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Design Development of Advanced Power Reactor 1400

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Design Development of Advanced Power Reactor 1400

Drainage control and slope stability at an open pit mine:A GIs-based hydrological modeling

第13届太平洋地区核能大会

作者： y.s.choi s.J.Cho D.W.Jerng Center for Advanced Reactors Development Nuclear Environment Technology Institute Korea Hydro ＆ Nuclear Power Co. Ltd. 103-16 Munji-Dong Yuseong-Gu Daejon 305-380 Korea Center for Advanced Reactors Development Nuclear Environment Technology Institute Korea Hydro ＆ Nuclear Power Co. Ltd. 103-16 Munji-Dong Yuseong-Gu Daejon 305-380 Korea Center for Advanced Reactors Development Nuclear Environment Technology Institute Korea Hydro ＆ Nuclear Power Co. Ltd. 103-16 Munji-Dong Yuseong-Gu Daejon 305-380 Korea

＜正＞Advanced Power Reactor 1400 （APR1400） has been developed since 1992 asone of long-term national R＆D projects in Korea. APR1400 is an evolutionary typenuclear power plant of a 1400 MWe class, which upgrades the safety and economiccompetitiveness of nuclear power incorporating up-to-date advanced technologywhile stands on the proven basis of the experience from currently operating nuclearpower plants. Major advanced features were focused on the safety enhancement andthe incorporation of digital technology was made in the control room design. To verifysome of the new design features of APR1400, experimental programs were ***, the system and layout were optimized for cost reduction through the reflectionof the construction and operation experiences of currently operating plants in *** accordance with the design development, the licensing review of the standarddesign was performed and design certification was issued. The first of APR1400 is inthe construction plan to be commissioned in september 2010. The site is preparednext the Kori site, the east-south seashore of Korea, where the first nuclear powerplant in Korea was installed.

关键词： ALWR APR1400 KNGR URD

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Drainage control and slope stability at an open pit mine:A G...

采用常规MR成像和扩散张量成像的影像组学和机器学习可准确预测脑膜瘤分级和组织学分型

The Tenth International symposium on Landslides and Engineered slopes

作者： C. sunwoo y.s. choi H.D. Park y.B. Jung Geotechnical Engineering Division Korea Institute of Geoscience & Mineral Resources (KIGAM) Department of Energy systems Engineering Seoul National University (SNU)

slope erosion and flooding of the open-pit mines are typical problems which need proper drainage controls at the heavy rainfall region where surface drainage pattern is dominated by the fast change of landform due to mining operation. This paper presents an application of GIs-based hydrological modeling, spatial analysis and slope stability in a region of Pasir coal mine, Indonesia. A detailed topographical survey was performed at the study area to generate a reliable DEM. By using GIs, the more reproducible information about hydrological characteristic of drainage system could be extracted from DEM. The results from drainage analysis and raster- based spatial analysis showed that current arrangement of pumping facility is not suitable and some vulnerable places to erosion exist on the bench face due to concentrated surface runoff. Finally, some practical measures were suggested to optimize the design of drainage system and to monitor the slope stability by the surface water management at the study region during heavy rainfall.

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国际医学放射学杂志 2019年第5期 627-628页

作者： y.W.Park J.Oh s.C.you K.Han s.s.Ahn y.s.choi 彭攀 Department of Radiology Ewha Womans University College of Medicine

摘要目的术前对脑膜瘤进行无创性分级预测至关重要,因其会影响后续治疗决策的制定。本研究的目的在于评估基于全肿瘤体积的T;增强扫描（T;C）、表观扩散系数

关键词：扩散张量成像组织学分型影像组学 MR 机器学习

明胶基海绵的研究——Ⅲ.明胶╱藻酸盐、明胶╱透明质酸盐和壳聚糖╱透明质酸盐交联海绵及它们作为老鼠全厚度皮肤损伤的创伤敷料应用的比较研究

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明胶科学与技术 2003年第1期23卷 22-30页

作者： y.s.choi 李承明

制备和比较明胶/藻酸盐(GA),明胶/透明质酸盐(GH)和壳聚糖/透明质酸盐(CH)交联海绵,含有或不含有磺胺嘧啶银(AgsD)的6种不同海绵应用于治疗背部全厚度皮肤损伤的Wistar老鼠。这种皮肤损伤的组织学和表皮伤口愈合速度的研究是借助光学显... 详细信息

制备和比较明胶/藻酸盐(GA),明胶/透明质酸盐(GH)和壳聚糖/透明质酸盐(CH)交联海绵,含有或不含有磺胺嘧啶银(AgsD)的6种不同海绵应用于治疗背部全厚度皮肤损伤的Wistar老鼠。这种皮肤损伤的组织学和表皮伤口愈合速度的研究是借助光学显微镜和计算机的形态测量学5d和12d后的后期工作。在对我们的全厚度损伤试样(直径1cm)的治疗中,总体上说,含AgsD的海绵具有优良的伤口愈合能力。然而,明胶基海绵(GA,GH)和CH的伤口愈合的区别显得更有意义。通过对组织学研究结果和计算机化的形态测量学的表皮愈合分析发现,含AgsD的CH作为创伤敷料具有最强的伤口愈合能力。

关键词：伤口愈合 sD GH 皮肤损伤 CH 明胶治疗胶基海绵创伤敷料

非增强MR淋巴管（结）成像在术后乳糜胸或颈部乳糜漏的诊断和术前计划中的实用价值

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国际医学放射学杂志 2022年第3期 367-368页

作者： D.Hyun H.y.Lee J.H.Cho H.K.Kim y.s.choi J.Kim 孙素晔

摘要目的明确非增强MR淋巴管(结)成像(MRL)在治疗术后乳糜胸或颈部乳糜漏中的作用。方法 2016年5月—2020年4月间共有50例病人先后接受了非增强MRL和胸

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根据修订的2017年版国际共识指南比较CT和MRI诊断胰腺导管内乳头状黏液性肿瘤的恶性潜能

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国际医学放射学杂志 2019年第6期 737-738页

作者： J.E.Lee s.y.choi J.H.Min B.H.yi M.H.Lee s.s.Kim 殷常青 Department of Radiology Soonchunhyang University College of Medicine Bucheon Hospital

摘要 2017年修订的胰腺导管内乳头状黏液性肿瘤(IPMN)国际共识指南的诊断性能有待验证。目的评估该指南在预测胰腺癌IPMN的恶性潜能,并比较增强CT和MRI

关键词：胰腺导管内乳头状黏液性肿瘤国际共识指南 CT 恶性潜能 MRI

磁共振胰管成像:比较二维和三维成像序列对胰腺导管内乳头状黏液性肿瘤的评估能力

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国际医学放射学杂志 2009年第6期 594-595页

作者： J.y.choi J.M.Lee M.W.Lee s.J.Kim s.y.choi J.y.Kim 廖承德 Department of Radiology Research Institute of Radiological ScienceYonsei University Health SystemSeodaemun-ku Shinchon-dong 134Seoul120-752Korea

研究目的是比较二维(2D)磁共振胰管成像(MRP)与三维(3D)MRP对于胰腺导管内乳头状黏液性肿瘤(IPMN)的评估能力。34例病人(男性22例,女性12例;年龄45～80岁)罹患IPMN(n=40),同时接受2D和3D MRP序列扫描。2名医师独立阅片并对整体影像质量、

关键词：胰腺导管内乳头状黏液性肿瘤 MRP 胰管胰腺管 IPMN 磁共振

Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee Kim Rudolph ETanzi se Hoon choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： shan Ping yu Emily choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment