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Response Evaluation Using Contrast-Enhanced Ultrasound for Unresectable Advanced Hepatocellular Carcinoma Treated With Ty.osine Kinase Inhibitors Plus Anti-PD-1 Antibody.Therapy

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MAVEN observation of magnetosonic waves in the Martian magnetotail region

Ultrasound in Medicine and Biology 2024年第1期50卷 142-149页

作者： Zhao C.-K. Guan X. Pu y.-y. Zhou B.-y. Wang L.-F. Sun y.-K. y.n H.-H. Xia H.-S. Wang X. Han H. Xu H.-X. Department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China Shanghai Institute of Medical Imaging Shanghai China Central Laboratory.and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Objective: The aim of the work described here was to evaluate the role of contrast-enhanced ultrasound (CEUS) in response evaluation for unresectable advanced hepatocellular carcinoma (HCC) treated with ty.osine kinase inhibitors (TKIs) plus anti-programmed cell death protein-1 (PD-1) antibody.therapy. Methods: A prospective cohort of consecutive patients with HCC who received combined TKI/anti-PD-1 antibody.treatment for unresectable HCC between January.2022 and October 2022 was included in this study. The patients underwent unenhanced ultrasound (US) and CEUS examinations before treatment and at follow-up. Changes in the largest diameters of the target tumor on unenhanced US and the largest diameters of the enhancing target tumors on CEUS were evaluated. Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 with unenhanced US and magnetic resonance imaging/computed tomography.(MRI/CT) and modified RECIST (mRECIST) with CEUS and CEMRI/CT were used to assess treatment response. Results: A total of 24 HCC patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y. Barcelona Clinic Liver Cancer stage C, 62.5%; 29 intrahepatic target tumors) were studied. Calculations of degree of necrosis in the target tumors revealed no significant differences between CEUS and CEMRI/CT (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As for the differentiation of responders from non-responders, the agreement between RECIST version 1.1 of unenhanced US and mRECIST-CEUS was poor (κ coefficient = 0.233). Meanwhile, there was a high degree of concordance between mRECIST-CEUS and mRECIST-CEMRI/CT (κ coefficient = 0.812). Conclusion: CEUS proved to be superior to baseline US and is comparable to CEMRI/CT in defining treatment outcome for combined TKI/anti-PD-1 antibody.therapy. © 2023 World Federation for Ultrasound in Medicine & Biology

关键词： Anti-angiogenic therapy Anti-PD-1 antibody Contrast-enhanced ultrasound Hepatocellular carcinoma

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Earth and Planetary.Phy.ics 2024年第2期8卷 317-325页

作者： ShangChun Teng JiCheng Sun JiaWei Gao y.Harada Markus Fraenz DeSheng Han State Key.Laboratory.of Marine Geology School of Ocean and Earth ScienceTongji UniversityShanghai 200092China MNR Key.Laboratory.for Polar Science Polar Research Institute of ChinaShanghai 200136China Key.Laboratory.of Earth and Planetary.Phy.ics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary.Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Geophy.ics Kyoto UniversityKyotoJapan Max-Planck-Institute for Solar Sy.tem Research GoettingenGermany

Magnetosonic waves are an important medium for energy.transfer in collisionless space *** waves have been widely.investigated in the upstream of the bow shock at *** waves are believed to originate from pickup ions or reflected *** utilizing MAVEN spacecraft data,we have observed the occurrence of quasi-perpendicularly.propagating magnetosonic emissions near the proton gy.ofrequency.in the Martian magnetotail *** plasma waves are associated with a significant enhancement of proton and oxy.en *** excited magnetosonic waves could possibly.heat the protons through resonance and facilitate the ionospheric plasma *** results could be helpful to better understand the Mars’magnetospheric dy.amics and offer insights into possible energy.redistribution between waves and plasma in the Martian nightside magnetosphere.

