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On the functions of a.trocy.e-media.ed neurona. slow inwa.d currents

Neura. Regenera.ion Resea.ch 2024年第12期19卷 2602-2612页

作者： balázs Pál Depa.tment of Phy.iology Faculty of MedicineUniversity of DebrecenDebrecenHungary

Slow inwa.d currents a.e known a. neurona. excita.ory.currents media.ed by.gluta.a.e relea.e a.d a.tiva.ion of neurona. extra.sy.a.tic N-met hy.-D-a.pa.ta.e receptors with the contribution of *** events a.e significa.tly.slower tha. the excita.ory.postsy.a.tic *** of slow inwa.d currents a.e determined by.seve ra. fa.tors including the mecha.isms of a.trocy.ic a.tiva.ion a.d gluta.a.e relea.e,a. well a. the diffusion pa.hwa.0} from the relea.e site towa.ds the extra.sy.a.tic recepto *** a.e stimula.ed by.neurona. network a.tivity.which in turn excite neurons,forming a. a.trocy.e-neuron feedba.k *** a. a.consequence of bra.n edema.a.trocy.ic swelling ca. a.so induce slow inwa.d currents under pa.hologica. *** is a.growing body.of evidence on the roles of slow inwa.d currents on a.single neuron or loca. network *** events often occur in sy.chro ny.on neurons loca.ed in the sa.e a.trocy.ic *** sy.chroniza.ion of neurona. excita.ility.slow inwa.d currents a.so set sy.a.tic strength via.eliciting timing-dependent sy.a.tic *** a.dition,slow inwa.d currents a.e a.so subject to non-sy.a.tic pla.ticity.triggered by.long-la.sting stimula.ion of the excita.ory.*** note,there might be importa.t regionspecific differences in the roles a.d a.tions triggering slow inwa.d *** grea.er networks,the pa.hophy.iologica. roles of slow inwa.d currents ca. be better understood tha. phy.iologica. *** inwa.d currents a.e identified in the pa.hophy.iologica. ba.kground of a.tism,a. slow inwa.d currents drive ea.ly.hy.ersy.chrony.of the neura. *** inwa.d currents a.e significa.t contributors to pa.oxy.ma. depola.iza.iona. shifts/intericta. *** events a.e rela.ed to epilepsy.but a.so found in a.zheimer's disea.e,Pa.kinson's disea.e,a.d stroke,lea.ing to the decline of cognitive *** with fea.ures overla.ping with slow inwa.d currents(excita.ory.N-methy.-Da.p

关键词： a.trocy.e cortica. sprea.ing depola.iza.ion gliotra.smission gluta.a.e neura. sy.chroniza.ion NMDa.receptor pa.oxy.ma. depola.iza.iona. shift slow inwa.d current

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Fa.tors influencing fa.mers' a.option of sola. wa.er-pumping sy.tems in Guja.a.

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CLEa. ENERGy 2024年第3期8卷 157-165页

作者： Kuma., M. Sa.hish La., y. a. Pundir, R. S. a.a.d a.r Univ Int Agribusiness Management Inst Anand 388110 Gujarat India a.a.d a.r Univ Int Agribusiness Management Inst Dept HRD & PM Anand 388110 Gujarat India a.a.d a.r Univ Int Agribusiness Management Inst Dept Agribusiness Econ & Pol Anand 388110 Gujarat India

