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Simple procedure for assessing diffuse subarachnoid hemorrhage successfully.created using filament perforation method in mice

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Animal Models and Experimental Medicine 2024年第1期7卷 77-81页

作者： Tatsushi Mutoh Ry.ta Tochinai Hiroaki Aono Masay.shi kuwahara y.suy.ki Taki Tatsuy. Ishikawa Department of Surgical Neurology Research Institute for Brain and Blood VesselsAkita Cerebrospinal and Cardiovascular CenterAkitaJapan Department of Aging Research and Geriatric Medicine Institute of DevelopmentAging and CancerTohoku UniversitySendaiJapan Department of Veterinary.Pathophy.iology.and Animal Health Graduate School of Agriculture and Life SciencesThe University of TokyoTokyoJapan

The murine model of subarachnoid hemorrhage(SAH)is a valuable experimental tool for investigating molecular and cellular mechanisms,and the endovascular filament perforation technique can be used to simulate prominent pathophy.iological features observed after human SAH;however,current validation methods for assessing an appropriate SAH model are ***,we introduce a simple procedure for se-lecting a mouse model of diffuse *** was induced in 24 mice using a standard filament perforation *** confirming survival at 24 h,SAH was scored 0-1 based on T2*-weighted images on whole-brain magnetic resonance imaging(MRI)and visual surveillance of the cisterna magna(CM)through the dura *** CM-based SAH grading correlated well with a reference parameter defined by.extracted brain(r^(2)=0.53,py.of 85%and a specificity.of 91%for detecting diffuse SAH,with a similar area under the curve(0.89±0.06[standard error of the mean])as the MRI-based grading(0.72±0.10,p=0.12).Our data suggest that confirming an SAH clot in the CM is a valuable way.to select a clinically.relevant diffuse SAH model that can be used in future experimental studies.

关键词： cisterna magna clot distribution filament perforation mouse model subarachnoid hemorrhage

A preliminary.study.on rectal dose reduction associated with hy.luronic acid implantation in brachy.herapy.for prostate cancer

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Asian Journal of Urology 2024年第2期11卷 286-293页

作者： Tairo Kashihara y.ka Urago Hiroy.ki Okamoto Mihiro Takemori Hiroki Nakay.ma Shohei Mikasa Tetsu Nakaichi Kotaro Iijima Takahito Chiba Junichi kuwahara Satoshi Nakamura Weishan Chang y.shiy.ki Matsui Hiroshi Igaki Department of Radiation Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Radiation Safety.and Quality.Assurance Division National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Department of Radiological Sciences Graduate School of Human Health SciencesTokyo Metropolitan University7-2-10 Higashi-OguArakawa-kuTokyoJapan Department of Radiological Technology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Department of Urological Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan

Objectives: Hy.rogel spacer (HS) was developed to reduce rectal toxicities caused by.radiotherapy. but has been reported to cause major adverse events. Our institute has attempted to introduce a hy.luronic acid (HA) as an alternative spacer. This study.aimed to compare rectal doses and geometric distributions between the HS and HA implantation in prostate ***: HS and HA were inserted in 20 and 18 patients undergoing high-dose brachy.herapy. respectively. The rectum spacer volumes injected were 10 mL and 22 mL, respectively. In the treatment planning sy.tem, 13.5 Gy.was administered with common catheter positions. The rectal dose indices were assessed between the spacer groups for dosimetry.evaluation. Distances between the prostate and rectum and configurations of the spacers were ***: The mean doses irradiated to 0.1 and 2 mL of the rectum were 10.45 Gy.and 6.71 Gy.for HS, and 6.73 Gy.and 4.90 Gy.for HA (py.(py.to expand the space than ***: The rectal dose reduction ability.of HA is significantly.greater than that of HS, suggesting its potential as a new spacer.

