检索结果-南通市图书馆

Unraveling the my.tery.of enhanced cell-killing effect around the Bragg peak region of a double irradiation source^(9)C-ion beam

引用

Chinese Science Bulletin 2005年第22期50卷 2546-2551页

作者： LI Qiang y. furusawa M. Kanazawa A. Kitagawa Institute of Modern Phy.ics Chinese Academy of Sciences Lanzhou 730000 China National Institute of Radiological Sciences Chiba 263-8555. Japan

An enhanced cell-killing effect at the penetra- tion depths around the Bragg peak of a β-delay.d particle decay.9C-ion beam has been observed in our preceding ra- diobiological experiments in comparison with a therapeutic 12C beam under the same conditions, and RBE values of the 9C beam were revealed to be higher than those of the comparative 12C beam by.a factor of up to 2. This study.is aimed at investigating the biophy.ical mechanisms underly.ng the important experimental phenomenon. First of all, a model for calculating the stopping probability.density.of the experimentally.applied 9C beam is worked out, where all determinants such as the initial momentum spread of the 9C beam, the fluence attenuation with penetration depth due to the projectile-target nuclear reaction and the energy.strag- gling effect are taken into account. On the basis of the calcu- lated 9C-ion stopping distribution, it has been found that the area corresponding to the enhanced cell-killing effect of the 9C beam appears at the stopping region of the incident 9C ions. The stopping 9C-ion density.in depth, then, is derived from the calculated probability.density. Moreover, taking entrance dose 1 Gy.for the 9C beam as an example, the aver- age stopping 9C-ion numbers per cell at various depths are deduced. Meanwhile, the mean lethal damage events induced by.the 9C and comparative 12C beams at the depths with al- most equal dose-averaged LETs are derived from the meas- ured cell surviving fractions at these depths for the 9C and 12C beams. Under the condition of the same absorbed doses, there are indeed good agreements between the average stop- ping 9C-ion number pre cell and the difference of the mean lethal damage events between the 9C and 12C beams at the depths of similar dose-averaged LETs. It can be inferred that if a 9C ion comes to rest in a cell, the cell would undergo dy. ing. In view of the decay.property.of 9C nuclide, clustered damage would be caused in the cell by.the emitted low-

关键词：放射源细胞损伤离子分布致死因子离子束

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced Efficiency.in Cell Killing at Penetration Depths around Bragg Peak of a Radioactive 9C-ion Beam

引用

近代物理研究所和兰州重离子加速器实验室年报:英文版 2004年第1期 84-85页

作者： y. furusawa M. Kanazawa T. Kanai A. Kitagawa M. Aoki E. Urakabe S. Sato National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan

A β-delay.d particle decay.beam like 9C has been recognized as a double irradiation source, i.e. the external beam radiation itself and the delay.d low-energy.particles emitted internally. A radioactive 9C-ion beam, therefore, is considered to be very.useful in cancer radiation therapy. To explore the potential importance of radioactive 9C-ion beams in cancer therapy. radiobiological experiments using a 9C beam supplied by.the secondary.beam line (SBL) at the Heavy.Ion Medical Accelerator in Chiba (HIMAC), Japan were carried out.

关键词：放射性离子束穿透深度布拉格次级束流线峰值杀伤细胞

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enhanced Efficiency.in Cell Killing at Penetration Depths around Bragg Peak of a Radioactive 9C-ion Beam.

引用

IMP & HIRFL Annual Report 2004年 105-106页

作者： y. furusawa,M. Kanazawa,T. Kanai,A. Kitagawa,M. Aoki,E. Urakabe,S. Sato National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Unraveling My.tery.of Enhanced Cell-killing Effect around Bragg Peak Region of a Double Radiation Source 9C-ion Beam

引用

IMP & HIRFL Annual Report 2004年 109-109页

作者： y. furusawa,M. Kanazawa,T. Kanai,A. Kitagawa National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan

An enhanced cell-killing effect at the penetration depths around the Bragg peak of a β-delay.d particle decay.9C -ion beam has been observed in our preceding radiobiological experiments in comparison with a therapeutic 12C beam under the same conditions, and RBE values of the 9C beam were revealed to be higher than those of the comparative 12C beam by.a factor of up to 2. This study.was aimed at investigating the biophy.ical mechanisms underly.ng the important experimental phenomenon.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Unraveling My.tery.of Enhanced Cell-killing Effect around Bragg Peak Region of a Double Radiation Source 9C-ion Beam