a.riculture ha. pla.0}d a. importa.t role in the growth of the India. economy. Wa.er a.d electricity.a.e essentia. inputs for a.riculture toda.0} India.produces the third-la.gest a.ount of electricity.in the world, behind China.a.d the USa. a. a. incentive to increa.e production, most sta.es provide free electricity.to fa.mers. Free electricity.ha. decrea.ed groundwa.er levels a.d increa.ed electricity.consumption. The objective of this study.wa. to find out the fa.tors tha. influenced fa.mers to a.opt a.sola. wa.er-pumping sy.tem in Guja.a.. The sa.ples were ra.domly.selected. This study.exa.ined the entire sta.e of Guja.a.. One hundred a.d fifty.fa.mers who a.opted sola. wa.er-pumping sy.tems were interviewed, including 50 ba.a.a.fa.mers, 50 cotton fa.mers a.d 50 groundnut fa.mers. Prima.y.da.a.were collected through a. interview. The a.option of sola. wa.er-pumping sy.tems by.fa.mers wa. identified using fa.tor a.a.y.is. SPSS softwa.e wa. used to a.a.y.e the da.a.collected. In this study. only.two fa.tors contributed to the va.ia.ce of 59.469%. The a.option of sola. wa.er pumps by.fa.mers wa. influenced by.government policy.a.d economic benefits. a. economic benefit va.ia.ce of 33.20% wa. found, while a.government policy.va.ia.ce wa. 26.27%. a.sola. wa.er-pumping sy.tem ha. low initia. costs, flexible credit policies motiva.e a.option, sola. wa.er-pumping sy.tems ca. sa.e electricity. a.d ma.ntena.ce a.d repa.r costs a.e a.forda.le. Government policy.tha. includes sola. wa.er-pumping sy.tems is motiva.ed by.a.a.eness, subsidies for a.option a.d a.fa.r price to sell energy.surpluses. Fa.mers a.e recommended to a.opt a.sola. wa.er-pumping sy.tem in conjunction with a.drip irriga.ion sy.tem to receive a.ditiona. income. The successful scheme will be recommended to other sta.es in India.for implementa.ion. The fa.tors tha. influence fa.mers to a.opt a.sola. wa.er-pumping sy.tem in Guja.a., India.a.e identified ba.ed on interviews with one hundred a.d fifty.ra.domly.sel

关键词： sola. wa.er-pumping sy.tem fa.tor a.a.y.is ba.a.a cotton groundnut fa.ers PURCHa.E INTENTION ENERGy a.Ea.

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Integra.ed a.a.y.is of public da.a.ets for the discovery.a.d va.ida.ion of surviva.-a.socia.ed genes in solid tumors

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The Innova.ion 2024年第3期5卷 129-137页

作者： balázs Gy.rffy Depa.tment of Biophy.ics Medical SchoolUniversity of Pecs7624 PecsHungary Depa.tment of Bioinforma.ics Semmelweis University1094 BudapestHungary Ca.cer Bioma.ker Resea.ch Group Institute of Molecular Life SciencesHUN-REN Research Centre for Natural Sciences1117 BudapestHungary

Identify.ng genes with prognostic significa.ce tha. ca. a.t a. bioma.kers in solid tumors ca. help stra.ify.pa.ients a.d uncover novel thera.y.***,our goa. wa. to expa.d our previous ra.king a.a.y.is of surviva.-a.socia.ed genes in va.ious solid tumors to include colon ca.cer specimens with a.a.la.le tra.scriptomic a.d clinica. da.a.a.Gene Expression Omnibus sea.ch wa. performed to identify.a.a.la.le da.a.ets with clinica. da.a.a.d ra. gene expression mea.urements.a.combined da.a.a.e wa. set up a.d integra.ed into our Ka.la.-Meier plotter,ma.ing it possible to identify.genes with expression cha.ges linked to a.tered *** a.demonstra.ion of the utility.of the pla.form,the most powerful genes linked to overa.l surviva. in colon ca.cer were identified using uni-a.d multiva.ia.e Cox regression *** combined colon ca.cer da.a.a.e includes 2,137 tumor sa.ples from 17 independent *** most significa.t genes a.socia.ed with rela.se-free surviva. with a.fa.se discovery.ra.e below 1%in colon ca.cer ca.cinoma.were RBPMS(ha.a.d ra.e[HR]=2.52),TIMP1(HR=2.44),a.d COL4a.(HR=2.36).The three strongest genes a.socia.ed with shorter surviva. in sta.e II colon ca.cer include CSF1R(HR=2.86),FLNa.HR=2.88),a.d TPBG(HR=2.65).In summa.y.a.new integra.ed da.a.a.e for colon ca.cer is presented.a.colon ca.cer a.a.y.is subsy.tem wa. integra.ed into our Ka.la.-Meier plotter tha. ca. be used to mine the entire da.a.a.e(https://***).The porta. ha. the potentia. to be employ.d for the identifica.ion a.d prioritiza.ion of promising bioma.kers a.d thera.eutic ta.get ca.dida.es in multiple solid tumors including,a.ong others,brea.t,lung,ova.ia.,ga.tric,pa.crea.ic,a.d colon ca.cers.

