s.res. El.s.ic buoy.ncy Corres.ondence principl.

Expl.ring the effects.of taurol.dine on tumor w.ight and microves.el.dens.ty.in a murine model.of os.eos.rcoma

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oncol.gy.Res.arch 2024年第7期32卷 1163-1172页

作者： l.s.NNE K.A.NEIJENHUIs.l.UTA l.NAUMANN s.NIA A.M.FERKEl.s.MUEl.J.s.RUBIN s.EPHAN RoGAl.A Divis.on of Gas.roenterol.gy.and Hepatol.gy Department of MedicineSchool of MedicineStanford UniversityStanford94305USA Department of s.rgery Leiden University Medical CenterLeiden2333 ZAThe Netherlands Centre for Human Drug Res.arch Leiden2333 CLThe Netherlands Department of General VisceralVascular and Thoracic SurgeryCharite University Medicine BerlinBerlin10117Germany

Background:os.eos.rcoma is.the mos. common mal.gnant primary.bone *** prognos.s.for patients.w.th dis.eminated dis.as. remains.very.poor des.ite recent advancements.in ***,current treatment regimens.bear a s.gniﬁcant ris. of s.rious.s.de ***,there is.an unmet cl.nical.need for effective therapies.w.th improved s.fety.proﬁ*** is.an antibacterial.agent that has.been s.ow. to induce cel. death in different ty.es.of cancer cel. ***:In this.s.udy.w. examined both the antineopl.s.ic and antiangiogenic effects.of taurol.dine in animal.model.0}of os.eos.rcoma.K7M2 murine os.eos.rcoma cel.s.w.re injected,both intramus.ul.r and intraperitoneal.into 60 BAl./c mice on day.*** w.re then randomized to receive treatment w.th taurol.dine 2%(800 mg/kg),taurol.dine 1%(400 mg/kg),or NaCl.0.9%control.for s.ven day. by.intravenous.or intraperitoneal.***:After 35 day.,mice w.re euthanized,and the tumors.w.re harves.ed for *** mice w.re excl.ded from the anal.4}is.due to *** w.ight w.s.s.gniﬁcantl.4}l.w.r in the 2%taurol.dine intraperitoneal.treatment group from day.9 to 21,cons.s.ent w.th el.vated mortal.ty.in this.*** tumor w.ight w.s.s.gniﬁcantl.4}l.w.r in the 1%(p=0.003)and 2%(p=0.006)intraperitoneal.taurol.dine treatment groups.compared to the *** antineopl.s.ic effects.w.re obs.rved on intramus.ul.r tumors.or for intravenous.adminis.ration of *** w.re no s.gniﬁcant differences.in microves.el.dens.ty.or mitotic rate betw.en treatment *** body.w.ight and el.vated mortal.ty.in the 2%taurol.dine intraperitoneal.group s.gges. that the l.w.r 1%dos. is.***:In concl.s.on,there is.no evidence of antiangiogenic activity.and the antitumor effects.of taurol.dine on os.eos.rcoma obs.rved in this.s.udy.are ***,its.toxic proﬁl. grants.further *** thes. obs.rvations.further res.arch is.neces.ary.to

关键词： os.eos.rcoma Taurol.dine Cancer treatment Chemotherapy Murine model.

Ground-s.ate mas. of ^(22)Al.and tes. of s.ate-of-the-art ab initio cal.ul.tions

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Chines. Phy.ics.C 2024年第3期48卷 72-78页

作者：孙铭泽于越王新鹏王猛李健国张玉虎 K.Bl.um 陈祖毅陈瑞九邓涵宇付超义葛文文黄文嘉焦红扬李红蕙李宏福罗胤芳廖挺 y.Al.tvinov 司敏帅鹏史金阳王茜邢元明徐星徐瑚珊许甫荣袁琪 T.y.maguchi 颜鑫亮杨建成原有进周小红周旭张敏曾奇 CAs.Key.l.boratory.of High Precis.on Nucl.ar s.ectros.opy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China s.hool.of Nucl.ar s.ience and Technol.gy University of Chinese Academy of SciencesBeijing 100049China Max-Pl.nck-Ins.itut für Kernphy.ik Saupfercheckweg 169117 HeidelbergGermany Gs. Hel.hol.zzentrum für s.hw.rionenfors.hung Planckstraße 164291 DarmstadtGermany Advanced Energy.s.ience and Technol.gy.Guangdong l.boratory Huizhou516007China s.ate Key.l.boratory.of Nucl.ar Phy.ics.and Technol.gy School of PhysicsPeking UniversityBeijing 100871China Department of Phy.ics Saitama UniversitySaitama 338-8570Japan s.hool.of Nucl.ar s.ience and Engineering East China University of TechnologyNanchang 330013China

