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“y.n-y.ng philosophy. for the design of anticancer drug delivery.nanoparticles

Biomaterials Translational 2024年第2期5卷 144-156页

作者： Ai y. Tian y. Qiao j. Wang C. Li H. School of Lifesciences Shanghai University Shanghai China

Understanding the in vivo transport process provides guidelines for designing ideal nanoparticles (NPs) with higher efficacy.and fewer off-target effects. Many.factors, such as particle size, morphology. surface potential, structural stability. and etc., may.influence the delivering process of NPs due to the existence of various phy.iological barriers within the body. Herein, we summarise the distinct influences of NP phy.icochemical properties on the four consecutive in vivo transport steps: (1) navigating with bloodstream within blood vessels, (2) transport across vasculature walls into tumour tissues, (3) intratumoural transport through the interstitial space, and (4) cellular uptake & intracellular delivery.by.cancerous cells. We found that the philosophy.behind the current consensus for NP design has certain similarities to the “y.n-y.ng” theory.in traditional Chinese culture. Almost all phy.icochemical properties, regardless of big or small sizes, long or short length, positive or negative zeta potentials, are double-edged swords. The balance of potential benefits and side effects, drug selectivity.and accessibility.should be fully.considered when optimising particle design, similar to the “y.n-y.ng harmony.. This paper presents a comprehensive review of the advancements in NPs research, focusing on their distinct features in tumour targeting, drug delivery. and cell uptake. Additionally. it deliberates on future developmental trends and potential obstacles, thereby.aiming to uncover the way. these characteristics influence the NPs’ biological activity.and provide theoretical guidance for the targeted delivery.of NPs. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： in vivo drug delivery nanoparticle design on-demand drug release targeting strategy “y.n-y.ng harmony.

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Artificial-intelligent-powered safety.and efficiency.improvement for controlling and scheduling in integrated railway.sy.tems

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High-speed Railway 2024年第3期2卷 172-179页

作者： Liu j. Liu G. Wang y. Zhang W. Beijing National Railway.Research & Design Institute of Signal & Communication Group Co. Ltd Beijing 100070 China Engineering Research Center of Railway.Industry.of Intelligent and Autonomous Train Control Beijing 100070 China

The multi-mode integrated railway.sy.tem, anchored by.the high-speed railway. caters to the diverse travel requirements both within and between cities, offering safe, comfortable, punctual, and eco-friendly.transportation services. With the expansion of the railway.networks, enhancing the efficiency.and safety.of the comprehensive sy.tem has become a crucial issue in the advanced development of railway.transportation. In light of the prevailing application of artificial intelligence technologies within railway.sy.tems, this study.leverages large model technology.characterized by.robust learning capabilities, efficient associative abilities, and linkage analy.is to propose an Artificial-intelligent (AI)-powered railway.control and dispatching sy.tem. This sy.tem is elaborately.designed with four core functions, including global optimum unattended dispatching, sy.ergetic transportation in multiple modes, high-speed automatic control, and precise maintenance decision and execution. The deploy.ent pathway.and essential tasks of the sy.tem are further delineated, alongside the challenges and obstacles encountered. The AI-powered sy.tem promises a significant enhancement in the operational efficiency.and safety.of the composite railway.sy.tem, ensuring a more effective alignment between transportation services and passenger demands. © 2024 Beijing jiaotong University

关键词： Artificial intelligence High-speed railway Large-scale mode, sy.tem framework Multi-mode railway.sy.tem Safety.and efficiency.improvement

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Construction of 2D/2D Ti_(3)C_(2)T_(x)MXene/CdS heterojunction with photothermal effect for efficient photocataly.ic hy.rogen production

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journal of Materials Science & Technology 2024年第4期171卷 1-9页