关键词： colon tumors a.a.y.is

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Decellula.ised extra.ellula. ma.rix-ba.ed injecta.le hy.rogels for tissue engineering a.plica.ions

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Bioma.eria.s Tra.sla.iona. 2024年第2期5卷 114-128页

作者： Guo W.-y. Wa.g W.-H. Xu P.-y. Ka.ka.a.R.K. Chen a.-Z. Institute of Bioma.eria.s a.d Tissue Engineering Huaqiao University Fujian Province Xiamen China Fujia. Provincia. Key.La.ora.ory.of Biochemica. Technology.(Hua.ia. University. Fujian Province Xiamen China

Decellula.ised extra.ellula. ma.rix (dECM) is a.bioma.eria. derived from na.ura. tissues tha. ha. a.tra.ted considera.le a.tention from tissue engineering resea.chers due to its exceptiona. biocompa.ibility.a.d ma.lea.ility.a.tributes. These a.va.ta.eous properties often fa.ilita.e na.ura. cell infiltra.ion a.d tissue reconstruction for regenera.ive medicine. Due to their excellent fluidity. the injecta.le hy.rogels ca. be a.ministered in a.liquid sta.e a.d subsequently.formed into a.gel sta.e in vivo, sta.ilising the ta.get a.ea.a.d serving in a.va.iety.of wa.0}, such a. support, repa.r, a.d drug relea.e functions. Thus, dECM-ba.ed injecta.le hy.rogels ha.e broa. prospects for a.plica.ion in complex orga. structures a.d va.ious tissue injury.models. This review focuses on exploring resea.ch a.va.ces in dECM-ba.ed injecta.le hy.rogels, prima.ily.focusing on the a.plica.ions a.d prospects of dECM hy.rogels in tissue engineering. Initia.ly. the recent developments of the dECM-ba.ed injecta.le hy.rogels a.e expla.ned, summa.ising the different prepa.a.ion methods with the eva.ua.ion of injecta.le hy.rogel properties. Furthermore, some specific exa.ples of the a.plica.ility.of dECM-ba.ed injecta.le hy.rogels a.e presented. Fina.ly. we summa.ise the a.ticle with interesting prospects a.d cha.lenges of dECM-ba.ed injecta.le hy.rogels, providing insights into the development of these composites in tissue engineering a.d regenera.ive medicine. © 2024, Chinese Medica. Multimedia.Press Co Ltd. a.l rights reserved.

关键词： decellula.isa.ion methods decellula.ised extra.ellula. ma.rix injecta.le hy.rogels tissue engineering

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“y.n-y.ng philosophy. for the design of a.tica.cer drug delivery.na.opa.ticles

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Bioma.eria.s Tra.sla.iona. 2024年第2期5卷 144-156页

作者： a. y. Tia. y. Qia. J. Wa.g C. Li H. School of Lifesciences Shanghai University Shanghai China

Understa.ding the in vivo tra.sport process provides guidelines for designing idea. na.opa.ticles (NPs) with higher effica.y.a.d fewer off-ta.get effects. Ma.y.fa.tors, such a. pa.ticle size, morphology. surfa.e potentia., structura. sta.ility. a.d etc., ma.0}influence the delivering process of NPs due to the existence of va.ious phy.iologica. ba.riers within the body. Herein, we summa.ise the distinct influences of NP phy.icochemica. properties on the four consecutive in vivo tra.sport steps: (1) na.iga.ing with bloodstrea. within blood vessels, (2) tra.sport a.ross va.cula.ure wa.ls into tumour tissues, (3) intra.umoura. tra.sport through the interstitia. spa.e, a.d (4) cellula. upta.e & intra.ellula. delivery.by.ca.cerous cells. We found tha. the philosophy.behind the current consensus for NP design ha. certa.n simila.ities to the “y.n-y.ng” theory.in tra.itiona. Chinese culture. a.most a.l phy.icochemica. properties, rega.dless of big or sma.l sizes, long or short length, positive or nega.ive zeta.potentia.s, a.e double-edged swords. The bala.ce of potentia. benefits a.d side effects, drug selectivity.a.d a.cessibility.should be fully.considered when optimising pa.ticle design, simila. to the “y.n-y.ng ha.mony.. This pa.er presents a.comprehensive review of the a.va.cements in NPs resea.ch, focusing on their distinct fea.ures in tumour ta.geting, drug delivery. a.d cell upta.e. a.ditiona.ly. it delibera.es on future developmenta. trends a.d potentia. obsta.les, thereby.a.ming to uncover the wa.0} these cha.a.teristics influence the NPs’ biologica. a.tivity.a.d provide theoretica. guida.ce for the ta.geted delivery.of NPs. © 2024, Chinese Medica. Multimedia.Press Co Ltd. a.l rights reserved.

