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The Strength Characters of C/C Composite Material with Opening Hole and Typical Application

Journal of Materials Science and Chemical Engineering 2017年第1期5卷 61-68页

作者： Zhiyong Tan Changwan Min xuyun zhan Weili Dong Science and Tehnology on Space Physics Laboratory Beijing China

Research on the opening hole and connecting problem of C/C composite material was conducted. The strength characteristics of plate with opening hole were tested and the applicability of strength criteria focused on particular point was analyzed. Conclusion is obtained that obviously conservative to evaluate open hole and joint strength by hole-edge stress. Based on these, high and nor-mal temperature strength test of typical circular shaft was completed, proving that comprehensive joint performance can be significantly improved by appropriately optimized design.

关键词： Composite Material Opening’s Characteristics Joint Strength

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Guest Editorial:Special issue on trustworthy machine learning for behavioural and social computing

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CAAI Transactions on Intelligence Technology 2024年第3期9卷 541-543页

作者： Zhi-Hui zhan Jianxin Li xuyun zhang Deepak Puthal Nankai University TianjinChina Deakin University BurwoodVictoriaAustralia Macquarie University SydneyNew South WalesAustralia Khalifa University Abu DhabiUAE

Machine learning has been extensively applied in behavioural and social computing,encompassing a spectrum of applications such as social network analysis,click stream analysis,recommendation of points of interest,and sentiment *** datasets pertinent to these applications are inherently linked to human behaviour and societal dynamics,posing a risk of disclosing personal or sensitive information if mishandled or subjected to attacks.

关键词： computing handle learning

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Newborn screening with targeted sequencing:a multicenter investigation and a pilot clinical study in China

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Journal of Genetics and Genomics 2022年第1期49卷 13-19页

作者： Chanjuan Hao Ruolan Guo xuyun Hu zhan Qi Qi Guo Xuanshi Liu Yuanhu Liu Yanhua Sun Xiaofen zhang Feng Jin Xiujie Wu Ren Cai Dingyuan Zeng Xijiang Hu Xiaohua Wang Xiaoping Ji Wenjie Li Quansheng Xing Lanfang Mu Xiulian Jiang Xue Yang Weimin Yang Yan zhang Qianli Yin Xin Ni Wei Li Beijing Key Laboratory for Genetics of Birth Defects Beijing Pediatric Research InstituteBeijing 100045China MOE Key Laboratory of Major Diseases in Children Beijing 100045China Rare Disease Center National Center for Children’s HealthBeijing 100045China Beijing Children’s Hospital Capital Medical UniversityBeijing 100045China Shunyi Women and Children’s Healthcare Hospital of Beijing Children’s Hospital Beijing 101300China Liuzhou Maternal and Child Healthcare Hospital LiuzhouGuangxi 545001China Wuhan Maternal and Child Healthcare Hospital Tongji Medical CollegeHuazhong University of Science&TechnologyWuhanHubei 430016China Inner Mongolia Maternity and Child Healthcare Hospital HohhotInner Mongolia Autonomous Region 010020China Qingdao Women and Children’s Hospital QingdaoShandong 266012China Qinghai Maternal and Child Health Hospital XiningQinghai 810007China Guiyang Maternity and Child Healthcare Hospital GuiyangGuizhou 550003China Urumqi First People’s Hospital UrumqiXinjiang 830011China

Different newborn screening(NBS) programs have been practiced in many countries since the 1960 s. It is of considerable interest whether next-generation sequencing is applicable in NBS. We have developed a panel of 465 causative genes for 596 early-onset, relatively high incidence, and potentially actionable severe inherited diseases in our Newborn Screening with Targeted Sequencing(NESTS) program to screen 11,484 babies in 8 Women and Children’s hospitals nationwide in China retrospectively. The positive rate from preliminary screening of NESTS was 7.85%(902/11,484). With 45.89%(414/902) follow-up of preliminary positive cases, the overall clinically confirmative diagnosis rate of monogenic disorders was 12.07%(50/414), estimating an average of 0.95%(7.85% × 12.07%) clinical diagnosis rate, suggesting that monogenic disorders account for a considerable proportion of birth defects. The disease/gene spectrum varied in different regions of China. NESTS was implemented in a hospital by screening 3923 newborns to evaluate its clinical application. The turn-around time of a primary report, including the sequencing period of < 7 days, was within 11 days by our automatic interpretation pipeline. Our results suggest that NESTS is feasible and cost-effective as a first-tier NBS program, which will change the status of current clinical practice of NBS in China.

