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Icariin ameliorates viral myocarditis by inhibiting TLR4-mediated ferroptosis

Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 106-114,I0002-I0005页

作者： Wei Luo yi Lu Jun-Hua Deng Peng Liu yan huang Wan-Xi Liu Chun-Li huang Laboratory of the Atherosclerosis and Ischemic Cardiovascular Diseases Department of CardiologyAffiliated Hospital of Youjiang Medical University for NationalitiesYoujiang Medical University for NationalitiesBaiseGuangxi 533000China Department of Critical Care Medicine Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China Department of Respiratory and Critical Care Medicine Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China Postgraduate School of youjiang Medical University for Nationalities BaiseGuangxi 533000China Department of Neonatology Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China Department of Nephrology People’s Hospital of PubeiQinzhouGuangxi 535300China Urban Community Health Service Center of youjiang District BaiseGuangxi 533000China

Objective:To explore the mechanism by which icariin alleviates viral ***:CVB3-induced cardiomyocytes were used as an in vitro model of viral myocarditis to assess the effects of icariin treatment on cell viability,inflammation,and ***,the effects of icariin on ferroptosis and TLR4 signaling were *** AC16 cells were transfected with TLR4 overexpression plasmids,the role of TLR4 in mediating the regulatory effect of icariin in viral myocarditis was ***:Icariin significantly elevated cell viability and reduced inflammatory factors TNF-α,IL-1β,IL-6,and *** cytometry revealed that icariin decreased apoptosis rate,and the protein expression of Bax and cleaved caspase 3 and 9 in CVB3-induced ***,it suppressed ferroptosis including lipid peroxidation and ferrous ion,as well as the TLR4 ***,TLR4 overexpression abrogated the modulatory effects of ***:Icariin mitigates CVB3-induced myocardial injury by inhibiting TLR4-mediated *** animal study is needed to verify its efficacy.

关键词： Viral myocarditis CVB3 TLR4 Ferroptosis Icariin

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Drug repurposing for cancer therapy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1981-2013页

作者： ying Xia Ming Sun Hai huang Wei-Lin Jin Center for Clinical Laboratories The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004PR China The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550001PR China School of Clinical Laboratory Science Guizhou Medical UniversityGuiyang 550004PR China Division of Gastroenterology and Hepatology Department of Medicine andDepartment of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21287USA Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhou 730000PR China

Cancer,a complex and multifactorial disease,presents a significant challenge to global *** significant advances in surgical,radiotherapeutic and immunological approaches,which have improved cancer treatment outcomes,drug therapy continues to serve as a key therapeutic ***,the clinical efficacy of drug therapy is often constrained by drug resistance and severe toxic side effects,and thus there remains a critical need to develop novel cancer *** promising strategy that has received widespread attention in recent years is drug repurposing:the identification of new applications for existing,clinically approved *** repurposing possesses several inherent advantages in the context of cancer treatment since repurposed drugs are typically cost-effective,proven to be safe,and can significantly expedite the drug development process due to their already established safety *** light of this,the present review offers a comprehensive overview of the various methods employed in drug repurposing,specifically focusing on the repurposing of drugs to treat *** describe the antitumor properties of candidate drugs,and discuss in detail how they target both the hallmarks of cancer in tumor cells and the surrounding tumor *** addition,we examine the innovative strategy of integrating drug repurposing with nanotechnology to enhance topical drug *** also emphasize the critical role that repurposed drugs can play when used as part of a combination therapy *** conclude,we outline the challenges associated with repurposing drugs and consider the future prospects of these repurposed drugs transitioning into clinical application.