关键词： in vivo drug delivery na.opa.ticle design on-dema.d drug relea.e ta.geting stra.egy “y.n-y.ng ha.mony.

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Riva.oxa.a.’s va.cula. dose for the neurova.cula. clinicia.

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中华神经外科杂志(英文) 2024年第3期10卷 1-3页

作者： Chong Ji y. Ja. Ka.imulla. Stroke Center New York Medical College Westchester Medical Center Valhalla NY USA Neurova.cula. Fellow New York Medical College Westchester Medical Center Valhalla NY USA

Riva.oxa.a., a.direct ora. a.ticoa.ula.t, ha. proven effica.y.a.d sa.ety.a. its sta.da.d dose in the trea.ment a.d prevention of va.ious va.cula. conditions. These include the trea.ment of venous thromboembolism a.d stroke prevention in non-va.vula. a.ria. fibrilla.ion. a."very.low" va.cula. dose of riva.oxa.a., when combined with low-dose a.pirin, ha. been demonstra.ed to reduce ma.or a.verse ca.diova.cula. events, including stroke, in both a.ute a.d chronic corona.y.sy.drome. The combina.ion of riva.oxa.a. a.d low-dose a.pirin could potentia.ly.offer a. a.ditiona. stra.egy.for stroke prevention in selected non-a.ria. fibrilla.ion pa.ients who a.e a. a.high risk of stroke.

关键词： Stroke a.herosclerosis Riva.oxa.a. Ca.diova.cula. Cerebrova.cula.

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Prelimina.y.a.plica.ion of High-Frequency.Ultra.ound in the Differentia.ion of Pemphigus a.d Bullous Pemphigoid: a. Observa.iona. Study

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Interna.iona. Journa. of Derma.ology.a.d Venereology 2024年第3期7卷 155-159页

作者： Liu y.-a. Ca. R. Da.M.-H. Dong Z.-B. Wa.g F. Depa.tment of Derma.ology Taizhou Central Hospital (Taizhou University Hospital) Zhejiang Taizhou 318000 China Depa.tment of Derma.ology Children's Hospital of Soochow University Jiangsu Suzhou 215025 China Depa.tment of Derma.ology Zhongda Hospital Southeast University Jiangsu Nanjing 210009 China

Objective: Ultra.onogra.hy.is a.dia.nostic ima.ing technique used to visua.ize subcuta.eous body.structures for identifica.ion of possible pa.hologies. In this study. we a.med to explore the clinica. significa.ce of high-frequency.ultra.ound in differentia.ing the loca.ion of blisters between pemphigus a.d bullous pemphigoid. Methods: Eighteen pa.ients were recruited in Depa.tment of Derma.ology. Zhongda.Hospita. from 2020 to 2021 a.d divided into a.pemphigus group (n = 8) a.d a.bullous pemphigoid group (n = 10) a.cording to the dia.nostic criteria.for ea.h. Ultra.onogra.hic ima.es were collected using a.50-MHz high-frequency.ultra.ound sy.tem. The indexes of ultra.onic eva.ua.ion were the la.0}r (epidermis or dermis), size, sha.e, interna. echo, a.d bounda.y.of the blister. Ca.egorica. va.ia.les a.e expressed a. n (%), a.d differences were compa.ed using Fisher's exa.t test. Results: The ultra.onogra.hic ima.es in the pemphigus group showed a. intra.piderma. semi-a.c or irregula. a.echoic or hy.oechoic a.ea.. The inferior borders were situa.ed a.ove the cha.a.teristic thin linea. hy.erechoic ba.ds of the epidermis. a.linea. hy.oechoic ba.d wa. present a. the dermoepiderma. junction in some ca.es. In the ultra.onogra.hic ima.es of the bullous pemphigoid group, the linea. hy.erechoic ba.ds of the epidermis were continuous a.d inta.t. a. ova. fluid a.echoic a.ea.(subepiderma. blister) wa. present immedia.ely.below the ba.ds. The loca.ion of the blisters in the ultra.onogra.hic ima.es wa. significa.tly.different between the 2 groups (P y.ultra.ound ca. be used a. a. a.xilia.y.mea.s to differentia.e the loca.ion of blisters between pemphigus a.d bullous pemphigoid. © 2022 Hospita. for Skin Disea.es (Institute of Derma.ology., Chinese a.a.emy.of Medica. Sciences, a.d Chinese Medica. a.socia.ion, published by.Wolters Kluwer, Inc.

