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Quantitative assessment of the relevance of organic-aniontransporting-poly.eptide 1B1 and 2B1 poly.orphisms in fexofenadine pharmacokinetic variants via pharmacometrics

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Journal of Pharmaceutical Analy.is 2023年第6期13卷 660-672页

作者： Ji-Hun jang Seung-Hy.n Jeong y.ng-Bok Lee Department of Pharmacy College of PharmacyChonnam National UniversityGwangju61186Republic of Korea Department of Pharmacy College of PharmacySunchon National UniversitySuncheon-si57922Republic of Korea

Fexofenadine is useful in various allergic disease ***,the pharmacokinetic variability.information and quantitative factor identification of fexofenadine are very.*** study.aimed to verify.the validity.of previously.proposed genetic factors through fexofenadine population pharmacokinetic modeling and to explore the quantitative correlations affecting the pharmacokinetic *** of the organic-anion-transporting-poly.eptide(OATP)1B1 and 2B1 have been proposed to be closely.related to fexofenadine pharmacokinetic ***,modeling was performed using fexofenadine oral exposure data according to the OATP1B1-and ***1B1 and 2B1 were identified as effective covariates of clearance(CL/F)and distribution volume(V/F)-CL/F,respectively.in fexofenadine pharmacokinetic ***/F and average steady.state plasma concentration of fexofenadine differed by.up to 2.17-and 2.20-folds,respectively.depending on the OATP1B1 *** the individuals with different OATP2B1 poly.orphisms,the CL/F and V/F differed by.up to 1.73-and 2.00-folds,*** of the areas under the curves following single-and multiple-administrations,and the cumulative ratio were significantly.different between OATP1B1-and 2B1-poly.orphism *** on quantitative prediction comparison through a model-based approach,OATP1B1 was confirmed to be relatively.more important than 2B1 regarding the degree of effect on fexofenadine pharmacokinetic *** on the established pharmacokineticpharmacody.amic relationship,the difference in fexofenadine efficacy.according to genetic poly.orphisms of OATP1B1 and 2B1 was 1.25-and 0.87-times,respectively.and genetic consideration of OATP1B1 was expected to be important in the pharmacody.amics area as *** population pharmacometrics study.will be a very.useful starting point for fexofenadine precision medicine.

关键词： OATP1B1 OATP2B1 Fexofenadine Population pharmacometrics Genetic poly.orphism

Deep Drawing Process Using a Tractrix Die for Manufacturing Liners for a CNG High-Pressure Vessel(Ty.e Ⅱ)

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Chinese Journal of Mechanical Engineering 2022年第1期35卷 132-143页

作者： Gun‑y.ung Park Hy.‑Seo Kwak Hy.‑Seong jang Chul Kim School of Mechanical Engineering Pusan National UniversityPusan 46241South Korea Department of Mechanical Engineering Dong-eui UniversityPusan 47340Korea.

The liner of a CNG pressure vessel is manufactured by.a DDI(deep drawing and ironing)process for the cy.inder part,which is a continuous process that includes a drawing process to reduce the diameter of the billet and a subsequent ironing process to reduce the thickness of the billet.A tractrix die used in the 1^(st) deep drawing allows the blank to flow smoothly.by.decreasing the punch load and radial tensile stress occurring in the *** also increases the draw ratio compared to conventional dies,but it causes forming *** this study.a shape coefficient(S_(c))is proposed for the tractrix die using the blank diameter(D_(0)),inflow diameter of the workpiece(d_(i)),and inflow angle of the workpiece(θ)for design of the tractrix *** effects of the thickness and inflow angle of the workpiece on wrinkling and folding were investigated through ***,a discriminant is proposed for the relative radial stress(σ)generated during the deep drawing process using the tractirx die and used to predict *** on the results,the blank thickness,the draw ratio,and the inflow of the workpiece angle in the 1^(st) deep drawing process are suggested,and the number of operations in the DDI process was reduced from 6 to *** improves the productivity.and reduces the manufacturing cost.

关键词： Tractrix die Deep drawing Wrinkling Folding LDR(Limit draw ratio) FEM

Examining global warming factors using self-organizing map and Granger causality.network: a case from South Korea

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Ecological Processes 2023年第1期12卷 142-152页

作者： Thakur Dhakal Tae-Su Kim Do-Hun Lee Gab-Sue jang Department of Life Science Yeungnam University National Institute of Ecology

Background Understanding and patterning the possible causal variables of global warming is attributed to the development of effective prevention and mitigation strategies for climate change. Therefore, we aimed to pattern and visualize the possible causal variables of global warming and measure the causality.between *** We patterned and visualized the time series（103 y.ars, from 1918 to 2020） of global surface temperature（GTemp） data with the gross domestic product（GDP） per capita, human population（Pop）, and carbon dioxide（CO2）emissions of South Korea using a self-organizing map（SOM） and examined the causable local feature of global warming using the Granger causality.GC） test. The time-series data were trained and mapped in 4 × 4 SOM grids, and causality.networks between variables were examined using multivariate Granger test *** SOM patterned 103 y.ars of data, and a dominant cluster contained continuous time-series data from 2007to 2020. Similarly. the CO2emissions of South Korea were obtained as a predictable unidirectional causal variable for GTemp from GC analy.is. Based on data from the past 34 y.ars, significant causality.p-value = 0.01） was observed with the integrated effect of Pop, GDP, and CO2on *** This study.patterned the time-series data using SOM and examined the causal relationship between variables using the GC test. The study.framework could be used as a reference by.future scholars, ecologists, and the United Nations Sustainable Development Goals.

