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Multifunctional polyeugenol-based nanoparticles with antioxidant and antibacterial properties

Particuology 2024年第4期87卷 194-204页

作者： Qiaoqiao Lan xuying zhang Jiaming Liang Wei Wang Leili Lv Jiamin He Zefeng Wang Chunsheng Qu The People's Hospital of Lishui Lishui323000China College of Ecology Lishui UniversityLishui32300China R&D Center of Green Manufacturing New Materials and Technology of Synthetic Leather Sichuan University-Lishui University Lishui323000China

Over the past few decades,extensive scientific has been dedicated to polymer synthesis employing renewable resources.In this study,we devised and synthesized multifunctional polyeugenol-based nanoparticles,exhibiting remarkable antioxidant and antibacterial properties.The grafting of eugenol onto the nanoparticle surface was achieved via a thiol-ene chemical reaction with a grafting rate of 3.5%.To comprehend the properties of the synthesized nanoparticles,we employed Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy and pyrolysis-gas chromatography mass spectrometry.Subsequent scanning electron microscopic and transmission electron microscopic analyses revealed the presence of a crosslinked structure within the polyeugenol-based nanoparticles,as well as a heteroge-neous microsphere structure on the surface.Due to the inherent crosslinking structure,the polyeugenol-based nanoparticles demonstrated robust the resistance to solvents,as ascertained through thermog-ravimetric analysis and solvent resistance tests.Notably,nitrogen adsorption/desorption studies confirmed the adsorption capacity of the polyeugenol-based nanoparticles,rendering them potentially suitable for drug transport applications.Moreover,the assays for assessing cytocompatibility and reactive oxygen species scavenging activities demonstrated better performance of the eugenol-based nano-particles compared to eugenol.Furthermore,the polyeugenol-based nanoparticles exhibited certain bactericidal activities against Escherichia coli,Staphylococcus aureus,and Fusobacterium nucleatum.Consequently,these observations indicated the nontoxic nature and expansive application prospects of the polyeugenol-based nanoparticles in the domains of medicine and food preservation.This work presented a pioneering concept for the development of antioxidant and antibacterial multifunctional polymer materials derived from eugenol.

关键词： Polyeugenol-based nanoparticles Bactericidal activities Cytocompatibility

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Which month to give a birth?The analysis on birth seasonality of China

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China Population and Development Studies 2023年第3期7卷 220-238页

作者： Cuiling zhang Danyin Wang xuying zhang China Population and Development Research Centre No.12Dahuisi RoadHaidian DistrictBeijing CityPeople’s Republic of China

A series of medical and biological studies have identified a strong link between the season during which a child is born and early childhood development and adult health.While providing an explanation for the seasonal determinants of birth remains one of the key challenges for demographers,understanding seasonal birth peaks and troughs can inform both public health planning and efforts to prevent childhood diseases.The seasonality of births varies across and within countries.Nonetheless,there has been scant research into the seasonality of births in China.This study takes an in depth look at the seasonal fluctuations in China’s births since 1960 and investigates the effects on seasonality of several key factors such as parity,residence(urban or rural area),and changes to fertility policies.Traditionally,winter has been the peak season of births in China,while spring and summer have been lean seasons,a pattern which is quite different than patterns in Europe and the United States.After 1990,the sweeping implementation of one-child policy and the wider use of modern contraceptives among Chinese women prompted a fundamental shift in the seasonality of births,with the deviation of births from month to month gradually diminishing over time.People’s self-control may serve as a key determinant accounting for such seasonal changes.First births exhibit pronounced and steady seasonality,while second and subsequent births follow a vague seasonal pattern,suggesting that later births are more likely affected by self-choice and self-intervention.The analysis also reveals that the monthly distribution pattern of second births experienced a dramatic change following the roll-out of the selective-two-child policy and the Universal Two-child Policy in 2014 and 2016,changes that reflects the adjustments people made to achieve their fertility plans under the new policy.