The ground-s.ate mas. exces. of the T_(z)=−2 drip-l.ne nucl.us.^(22)Al.is.meas.red for the firs. time as.18103(10)keV us.ng the new.y.devel.ped Bρ-defined is.chronous.mas. s.ectrometry.method at the cool.r s.orage ring in *** new.mas. exces. val.e al.ow.d us.to determine the excitation energies.of the tw. l.w.l.10}ng 1+s.ates.in ^(22)Al.w.th s.gnificantl.10}reduced uncertainties.of 51 *** compared to the anal.gue s.ates.in its.mirror nucl.us.^(22)F,the mirror energy.differences.of the tw. 1^(+)s.ates.in the ^(22)Al.^(22)F mirror pair are determined to be−625(51)keV and−330(51)*** excitation energies.and mirror energy.differences.are us.d to tes. the s.ate-of-the-art ab initio val.nce-s.ace in-medium s.mil.rity.renormal.zation group cal.ul.tions.w.th four s.ts.of interactions.derived from the chiral.effective fiel. *** mechanis. l.ading to the l.rge mirror energy.differences.is.inves.igated and attributed to the occupation of theπs.(1/2) orbital.

关键词： nucl.ar mas. Bρ-defined IMs mirror energy.difference ab initio Vs.IMs.G cal.ul.tions chiral.interactions

Hy.rothermal.carbonization of l.ves.ock mortal.ty.for the reduction of pathogens.and microbial.y.derived DNA

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Frontiers.of Environmental.s.ience & Engineering 2017年第3期11卷 107-114页

作者： Thomas.F. Ducey.Jes.ica C. Col.ins.Ky.ung s. Ro Bry.n l. w.odbury.D. Dee griffin Coas.al.Pl.ins.s.il Water and Plant Research Center Agricultural Research Service United States Department of Agriculture Florence SC 29501 USA s.uth Carol.na Governor's.s.hool.for s.ience and Mathematics Hartsville SC 29550 USA U.s. Meat Animal.Res.arch Center Agricultural Research Service United States Department of Agriculture Clay Center NE 68933 USA Univers.ty.of Nebras.a-l.ncol. Great Plains Veterinary Education Center Lincoln NE 68588 USA

Hy.rothermal.carbonization （HTC）, util.zing high temperature and pres.ure, has.the potential.to treat agricul.ural.w.s.e via inactivating pathogens. antibiotic res.s.ance genes.（ARG）, and contaminants.of emerging concern （CEC） in a environmental.and economical.manner. l.ves.ock mortal.ty.is.one facet of agricul.ural.w.s.e that can pos. a threat to the s.rrounding environment. w.il. s.veral.methods.are util.zed to treat l.ves.ock mortal.ty. there remains.a paucity.of data on the el.mination of microbial.y. derived DNA in thes. treatment practices. This.DNA, mos. notabl.0}ARGs. if it s.rvives.treatment can be reintroduced in agricul.ural.environments.w.ere it coul. potential.y.be pas.ed to pathogens. pos.ng a ris. to animal.and human popul.tions. HTC treatments.have been s.cces.ful.y.util.zed for the treatment of CECs. how.ver very.l.ttl. is.unders.ood on how.ARGs.s.rvive HTC treatment. This.s.udy.aims.to fil. this.know.edge gap by.examining the s.rvivabil.ty.ofmicrobial.y.derived DNA in the HTC treatment of l.ves.ock mortal.ty. w. examined three treatment temperatures.（100℃, 150℃, and 200℃） at autogenic pres.ures.at three treatment times.（30, 60, and 240 min）. w. examined the ampl.fication of a pl.s.id-bome reporter gene carried by.Es.herichia col. DH 10B introduced to both beef bone and tis.ue. Res.l.s.indicate that w.il. al. three temperatures. at al. treatment times. w.re s.itabl. for compl.te pathogen kil., onl.0}temperatures.of 150℃ and 200℃ w.re s.fficient for el.minating microbial.DNA. Thes. res.l.s.s.rve as.the bas.s.for future potential.HTC treatment recommendations.for l.ves.ock mortal.ty.w.en cons.dering the el.mination of pathogens.and ARGs.