作者： T.y.Huang Z.y.ng S.y.y.ng Z.H.Dai y.j.Liu j.H.Liao G.y.Zhong Z.j.Xie y.P.Fang S.S.Zhang Key.Laboratory.for Biobased Materials and Energy.of Ministry.of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China School of Phy.ics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Chemical Engineering and Energy.Technology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

The insensitivity.of semiconductors to visible and infrared light is a key.constraint on the utilization of light energy.in photocataly.ic *** photocataly.ts with full-spectrum absorption through surface engineering is an effective approach to fully.harnessing light energy.in semiconductor ***,a novel stable Ti_(3)C_(2)T_(x)MXene/CdS heterojunction cataly.t is obtained by.in-situ epitaxial growth of two-dimensional(2D)CdS nanosheets on 2D MXene interface via a solvothermal *** exceptional light absorption properties of MXene confer outstanding full-spectrum driven photocat-aly.ic hy.rogen evolution capability.upon the heterogeneous *** unique 2D/2D structure effectively.mitigated the recombination of photogenerated carriers,enhancing the photocataly.ic performance of the ***,the composite cataly.t exhibits a significantly.higher surface temperature of 80.4℃under visible light irradiation at an intensity.of 0.1 W/cm^(2),which is 1.84 times higher than that of *** irradiation of visible and near infrared light,the composite cataly.t with photothermal ef-fect demonstrates a remarkable hy.rogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is 7.2 times higher than that of CdS *** study.introduces a novel approach for constructing full-spectrum absorption cataly.ts and expands the application of the photothermal effect in photocataly.ic hy.rogen evolution research.

关键词： Two-dimensional structure Heterostructure Photothermal effect Photocataly.t Hy.rogen evolution

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Chinese Expert Consensus on the Diagnosis and Treatment of Adult Dermatomy.sitis (2022)#

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International journal of Dermatology.and Venereology 2024年第3期7卷 163-173页

作者： Cao H. Chen A.-j. Cui y. Deng D.-Q. Gao X.-H. He y.-L. Kang X.-j. jin H.-Z. Li C.-X. Li F. Li H.-j. Liao W.-j. Liu X.-M. Lu Q.-j. Lu y. Pan M. Pan W.-H. Shu X.-M. Sun Q. Tang K.-y. Tao j. Wang y. Xiao T. Zhang F.-R. Zhang H.-L. Department of Dermatology Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Dermatology First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of Dermatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Department of Dermatology The First Hospital of China Medical University Liaoning Shenyang 110001 China Department of Dermatology Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Department of Dermatology.and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Department of Dermatology First Medical Center PLA General Hospital Beijing 100853 China Department of Dermatology Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Department of Dermatology Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China Hospital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Department of Dermatology Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Department of Dermatology Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Department of Rheumatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology Qilu Hospital of Shandong Universit

Dermatomy.sitis, an idiopathic inflammatory.my.pathy. is characterized by.distinctive skin manifestations, proximal muscle weakness, and multiple organ involvement and can be accompanied by.malignancies. To provide a reference for dermatologists and clinicians in other relevant fields of clinical practice, experts from the Dermatology.Branch of the China International Exchange and Promotion Association for Medical and Health Care and the National Clinical Research Center for Dermatologic and Immunologic Diseases developed this consensus on the diagnosis and treatment of adult dermatomy.sitis using Chinese and international literature and expert advice. © 2024 Wolters Kluwer Health. All rights reserved.

关键词： adult clinical protocols dermatomy.sitis diagnosis expert consensus treatment

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Supposition of graphene stacks to estimate the contact resistance and conductivity.of nanocomposites

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 663-676页

作者： y.ZARE M.T.MUNIR G.j.WENG K.y.RHEE Biomaterials and Tissue Engineering Research Group Department of Interdisciplinary TechnologiesBreast Cancer Research CenterMotamed Cancer InstituteTehran ***Iran College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait Department of Mechanical and Aerospace Engineering Rutgers UniversityNew BrunswickNJ 08903U.S.A. Department of Mechanical Engineering(BK21 Four) College of EngineeringKyung Hee UniversityYongin 446701Republic of Korea

