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Identification of microRNA-mRNA regulatory networks and pathways related to retinoblastoma across human and mouse

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International Journal of Ophthalmology(English edition) 2020年第4期13卷 535-544页

作者： Rui Tian He zou lu-Fei Wang Mei-Jiao Song lu Liu Hui zhang Department of Ophthalmology the Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

AIM: To explore the m RNA and pathways related to retinoblastoma(RB) genesis and ***: Microarray datasets GSE29683(human) and GSE29685(mouse) were downloaded from NCBI GEO database. Homologous genes between the two species were identified using WGCNA, followed by protein-protein interaction(PPI) network construction and gene enrichment analysis. Disease-related mi RNAs and pathways were retrieved from mi R2 Disease database and Comparative Toxicogenomics Database(CTD), ***: A total of 352 homologous genes were identified. Two pathways including "cell cycle" and "pathway in cancer" in CTD and enrichment analysis were identified and seven mi RNAs(including hsa-mi R-373, hsa-mi R-34 a, hsami R-129, hsa-mi R-494, hsa-mi R-503, hsa-let-7 and hsami R-518 c) were associated with RB. mi RNAs modulate "cell cycle" and "pathway in cancer" pathways via regulating 13 genes(including CCND1, CDC25 C, E2 F2, CDKN2 D and TGFB2).CONCluSION: These results suggest that these mi RNAs play crucial roles in RB genesis through "cell cycle" and "pathway in cancer" pathways by regulating their targets including CCND1, CDC25 C, E2 F2 and CDKN2 D.

关键词： Kyoto Encyclopedia of Genes and Genomes pathway micro RNA retinoblastoma weighted gene co-expression network analysis

Real-time mosaicking for infrared videos from an oblique sweeping camera

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Chinese Journal of Aeronautics 2021年第1期34卷 309-319页

作者： Jiazhen lu Fangde SUN Jing DONG Songlai HAN Ang SU School of Aeronautics and Astronautics Central South UniversityChangsha 410083China Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

Image mosaicking is widely used in Geographic Information Systems(GISs)for largescale ground surface ***,most existing mosaicking methods can only be used in offline processing due to the enormous amounts of *** this paper,we propose a novel and practical algorithm for real-time infrared video *** achieve this,a novel fast template matching algorithm based on Sum of Cosine Differences(SCD)is proposed to coarsely match the sequential *** high speed of the proposed template matching algorithm is obtained by computing correlation with Fast Fourier Transform(FFT).We also propose a novel fast Least Squares Matching(LSM)algorithm for inter-frame fine registration,which can significantly reduce the computation without degrading the matching *** addition,the proposed fast LSM can effectively adapt for noise degradation and geometric *** on the proposed fast template matching algorithm and fine registration algorithm,we develop a practical real-time mosaicking approach which can produce seamless mosaic image highly *** on synthetic and real-world datasets demonstrate that the proposed algorithm is not just computationally efficient but also robust against various noise distortions.

关键词： Fast Fourier transform Least squares matching Map fusion Mosaic Real-time Template matching

Effect of Carbon Migration on Interface Fatigue Crack Growth Behavior in 9Cr/CrMoV Dissimilar Welded Joint

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Acta Metallurgica Sinica(English Letters) 2022年第5期35卷 714-726页

作者： Qi Wang Chendong Shao Haichao Cui yuan Gao Fenggui lu Shanghai Key Laboratory of Materials Laser Processing and Modification School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China

Fatigue crack growth(FCG)behavior of 9 Cr/CrMoV dissimilar welded joint at elevated temperature and different stress ratios was *** was paid to the region near the fusion line of 9 Cr where carbon-enriched zone(CEz)and carbon-depleted zone(CDz)formed due to carbon migration during the welding *** and brittle tempered martensite dominated the stress ratio-insensitive FCG behavior in the coarse grain zone(CGz)of 9 *** crack near the CGz-CEz interface,crack deflection through the CEz and into the CDz was observed,accompanied by an accelerating FCG *** with the severe plastic deformation near the secondary crack in 9 Cr-CGz,the electron back-scattered diffraction analysis showed less deformation and lower resistance in the direction toward the brittle CEz,which resulted in the transverse *** spite of the plastic feature in CDz revealed by fracture morphology,the less carbides due to carbon migration led to lower strength and weaker FCG resistance property in this *** conclusion,the plasticity deterioration in CEz and strength loss in CDz accounted for the FCG path deflection and FCG rate acceleration,respectively,which aggravated the worst FCG resistance property of 9 Cr-HAz in the dissimilar welded joint.