关键词： Birth Seasonality China Deviation Policy effect

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Immunogenicity and safety of a booster COVID-19 vaccination in patients with chronic liver disease:A multicenter study

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Portal Hypertension & Cirrhosis 2023年第3期2卷 127-135页

作者： Jitao Wang Jingwen Ai Huiling Xiang Yanliang zhang Zhiyun Hou Qiran zhang Jiaojian Lv Shubo Chen Chuan Liu Qianqian Li Jing Liang Faren Xie Shujun Jiang Nina zhang Aiguo zhang Xiaolin Lan xuying zhang Jinlong Li Dengxiang Liu Wenchuan Wang Wei Rao zhang Qun Qiuju Tian Xiaolong Qi Wenhong zhang Department of Radiology Center of Portal HypertensionZhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsuChina Xingtai Key Laboratory of Precision Medicine for Liver Cirrhosis and Portal Hypertension Xingtai People's Hospital of Hebei Medical UniversityXingtaiHebeiChina Department of Infectious Diseases Huashan Hospital Affiliated to Fudan UniversityShanghaiChina Department of Hepatology and Gastroenterology The Third Central Hospital of TianjinTianjinChina Department of Infectious Diseases Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjingJiangsuChina Nanjing Research Center for Infectious Diseases of Integrated Traditional Chinese and Western Medicine NanjingJiangsuChina Department of Hepatobiliary Surgery Jincheng People's HospitalJinchengShanxiChina Department of Infectious Diseases Lishui People's HospitalLishuiZhejiangChina Clinal Laboratory Lishui People's HospitalLishuiZhejiangChina Liver Disease Center Organ Transplant CenterAffiliated Hospital of Qingdao UniversityQingdaoShandongChina

Aim:Patients with chronic liver disease(CLD),especially cirrhosis,are at a high risk of severe illness or death from coronavirus disease-2019(COVID-19)and may have a suboptimal immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccine.This study aimed to evaluate the safety and immunogenicity of the COVID-19 booster vaccination in patients with CLD.Methods:The study protocol was prospectively registered at ClinicalTrials.gov(No.NCT05204602)after approval by the Ethics Committee.Adult participants with CLD were enrolled in this multicenter prospective study.They completed two doses of the inactivated COVID-19 vaccine and received booster doses at least 6 months later.Adverse reactions were recorded within 14 days after the booster dose.Serum samples of the enrolled patients were collected before and after booster vaccination and tested for SARS-CoV-2 receptor-binding domain(RBD)immunoglobulin G and neutralizing anti-bodies.The chi-squared or Fisher's exact test was used to compare categorical data,and the Mann-Whitney U test was used to compare continuous variables.Two-sided p<0.05 were considered statistically significant.Results:In total,63 patients were enrolled from four hospitals in China,including 29 patients with cirrhosis.The median age of all patients was 55 years,and 61.9%(39/63)were male.The vaccines were well tolerated;most adverse reactions were mild and transient,and injection site pain(6.4%;4/63)and fatigue(3.2%,2/63)were the most frequent local and systemic adverse events.Following the booster vaccination,our results showed that in the whole cohort,the levels and positive rates of anti-RBD IgG and neutralizing antibodies were significantly higher than baseline levels(all p<0.05).Conclusions:The inactivated COVID-19 booster vaccine was safe and significantly increased antibody levels and positivity rates following standard vaccination regimens in patients with CLD,especially those with cirrhosis.

关键词： booster vaccine coronavirus disease‐2019 immunogenicity liver disease safety SARS‐CoV‐2

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基于双给体三元体异质结的高性能倍增型有机光电探测器

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光子学报 2024年第3期53卷 251-261页

作者：李尧王奋强王爱玲蓝俊刘虎刘良朋张鹏杰吴回州牛瑞霞张栩莹兰州交通大学电子与信息工程学院兰州730070

为了拓展光谱响应范围至近红外,采用双给体单受体的三元体异质结策略,基于溶液法制备了以ITO/PEDOT∶PSS/活性层/Al为基本结构的倍增型有机光电探测器,活性层由P3HT∶PTB7-Th∶IEICO-4F(100-x∶x∶1,wt/wt/wt)组成,研究了不同质量比的PT... 详细信息

