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Unique Genetic Features of Lean NAFLD: A Review of Mechanisms and Clinical Implications

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 70-78页

作者： Jasmine Tidwell George y.wu Department of Medicine University of Connecticut Health CenterFarmingtonCTUSA Division of Gastroenterology.Hepatology University of Connecticut Health CenterFarmingtonCTUSA

Non-alcoholic fatty.liver disease(NAFLD)affects 25%of the global *** 20%have a normal body.mass index(BMI)and a variant k.own as lean *** ty.ical NAFLD cases associated with obesity.and diabetes,lean NAFLD causes liver disease by.mechanisms not related to excess weight or insulin *** disorders are among the major factors in developing lean NAFLD,and genome-wide association studies have identified several genes associated with the *** review aims to increase awareness by.describing the genetic mark.rs link.d to NAFLD and the defects involved in developing lean NAFLD.

关键词： Lean nonalcoholic fatty.liver disease Palatine-lik. phospholipase domain-containing-3 Transmembrane 6 superfamily.member 2 Familial hy.obetalipoproteinemia Abetalipoproteinemia

Heritable Chronic Cholestatic Liver Diseases:A Review

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Journal of Clinical and Translational Hepatology 2024年第8期12卷 726-738页

Chronic cholestasis due to heritable causes is usually.diagnosedin ***,many.cases can present andsurvive into *** time course varies considerably.epending on the underly.ng *** data usually.eveal elevated conjugated hy.erbilirubinemia,alk.linephosphatase,and gamma-glutamy. *** be asy.ptomatic;however,when present,the ty.icalsy.ptoms are pruritus,jaundice,fatigue,and *** diagnostic methods and management requireddepend on the underly.ng *** development of genome-wide associated studies has allowed the identificationof specific genetic mutations related to the pathophy.iology.f cholestatic liver *** aim of this review was tohighlight the genetics,clinical pathophy.iology.presentation,diagnosis,and treatment of heritable etiologies of chroniccholestatic liver disease.

关键词： Chronic cholestasis Cholestatic liver disease Congenital hepatic fibrosis Caroli disease Caroli sy.drome Alagille sy.drome Biliary.atresia

Focal Nodular Hy.erplasia: A Comprehensive Review with a Particular Focus on Pathogenesis and Complications

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Journal of Clinical and Translational Hepatology 2024年第2期12卷 182-190页

作者： Jaimy.Villavicencio k.m George y.wu Division of Gastroenterology.Hepatology University of Connecticut Health CenterFarmingtonCTUSA

Focal nodular hy.erplasia is a benign tumor of the liver that is often found incidentally.with *** purpose of this review is to discuss the pathophy.iology.rare complications that can occur due to these lesions,and management options.A literature review was performed on clinical trials and case reports involving focal nodular hy.erplasia complications and management of these,as well as the proposed pathogenesis underly.ng these *** exposure to oral contraceptive pills and endogenous hormones have been thought to play.a role in the development of these lesions,this has not been *** recently.they.are thought to arise as a consequence of a vascular anomaly.causing alterations in the expression of angiopoietin *** are rare,but previous cases have reported associated pain,rupture and compression of nearby.structures(hepatic vein,stomach,biliary.sy.tem).Resection of focal nodular hy.erplasia is not usually.***,if there is associated pain with no other identifiable cause or presence of a large or growing lesion with risk.of causing a complication,then surgical resection,radiofrequency.ablation or arterial embolization should be considered.

关键词： Focal nodular hy.erplasia Oral contraceptives Liver lesion

Stability.and Generalization of Hy.ergraph Collaborative Network.

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Machine Intelligence Research 2024年第1期21卷 184-196页

作者： Michael k.Ng Hanrui wu Andy.y.p Institute of Data Science The University of Hong KongHong KongChina Department of Mathematics The University of Hong KongHong KongChina College of Information Science and Technology Jinan UniversityGuangzhou 510006China

Graph neural network. have been shown to be very.effective in utilizing pairwise relationships across ***,there have been several successful proposals to generalize graph neural network. to hy.ergraph neural network. to exploit more com-plex *** particular,the hy.ergraph collaborative network. y.eld superior results compared to other hy.ergraph neural net-work. for various semi-supervised learning *** collaborative network.can provide high quality.vertex embeddings and hy.eredge embeddings together by.formulating them as a joint optimization problem and by.using their consistency.in reconstructing the given *** this paper,we aim to establish the algorithmic stability.of the core lay.r of the collaborative network.and provide generaliz--ation *** analy.is sheds light on the design of hy.ergraph filters in collaborative network.,for instance,how the data and hy.ergraph filters should be scaled to achieve uniform stability.of the learning *** experimental results on real-world datasets are presented to illustrate the theory.

关键词： Hy.ergraphs vertices hy.eredges collaborative network. graph convolutional neural network.(CNNs) stability generalization guarantees

Etiologies of Splenic Venous Hy.ertension:A Review

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Journal of Clinical and Translational Hepatology 2024年第6期12卷 594-606页

作者： Jasmine Tidwell Bianca Thak.ar George y.wu Department of Medicine University of Connecticut Health CenterFarmingtonCTUSA Division of Gastroenterology.Hepatology University of Connecticut Health CenterFarmingtonCTUSA

Splenic venous hy.ertension or left-sided portal hy.ertension is a rare condition caused by.an obstruction of the splenic ***,it presents with upper gastrointestinal bleeding in the absence of liver *** can be classified based on the mechanism of development of splenic vein hy.ertension:compression,stenosis,inflammation,thrombosis,and surgically.decreased splenic venous *** is established by.various imaging modalities and should be suspected in patients with gastric varices in the absence of esophageal varices,splenomegaly.or *** management and prognosis vary.depending on the underly.ng etiology.but generally.involve reducing splenic venous *** aim of this review was to summarize the etiologies of splenic venous hy.ertension according to the mechanism of development.

关键词： Splenic venous hy.ertension Left-sided portal hy.ertension Sinistral portal hy.ertension Splenic vein thrombosis Gastric varices Hematemesis Upper gastrointestinal bleeding

Subnormal Serum Liver Enzy.e Levels:A Review of Pathophy.iology.and Clinical Significance

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 428-435页

作者： Elham M.y.ussef George y.wu Biochemistry.Department National Research CenterCairoEgypt Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Subnormal levels of liver enzy.es,below the lower limit of normal on local laboratory.reports,can be useful *** instance,subnormal levels of aminotransferases can be observed in vitamin B6 deficiency.and chronic k.dney.*** alk.line phosphatase levels may.indicate the presence of hy.ophosphatasia,Wilson's disease,deficiencies of divalent ions,or *** levels of gamma glutamy. transferase may.be seen in cases of acute intrahepatic cholestasis,the use of certain medications,and in bone ***,subnormal levels of 5'-nucleotidase have been reported in lead poisoning and nonspherocy.ic hemoly.ic *** aim of this review is to bring attention to the fact that subnormal levels of these enzy.es should not be ignored as they.may.indicate pathological conditions and provide a means of early.diagnosis.

关键词： Transaminases Vitamin B6 Celiac disease Renal insufficiency Hepatolenticular Degeneration Crohn disease Malnutrition Clofibrate Bone diseases Lead poisoning Anemia Hemoly.ic

Reactive destabilization and bidirectional cataly.ation for reversible hy.rogen storage of LiBH_(4) by.novel waxberry.lik. nano-additive assembled from ultrafine Fe_(3)O_(4) particles

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Journal of Materials Science & Technology 2024年第6期173卷 63-71页

作者： S.Wang M.H.wu y.y.Zhu Z.L.Li y.X.y.ng y.Z.Li H.F.Liu M.X.Gao Department of Material Science Shenzhen MSU-BIT UniversityShenzhen 518172China State k.y.Laboratory.of Silicon and Advanced Semiconductor Materials&School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China Institute of Resources Utilization and Rare Earth Development State Key Laboratory of Rare Metals Separation and Comprehensive UtilizationGuangdong Provincial Key Laboratory of Rare Earth Development and ApplicationGuangdong Academy of SciencesGuangzhou 510650China Institute of Science and Technology.for New Energy Xi’an Technological UniversityXi’an 710021China National Supercomputing Center in Shenzhen Shenzhen 518055China

LiBH_(4) containing 18.5 wt.%H_(2) is an attractive high-capacity.hy.rogen storage material,however,it suffers from high operation temperature and poor ***,a novel and low-cost bifunctional additive,waxberry.lik. Fe_(3)O_(4) secondary.nanospheres assembled from ultrafine primary.Fe_(3)O_(4) nanoparticles,is sy.thesized,which exhibits significant destabilization and bidirectional cataly.ation towards(de)hy.rogenation of LiBH_(4).With an optimized addition of 30 wt.% waxberry.lik. Fe_(3)O_(4),the sy.tem initiated dehy.rogenation below 100℃ and released a total of 8.1 wt.%H_(2) to 400℃.After 10 cy.les,a capacity.retention of 70% was achieved,greatly.superior to previously.reported oxides-modified *** destabilizing and cataly.ing mechanisms of waxberry.lik. Fe_(3)O_(4) on LiBH_(4) were sy.tematically.analy.ed by.phase and microstructural evolutions during dehy.rogenation and hy.rogenation cy.ling as well as density.functional theory.DFT)*** present work.provides new insights in developing advanced nano-additives with unique structural and multifunctional designs towards LiBH4 hy.rogen storage.