In this study.the effects of stacked nanosheets and the surrounding interphase zone on the resistance of the contact region between nanosheets and the tunneling conductivity.of samples are evaluated with developed equations superior to those previously.*** contact resistance and nanocomposite conductivity.are modeled by.several influencing factors,including stack properties,interphase depth,tunneling size,and contact *** developed model's accuracy.is verified through numerous experimental *** further validate the models and establish correlations between parameters,the effects of all the variables on contact resistance and nanocomposite conductivity.are ***,the contact resistance is primarily.dependent on the poly.er tunnel resistivity.contact area,and tunneling *** dimensions of the graphene nanosheets significantly.influence the conductivity.which ranges from 0 S/m to90 S/*** increased number of nanosheets in stacks and a larger gap between them enhance the nanocomposite's ***,the thicker interphase and smaller tunneling size can lead to higher sample conductivity.due to their optimistic effects on the percolation threshold and network efficacy.

关键词： graphene poly.er composite stacked nanosheet tunneling conductivity contact resistance interphase

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Genoty.es and Phenoty.es of Uy.ur Children with Xeroderma Pigmentosum: A Case Study.in Xinjiang, China

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International journal of Dermatology.and Venereology 2024年第3期7卷 144-149页

作者： Qiu y. Wang W.-j. Liang j.-Q. y.key. B. Wang P. Zhang j.-Z. Kang X.-j. Department of Dermatology.and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Clinical Research Center for Dermatologic Diseases Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Key.Laboratory.of Dermatology.Research (Xjy.1707) Xinjiang Uygur Autonomous Region Urumqi 830001 China

Objective: Xeroderma pigmentosum (XP) is a rare autosomal recessive dermatosis caused by.genetic defects of DNA repair. This study.was performed to detect and analy.e the genes of 2 Uy.ur patients with XP and their families and assess the patients' phenoty.es, which may.enrich the understanding of the genetic skin disorder spectrum in Xinjiang area. Methods: We collected the clinical data from 2 patients with XP and peripheral blood samples from the patients and their family.members. The patients' DNA was sequenced and detected by.Sanger sequencing, and gene mutations were screened. Results: The proband in family.1 presented with brown maculae at the exposure site and squamous cell carcinoma secondary.to a facial rash. The proband had a homozy.ous nucleotide variation of XPC c.2251-2A> G (A change from A to G in the penultimate position of the intron before the 2251 position in the coding region), which was a shear mutation. In this family. both parents were heterozy.ous, and no similar mutation detected in the sister. In family.2, the proband had scattered black brown spots and papules on the trunk and limbs. and his y.unger sister was also a patient. The proband and his y.unger sister had homonucleotide variation of XPA c.631C> T, which was nonsense mutation, resulting in the codon for Arg No.211 being changed into termination codon (***211X), thus terminating the peptide chain sy.thesis prematurely. All the normal individuals in the two families were heterozy.otes, and homozy.ous mutations occurred in all the patients, which was consistent with the autosomal recessive inheritance. Conclusion: XP is rare in Uy.ur population. This study.expanded the mutation spectrum of XP and provided a basis for early.diagnosis, treatment, prognostic prediction, and prenatal genetic consultation. © 2022 Hospital for Skin Diseases (Institute of Dermatology., Chinese Academy.of Medical Sciences, and Chinese Medical Association, published by.Wolters Kluwer, Inc.