为了拓展光谱响应范围至近红外,采用双给体单受体的三元体异质结策略,基于溶液法制备了以ITO/PEDOT∶PSS/活性层/Al为基本结构的倍增型有机光电探测器,活性层由P3HT∶PTB7-Th∶IEICO-4F(100-x∶x∶1,wt/wt/wt)组成,研究了不同质量比的PTB7-Th对器件光电特性的影响。优化后的三元倍增型有机光电探测器以P3HT∶PTB7-Th∶IEICO-4F(60∶40∶1,wt/wt/wt)为活性层,在-15 V偏压下,在450、520、655和850 nm处的外量子效率分别为2 666.40%、1 752.11%、1 894.26%和938.22%,响应度分别为965.80、733.35、998.68和641.91 A/W,比探测率均超过10^(13)Jones,在850 nm处的响应度与比探测率分别是相同条件下二元器件P3HT∶IEICO-4F(100∶1,wt/wt)的2.23倍和7.08倍。结果表明,在二元体系P3HT∶IEICO-4F中掺入适量的PTB7-Th,不仅能拓展光谱响应范围至近红外,还能改变活性层中激子解离界面、电子陷阱类型和空穴注入势垒高度,优化器件的电学性能。

关键词：倍增型有机光电探测器三元体异质结溶液法近红外激子解离

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China fertility report,2006-2016 An analysis based on China fertility survey 2017

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China Population and Development Studies 2019年第2期2卷 430-439页

作者： Dan He xuying zhang Ya’er Zhuang Zhili Wang Yu Jiang China Population and Development Research Center Beijing 100081China Renmin University of China Beijing 100872China

Based on China fertility survey 2017,this report presents the national fertility level,age-specific fertility rate and parity distribution.The survey results show that during 2006-2016 the mean ages at first marriage and first birth increased by 2.7 and 2.6 years respectively.From 2006 to 2011,the total fertility rate was around 1.60-1.70,and experienced notable fluctuations during 2012-2016.Compared the age-specific fertility in 2006 with in 2011,the curve in 2016 shifted significantly to the right side.Affected by the relaxation of the fertility policy,the proportion of second births among the total births had increased year by year since 2012.

关键词： China fertility survey Total fertility rate Age-specific fertility Parity distribution

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1000V 4H-SiC VDMOS结构设计与特性研究

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半导体光电 2024年第3期45卷 378-383页

作者：李尧牛瑞霞王爱玲王奋强蓝俊张栩莹张鹏杰刘良朋吴回州兰州交通大学电子与信息工程学院兰州730070

设计并优化了一种基于4H-SiC的1000V垂直双扩散金属氧化物半导体场效应晶体管(VDMOS),在留有50%的裕度后,通过Silvaco仿真软件详细研究了器件各项参数与耐压特性之间的关系。经优化,器件的阈值电压为2.3V,击穿电压达1525V,相较于相同耐... 详细信息

设计并优化了一种基于4H-SiC的1000V垂直双扩散金属氧化物半导体场效应晶体管(VDMOS),在留有50%的裕度后,通过Silvaco仿真软件详细研究了器件各项参数与耐压特性之间的关系。经优化,器件的阈值电压为2.3V,击穿电压达1525V,相较于相同耐压条件下的Si基VDMOS,4H-SiC VDMOS的击穿电压提升了12%。此外,击穿时4H-SiC VDMOS表面电场分布相对均匀,最大值为3.4×10^(6)V/cm。终端有效长度为15μm,约为Si基VDMOS的6%,总体面积减小了近1/10。并且4H-SiC VDMOS结构简单,与相同耐压条件下的Si基VDMOS相比,未增加额外的工艺步骤,易于实现。