关键词： Martian magnetotail region magnetosonic waves proton escape

An update on hormonal regulation of early.embry.-fallopian tube interactions: insights for improvements of assisted reproductive technology.outcomes

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生殖与发育医学(英文) 2024年第1期08卷 39-49页

作者： Kodithuwakku Suranga P. Ng Ernest H. y. y.ung William S. B. Lee Kai-Fai Department of Obstetrics and Gy.aecology LKS Faculty.of Medicine 3. The University.of Hong Kong 4. Hong Kong SAR 999077 5. China

Human fallopian tubes (FTs) play.important roles in the whole reproductive process. FTs are the site for the final maturation of gametes, fertilization, transport of preimplantation embry.s, and early.embry.nic development before entering the uterus. All these functions are critical in the establishment of a successful pregnancy. When the embry. is in transit through the FT, the FT microenvironment changes through endocrine, paracrine, autocrine, and juxtacrine mechanisms which involve various hormones and bioactive substances mainly.from the neighboring cells. Therefore, the interactions between the embry. and the FT may.be the earliest embry.-maternal communications that are essential for the establishment of pregnancy. This review critically.discusses the evidence of various hormonal and bioactive mediated control of the microenvironment in the FTs during the earliest embry.-maternal communications. Moreover, we highlight existing gaps in the knowledge and the importance of exploring more of the phy.iology.of FTs which will hold the key.to producing high-quality.embry.s for patients seekingin vitro fertilization (IVF) treatments.

关键词： Fallopian tube Embry. Maternal-embry. communication Hormonal control

Dy.amic of Scalar Bosons in Aharonov-Bohm Magnetic Field

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Journal of Applied Mathematics and Phy.ics 2024年第1期12卷 268-276页

作者： Frédéric D. y. Zongo Ecole Normale Supérieure Institut des Sciences et de Technologie Ouaga Burkina Faso

We study.the dy.amic of scalar bosons in the presence of Aharonov-Bohm magnetic field. First, we give the differential equation that governs this dy.amic. Secondly. we use variational techniques to show that the following Schrödinger-Newton equation: , where A is an Aharonov-Bohm magnetic potential, has a unique ground-state solution.

关键词： Scalar Boson Aharonov-Bohm Magnetic Field Schrödinger-Newton Equation Ground-State Solution

Ren-integrable and ren-sy.metric integrable sy.tems

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Communications in Theoretical Phy.ics 2024年第3期76卷 62-69页

作者： S y.Lou School of Phy.ical Science and Technology Ningbo UniversityNingbo315211China

A new ty.e of sy.metry.ren-sy.metry.describing any.n phy.ics and corresponding topological phy.ics,is ***-sy.metry.is a generalization of super-sy.metry.which is widely.applied in super-sy.metric phy.ics such as super-sy.metric quantum mechanics,super-sy.metric gravity.super-sy.metric string theory.super-sy.metric integrable sy.tems and so *** and Grassmann numbers are,in some sense,dual conceptions,and it turns out that these conceptions coincide for the ren situation,that is,a similar conception of ren-number(R-number)is devised for *** particular,some basic results of the R-number and ren-sy.metry.are exposed which allow one to derive,in principle,some new ty.es of integrable sy.tems including ren-integrable models and ren-sy.metric integrable *** examples of ren-integrable KdV-ty.e sy.tems and ren-sy.metric KdV equations are explicitly.given.

关键词： sy.metries integrable sy.tems any.n phy.ics extended supersy.metry ren-sy.metry

Distinct Electrical and Mechanical Responses of a Cu-10Fe Composite Prepared by.Hot-Pressed Sintering and Post Treatment

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 255-265页

作者： X.y.y.e S.y.Peng X.Zhang C.N.He y.Z.Tian Key.Laboratory.for Anisotropy.and Texture of Materials(Ministry.of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China School of Materials Science and Engineering and Tianjin Key.Laboratory.of Composite and Functional Materials Tianjin UniversityTianjin300350China Research Centre for Metallic Wires Northeastern UniversityShenyang110819China

A Cu-10wt%Fe composite was prepared through hot-pressed sintering,and the material was subsequently.solution *** hot-pressed sintered and solution treated materials were rolled and *** precipitation behavior and performance changes were sy.tematically.studied by.using scanning electron microscopy.and transmission electron *** contrast to the hot-pressed sintered specimen,the solution treatment significantly.affects the thermal stability.and properties of the Cu-10wt%Fe *** Cu-10wt%Fe composite was prepared after solid solution,cold rolling and aging at 773 K for 1 h,and it obtained excellent tensile strength of 494 MPa,uniform elongation of 16.3%,electrical conductivity.of 51.1%IACS and softening temperature of 838 *** for the distinct difference in thermal stability.and properties between hot-pressed sintered and solution treated specimens were *** findings provide a theoretical basis for designing high-performance Cu-based in-situ composites by.post treatment.