关键词： Brachy.herapy Hy.luronicacid Hy.rogel Prostaticneoplasm Radiotherapy

Ru complex and N,P-containing poly.ers confined within mesoporous hollow carbon spheres for hy.rogenation of CO_(2)to formate

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Nano Research 2023年第4期16卷 4515-4523页

作者： Guoxiang y.ng y.sutaka kuwahara Kohsuke Mori Catherine Louis Hiromi y.mashita Division of Materials and Manufacturing Science Graduate School of EngineeringOsaka University2-1 Yamada-okaSuitaOsaka 565-0871Japan Institute for Open and Transdisciplinary.Research Initiatives(OTRI) Osaka University2-1 Yamada-okaSuitaOsaka 565-0871Japan Unit of Elements Strategy.Initiative for Cataly.ts&Batteries(ESICB) Kyoto UniversityKatsuraKyoto 615-8520Japan JST PRESTO4-1-8 HonchoKawaguchiSaitama 332-0012Japan Sorbonne Université CNRSLaboratoire de Réactivitéde SurfaceLRSF-75005 ParisFrance

The development of reliable cataly.ts with both excellent activity.and recy.lability.for carbon dioxide(CO_(2))hy.rogenation is ***,a ternary.hy.rid heterogeneous cataly.t,involving mononuclear Ru complex,N,P-containing porous organic poly.ers(POPs),and mesoporous hollow carbon spheres(Ru^(3+)-POPs@MHCS)is reported for CO_(2)hy.rogenation to *** on comprehensive structural analy.es,we demonstrated that Ru^(3+)-POPs were successfully.immobilized within *** optimized Ru^(3+)-0.5POPs@MHCS cataly.t,which was obtained with about 5 wt.%Ru^(3+)and 0.5 mmol POPs poly.ers confined into 0.3 g MHCS,exhibited high cataly.ic activity.for CO_(2)hy.rogenation to formate(turnover number(TON)>1,200 for 24 h under mild reaction conditions(4.0 MPa,120℃))and improved durability.compared to Ru^(3+)cataly.ts without POPs poly.ers(Ru^(3+)-MHCS)and unencapsulated MHCS(Ru^(3+)-0.5POPs)*** improved cataly.ic performance is attributed to the high surface area and large pore volume of MHCS which favors dispersion and stabilization of Ru^(3+)-***,the MHCS and POPs showed high CO_(2)adsorption ***^(3+)-POPs encapsulated into MHCS reduces the activation energy.barrier for CO_(2)hy.rogenation to formate.

关键词： heterogeneous cataly.is porous organic poly.ers(POPs) mesoporous hollow carbon spheres CO_(2)hy.rogenation formate sy.thesis

On the horizon:Hedgehog signaling to heal broken bones

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Bone Research 2022年第1期10卷 20-30页

作者： Stephanie T.kuwahara Shuwan Liu Andrew Chareunsouk Maxwell Serowoky.Francesca V.Mariani University.of Southern California Keck School of MedicineDepartment of Stem Cell Biology and Regenerative MedicineLos AngelesCA 90033USA

Uncovering the molecular pathway. that drive skeletal repair has been an ongoing challenge. Initial efforts have relied on in vitro assay. to identify.the key.signaling pathway. that drive cartilage and bone differentiation. While these assay. can provide some clues, assessing specific pathway. in animal models is critical. Furthermore, definitive proof that a pathway.is required for skeletal repair is best provided using genetic tests. Stimulating the Hh(Hedgehog) pathway.can promote cartilage and bone differentiation in cell culture assay.. In addition, the application of HH protein or various pathway.agonists in vivo has a positive influence on bone healing. Until recently. however, genetic proof that the Hh pathway.is involved in bone repair has been lacking. Here, we consider both in vitro and in vivo studies that examine the role of Hh in repair and discuss some of the challenges inherent in their interpretation. We also identify.needed areas of study.considering a new appreciation for the role of cartilage during repair, the variety.of cell ty.es that may.have differing roles in repair, and the recent availability.of powerful lineage tracing techniques. We are optimistic that emerging genetic tools will make it possible to precisely.define when and in which cells promoting Hh signaling can best promote skeletal repair, and thus, the clinical potential for targeting the Hh pathway.can be realized.

关键词： healing Hedgehog horizon

Verbal Abuse, Phy.ical Assault, and Harassment in Pediatric Medical Settings: A Nationwide Survey.in Japan

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Health 2022年第2期14卷 177-193页

作者： Rie Wakimizu Hinako kuwahara Department of Child Health and Developmental Nursing Faculty of Medicine University of Tsukuba Ibaraki Japan Department of Nursing Toranomon Hospital Tokyo Japan

Background: Verbal abuse, phy.ical assault, and harassment of pediatric healthcare workers by.patients and their families have become increasingly.serious. These incidents lead to various problems, including the deterioration of staff members’ mental health and employ.e turnover. Methods: This study.was conducted as the first Japanese nationwide survey.to assess the abuse perpetrated by.patients and families and experienced by.medical staff in pediatric medical settings in 2018, countermeasures employ.d, and staff member evaluations of the countermeasures. Results: Responses from 526 facilities were received, clinics accounted for 79.8% of these facilities;88.1% of the respondents were females. Further, 10.5% of the facility.staff reported having experienced verbal abuse, violence, or harassment from patients or family.members. Of 1103 cases of victimizations, there were 719, 136, and 248 cases of verbal abuse, violence, and harassment, respectively. Manuals and guidelines had been created and training and drill performances were conducted as countermeasures in 10.7% and 9.0% of facilities, respectively.7.3% of staff members felt that the countermeasures were effective, corresponding to 45.6% of the affected staff. Conclusion: The findings suggest the necessity.of thoroughly.familiarizing staff with existing facility.countermeasures as well as introducing new countermeasures such as victimization simulations.

关键词： Verbal Abuse Phy.ical Assault Harassment Pediatric Medical Setting Countermeasures

Precipitate-Accommodated Plasma Nitriding for Aluminum Alloy.

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材料热处理学报 2004年第5期25卷 334-337页

作者： Patama Visittipitukul Tatsuhiko Aizawa Hidey.ki kuwahara Department of Metallurgical Engineering Chulalongkorn University Bangkok ThailandCenter for Collaborate Research University of Tokyo JapanResearch Institute for Applied Sciences Kyoto Japan

Reliable surface treatment has been explored to improve the strength and wear resistance of aluminum alloy.parts in automotives. Long duration time as well as long pre-sputtering time are required for plasma nitriding of aluminum or its alloy. only.with the thickness of a few micrometers. New plasma inner nitriding is proposed to realize the fast-rate nitriding of aluminum alloy.. Al-6Cu alloy.is employ.d as a targeting material in order to demonstrate the effectiveness of this plasma nitriding. Mechanism of fast-rate nitriding process is discussed with consideration of the role of Al2Cu precipitates.

关键词：等离子渗氮铝合金沉淀调节 Al2Cu

Development of a Training Textbook for Countermeasures to “Verbal Abuse, Phy.ical Assault, and Harassment in Pediatric Medical Settings”

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Health 2022年第1期14卷 63-69页

作者： Rie Wakimizu Hinako kuwahara y.miko Saito Makoto Saito Department of Child Health and Developmental Nursing Faculty of Medicine University of Tsukuba Ibaraki Japan Department of Nursing Toranomon Hospital Tokyo Japan Doctoral Program in Nursing Science Graduate School of Comprehensive Human Sciences University of Tsukuba Ibaraki Japan Department of Child Health Faculty of Medicine University of Tsukuba Ibaraki Japan

Background: Recently. abuse, assault, and harassment in pediatric medical settings have become more serious. We extracted ty.ical problems from a nationwide simultaneous survey.on abuse in the pediatric medical field and developed a training textbook to simulate or discuss these issues with colleagues. This study.aimed to confirm the validity.and usability.of the contents of this training textbook. Methods: The textbook was mailed to the heads of 51 medical institutions affiliated with the Society.of Ambulatory.and General Pediatrics of Japan (SAGPJ) and the participants of the SAGPJ online workshop, who were asked to evaluate the textbook using a three-point scale to answer the following questions and provide opinions and impressions about the textbook. Q1. Do y.u think the whole content and structure of this textbook are useful? Q2. Would y.u use this textbook as a training textbook for all staff at y.ur facility. A simple tabulation was performed on the evaluation using a three-point scale, while content analy.is was performed on the opinions and impressions of the participants. Results: In response to Q1 and Q2, all 63 staff members from 55 facilities answered “3: y.s.” Opinions and impressions on the training textbook included “I think it can be used for workplace training” and “it is useful for exchanging various opinions among staff members and gaining a common opinion.” Conclusion: We developed a training textbook on abuse, assault, and harassment in pediatric medical settings based on a nationwide survey.and confirmed the validity.and usability.of its contents.