关键词： High-temperature carbonization Microbial.DNA l.ves.ock mortal.ty

Fuzzy.Difference Equations.in Diagnos.s.of Gl.ucoma from Retinal.Images.Us.ng Deep l.arning

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Computer Model.ng in Engineering & s.iences 2024年第4期139卷 801-816页

作者： D.Dorathy.Prema Kavitha l.Francis.Raj s.ndeep Kautis. Abdul.ziz s.Al.azy.d Karam M.s.l.am Al. w.gdy.Mohamed Department of Mathematics Voorhees CollegeVelloreTamil NaduIndia Chandigarh Group of Col.eges JhanjeriMohaliPunjabIndia Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Facul.y.of s.ience and Technol.gy School of IT and SystemsUniversity of CanberraCanberraAustralia operations.Res.arch Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Appl.ed s.ience Res.arch Center Applied Science Private UniversityAmman11937Jordan

The intuitive fuzzy.s.t has.found important appl.cation in decis.on-making and machine *** enrich and util.ze the intuitive fuzzy.s.t,this.s.udy.des.gned and devel.ped a deep neural.netw.rk-bas.d gl.ucoma ey. detection us.ng fuzzy.difference equations.in the domain w.ere the retinal.images.*** image detections.are categorized as.normal.ey. recognition,s.s.ected gl.ucomatous.ey. recognition,and gl.ucomatous.ey. *** degrees.as.ociated w.th w.ighted val.es.are cal.ul.ted to determine the l.vel.of concentration betw.en the fuzzy.partition and the retinal.*** propos.d model.w.s.us.d to diagnos. gl.ucoma us.ng retinal.images.and invol.ed util.zing the Convol.tional.Neural.Netw.rk(CNN)and deep l.arning to identify.the fuzzy.w.ighted regul.rization betw.en *** methodol.gy.w.s.us.d to cl.rify.the input images.and make them adequate for the proces. of gl.ucoma *** objective of this.s.udy.w.s.to propos. a novel.approach to the earl.0}diagnos.s.of gl.ucoma us.ng the Fuzzy.Expert s.0}tem(FEs.and Fuzzy.differential.equation(FDE).The intens.ties.of the different regions.in the images.and their res.ective peak l.vel.1}w.re *** the peak regions.w.re identified,the recurrence rel.tions.ips.among thos. peaks.w.re then *** partitioning w.s.done due to vary.ng degrees.of s.mil.r and dis.imil.r concentrations.in the *** and dis.imil.r concentration l.vel.1}and s.atial.frequency.generated a thres.ol. image from the combined fuzzy.matrix and *** dis.inguis.ed betw.en a normal.and abnormal.ey. condition,thus.detecting patients.w.th gl.ucomatous.ey.s.

关键词： Convol.tional.Neural.Netw.rk(CNN) gl.ucomatous.ey.s fuzzy.difference equation intuitive fuzzy.s.ts image s.gmentation retinal.images

Hitchhiker＇s.guide to genetic divers.ty.in s.cial.y.s.ructured popul.tions

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Current Zool.gy 2012年第2期58卷 287-297页

作者： l. s. PREMo Department of Anthropol.gy Washington State University Pullman WA 99164-4910 USA Department of Human Evol.tion Max Planck Institute for Evolutionary Anthropology 04103 Leipzig Germany

w.en s.l.ction increas.s.the frequency.of a beneficial.gene s.bs.itution it can al.1} increas. the frequencies.of l.nked neutral.al.el.s.through a proces. cal.ed genetic hitchhiking. A model.buil. to inves.igate reduced genetic divers.ty.in Pl.is.ocene hominins.s.ow.0}that genetic hitchhiking can have a s.rong effect on neutral.divers.ty.in the pres.nce of cul.ural.y.mediated mi- gration. Under conditions.in w.ich genetic and cul.ural.variants.are trans.itted s.0}metrical.y. neutral.genes.may.al.1} hitchhike to higher frequencies.on the coattail.1}of adaptive cul.ural.traits.through a proces. cal.ed cul.ural.hitchhiking. Cul.ural.hitchhiking has.been propos.d to expl.in w.y.s.me s.ecies.of matril.neal.w.al.s.dis.l.y.rel.tivel.4}l.w.l.vel.1}of mitochondrial.DNA diver- s.ty. and it may.be appl.cabl. to humans.as.w.l.. This.paper provides.a critical.review.of recent model.1}of both ty.es.of hitch- hiking in s.cial.y.s.ructured popul.tions. The model.1} as.umptions.and predictions.are compared and dis.us.ed in the hope that s.udies.of reduced genetic divers.ty.in humans.might improve our unders.anding of reduced genetic divers.ty.in other s.ecies. and vice vers.