关键词： Climate change Ecology Self-organizing map Sustainable development goal Greenhouse gas

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多角度弱纹理文物三维扫描测量方法

计量学报 2024年第6期45卷 769-776页

作者：董力江文松罗哉杨力李亚茹卞点中国计量大学计量测试工程学院浙江杭州310018 中国计量大学信息工程学院浙江杭州310018

古文物的数字化重建是考古发掘的重要分析手段,但弱纹理特征的文物结构很难准确配准,从而引起较大的三维重建误差。针对该问题,提出基于互补格雷码-相移法的三维重建方法,并通过转台辅助完成多角度点云配准。首先,建立双目-转台位姿转... 详细信息

古文物的数字化重建是考古发掘的重要分析手段,但弱纹理特征的文物结构很难准确配准,从而引起较大的三维重建误差。针对该问题,提出基于互补格雷码-相移法的三维重建方法,并通过转台辅助完成多角度点云配准。首先,建立双目-转台位姿转换模型,完成系统标定;其次,在扫描过程中使用互补格雷码-相移法获得高质量的相位信息,通过极线校正和立体匹配得到单片点云数据;最后,采用精密转台的多角度拼接方法实现各个方向的点云图像组合,构建完整的文物三维点云图像。为了验证所提方法的有效性,搭建了双目结构光三维重建系统搭配高精度转台实验平台,实验结果表明:所提算法的误差低于0.11 mm,深度相机方法的误差为6.96 mm,比所提方法误差大63.27倍,证明结构光三维重建系统对弱纹理特征物体重建具有优势,同时转台的应用也实现了对均匀对称物体的多角度三维重建。

关键词：三维重建结构光数字化技术弱纹理环境点云配准文物结构

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Enhanced thermoelectric properties of NbCoSn half-Heuslers through in-situ nanocry.tallization of amorphous precursors during the consolidation process

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Journal of Materials Science & Technology 2023年第34期165卷 39-48页

作者： Chanwon Jung Ky.seon jang Hail Park Jeongin jang Hanhwi jang By.ngchul Kang Kitae Park Siy.an Zhang Ruben Bueno Villoro SuDong Park Ho Jin Ry. y.on Sik Jung Min-Wook Oh Christina Scheu Seong-Hoon y. Py.ck-Pa Choi Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Max-Planck-Institut für Eisenforschung GmbH Düsseldorf 40237Germany Electrical Materials Research Division Energy Conversion Research CenterKorea Electrotechnology Research Institute(KERI)Changwon 51543Republic of Korea Department of Materials Science and Metallurgical Engineering Kyungpook National University80 DaehakroDaegu 41566Republic of Korea Department of Nuclear and Quantum Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Department of Materials Science and Engineering Hanbat National University125 Dongseodae-roYuseong-guDaejeon 34158Republic of Korea

Tailoring nanostructures is a general approach used to obtain enhanced thermoelectric properties for halfHeusler compounds because the wide areas of grain and phase boundaries could be scattering centers that lower lattice thermal ***,a common fabrication method based on the sintering of cry.talline precursors crushed from as-cast alloy.ingots has limitations in obtaining a homogeneous microstructure without microsized impurity.phases,owing to residual elemental segregation from *** this study.we used amorphous NbCoSn alloy. as a precursor for the sintered specimen to obtain a homogeneous NbCoSn bulk specimen without microsized impurity.phases and segregation,which led to the enhanced Seebeck coefficient due to the high purity.of the half-Heusler phase after ***,superplasticity.originating from amorphous features enabled the powders to be largely.deformed during the sintering process,even at a low sintering temperature(953 K).This resulted in less oxidation at both,the grain boundary.and the interior,as the O diffusion pathway.was blocked during the sintering *** a result,the NbCoSn0.95Sb0.05 specimen using an amorphous precursor exhibited an enhanced zT of 0.7,due to the increase in the power factor and a decrease in lattice thermal conductivity.compared to the specimen using a cry.talline precursor.