关键词： drugs integrating spite

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2D DOA Estimation of Coherent Signals with a Separated Linear Acoustic Vector-Sensor Array

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China Communications 2024年第2期21卷 155-165页

作者： Sheng Liu Jing Zhao Decheng Wu yiwang huang Kaiwu Luo School of Data Science Tongren UniversityTongren 554300China School of Automation Chongqing University of Posts and TelecommunicationsChongqing 400065China

In this paper, a two-dimensional(2D) DOA estimation algorithm of coherent signals with a separated linear acoustic vector-sensor(AVS) array consisting of two sparse AVS arrays is proposed. Firstly,the partitioned spatial smoothing(PSS) technique is used to construct a block covariance matrix, so as to decorrelate the coherency of signals. Then a signal subspace can be obtained by singular value decomposition(SVD) of the covariance matrix. Using the signal subspace, two extended signal subspaces are constructed to compensate aperture loss caused by *** elevation angles can be estimated by estimation of signal parameter via rotational invariance techniques(ESPRIT) algorithm. At last, the estimated elevation angles can be used to estimate automatically paired azimuth angles. Compared with some other ESPRIT algorithms, the proposed algorithm shows higher estimation accuracy, which can be proved through the simulation results.

关键词： acoustic vector-sensor coherent signals extended signal subspace sparse array

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酰胺质子转移加权MRI预测膀胱癌的组织学分级

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国际医学放射学杂志 2022年第6期45卷 735-736页

作者： H.J.Wang Q.Cai y.P.huang M.Q.Li Z.H.Wen y.y.Lin 赵泽豫

摘要膀胱癌高、低级别不同，临床治疗和预后也不同，因此通过影像技术对组织学分级进行术前准确评估至关重要。目的探讨酰胺质子转移加权（APTw）MRI 在评估膀胱癌

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On the Pre-Sinian Crystalline Rocks of the Muchiapa-Sintsi Area in Southern Shensi

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地质学报 1948年第Z1期 38-68页

作者： y.S.huang Geological Survey of China

The Muchiapa-Sintsi;area,occupied mostly by the crystalline rocks ofpre-Sinian age,lies to the SW of the city of Hanchung （Nanchenghsien）;and along the northern slope of the Tapashan *** covers practical-

关键词： On the Pre-Sinian Crystalline Rocks of the Muchiapa-Sintsi Area in Southern Shensi

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A Gaussian Noise-Based Algorithm for Enhancing Backdoor Attacks

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Computers, Materials & Continua 2024年第7期80卷 361-387页

作者： Hong huang yunfei Wang Guotao yuan Xin Li School of Computer Science and Engineering Sichuan University of Science&EngineeringYibin644000China

Deep Neural Networks(DNNs)are integral to various aspects of modern life,enhancing work ***-less,their susceptibility to diverse attack methods,including backdoor attacks,raises security *** aim to investigate backdoor attack methods for image categorization tasks,to promote the development of DNN towards higher *** on backdoor attacks currently faces significant challenges due to the distinct and abnormal data patterns of malicious samples,and the meticulous data screening by developers,hindering practical attack *** overcome these challenges,this study proposes a Gaussian Noise-Targeted Universal Adversarial Perturbation(GN-TUAP)*** approach restricts the direction of perturbations and normalizes abnormal pixel values,ensuring that perturbations progress as much as possible in a direction perpendicular to the decision hyperplane in linear *** limits anomalies within the perturbations improves their visual stealthiness,and makes them more challenging for defense methods to *** verify the effectiveness,stealthiness,and robustness of GN-TUAP,we proposed a comprehensive threat *** on this model,extensive experiments were conducted using the CIFAR-10,CIFAR-100,GTSRB,and MNIST datasets,comparing our method with existing state-of-the-art attack *** also tested our perturbation triggers using various defense methods and further experimented on the robustness of the triggers against noise filtering *** experimental outcomes demonstrate that backdoor attacks leveraging perturbations generated via our algorithm exhibit cross-model attack effectiveness and superior ***,they possess robust anti-detection capabilities and maintain commendable performance when subjected to noise-filtering methods.

关键词： Image classification model backdoor attack gaussian distribution Artificial Intelligence(AI)security

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BSTFNet:An Encrypted Malicious Traffic Classification Method Integrating Global Semantic and Spatiotemporal Features

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Computers, Materials & Continua 2024年第3期78卷 3929-3951页

作者： Hong huang Xingxing Zhang ye Lu Ze Li Shaohua Zhou School of Computer Science and Engineering Sichuan University of Science&EngineeringYibin644002China School of Mathematics and Statistics Sichuan University of Science&EngineeringYibin644002China

