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男性不育症患者外周血染色体核型分析的临床意义

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中国男科学杂志 2014年第2期28卷 14-18页

作者：陈亮付杰于丽齐雯马京梅潘虹陈菲张娜王晟鞠慧岩薛晴左文莉徐阳杨慧霞北京大学第一医院生殖与遗传医疗中心北京100034

目的：基于外周血染色体核型分析，探讨男性不育症患者染色体核型异常的特点及临床意义。方法回顾性分析男性不育患者的外周血染色体核型分析结果，对异常核型的检出率及临床效应进行分析与总结。结果在813例患者中，检出染色体异常55... 详细信息

目的：基于外周血染色体核型分析，探讨男性不育症患者染色体核型异常的特点及临床意义。方法回顾性分析男性不育患者的外周血染色体核型分析结果，对异常核型的检出率及临床效应进行分析与总结。结果在813例患者中，检出染色体异常55例，检出率为6.76%。其中，染色体数目异常36例，检出率为4.43%，占总异常数目的65.4%；染色体结构异常17例，检出率为2.09%，占总异常数目的30.91%；假两性畸形2例（核型为46, XX，社会性别为男性）。其中，最常见的染色体数目异常为46, XXY，即克氏征（非嵌合型）；最常见的结构异常为染色体相互易位14例，其中罗氏易位5例，涉及13、14、15、22及22号等染色体。导致男性不育临床效应的直接表现分别为少、弱、畸形精子症以及无精子症等。另外，共检出44例染色体多态性，检出率为5.41%。其中，常染色体多态性11例，检出率为1.35%，占总多态性数目的25%（11/44），表现为随体变异及次缢痕增长。Y染色体的多态性包括大Y核型21例，检出率为2.58%，占多态性总数目的44.73%（21/44）；小Y核型12例，检出率为1.48%，占多态性总数目的27.27%（12/44）。最常见的多态性为Y染色体的变异，其次是常染色体的多态性。染色体多态性导致男性不育临床效应的直接表现为少、弱、畸形精子症及无精子症等。结论染色体异常及多态性变异均可能是导致男性生育力低下的重要因素，主要包括性染色体数目异常（非嵌合克氏征）、Y染色体多态性、染色体倒位及易位等。对于男性不育症，染色体核型分析是重要的辅助诊断依据，应用ICSI技术能解决部分遗传相关男性不育患者的体外受精问题，合理应用PGD技术进行移植前胚胎选择，能避免遗传缺陷的传代，具有重要临床意义。

关键词：不育男性染色体畸变多态现象,遗传核型分析

A Search for Solar Axions and Anomalous Neutrino Magnetic Moment with the Complete Panda X-Ⅱ Data

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Chinese Physics Letters 2021年第1期38卷 30-34页

作者： Xiaopeng Zhou Xinning Zeng xuyang Ning Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo fu Mengting fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Di Huang Yan Huang Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Huaxuan Liu Jianglai Liu Xiaoying Lu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Kaixiang Ni Jinhua Ning Xiangxiang Ren Changsong Shang Guofang Shen Lin Si Andi Tan Anqing Wang Hongwei Wang Meng Wang Qiuhong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Pengwei Xie Binbin Yan Jijun Yang Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou INPAC School of Physics and AstronomyShanghai Jiao Tong Universityand Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China School of Physics Beihang UniversityBeijing 100191China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China School of Physics Nankai UniversityTianjin 300071China Key Laboratory of Nuclear Physics and Ion-Beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Peking UniversityBeijing 100871China International Research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityJinan 250100China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Center for High Energy Physics Peking UniversityBeijing 100871China

We report a search for new physics signals using the low energy electron recoil events in the complete data set from PandaX-Ⅱ,in light of the recent event excess reported by XENON1 *** data correspond to a total exposure of 100.7 ton·day with liquid *** robust estimates of the dominant background spectra,we perform sensitive searches on solar axions and neutrinos with enhanced magnetic *** is found that the axionelectron coupling gAe<4.6×10^(-12) for an axion mass less than 0.1 keV/c^(2) and the neutrino magnetic moment μv<4.9×10^(-11)μB at 90%confidence *** observed excess from XENON1 T is within our experimental constraints.