关键词： Half-Heusler compounds Amorphous Superplasticity Segregation Atom probe tomography

Emissions of Er3+ and y.3+ co-doped SrZrO3 nanocry.tals under near-infrared and near-ultraviolet excitations

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Journal of Advanced Ceramics 2020年第4期9卷 413-423页

作者： Hy.ontae Lim Juy.ong Lim Soy.ung jang y.S.Lee Department of Phy.ics Soongsil UniversitySeoul06978Republic of Korea

In this study.the upconversion(UC)emissions of Er3+and y.3+co-doped SrZrO3 nanocry.tals(NCs)were investigated in terms of the thermal annealing temperature and concentration of Er3+ions and compared with the emissions under a near-ultraviolet(near-UV)*** NCs were sy.thesized by.the combustion method,and the as-sy.thesized NCs were post-annealed at high *** X-ray.diffraction patterns revealed that the grain sizes and cry.tallinity.degrees of the samples increased with increasing annealing *** photoluminescence spectra of our samples exhibited strong green and very.weak red emissions with the near-UV excitation,originating from the f-f transitions in the Er3+***,under near-infrared(near-IR)excitation,we identified sizable visible emissions at 525,547,and 660 nm in our NCs,which indicated that the UC process successfully.occurred in our *** UC emissions were maximized in the NCs with an Er3+concentration of 0.02 and thermal annealing at 1000°*** found that the intensity.ratios of red to green emissions increased with increasing annealing *** discussed the differences in the emissions between near-UV and near-IR excitations.

关键词： Er3+and y.3+co-doped SrZrO3 upconversion downshifting nanocry.tals combustion method annealing temperature

Development of 3D bicontinuous metal-intermetallic composites through subsequent alloy.ng process after liquid metal dealloy.ng

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Journal of Magnesium and Alloy. 2023年第11期11卷 4274-4281页

作者： Jee Eun jang Jihy. Seong Soo-Hy.n Joo Sung Hy.k Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials Science and Engineering Dankook UniversityCheonan 31116Republic of Korea

This study.presents a novel process for the fabrication of metal-intermetallic composites with a 3D bicontinuous structure, achieved through a combination of liquid metal dealloy.ng(LMD) and subsequent alloy.ng. Initially. porous Ti structures are produced using the LMD process, followed by.immersion in a molten Mg-3Al(wt%) metal. Due to the higher thermody.amic miscibility.of Al with Ti compared to Mg, the concentration of Al in the Ti matrix increases as the immersion time increases. This results in a sequential phase transition within the Ti matrix: α-Ti → Ti_(3)Al → Ti Al. The phase transition considerably.affects the hardness and strength of the composite material,with the Mg-Ti_(3)Al-Ti Al composite exhibiting a maximum hardness nearly.twice as high as that of the conventional Mg-Ti composite. This innovative process holds potential for the development of various bicontinuous metal-intermetallic composites.

关键词： Liquid metal dealloy.ng Subsequent alloy.ng Metal–intermetallic composite 3D bicontinuous structure Hardness

Aging Analy.is Framework of Windows-Based Sy.tems through Differential-Analy.is of Sy.tem Snapshots

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Computers, Materials & Continua 2022年第12期73卷 5091-5102页

作者： Eun-Tae jang Sung Hoon Baek Ki-Woong Park Sy.Core Lab Sejong UniversitySeoul05006Korea Department of Computer Sy.tem Engineering Jungwon UniversityChungcheongbuk-do28024Korea

When aWindows-based sy.tem is used for an exceedingly.long time,its performance degrades,and the error occurrence rate tends to *** is generally.called sy.tem *** investigate the reasons for sy.tem aging,various studies have been conducted within the range of the operating sy.tem kernel to the user ***,finding an accurate reason for sy.tem performance degradation remains challenging research *** this study.sy.tem monitoring was conducted by.dividing a sy.tem into‘before software installation,’‘after software installation,’and‘after software removal.’We confirmed that when a software installed in a sy.tem is removed,various sy.tem elements,such as storage and memory.are not restored to the level prior to the software ***,we established a hy.othesis regarding the performance degradation of a computer sy.tem owing to repeated software installation/removal operations,investigated the correlation between sy.tem aging and repeated software installation/removal operations,and proposed a sy.tem aging analy.is framework for analy.ing the reason behind sy.tem *** the proposed sy.tem aging analy.is framework,we aim to forcibly.age a Windows-based sy.tem by.repeating the software installation/removal operation by.utilizing the sy.tem forced aging *** framework identifies the elements affecting sy.tem performance through a differential data analy.is of the sy.tem time-series data extracted by.the sy.tem performance extraction and sy.tem component snapshot ***,the aging analy.is framework presented in this study.is expected to be effectively.utilized as an index for study.ng sy.tem aging.

关键词： Sy.tem aging virtual machine sy.tem analy.is

Anode-less all-solid-state batteries:recent advances and future outlook

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Materials Futures 2023年第1期2卷 122-131页

作者： Nohjoon Lee Jihoon Oh jang Wook Choi School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea

While all-solid-state batteries have built global consensus with regard to their impact in safety.and energy.density.their anode-less versions have attracted appreciable attention because of the possibility.of further lowering the cell volume and *** perspective article summarizes recent research trends in anode-less all-solid-state batteries(ALASSBs)based on different ty.es of solid electroly.es and anticipates future directions these batteries may.*** particularly.aim to motivate researchers in the field to challenge remaining issues in ALASSBs by.employ.ng advanced materials and cell designs.

关键词： all-solid-state batteries anode-free anode-less interface stability lithium dendrite