While encryption technology safeguards the security of network communications,malicious traffic also uses encryption protocols to obscure its malicious *** address the issues of traditional machine learning methods relying on expert experience and the insufficient representation capabilities of existing deep learning methods for encrypted malicious traffic,we propose an encrypted malicious traffic classification method that integrates global semantic features with local spatiotemporal features,called BERT-based Spatio-Temporal Features Network(BSTFNet).At the packet-level granularity,the model captures the global semantic features of packets through the attention mechanism of the Bidirectional Encoder Representations from Transformers(BERT)*** the byte-level granularity,we initially employ the Bidirectional Gated Recurrent Unit(BiGRU)model to extract temporal features from bytes,followed by the utilization of the Text Convolutional Neural Network(TextCNN)model with multi-sized convolution kernels to extract local multi-receptive field spatial *** fusion of features from both granularities serves as the ultimate multidimensional representation of malicious *** approach achieves accuracy and F1-score of 99.39%and 99.40%,respectively,on the publicly available USTC-TFC2016 dataset,and effectively reduces sample confusion within the Neris and Virut *** experimental results demonstrate that our method has outstanding representation and classification capabilities for encrypted malicious traffic.

关键词： Encrypted malicious traffic classification bidirectional encoder representations from transformers text convolutional neural network bidirectional gated recurrent unit

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On the Performances of Estimating Stellar Atmospheric Parameters from CSST Broad-band Photometry

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Research in Astronomy and Astrophysics 2024年第4期24卷 161-173页

作者： Rui-Feng Shi yang huang Xin-yi Li Hua-Wei Zhang School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China South-Western Institute for Astronomy Research Yunnan UniversityKunming 650500China CAS Key Lab of Optical Astronomy Key Laboratory of Space Astronomy and TechnologyNational Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics and Electronic Engineering Qilu Normal UniversityJinan 250200China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China

Deriving atmospheric parameters of a large sample of stars is of vital importance to understand the formation and evolution of the Milky *** surveys,especially those with near-ultraviolet filters,can offer accurate measurements of stellar parameters,with the precision comparable to that from low/medium resolution *** this study,we explore the capability of measuring stellar atmospheric parameters from Chinese Space Station Telescope(CSST)broad-band photometry(particularly in the near-ultraviolet bands),based on synthetic colors derived from model *** find that colors from the optical and near-ultraviolet filter systems adopted by CSST show significant sensitivities to the stellar atmospheric parameters,especially the *** to our mock data tests,the precision of the photometric metallicity is quite high,with typical values of0.17 and 0.20 dex for dwarf and giant stars,*** precision of the effective temperature estimated from broad-band colors are within 50 K.

关键词： methods:data analysis stars:abundances surveys

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Reconstruction of Cherenkov image bymultiple telescopes of LHAASO-WFCTA

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Radiation Detection Technology and Methods 2022年第4期6卷 544-557页