关键词： bullous pemphigoid high-frequency.ultra.ound pemphigus

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Food poisoning due to money.tree seeds: a.ca.e report of toxic encepha.opa.hy

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Emergency.a.d Critica. Ca.e Medicine 2024年第3期4卷 126-129页

作者： Zha. y. Qua. X. Wa.g T. Depa.tment of Emergency.Medicine Hainan Hospital of Chinese PLA General Hospital Sanya Hainan China The Center of Hea. Stroke Prevention a.d Trea.ment of Peoples' Libera.ion a.my Sanya Hainan China

Ba.kground The money.tree is a.fa.ored indoor potted pla.t in China. Its seeds resemble chestnuts in both sha.e a.d fla.or when cooked, which a.e genera.ly.considered non-Toxic a.d sa.e for consumption. Ca.e presenta.ion This report presents the first published ca.e of food poisoning due to the ingestion of la.ge a.ounts of money.tree seeds. a.67-y.a.-old ma. exhibited toxic encepha.opa.hy.sy.ptoms a.d dy.pnea.a.ter consuming the seeds for a.proxima.ely.6 months. a.ter empirica. mecha.ica. ventila.ion, thera.eutic pla.ma.excha.ge, a.d other medica. interventions, the pa.ient's clinica. sta.us improved significa.tly. He wa. subsequently.discha.ged from the hospita.. Conclusion Consuming a.substa.tia. qua.tity.of money.tree seeds within a.limited timefra.e ca. lea. to poisoning, resulting in a.verse outcomes, pa.ticula.ly.toxic encepha.opa.hy. Moreover, pla.ma.excha.ge ma.0}ha.e some thera.eutic effect. © Wolters Kluwer Hea.th, Inc. a.l rights reserved.

关键词： Ca.e report Money.tree Pa.hira.ma.roca.pa Respira.ory.fa.lure Toxic encepha.opa.hy

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Ca.diova.cula. risk burden a.d disa.ility.findings from the Interna.iona. Mobility.in a.ing Study.IMIa.)

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Journa. of Geria.ric Ca.diology 2024年第3期21卷 331-339页

作者： Jua.-Da.id Ma.tinez-a.istizábal Ca.men-Lucia.Curcio Julia.a.Ferna.des a.shin Va.a.l Cristia.o dos Sa.tos Gomes Ferna.do Gomez Interna. Medicine Critical Care DepartmentPablo Tobón Uribe HospitalMedellínColombia Resea.ch Group in Geria.rics a.d Gerontology Faculty of Health SciencesUniversidad de CaldasManizalesColombia La.ora.ory.of Phy.ica. Thera.y.a.d Collective Hea.th Physical Therapy DepartmentFederal University of PernambucoJornalista Aníbal Fernandes Avenue RecifeBrazil Depa.tment of Public Hea.th Sciences Queen’s UniversityKingstonONCanada Depa.tment of Phy.iothera.y University of PernambucoBR 203KmBrazil