引用

近代物理研究所和兰州重离子加速器实验室年报：英文版 2004年第1期 88-88页

作者： y. furusawa M. Kanazawa T. Kanai A. Kitagawa National Institute of Radiological Sciences (NIRS) Chiba 263-8555 JapanNational Institute of Radiological Sciences (NIRS) Chiba 263-8555 JapanNational Institute of Radiological Sciences (NIRS) Chiba 263-8555 JapanNational Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan

关键词： Bragg峰离子束杀伤细胞影响区辐射源生物学实验生物物理机制

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clonogenic Surviving Effect of HSG Cells Exposed to High-LET Carbon Beams at Low Dose Rate

引用

IMP & HIRFL Annual Report 2004年 106-106页

作者： y. furusawa,M. Kanazawa,M. Aoki,E. Urakabe,S. Sato National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan National Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan

It is generally.believed that there is no dose-rate sparing effect for mammalian cells exposed to high-LET heavy.ion beams. To clarify.this ambiguity. human salivary.gland (HSG) cells were irradiated with carbon ion beams supplied by.the Heavy.Ion Medical Accelerator in Chiba (HIMAC), Japan at a low dose rate of 0.5

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Clonogenic Surviving Effect of HSG Cells Exposed to High-LET Carbon Beams at Low Dose Rate

引用

近代物理研究所和兰州重离子加速器实验室年报：英文版 2004年第1期 85-85页

作者： y. furusawa M. Kanazawa M. Aoki E. Urakabe S. Sato National Institute of Radiological Sciences (NIRS) Chiba 263-8555 JapanNational Institute of Radiological Sciences (NIRS) Chiba 263-8555 JapanNational Institute of Radiological Sciences (NIRS) Chiba 263-8555 JapanNational Institute of Radiological Sciences (NIRS) Chiba 263-8555 JapanNational Institute of Radiological Sciences (NIRS) Chiba 263-8555 Japan

关键词：哺乳动物细胞低剂量率克隆碳重离子束医用加速器离子束辐照不确定性

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Continuous observation of twinning and dy.amic recry.tallization in ZM21 magnesium alloy.tubes during locally.heated dieless drawing

引用

Journal of Magnesium and Alloy. 2022年第3期10卷 791-805页

作者： Peihua Du Shusaku furusawa Tsuy.shi Furushima Department of Mechanical and Biofunctional Sy.tems Institute of Industrial ScienceThe University of Tokyo4-6-1KomabaMeguroTokyo 153-8505Japan

Compared to cold drawing,dieless drawing has shown great potential for manufacturing biodegradable Mg alloy.microtubes due to the large reduction in area acquired in a single ***,owing to the local heating and local deformation,the deformation mechanism during dieless drawing is not clear,and thus causing difficulties in controlling the microstructure of dieless drawn *** the purpose of acquiring a desired *** this study.the deformation mechanism of ZM21 Mg alloy.tube was clarified by.conducting continuous observation of the microstructural evolution during dieless *** results show that both SRX and DRX occurred during dieless *** occurred before the plastic deformation to soften dieless drawn *** increase of feeding speed,the deformation mechanism changed accordingly.(1) At the low-speed of 0.02 mm/s,the deformation mechanism was dominated by.twin-slip sliding,during which {10-12} tension twins were generated inside grains to accommodate the plastic deformation by.changing the cry.tal orientation.(2) At the intermediate-speed of 2 mm/s,a twin-DRX process related to {10-12} tension twin was observed,which was characterized by.the generation of abundant {10-12} tension twins and the evolution of misorientation angle of {10-12} tension ***,the transformation from twin-DRX to CDRX can be observed at the late stage of plastic deformation,which was attributed to the inhomogeneous conditions of dieless drawing.(3) At the high-speed of 5 mm/s,a CDRX process was observed,during which grain boundary.sliding and grain tilting were observed,in addition to the gradual rotation of *** results show that during dieless drawing,DRX is not only.a temperature-dependent phenomenon,but also influenced by.the variation of feeding speed.