关键词： 4H-SiC 垂直双扩散金属氧化物半导体场效应晶体管击穿电压漂移区参数沟道长度

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宽带和窄带有机光电倍增探测器研究进展

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半导体光电 2024年第2期45卷 167-180页

作者：李尧蓝俊王奋强王爱玲牛瑞霞刘良朋张鹏杰吴回州张栩莹兰州交通大学电子与信息工程学院兰州730070

有机光电倍增探测器因具有可大面积加工、柔性、光谱响应范围可调、低成本和轻质等优点而备受关注,在智能监测、通信、生物医疗、图像传感器和荧光显微镜等领域具有潜在的应用价值。根据光谱响应范围,有机光电倍增探测器可分为宽带和窄... 详细信息

有机光电倍增探测器因具有可大面积加工、柔性、光谱响应范围可调、低成本和轻质等优点而备受关注,在智能监测、通信、生物医疗、图像传感器和荧光显微镜等领域具有潜在的应用价值。根据光谱响应范围,有机光电倍增探测器可分为宽带和窄带有机光电探测器。文章首先详细介绍了有机光电倍增探测器的结构、工作原理及关键性能参数,其次阐述了宽带和窄带有机光电倍增探测器的研究进展,最后对宽带和窄带有机光电倍增探测器未来的发展前景进行了展望。

关键词：有机光电倍增探测器宽带窄带

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超高速数据采集及分析平台的设计与验证

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微电子学 2024年第2期54卷 323-329页

作者：张续莹刘漾彭祖国徐德凯伍江雄魏亚峰陈超王聪温显超王健安俞宙电磁空间安全全国重点实验室重庆吉芯科技有限公司技集团公司

设计并实现了超高速数据采集及分析平台，由FPGA数据采集激励板卡、测试分析软件和PC机构成，该系统用于JESD204C接口协议的模数转换器(ADC)和数模转换器(DAC)的测试分析。从元器件选型、PCB设计与仿真、激励和软件测试三个方面进行平... 详细信息

设计并实现了超高速数据采集及分析平台，由FPGA数据采集激励板卡、测试分析软件和PC机构成，该系统用于JESD204C接口协议的模数转换器(ADC)和数模转换器(DAC)的测试分析。从元器件选型、PCB设计与仿真、激励和软件测试三个方面进行平台的搭建，以保证平台能够在JESD204C协议的传输速率下稳定运行。基于该平台对一款6 GSPS双通道16位ADC和12 GSPS四通道16位DAC芯片进行动态性能测试，测试结果显示，ADC的SNR为56.3 dBFS,DAC的SFDR为65.5 dBFS,性能指标与手册值接近，表明该数据采集平台的功能与性能得到验证，可推广至JESD204C接口协议的其他芯片的测试，具备一定的通用性。

关键词：采集激励板卡 JESD204C 模数转换器数模转换器测试与应用

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Side Event on Latest Development and Application of PADIS-INT was Convened at United Nations Headquarters in New York

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China Population Today 2014年第3期31卷 3-5页

作者： zhang xuying

On the afternoon of April 8,2014,the Chinese government successfully held the Side Event on Latest Development and Application of PADIS-INT during the47th Session of the United Nations Commission on Population and Development in UN Headquarters.The side event was chaired by zhang Yang,Deputy Director-General of Department of International Cooperation of National Health and Family Planning Commission(NHFPC)of the People's Republic of China.Ambassador Wang Min。

关键词：应用程序联合国纽约事件中国政府委员会

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Correction to:China fertility report,2006-2016 An analysis based on China fertility survey 2017

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China Population and Development Studies 2019年第2期2卷 440-440页

作者： Dan He xuying zhang Ya’er Zhuang Zhili Wang Yu Jiang China Population and Development Research Center Beijing 100081China Renmin University of China Beijing 100872China

The article China fertility report,2006-2016,written by Dan He,xuying zhang,Ya’er Zhuang,Zhili Wang,Yu Jiang,was originally published electronically in SpringerLink on 25 January without Open Access.With the author(s)’decision to opt for Open Choice the copyright of the article changed on 25 January 2019 to©The Author(s)2019 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License(http://***/licenses/by/4.0/),which permits use,duplication,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons license,and indicate if changes were made.

关键词： fertility license analysis

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