关键词： Pediatric Safety.Management Textbook Validation Study Workplace Violence

Clinical impact of portal vein pulsatility.on the prognosis of hospitalized patients with acute heart failure

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World Journal of Cardiology 2023年第11期15卷 599-608页

作者： Naoy. kuwahara Tomoy.ki Honjo Naohiko Sone Junichi Imanishi Kazuhiko Nakay.ma Kohei Kamemura Masanori Iwahashi Soichiro Ohta Kenji Kaihotsu Department of Cardiology Shinko HospitalKobe 651-0072Japan

BACKGROUND Heart failure(HF)causes extracardiac organ congestion,including in the hepatic portal *** venous congestion is essential for HF treatment,but evaluating venous congestion is sometimes difficult in patients with chronic *** portal vein(PV)flow pattern can be influenced by.right atrial *** images of the PV are quite easy.to obtain and are reproducible among ***,the association between PV pulsatility.and the condition of HF remains *** hy.othesize that PV pulsatility.at discharge reflects the condition of *** To evaluate the usefulness of PV pulsatility.as a prognostic marker for hospit-alized patients with acute *** This observational study.was conducted from April 2016 to January.2017 and April 2018 to April 2019 at Shinko *** enrolled 56 patients with acute HF,and 17 patients without HF served as *** flow velocity.was mea-sured by.ultrasonography.on admission and at *** calculated the PV pulsatility.ratio(PVPR)as the ratio of the difference between the peak and minimum velocity.to the peak *** primary.endpoint was cardiac death and HF *** observation period was 1 y.ar from the first *** Kaplan-Meier method was used to determine the stratified composite event-free rates,and the log-rank test was used for comparisons between *** On admission,the PVPR was significantly.higher in patients with acute HF than controls(HF:0.29±0.20 vs controls:0.08±0.07,Py.decreased after the improvement in HF(admission:0.29±0.20 vs discharge:0.18±0.15,Py.admission:12.6±4.5 vs discharge:14.6±4.6 cm/s,P=0.03).To elucidate the association between the PVPR and cardiovascular outcomes,the patients were divided into three groups according to the PVPR tertile at discharge(PVPR-T1:0≤PVPR≤0.08,PVPR-T2:0.080.21).The Kaplan-Meier analy.is s

关键词： Heart failure Venous congestion Atrial pressure Ultrasonography Portal vein Prognosis

Erratum to:Influence of structural defects on charge density.waves in 1T-TaS_(2)

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Nano Research 2024年第3期17卷 2204-2204页

作者： Iaroslav Lutsy. Karol Szalowski Pawel Krukowski Pawel Dabrowski Maciej Rogala Witold Kozlowski Maxime Le Ster Michal Piskorski Dorota A.Kowalczy. Wojciech Ry. Rafal Dunal Aleksandra Nadolska Klaudia Toczek Przemy.law Przy.y.z Ewa Lacinska Johannes Binder Andrzej Wy.molek Natalia Olszowska Jacek J.Kolodziej Martin Gmitra Takuma Hattori y.ji kuwahara Guang Bian Tai-Chang Chiang Pawel J.Kowalczy. Faculty.of Phy.ics and Applied Informatics University of LodzPomorska 149/15390-236 LodzPoland Faculty.of Phy.ics University of WarsawPasteura 502-093 WarsawPoland Faculty.of Phy.ics Astronomyand Applied Computer ScienceJagiellonian UniversityLojasiewicza 1130-348 KrakowPoland National Sy.chrotron Radiation Centre SOLARIS Jagiellonian UniversityCzerwone Maki 9830-392 KrakówPoland Institute of Phy.ics Faculty of SciencePavol JozefŠafárik University in KošicePark Angelinum 904001 KošiceSlovakia Institute of Experimental Phy.ics Slovak Academy of SciencesWatsonova 4704001 KošiceSlovakia Department of Precision Engineering Graduate School of EngineeringOsaka University2-1 Yamada-okaSuita 565-0871Japan Department of Phy.ics and Astronomy University of MissouriColumbiaMissouri 65211USA Department of Phy.ics and Frederick Seitz Materials Research Laboratory University of Illinois at Urbana-ChampaignUrbanaIllinois 61801-3080USA

The name of the second author in original paper was unfortunately.*** should be“Karol Szalowski”,instead of“Karoli Szalowski”.

关键词： structural charge defects