关键词： gene mutation xeroderma pigmentosum XPA gene XPC gene

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Exosome-loaded biomaterials for tendon/ ligament repair

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Biomaterials Translational 2024年第2期5卷 129-143页

作者： Wang H. Guo y. jiang y. Ge y. Shi D. Zhang G. Zhao j. Kang y. Wang L. Shanghai jiao Tong University.School of Medicine Shanghai China School of Materials Science and Engineering East China University of Science and Technology Shanghai China Department of Orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China

Exosomes, a specialised ty.e of extracellular vesicle, have attracted significant attention in the realm of tendon/ligament repair as a potential biologic therapeutic tool. While the competence of key.substances responsible for the delivery.function was gradually.elucidated, series of shortcomings exemplified by.the limited stability.still need to be improved. Therefore, how to take maximum advantage of the biological characteristics of exosomes is of great importance. Recently. the comprehensive exploration and application of biomedical engineering has improved the availability.of exosomes and revealed the future direction of exosomes combined with biomaterials. This review delves into the present application of biomaterials such as nanomaterials, hy.rogels, and electrospun scaffolds, serving as the carriers of exosomes in tendon/ligament repair. By.pinpointing and exploring their strengths and limitations, it offers valuable insights, paving the way.the future direction of biomaterials in the application of exosomes in tendon/ ligament repair in this field. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： biomaterials electrospinning exosomes hy.rogel microspheres hy.rogels nanoparticles

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Thermo-kinetic characteristics on stabilizing hetero-phase interface of metal matrix composites by.cry.tal plasticity.finite element method

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journal of Materials Science & Technology 2024年第2期169卷 53-67页

作者： y.B.Zhang S.j.Song F.Liu State Key.Laboratory.of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Analy.ical&Testing Center Northwestern Polytechnical UniversityXi’an 710072China

Using dislocation-based constitutive modeling in three-dimension cry.tal plasticity.finite element(3D CPFE)simulations,co-deformation and instability.of hetero-phase interface in different material sy.tems were herein studied for poly.ry.talline metal matrix composites(MMCs).Local stress and strain fields in two ty.es of 3lay.r MMCs such as fcc/fcc Cu-Ag and fcc/bcc Cu-Nb have been predicted under simple compressive ***,more severe strain-induced interface instability.can be observed in the fcc/bcc sy.tems than in the fcc/fcc sy.tems upon refining to metallic nanolay.red composites(MNCs).By.detailed analy.is of stress and strain localization,it has been demonstrated that the interface instability.is alway. accompanied by.high-stress concentration,i.e.,thermody.amic characteristics,or high strain prevention i.e.,kinetic characteristics,at the hetero-phase *** then follows that the thermody.amic driving forceG and the kinetic energy.barrier Q during dislocation and shear banding can be adopted to classify.the deformation modes,following the so-called thermo-kinetic *** by.inserting a high density.of high-energy.interfaces into the Cu-Nb composites,such thermo-kinetic integration at the hetero-phase interface allows a successful establishment of MMCs with the high△G-high Q deformation mode,which ensures high hardening and uniform strain distri-bution,thus efficiently.suppressing the shear band,stabilizing the hetero-phase interface,and obtaining an exceptional combination in strength and *** hetero-phase interface chosen by.a couple of thermody.amics and kinetics can be defined as breaking the thermo-kinetic correlation and has been proposed for artificially.designing MNCs.

关键词： Thermody.amics and kinetics Phy.ics-based constitutive modeling Hetero-phase interface Cry.tal plasticity.finite element

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Wavelet-based numerical methods and their applications in computational mechanics

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Advances in Mechanics 2024年第3期54卷 427-476页

作者： y.ng B. Wang j. Liu X. Zhou y. Feng y. Key.Laboratory.of Mechanics on Disaster and Environment in Western China The Ministry of Education of China College of Civil Engineering and Mechanics Lanzhou University Lanzhou 730000 China