关键词： moment. excess estimates

Study of background from accidental coincidence signals in the PandaX-Ⅱexperiment

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Chinese Physics C 2022年第10期46卷 11-24页

作者： Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo fu Mengting fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Di Huang Yan Huang Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Huaxuan Liu Jianglai Liu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Kaixiang Ni Jinhua Ning xuyang Ning Xiangxiang Ren Changsong Shang Lin Si Guofang Shen Andi Tan Anqing Wang Hongwei Wang Meng Wang Qiuhong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Pengwei Xie Binbin Yan Jijun Yang Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou School of Physics and Astronomy Shanghai Jiao Tong UniversityMOE Key Laboratory for Particle Astrophysics and CosmologyShanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Tsung-Dao Lee Institute Shanghai 200240China School of Physics Nankai UniversityTianjin 300071China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Peking UniversityBeijing 100871China School of Physics Beihang UniversityBeijing 102206China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing102206China School of Physics and Microelectronics Zhengzhou UniversityZhengzhouHenan 450001China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityJinan 250100China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Center for High Energy Physics Peking UniversityBeijing 100871China

Ⅰ.INTRODUCTION The direct detection of dark matter particles,especially the weakly interacting massive particles(WIMPs),is being actively carried out by a couple of experiments worldwide[1].In recent years,the PandaX-Ⅱ experiment located in the China Jinping Underground Laboratory(CJPL)[1-3],which uses the technology of dual phase liquid xenon time projection chambers(TPCs),has pushed the limits of the cross section between WIMPs and nucleons to a new level for most of the possible WIMP masses;other experiments of the same type are also being performed[4–10].

关键词： dark matter xenon detector background accidental coincidence machine learning

Determination of responses of liquid xenon to low energy electron and nuclear recoils using a PandaX-Ⅱ detector

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Chinese Physics C 2021年第7期45卷 273-282页

作者： Binbin Yan Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo fu Mengting fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Di Huang Peiyao Huang Yan Huang Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Jianglai Liu Zhuoqun Lei Wenbo Ma Yugang Ma Yajun Mao Yue Meng Kaixiang Ni Jinhua Ning xuyang Ning Xiangxiang Ren Changsong Shang Lin Si Guofang Shen Andi Tan Anqing Wang Hongwei Wang Meng Wang Qiuhong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Pengwei Xie Rui Yan Jijun Yang Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Jianfeng Yue Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou School of Physics and Astronomy Shanghai Jiao Tong UniversityMOE Key Laboratory for Particle Astrophysics and CosmologyShanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Tsung-Dao Lee Institute Shanghai 200240China School of Physics Nankai UniversityTianjin 300071China School of Physics Peking UniversityBeijing 100871China School of Physics Beihang UniversityBeijing 100191China International Research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityJinan 250100China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Center for High Energy Physics Peking UniversityBeijing 100871China

We present a systematic determination of the responses of PandaX-Ⅱ,a dual phase xenon time projection chamber detector,to low energy *** electron recoil(ER) and nuclear recoil(NR) responses are calibrated,respectively,with injected tritiated methane or 220Rn source,and with 241Am-Be neutron source,in an energy range from 1-25 keV(ER) and 4-80 keV(NR),under the two drift fields,400 and 317 V/*** empirical model is used to fit the light yield and charge yield for both types of *** best fit models can describe the calibration data *** systematic uncertainties of the fitted models are obtained via statistical comparison to the data.

关键词： dark matter liquid xenon time projection chamber calibration electron recoil nucleon recoil NEST2.0

大豆bHLH转录因子家族成员的进化及功能分化研究

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信阳师范学院学报（自然科学版） 2019年第1期32卷 27-38页

作者：程琳薛亚杰付觉民刘旭阳曲骁冲代幸龙董沛峰徐月霞洪一峰姚远赵基海信阳师范学院生命科学学院河南信阳464000 鸡公山自然保护区河南信阳464000

碱性螺旋-环-螺旋蛋白(basic Helix-Loop-Hleix,bHLH)转录因子家族是动植物中最大的转录因子家族之一,主要由碱性氨基酸区域和螺旋-环-螺旋区域组成,在动植物生长发育和胁迫应答反应中发挥着重要作用.本研究通过对大豆全基因组生物信息... 详细信息