关键词： Fatigue crack growth Dissimilar welded joint Carbon migration Crack transverse deflection Carbonenriched zone

Segregation of binary particles in gas-solid fluidized bed

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 113-121页

作者： yaxiong yu Feng lu Xuan He Fei Wei Chenxi zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710049China Ordos Laboratory Ordos 017010China Institute for Carbon Neutrality Tsinghua UniversityBeijing 100084China

Particle segregation and mixing behavior play a crucial role in industrial *** study investigates the saturated jetsam fraction,which indicates the maximum capacity of flotsam to entrain jetsam,in an initially separated binary fluidized bed with particle size *** to the value of saturated jetsam fraction,three distinct regimes-segregation,mixing,and an intermediate regime-are ***,intriguing relationships between the saturated jetsam fraction and superficial gas velocity are observed,exhibiting monotonic trends in both the segregation and mixing regimes,while a unique volcano-shaped curve in the intermediate ***,a comprehensive entrainment model based on two-fluid model elucidates the observed phenomena,emphasizing the significance of mixing behavior in fluidized layer on the saturated jetsam *** work offers potential insights for evaluating segregation in industrial applications.

关键词： fluidized bed segregation binary bubbles entrainment

A blockchain-enabled wiki framework based on participatory design

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Digital Communications and Networks 2022年第6期8卷 995-1004页

作者： zheng Xu Chaofan Liu Peng zhang Tun lu Ning Gu School of Computer Science Fudan UniversityShanghaiChina Shanghai Key Laboratory of Data Science Fudan UniversityShanghaiChina

The 5G mobile Internet facilitates contents generation for online communities and platforms through human-to-human ***,a well-known online community,uses wiki technology to build an encyclopedia through collective intelligence and *** wiki systems adopt a centralized implementation,and while existing studies have optimized the efficiency of the wiki systems'centralized implementation,these systems still suffer from a lot of problems,for example,opacity and *** the years,blockchain has brought a flurry of fervour and decentralization to the system architecture,meanwhile giving users a sense of trust and ***,an innovative blockchain-enabled wiki framework called DecWiki is proposed to build one transparent,truthful,collaborative and autonomous *** several participatory design iterations,we present DecWiki's detailed architecture and its implementation in the form of a smart contract and use the interplanetary file system to complement the big data ***,we use the trusted execution environment to secure sensitive information in the wireless ***,the system overhead and the acceptance of the prototype are *** experiments present its significant performance.

关键词： Blockchain Wiki Participatory design Trusted execution envir onment Smart contract

Advances in metabolic engineering of yeasts for the production of fatty acid-derived hydrocarbon fuels

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Green Chemical Engineering 2022年第4期3卷 289-303页

作者： Ran lu Tian-Qiong Shi lu Lin Rodrigo Ledesma-Amaro Xiao-Jun Ji He Huang State Key Laboratory of Materials-Oriented Chemical Engineering College of Biotechnology and Pharmaceutical EngineeringNanjing Tech UniversityNanjing211816China School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNanjing210046China Department of Bioengineering and Imperial College Centre for Synthetic Biology Imperial College LondonLondonSW72AZUnited Kingdom

The reliance of the transport sector on fossil fuels has led to increasing concerns related to sustainability and environmental *** petroleum shortages and global climate change caused by greenhouse gas emissions have given an impetus to the development of renewable and low-carbon energy *** acidderived hydrocarbons are an attractive drop-in biofuel to substitute fossil fuels consumed by the transport sector,especially heavy *** to traditional biofuels such as ethanol and biodiesel,fatty acidderived hydrocarbons have higher energy density and better compatibility with existing storage and transport *** a common microbial platform for biofuel production,yeasts have been engineered to produce fatty acid-derived ***,we attempted to comprehensively review the latest advances in metabolic engineering strategies for the production of fatty acid-derived hydrocarbons in the yeasts Saccharomyces cerevisiae and yarrowia *** heterologous hydrocarbon synthesis pathways and combinational metabolic engineering strategies have been summarized,followed by a discussion of future research directions for the development of yeasts as industrial hydrocarbon producers.