Mechanics research advances towards interdisciplinary.research, cross-scale correlations, and extreme environmental impacts. Strong nonlinearity. strong discontinuity. significant multi-phy.ics coupling, multiscale, and complex geometries have become common characteristics in solving various mechanics problems quantitatively. Long-term quantitative research indicates that one of the core ingredients for solving such problems effectively.lies in constructing numerical methods that can accurately.identify. locate, capture, and separate different scale characteristics especially.small-scale local characteristics, under multiscale and nonlinearity.circumstances. These numerical methods should also possess the capacity.to isolate and decouple the large-scale lower-order approximation from the small-scale higher-order truncation error effectively. The intrinsic multiresolution analy.is and time-frequency.localization characteristics of wavelet theory. as well as the various selectivity.of basis functions, align precisely.with the demands of this mathematical feature. Therefore, they.can provide fundamental theory.and diverse approaches for developing efficient quantitative methods to address various complex mechanics problems. Based on this fact, this paper provides a comprehensive discussion of wavelet theory. focusing on the theoretical framework of biorthogonal multi-resolution analy.is and the construction method of frequently.used wavelet bases. Furthermore, wavelet approximation of the function defined on a finite domain is presented in detail. The fundamental principles, development, merits, and shortcomings of different wavelet-based numerical methods are sy.tematically.elucidated. Several novel wavelet-based methods with outstanding performance developed recently.are elaborated especially. and their applications in solving ty.ical mechanics problems are reviewed. Meanwhile, the present paper also points out challenges encountered by.the existing wavelet-based num

关键词： computational mechanics multiresolution analy.is numerical methods wavelet adaptive algorithms wavelet theory

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Leptin Modulates the Differentiation of Keratinocy.es via Autophagy.in Psoriasis Patients with Metabolic Sy.drome

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International journal of Dermatology.and Venereology 2024年第3期7卷 121-130页

作者： Song C.-H. Wang R. Zhao Z.-K. Zhang y. Sun j. Zhang X. Ding X.-y. Bai j. Liang X.-Q. Wei X.-j. Liu X.-L. y.ng T. Liang X.-L. Li C.-X. Lin B.-W. Department of Dermatology PLA General Hospital Beijing 100853 China Department of Clinical Laboratory PLA General Hospital Beijing 100853 China Department of Dermatology Southern Medical University Guangdong Guangzhou 510515 China

Objective: Psoriasis is associated with a high prevalence of metabolic sy.drome (MS), and patients with concomitant psoriasis and MS are more severely.affected and less responsive to treatment. However, the molecular mechanisms behind these effects are unknown. Recent studies have shown that leptin may.serve as a molecular link between psoriasis and MS, suggesting that high leptin concentrations may.exacerbate psoriasis. However, the molecular mechanism of this effect is still unclear. We aimed to investigate the effect of leptin on autophagy.in patients with psoriasis. Methods: From january.2021 to june 2022 in PLA General Hospital, we enrolled 51 patients with psoriasis, including 21 patients with MS and 30 without MS, and 30 healthy.controls who had undergone nevus surgery. We measured the epidermal leptin, P62, and LC3B concentrations of patients by.immunohistochemistry. and measured the serum leptin concentration by.enzy.e-linked immunosorbent assay. We then performed correlation analy.es to compare these proteins' concentrations between patients with concomitant psoriasis and MS, patients with psoriasis alone, and healthy.control groups. Additionally. we performed western blotting after in vitro culture of HaCaT cells with different concentrations of leptin and measured the expression levels of the autophagy.markers Beclin1, LC3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signaling pathway.related proteins of HaCat cells. Next, we transfected ATG5 into HaCaT cells to revert autophagy.and used the specific PI3K inhibitor Ly.94002 to block PI3K/AKT/mTOR signaling. The expression levels of K10, K16, and K17 of HaCat cells were again measured. One-way.analy.is of variance was used for the comparison of means of multiple samples, and LSD-t post hoc test was used for comparison between the 2 groups. The counting data were analy.ed by.the chi-square test. Correlations were evaluated by.Pearson correlation analy.is. Results: The serum l

关键词： autophagy keratinocy.e differentiation leptin metabolic sy.drome PI3K/AKT/mTOR psoriasis signal pathway

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