关键词： Cul.ural.group s.l.ction Cul.ural.hitchhiking Cul.ural.y.mediated migration Divers.ty Evol.tion Genetic hitch- hiking

Novel.ins.ghts.into D-Pinitol.bas.d therapies.a l.nk betw.en tau hy.erphos.hory.ation and ins.l.n res.s.ance

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Neural.Regeneration Res.arch 2024年第2期19卷 289-295页

作者： Dina Medina-Vera Antonio Jes.s.l.pez-Gambero Juan Antonio Navarro Carl.s.s.njuan El.na Baixeras.Juan Decara Fernando Rodríguez de Fons.ca Ins.ituto de Inves.igación Biomédica de Mál.ga y.Pl.taforma en Nanomedicina-IBIMA Pl.taforma BIoNAND UGC Salud MentalMálagaSpain Facul.ad de Ciencias Universidad de MálagaMálagaSpain CIBER Enfermedades.Cardiovas.ul.res.CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain Univers.ty.of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra s.l.Cal.e Johannes.Kepl.r MálagaSpain Departamento de Bioquímica y.Biol.gía Mol.cul.r Facultad de MedicinaUniversidad de MálagaMálagaSpain

Al.heimer’s.dis.as. is.a neurodegenerative dis.rder characterized by.the amy.oid accumul.tion in the brains.of patients.w.th Al.heimer’s.*** pathogenes.s.of Al.heimer’s.dis.as. is.mainl.5}mediated by.the phos.hory.ation and aggregation of tau *** the mul.ipl. caus.s.of tau hy.erphos.hory.ation,brain ins.l.n res.s.ance has.generated much attention,and inos.tol.0}as.ins.l.n s.ns.tizers.are currentl.5}cons.dered candidates.for drug *** pres.nt narrative review.revis.s.the interactions.betw.en thes. three el.ments.Al.heimer’s.dis.as.-tau-inos.tol.0}w.ich can eventual.y.identify.targets.for new.dis.as. modifiers.capabl. of bringing hope to the mil.ions.of peopl. affected by.this.devas.ating dis.as..

关键词： Al.heimer’s.dis.as. cy.l.n-dependent kinas. 5 diabetes D-Pinitol inos.tol. ins.l.n res.s.ance kinas.s phos.hory.ation PI3K/Akt tau

Effect of Ta_(2)o_(5)nanoparticl.s.on bioactivity.compos.tion,s.ructure,in vitro and in vivo behavior of PEo coatings.on Mg-al.oy

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Journal.of Magnes.um and Al.oy. 2024年第6期12卷 2360-2379页

作者： D.V.Mas.tal.1}r I.M.Ims.inets.iy.V.V.Kas.epa K.V.Nadaraia M.A.Piatkova A.I.Pl.s.kova K.A.Fomenko A.y..Us.inov s.l.s.nebry.khov s.V.Gnedenkov Ins.itute of Chemis.ry Far Eastern BranchRussian Academy of SciencesVladivostok690022Russia Far Eas.ern Federal.Univers.ty Vladivostok690950Russia Regional.Cl.nical.Dermatovenerol.gical.Dis.ens.ry Vladivostok690033Russia

The pres.nt s.udy.inves.igates.the phy.ical.and chemical.characteris.ics.behavior in vitro and in vivo,and biocompatibil.ty.of coatings.containing Ta_(2)o_(5),w.ich are obtained by.pl.s.a el.ctrol.2}ic oxidation(PEo)on MA8 magnes.um *** obtained coatings.demons.rate in vivo biocompatibil.ty.and in vitro *** to the bas. PEo coating,the l.y.rs.containing Ta_(2)o_(5)facil.tate the devel.pment of apatite in s.mul.ted body.fl.id,s.gges.ing that the incl.s.on of nanoparticl.s.improves.bioactivity.of the *** w.s.found that incorporation of Ta_(2)o_(5)nanoparticl.s.increas.s.roughnes. and poros.ty.of the formed l.y.rs.by.increas.ng particl. concentration in el.ctrol.2}es.for the PEo proces. contributing to s.fficient s.ft tis.ue ingrow.h in *** on in vivo s.udies.thes. coatings.al.0} provide favorabl. tis.ue res.ons. and minimal.infl.mmatory.reaction in comparis.n w.th the bare magnes.um al.oy.due to protection of l.ving tis.ues.from del.terious.corros.on events.of magnes.um impl.nt s.ch as.l.cal.al.al.zation and intens. hy.rogen *** res.l.s.obtained in the pres.nt s.udy.concl.ded biocompatibil.ty.tis.ue integration of the PEo coatings.containing Ta_(2)o_(5)nanoparticl.s.making them a promis.ng protective l.y.r for biodegradabl. magnes.um impl.nts.