关键词： Biofuel Metabolic engineering Fatty acid Hydrocarbon yeast

Three-dimensional time-varying sliding mode guidance law against maneuvering targets with terminal angle constraint

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Chinese Journal of Aeronautics 2022年第4期35卷 303-319页

作者： Xinxin WANG Hongqian lu Xianlin HUANG yefeng yANG zongyu zUO Center for Control Theory and Guidance Technology Harbin Institute of TechnologyHarbin 150001China The Seventh Research Division Beihang UniversityBeijing 100191China

This paper deals with the problem of intercepting maneuvering targets with terminal angle constraints for missiles subjected to three-dimensional non-decoupling engagement *** achieve the finite-time interception and satisfactory overload characteristics, a time varying sliding mode control methodology is developed based on a time base generator function. The main feature of the proposed guidance law guarantees the Line-of-Sight(LOS) angles to converge to small neighborhoods of the desired values at the interception time. First, a fractional power extended state observer is used to estimate the unknown target acceleration, which can significantly reduce the adaptive switching gain. The fractional power extended state observer enjoys the advantage of better noise tolerance. Then, a newly designed sliding mode surface is constructed by introducing a time base generator function and the time-varying sliding mode guidance law is developed based on this time-varying sliding surface. The proposed guidance law significantly reduces the overload magnitudes. Numerical simulations are carried out to verify the performance of the proposed guidance law.

关键词： Guidance law Maneuvering target Terminal angle constraint Three-dimensional Time-varying sliding mode

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中药多糖药理活性最新研究进展

化学试剂 2025年第1期47卷 1-8页

作者：吕嘉璐霍燕菊张翼黑龙江中医药大学教育部北药基础与应用研究重点实验室黑龙江哈尔滨150036 黑龙江中医药大学第一临床医学院黑龙江哈尔滨150036

近年来,中药多糖因较低的毒副作用,多样的药理活性以及广阔的应用前景,成为天然药物开发及应用研究的热点。对近5年的中药多糖研究进行了追踪,汇总整理了中药多糖发挥的抗肿瘤、免疫调节、糖脂代谢、肠道菌群、抗氧化及其他药理活性,并... 详细信息

近年来,中药多糖因较低的毒副作用,多样的药理活性以及广阔的应用前景,成为天然药物开发及应用研究的热点。对近5年的中药多糖研究进行了追踪,汇总整理了中药多糖发挥的抗肿瘤、免疫调节、糖脂代谢、肠道菌群、抗氧化及其他药理活性,并对影响中药多糖药理活性的因素进行了剖析。分析了当前中药多糖研究中存在的局限性,并对未来中药多糖的应用前景进行展望,旨在提高中药材的利用率,明确中药多糖的药理活性,从而加速中药多糖的成果转化及应用推广。

关键词：中药多糖药理活性抗肿瘤免疫调节肠道代谢稳态调节作用机制

A Fourier Spectral Moving Mesh Method for the Cahn-Hilliard Equation with Elasticity

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Communications in Computational Physics 2009年第2期5卷 582-599页

作者： W.M.Feng P.yu S.y.Hu z.K.Liu Q.Du L.Q.Chen Department of Materials Science and Engineering Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Mathematics Pennsylvania State UniversityUniversity ParkPA 16802USA Pacific Northwest National Laboratory RichlandWA 99354USA

In recent years,Fourier spectral methods have emerged as competitive numerical methods for large-scale phase field simulations of microstructures in computational materials *** further improve their effectiveness,we recently developed a new adaptive Fourier-spectral semi-implicit method(AFSIM)for solving the phase field equation by combining an adaptive moving mesh method and the semi-implicit Fourier spectral *** this paper,we present the application of AFSIM to the Cahn-Hilliard equation with inhomogeneous,anisotropic *** implementations and test examples in both two and three dimensions are considered with a particular illustration using the well-studied example of mis-fitting particles in a solid as they approach to their equilibrium *** is shown that significant savings in memory and computational time is achieved while accurate solutions are preserved.

关键词： Phase field diffuse interface moving mesh adaptive mesh Fourier-spectral method adaptive spectral method Cahn-Hilliard equation elasticity