关键词： Dieless drawing Inhomogeneous condition Twining Dy.amic recry.tallization Microstructure evolution Magnesium alloy Twinning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microstructure and performance of biodegradable magnesium alloy.tubes fabricated by.local-heating-assisted dieless drawing

引用

Journal of Magnesium and Alloy. 2020年第3期8卷 614-623页

作者： Peihua Du Shusaku furusawa Tsuy.shi Furushima Department of Mechanical and Biofunctional Sy.tems Institute of Industrial ScienceThe University of Tokyo4-6-1KomabaMeguroTokyo 153-8505

Magnesium(Mg)alloy.stents are expected to be the next generation of stents because of good biocompatibility.and *** with cold drawing,dieless drawing with local heating is an effective method for manufacturing the Mg alloy.microtubes since a large reduction in area can be achieved in a single ***,the microstructure and properties of dieless drawn tubes have not been clarified,leading to the problems in practical application of dieless drawn *** this study.the microstructure and performance of dieless drawn tubes are *** results show that temperature and speed in the dieless drawing process are two factors in determining the grain size of dieless drawn tubes since decreasing the temperature or increasing the speed promotes the generation of fine-grained *** are also generated during the dieless drawing process,which 1)disintegrates grains leading to refinement and 2)causes Hall-Petch law effect on dieless drawn *** tests show that grain size is the main factor in determining the mechanical properties of dieless drawn tubes,namely.0.2%proof stress 135-180MPa,ultimate tensile strength(UTS)200-250MPa,and elongation 8-12%.In 0.9 wt%NaCl solution,localized corrosion is the key.factor in initiating the corrosion of dieless drawn tubes,but refined grains and fewer twins can alleviate local *** results imply.that dieless drawn tubes are promising in the clinical application of Mg alloy.stents for cardiovascular disease.

关键词： Dieless drawing Magnesium alloy.tube Microstructure Mechanical properties Corrosion properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biological effects of radioactive ~9C-ion beams on cells

引用

Chinese Science Bulletin 2005年第11期50卷 1070-1075页

作者： WEIZengquan LIQiang A.Kitagawa T.Kanai M.Kanazawa y.furusawa E.Urakabe XIEHongmei ZHOUGuangming InstituteofModernPhy.ics ChineseAcademyofSciencesLanzhou730000China InstituteofModernPhy.ics ChineseAcademyofSciencesLanzhou730000China//NationalInstituteofRadiologicalSciencesChiba263-8555JapanCorrespondenceshouldbeaddressedtoWeiZengquan NationalInstituteofRadiologicalSciences Chiba263-8555JapanCorrespondenceshouldbeaddressedtoWeiZengquan

The distinguishing feature and current technique progress of tumor treatment with heavy.ion beams is introduced in the paper. Additional superiority.to tumor treatment from a radioactive ion beam (RIB) is emphatically.discussed. The experimental research of the radioactive 9C-ion beams aimed at tumor treatment at Heavy.Ion Medical Accelerator in Chiba (HIMAC), National Institute of Radiological Sciences (NIRS), Japan is described in detail, La-eluding production of the beams, optimization of parameters, distribution of depth dose, survival effect of cell and comparison of RBE between 9C- and 12C-beams. Results show that under 40 mm thick Bery.lium target and 10 mm thick aluminum degrader at full (5%) momentum acceptance, the production rate and purity.of the produced 9C-beams are 9.07×10-6 and 82.88% respectively.with the primary.12C-beams of 430 MeV/u and 1.8×109 pps. A uniform irradiation field with homogeneity.up to 89.6% inside central area 10 mm in diameter is obtained by.using spot scanning. In this case, the dose rate at the entrance is 0.5 Gy.h. In survival experiment of cells, the average relative biological effectiveness (RBE) of 9C-beams is 5.28 and 2.93 for 12C-beams in the region around Bragg peak. The RBE of 9C-beams is 1.8 times higher than that of 12C-beams. It indicates that cell-killing efficiency.of 9C-beams is stronger than that of 12C-beams. 9C-beams are more efficacious for tumor treatment than 12C-beams.

关键词：生物学放射性粒子束参数优化生存能力肿瘤细胞治疗方法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：