关键词： Pl.s.a el.ctrol.1}ic oxidation Bioactive coatings Tantal.m pentoxide s.mul.ted body.fl.id(s.F) Apatite formation His.ol.gy

Engineering hy.l.ronic acid-bas.d nanoas.embl.es.for monocl.nal.antibody.del.very.des.gn,characterization,and biol.gical.ins.ghts

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Nano Res.arch 2024年第10期17卷 9111-9125页

作者： Ana M.l.pez-Es.évez y.Zhang María Medel.Iker Arriaga l.cía s.njurjo Cris.ian Huck-Iriart Nicol. G.A.Abres.ia María J.Vicent Defang ouy.ng Dol.res.Torres.María Jos. Al.ns. Center for Res.arch in Mol.cul.r Medicine and Chronic Dis.as.s.CiMUs. University of Santiago de CompostelaSantiago de Compostela 15782Spain Department of Pharmacol.gy Pharmacy and Pharmaceutical TechnologySchool of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Heal.h Res.arch Ins.itute of s.ntiago de Compos.el.(IDIs. Santiago de Compostela 15782Spain s.ate Key.l.boratory.of Qual.ty.Res.arch in Chines. Medicine Institute of Chinese Medical Sciences(ICMS)University of MacaoMacao 999078China Pol.0}er Therapeutics.l.boratory.and CIBERoNC Prince Fel.pe Res.arch Centre Valencia E-46012Spain s.ructure and Cel. Biol.gy.of Virus.s.l.b CIC bioGUNEBasque Research and Technology Alliance(BRTA)Derio 48160Spain Al.A s.0}chrotron l.ght s.urce Experiments DivisionCerdanyola del VallèsBarcelona 08290Spain IKERBAs.UE Basque Foundation for ScienceBilbao 48009Spain

The current s.otl.ght of cancer therapeutics.is.s.ifting tow.rds.pers.nal.zed medicine w.th the w.des.read us. of monocl.nal.antibodies.mAbs..Des.ite their increas.ng potential.mAbs.have an intrins.c l.mitation rel.ted to their inabil.ty.to cros. cel. membranes.and reach intracel.ul.r *** offers.promis.ng s.l.tions.to overcome this.l.mitation,how.ver,formul.tion chal.enges.*** chal.enges.are the l.mited l.ading capacity.often ins.fficient to achieve cl.nical.dos.ng),the compl.x formul.tion methods.and the ins.fficient characterization of mAb-l.aded ***,w. pres.nt a new.nanocarrier cons.s.ing of hy.l.ronic acid-bas.d nanoas.embl.es.HANAs.s.ecifical.y.des.gned to entrap mAbs.w.th a high efficiency.and an outs.anding l.ading capacity.50%,w.w..HANAs.compos.d by.an mAb,modified HA and phos.hatidy.chol.ne(PC)res.l.ed in s.zes.of~100 nm and neutral.s.rface *** model.ng identified the principal.factors.governing the high affinity.of mAbs.w.th the amphiphil.c HA and *** compos.tion and s.ructural.configuration w.re anal.17}ed us.ng the orthogonal.techniques.cry.genic trans.is.ion el.ctron micros.opy.cry.-TEM),as.0}metrical.fl.w.fiel.-fl.w.fractionation(AF4),and s.al.-angl. X-ray.s.attering(s.Xs..Thes. techniques.provided evidence of the formation of core-s.el. nanos.ructures.compris.ng an aqueous.core s.rrounded by.a bil.y.r cons.s.ing of phos.hol.pids.and amphiphil.c *** vitro experiments.in cancer cel. l.nes.and macrophages.confirmed HANAs.l.w.toxicity.and abil.ty.to trans.ort mAbs.to the intracel.ul.r *** reproducibil.ty.of this.as.embl.ng proces. at indus.rial.s.al. batch s.zes.and the l.ng-term s.abil.ty.w.s.*** concl.s.on,thes. res.l.s.unders.ore the s.itabil.ty.of HANAs.technol.gy.to l.ad and del.ver biol.gical.0}w.ich hol.s.promis. for future cl.nical.trans.ation.

关键词： monocl.nal.antibody nanoparticl.s hy.l.ronic acid characterization particl. s.ze computational.model.ng