关键词： Newborn screening Next-generation sequencing Targeted sequencing Monogenic disorders Clinical practice

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达芬奇机器人“3+2”模式在胰体尾切除术中的应用

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中国普通外科杂志 2019年第9期28卷 1061-1067页

作者：詹渭鹏狐鸣田宏伟景武堂苗长丰汪旭云邓渊李小飞房伟马云涛甘肃省人民医院普通外科甘肃兰州730000

目的:探讨达芬奇机器人'3+2'模式胰体尾切除术的可行性、安全性及临床应用价值。方法:回顾分析2017年6月—2018年12月60例行达芬奇机器人胰体尾切除术患者的临床资料,其中,30例行'3+2'模式机器人胰体尾切除术(观察组),即3个机械臂(2个... 详细信息

目的:探讨达芬奇机器人'3+2'模式胰体尾切除术的可行性、安全性及临床应用价值。方法:回顾分析2017年6月—2018年12月60例行达芬奇机器人胰体尾切除术患者的临床资料,其中,30例行'3+2'模式机器人胰体尾切除术(观察组),即3个机械臂(2个操作臂,1个镜头臂)和2个助手,由第二助手替代经典模式下的机器人3号臂;30例行经典模式下机器人胰体尾切除术(对照组),对比两组的相关临床指标。结果:两组的基本临床资料具有可比性。两组的术中出血量、中转开腹率、输血率、术后排气时间、术后住院时间以及并发症的发生率以及计划保脾患者中的保脾率均无明显差异(均P>0.05),但观察组的手术时间及手术费用较对照组均明显减少(均P<0.05)。结论:采用达芬奇机器人'3+2'模式行胰体尾切除术可增强手术视野的显露,加强助手的配合,降低手术费用、缩短手术时间及学习曲线,且具有与经典模式机器人手术相似的临床疗效,该模式的远期临床疗效尚需更多的研究进一步证实。

关键词：胰腺肿瘤胰腺切除术机器人手术

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SIL1基因变异所致常染色体隐性Marinesco-Sj?gren综合征2例

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罕见病研究 2024年第3期3卷 358-362页

作者：齐展郭若兰胡旭昀郭俊郝婵娟首都医科大学附属北京儿童医院出生缺陷遗传学研究室、出生缺陷遗传学研究北京市重点实验室北京100045

Marinesco-Sj gren综合征(MSS)是一种罕见的常染色体隐性遗传病,以小脑共济失调、早发型白内障、慢性肌病、不同程度的智力残疾和运动发育迟缓为特征。患者还可表现出身材矮小、促性腺激素过低和肌肉无力导致的骨骼畸形等症状。本文报道... 详细信息

Marinesco-Sj gren综合征(MSS)是一种罕见的常染色体隐性遗传病,以小脑共济失调、早发型白内障、慢性肌病、不同程度的智力残疾和运动发育迟缓为特征。患者还可表现出身材矮小、促性腺激素过低和肌肉无力导致的骨骼畸形等症状。本文报道2例表现为全面发育迟缓的MSS患儿临床与分子诊断过程,分别检出SIL1基因复合杂合致病变异c.109delG(***37Serfs*4)、意义未明变异c.353G>C(***118Thr)和c.443delA(***148Argfs*10)、可能致病变异c.707A>G(***236Ser)。明确分子诊断后,予以遗传咨询,评估患儿父母再生育风险。本文通过典型病例报道及既往文献回顾,以期提高临床医生对该疾病的认识,并为该病的诊断提供借鉴。

关键词：罕见病 Marinesco-Sj gren综合征 SIL1基因外显子组测序

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