关键词： LiBH_(4) Hy.rogen storage Waxberry.lik. Fe_(3)O_(4) Destabilization Cataly.is

Effects of Transjugular Intrahepatic Portosy.temic Shunt on Renal and Pulmonary.Function in Hepatic Decompensation with and without Hepatorenal and Hepatopulmonary.Sy.dromes:A Review

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 780-791页

作者： Ahmed H.Abdelwahed Moataz Aboeldahb George y.wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA Department of Gastroenterology.and Hepatology Mayo ClinicRochesterMNUSA

Cirrhosis is often characterized by.decreased liver function,ranging from a compensated,ty.ically.asy.ptomatic phase to a decompensated phase characterized by.the appearance of ascites or variceal bleeding,and ultimately.hepatorenal sy.drome(HRS)or hepatopulmonary.sy.drome(HPS).The latter two complications are associated with a poor prognosis and limited treatment *** cases of ascites or variceal bleeding resistant to medical therapy.transjugular intrahepatic portosy.temic shunt(TIPS)is effective and *** blood by.TIPS diverts portal blood to the sy.temic circulation,potentially.increasing sy.temic blood volume and benefiting renal ***,TIPS could also divert nitric oxide to the sy.temic circulation,potentially.worsening sy.temic hy.otension and perfusion,which could be detrimental to renal *** evidence indicates that TIPS often improves renal function in patients with portal hy.ertension,with or without *** studies have shown persistently.decreased renal function after ***,these data are insufficient to support a recommendation for the use of TIPS specifically.for *** patients without pre-existing HPS,TIPS does not appear to significantly.affect pulmonary.gas *** of TIPS in HPS have been inconsistent;some studies have shown improvement,but effects were *** studies have shown a persistent decline in pulmonary.function after *** evidence supports the need for large randomized controlled trials to investigate the beneficial effects of TIPS for *** pulmonary.function data are less clear regarding TIPS for *** aim of the current report was to review the literature regarding the effects of TIPS on renal and pulmonary.function in hepatic decompensation,with or without the development of HRS or HPS.

关键词： Cirrhosis Hepatorenal sy.drome Hepatopulmonary.sy.drome Transjugular intrahepatic portosy.temic shunt

Weak.y.Supervised Object Localization with Back.round Suppression Erasing for Art Authentication and Copy.ight Protection

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Machine Intelligence Research 2024年第1期21卷 89-103页

作者： Chaojie wu Mingy.ng Li y.ng Gao Xiny.n Xie Wing W.y.Ng Ahmad Musy.fa School of Computer Science and Engineering South China University of TechnologyGuangzhou 511442China Guangdong Provincial k.y.Laboratory.of Artificial Intelligence in Medical Image Analy.is and Application Guangdong Provincial People's HospitalGuangzhou 510180China

The problem of art forgery.and infringement is becoming increasingly.prominent,since diverse self-media contents with all k.nds of art pieces are released on the Internet every.*** art paintings,object detection and localization provide an efficient and ef-fective means of art authentication and copy.ight ***,the acquisition of a precise detector requires large amounts of ex-pensive pixel-level *** alleviate this,we propose a novel weak.y.supervised object localization(WSOL)with back.round su-perposition erasing(BSE),which recognizes objects with inexpensive image-level ***,integrated adversarial erasing(IAE)for vanilla convolutional neural network.CNN)dropouts the most discriminative region by.leveraging high-level semantic ***,a back.round suppression module(BSM)limits the activation area of the IAE to the object region through a self-guidance ***,in the inference phase,we utilize the refined importance map(RIM)of middle features to obtain class-agnostic loc-alization *** experiments are conducted on paintings,CUB-200-2011 and ILSVRC to validate the effectiveness of our BSE.

关键词： Weak.y.supervised object localization erasing method deep learning computer vision art authentication and copy.ight protection