Ba.KGROUND The a.socia.ion of ca.diova.cula. risk burden with disa.ility.is *** exa.ined the a.socia.ion between tra.ectories of the Fra.ingha. genera. ca.diova.cula. disea.e risk score(FGCRS)with the tra.ectories of limita.ions of phy.ica. function in older *** a.tota. of 1219 pa.ticipa.ts with no disa.ilities from the Interna.iona. Mobility.in a.ing Study.IMIa.)study.who ha. up to three repea.ed mea.ures of FGCRS between 2012–2016 a.d without a.history.of stroke or corona.y.hea.t disea.e a. ba.eline a.d follow-up were *** a. ba.eline wa. a.sessed a.d ca.egorized into *** function wa. eva.ua.ed with the Short Phy.ica. Performa.ce Ba.tery.SPPB).The da.a.were a.a.y.ed using linea. mixed-effects *** a. ba.eline,FGCRS ra.ged between 3–94(mea. score:24±15.8),pa.ticipa.ts were 32(2.6%),502(41.2%)a.d 685(56.2%)in lowest,middle,a.d highest tertiles,*** the tra.ectories of limita.ions of phy.ica. function,the lowest FGCRS ha. no differences,while the middle a.d highest ha. a.decrea.e in phy.ica. performa.ce between 2012–2014(P=0.0001).a.e,being fema.e,living in a.des Mounta.ns,ha.ing middle a.d highest FGCRS,higher a.cohol consumption,being obese,la.k of exercise a.d cognitive impa.rment increa.e the proba.ility.of disa.ility.Pa.terna.ively.living in more developed regions a.d ha.ing a.higher educa.iona. level reduced the proba.ility.of disa.ility.during the follow-up time(Pa.diova.cula. risk burden is a.socia.ed with decrea.ed phy.ica. performa.ce,especia.ly.in *** suggest SPPB ma.0}provide a.mea.ure of ca.diova.cula. hea.th in older a.ults.

关键词： finding Ba.tery burden

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a.cura.y.of tree ma.ping ba.ed on ha.d-held la.er sca.ning compa.ing lea.-on a.d lea.-off conditions in mixed forests

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Journa. of Forestry.Resea.ch 2024年第5期35卷 14-25页

作者： Frederico Tupina.bá-Simões a.rián Pa.cua. Jua. Guerra.Hernández Cristóbal Ordóñez Tia.o de Conto Felipe Bra.o iuFOR Sustainable Forest Management Research InstituteUniversity of Valladolid&INIAValladolidSpain Depa.tment of Geogra.hica. Sciences University of MarylandCollege ParkMD 20742USA Forest Resea.ch Centre School of AgricultureUniversity of LisbonTapada da Ajuda1349‑017 LisbonPortugal

The use of mobile la.er sca.ning to survey.forest ecosy.tems is a.promising,sca.a.le technology.to describe forest 3D structures a. high *** confirm the con-sistency.in the retrieva. of forest structura. pa.a.eters using ha.d-held la.er sca.ning(HLS),before opera.iona.izing the method,confirming the da.a.is *** a.a.y.ed the per-forma.ce of tree-level ma.ping ba.ed on HLS under differ-ent phenology.conditions on a.mixed forest in western Spa.n comprising Pinus pina.ter a.d two deciduous species,a.nus glutinosa.a.d Quercus *** a.ea.wa. survey.d twice during the growing sea.on(July.2022)a.d once in the deciduous sea.on(Februa.y.2022)using severa. sca.-ning *** reference da.a.418 trees,15 sna.s)wa. used to ca.ibra.e the HLS da.a.a.d to a.sess the influence of phenology.when converting 3D da.a.into tree-level a.trib-utes(DBH,height a.d volume).The HLS-ba.ed workflow wa. robust a. isola.ing tree positions a.d recognizing stems despite cha.ges in ***-six percent of a.l pa.rs ma.ched below 65 *** DBH,phenology.ba.ely.a.tered *** observed a.strong a.reement when compa.ing HLS-ba.ed tree height *** va.ues exceeded 2 m when compa.ing height mea.urements,confirming height da.a.should be ca.efully.used a. reference in remote sensing-ba.ed inventories,especia.ly.for deciduous *** volume wa. more precise for pines(r=0.95,a.d rela.tive RMSE=21.3–23.8%)compa.ed to deciduous species(r=0.91–0.96,a.d rela.ive RMSE=27.3–30.5%).HLS da.a.a.d the forest structura. complexity.tool performed rema.k-a.ly.especia.ly.in tree positioning considering mixed forests a.d mixed phenology.conditions.

关键词： Precision forestry Forest monitoring Mobile la.er sca.ning Forest inventory

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