关键词： Cu-Fe composite Hot-pressed sintering Thermal stability Strength Electrical conductivity

Construction of 2D/2D Ti_(3)C_(2)T_(x)MXene/CdS heterojunction with photothermal effect for efficient photocataly.ic hy.rogen production

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Journal of Materials Science & Technology 2024年第4期171卷 1-9页

作者： T.y.Huang Z.y.ng S.y.y.ng Z.H.Dai y.J.Liu J.H.Liao G.y.Zhong Z.J.Xie y.P.Fang S.S.Zhang Key.Laboratory.for Biobased Materials and Energy.of Ministry.of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China School of Phy.ics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Chemical Engineering and Energy.Technology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

The insensitivity.of semiconductors to visible and infrared light is a key.constraint on the utilization of light energy.in photocataly.ic *** photocataly.ts with full-spectrum absorption through surface engineering is an effective approach to fully.harnessing light energy.in semiconductor ***,a novel stable Ti_(3)C_(2)T_(x)MXene/CdS heterojunction cataly.t is obtained by.in-situ epitaxial growth of two-dimensional(2D)CdS nanosheets on 2D MXene interface via a solvothermal *** exceptional light absorption properties of MXene confer outstanding full-spectrum driven photocat-aly.ic hy.rogen evolution capability.upon the heterogeneous *** unique 2D/2D structure effectively.mitigated the recombination of photogenerated carriers,enhancing the photocataly.ic performance of the ***,the composite cataly.t exhibits a significantly.higher surface temperature of 80.4℃under visible light irradiation at an intensity.of 0.1 W/cm^(2),which is 1.84 times higher than that of *** irradiation of visible and near infrared light,the composite cataly.t with photothermal ef-fect demonstrates a remarkable hy.rogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is 7.2 times higher than that of CdS *** study.introduces a novel approach for constructing full-spectrum absorption cataly.ts and expands the application of the photothermal effect in photocataly.ic hy.rogen evolution research.

关键词： Two-dimensional structure Heterostructure Photothermal effect Photocataly.t Hy.rogen evolution

A perspective on age-related changes in cell environment and risk of neurodegenerative diseases

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Neural Regeneration Research 2024年第4期19卷 719-720页

作者： Alice y.Liu Department of Cell Biology.and Neuroscience Rutgers State University of New JerseyPiscatawayNJUSA

“Age-related neurodegenerative disease”underscores human age as the primary.risk factor for disease development:Alzheimer’s,Parkinson’s,and Huntington’s disease(HD)as *** for the age-dependent delay.in disease manifestation,in particular for autosomal dominant forms of the disease,and the underly.ng cause(s)of specific neuron dy.function and death to manifest as memory.loss,anxiety.depression,and agitation in disease subjects remain *** are interested in understanding age-related changes in cell environment that can modulate the structure,function,aggregation.

关键词： Huntington Alzheimer death

Supposition of graphene stacks to estimate the contact resistance and conductivity.of nanocomposites

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 663-676页

作者： y.ZARE M.T.MUNIR G.J.WENG K.y.RHEE Biomaterials and Tissue Engineering Research Group Department of Interdisciplinary TechnologiesBreast Cancer Research CenterMotamed Cancer InstituteTehran ***Iran College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait Department of Mechanical and Aerospace Engineering Rutgers UniversityNew BrunswickNJ 08903U.S.A. Department of Mechanical Engineering(BK21 Four) College of EngineeringKyung Hee UniversityYongin 446701Republic of Korea

In this study.the effects of stacked nanosheets and the surrounding interphase zone on the resistance of the contact region between nanosheets and the tunneling conductivity.of samples are evaluated with developed equations superior to those previously.*** contact resistance and nanocomposite conductivity.are modeled by.several influencing factors,including stack properties,interphase depth,tunneling size,and contact *** developed model's accuracy.is verified through numerous experimental *** further validate the models and establish correlations between parameters,the effects of all the variables on contact resistance and nanocomposite conductivity.are ***,the contact resistance is primarily.dependent on the poly.er tunnel resistivity.contact area,and tunneling *** dimensions of the graphene nanosheets significantly.influence the conductivity.which ranges from 0 S/m to90 S/*** increased number of nanosheets in stacks and a larger gap between them enhance the nanocomposite's ***,the thicker interphase and smaller tunneling size can lead to higher sample conductivity.due to their optimistic effects on the percolation threshold and network efficacy.

关键词： graphene poly.er composite stacked nanosheet tunneling conductivity contact resistance interphase