作者： F.Aharonian Q.An Axikegu L.X.Bai y.X.Bai y.W.Bao D.Bastieri X.J.Bi y.J.Bi J.T.Cai Zhe Cao Zhen Cao J.Chang J.F.Chang E.S.Chen Liang Chen Liang Chen Long Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen y.Chen H.L.Cheng N.Cheng y.D.Cheng S.W.Cui X.H.Cui y.D.Cui B.D’Ettorre Piazzoli B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu Ddella Volpe K.K.Duan J.H.Fan y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng X.T.Feng y.L.Feng B.Gao C.D.Gao L.Q.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.H.Gong Q.B.Gou M.H.Gu F.L.Guo J.G.Guo X.L.Guo y.Q.Guo y.y.Guo y.A.Han H.H.He H.N.He S.L.He X.B.He y.He M.Heller y.K.Hor C.Hou X.Hou H.B.Hu Q.Hu S.Hu S.C.Hu X.J.Hu D.H.huang W.H.huang X.T.huang X.y.huang y.huang Z.C.huang X.L.Ji H.y.Jia K.Jia K.Jiang Z.J.Jiang M.Jin M.M.Kang T.Ke D.Kuleshov K.Levochkin B.B.Li Cheng Li Cong Li F.Li H.B.Li H.C.Li H.y.Li J.Li Jian Li Jie Li K.Li WLLi XRLi Xin Li Xin Li yZLi Zhe Li Zhuo Li E.W.Liang y.F.Liang S.J.Lin B.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.y.Liu M.y.Liu R.y.Liu S.M.Liu W.Liu y.Liu y.N.Liu W.J.Long R.Lu Q.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.R.Mao A.Masood Z.Min W.Mitthumsiri y.C.Nan Z.W.Ou B.y.Pang P.Pattarakijwanich Z.y.Pei M.y.Qi y.Q.Qi B.Q.Qiao J.J.Qin D.Ruffolo A.Sáiz C.y.Shao L.Shao O.Shchegolev X.D.Sheng J.y.Shi H.C.Song yu.V.Stenkin V.Stepanov y.Su Q.N.Sun X.N.Sun Z.B.Sun P.H.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.P.Wang L.y.Wang R.Wang R.N.Wang W.Wang X.G.Wang X.y.Wang y.Wang y.D.Wang y.J.Wang y.P.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei y.J.Wei T.Wen C.y.Wu H.R.Wu S.Wu X.F.Wu y.S.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang D.X.Xiao G.Xiao G.G.Xin y.L.Xin y.Xing Z.Xiong D.L.Xu R.X.Xu L.Xue D.H.yan J.Z.yan C.W.yang F.F.yang H.W.yang J.y.yang L.L.yang M.J.yang R.Z.yang S.B.yang y.H.yao Z.G.yao y.M.ye L.Q.yin N.yin X.H.you Z.y.you y.H.yu Q.yuan H.yue H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang F.Zhang H.M.Zhang H.y.Zhang J.L.Zhang L.X.Zhang Li Zhang Lu Zhang P.F.Zhang P.P.Zhang R.Zhang S.B.Zhang S.R.Zhang S. Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany State Key Laboratory of Particle Detection and Electronics BeijingChina University of Science and Technology of China Hefei 230026AnhuiChina School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of Physics Sichuan UniversityChengdu 610065SichuanChina School of Astronomy and Space Science Nanjing UniversityNanjing 210023JiangsuChina Center for Astrophysics Guangzhou UniversityGuangzhou 510006GuangdongChina Key Laboratory of Dark Matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Hebei Normal University Shijiazhuang 050024HebeiChina School of Physics and Astronomy(Zhuhai)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000China School of Physics(Guangzhou) Sun Yat-sen UniversityGuangzhou 510275GuangdongChina Dipartimento di Fisica dell’Universitàdi Napoli“Federico II” Complesso Universitario di Monte Sant’Angelovia Cinthia80126 NapoliItaly School of Physics and Astronomy Yunnan UniversityKunming 650091YunnanChina Département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève

Introduction One of main scientiﬁc goals of the Large High Altitude Air Shower Observatory(LHAASO)is to accurately measure the energy spectra of different cosmic ray compositions around the‘knee’*** Wide Field-of-View(FoV)Cherenkov Telescope Array(WFCTA),which is one of the main detectors of LHAASO and has 18 telescopes,is built to achieve this *** telescopes are put together and point to connected directions for a larger *** Telescopes are deployed spatially as close as possible,but due to their own size,the distance between two adjacent telescopes is about 10 ***,the Cherenkov lateral distribution and the parallax between the two telescopes should be considered in the event building process for images crossing over the boundaries of FoVs of the *** event building method for Cherenkov images measured by multiple telescopes of WFCTA is *** performance of the shower measurements using the combined images is evaluated by comparing with showers that are fully contained by a virtual telescope in *** and conclusion It is proved that the developed event building process can help to increase the FoV of WFCTA by 30%while maintaining the same reconstruction quality,compared to the separate telescope reconstruction method.

关键词： method directions conclusion

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Self-trapping of Necklace beams propagate in nonlinear Kerr media

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湘潭大学学报（哲学社会科学版） 2000年第S2期25卷 153-156页

作者： y.J.huang Xiang tan University

Since the word 'soliton' introduced by Zabusky and Kruskal[1], more than one hun dred different types of nonlinear partial differential equations have been found to have soliton solution, or solitonlike solutions math... 详细信息

关键词： propagate trapping

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