碱性螺旋-环-螺旋蛋白(basic Helix-Loop-Hleix,bHLH)转录因子家族是动植物中最大的转录因子家族之一,主要由碱性氨基酸区域和螺旋-环-螺旋区域组成,在动植物生长发育和胁迫应答反应中发挥着重要作用.本研究通过对大豆全基因组生物信息学分析和分子生物学研究手段,深入研究了大豆bHLH基因家族的进化机制,同时探讨了该基因家族在大豆中的功能分化.结果表明,大豆中含有340个非冗余的bHLH基因家族成员,通过对这些成员的Pfam蛋白结构域、Motif组成和系统进化关系的分析,将这些成员分为15组共24个亚家族,在大豆20条染色体上呈现不均匀分布.bHLH理化性质差异较大,编码的大豆氨基酸数量为91～815aa,相对分子量为10 273.88～91 300.38,理论等电点为4.56～10.40;碱性氨基酸区含有His5-Glu9-Arg13保守序列,与靶基因结合有关,HLH区含有Arg23和Arg55,与形成二聚体有关,同时含有5种保守元件.多数成员在大豆根以及花发育的5个时期中具有组织表达特异性,不同基因表达量差异较大.

关键词：大豆 HLH 转录因子系统发育分析表达分析

Neutron-induced nuclear recoil background in the PandaX-4T experiment

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Chinese Physics C 2022年第11期46卷 262-274页

作者： Zhou Huang Guofang Shen Qiuhong Wang Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo fu Mengting fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Chencheng Han Ke Han Changda He Jinrong He Di Huang Yanlin Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Wenbo Ma Yugang Ma Yajun Mao Yue Meng xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Nasir Shaheed Changsong Shang Lin Si Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Jijun Yang Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Dan Zhang Minzhen Zhang Peng Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China School of Physics Beihang UniversityBeijing 102206China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary SciencShandong UniversityQingdao 266237China Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai200240China School of Physics Nankai UniversityTianjin 300071China School of Physics Peking UniversityBeijing 100871China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing102206China School of Physics and Microelectronics Zhengzhou UniversityZhengzhouHenan 450001China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China SJTU Paris Elite Institute of Technology Shanghai Jiao Tong UniversityShanghai200240China

Neutron-induced nuclear recoil background is critical to dark matter searches in the PandaX-4T liquid xenon *** this study,we investigate the features of neutron background in liquid xenon and evaluate its contribution in single scattering nuclear recoil events using three *** first method is fully based on Monte Carlo *** last two are data-driven methods that also use multiple scattering signals and high energy signals in the *** the PandaX-4T commissioning data with an exposure of 0.63 tonne-year,all these methods give a consistent result,i.e.,there are 1.15±0.57 neutron-induced backgrounds in the dark matter signal region within an approximated nuclear recoil energy window between 5 and 100 keV.

关键词： dark matter neutron background multiple scattering high energy gamma

稀土掺杂上转换发光生物医用纳米材料的研究进展

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材料科学与工程学报 2020年第4期38卷 680-692页

作者：周国永梁旭阳赵宇胡海良王环江郑锦霖李廷耀任富李和平王志康罗迎春陶文亮贵州民族大学化学工程学院贵州贵阳550025 桂林理工大学化学与生物工程学院广西桂林541004 贵州民族大学生态环境工程学院贵州贵阳550025

近年来,稀土掺杂上转换发光纳米材料(UCNPs)发展迅速,应用范围较广。在前期研究的基础上,调研其作为生物医用材料并应用于这一较新的、多学科交叉领域。重点论述UCNPs的结构设计、组分遴选、工艺优化与形貌调控,力求构列出其组成、结构... 详细信息

近年来,稀土掺杂上转换发光纳米材料(UCNPs)发展迅速,应用范围较广。在前期研究的基础上,调研其作为生物医用材料并应用于这一较新的、多学科交叉领域。重点论述UCNPs的结构设计、组分遴选、工艺优化与形貌调控,力求构列出其组成、结构、形貌与上转换发光效率间内在的规律性,以提高其上转换发光效率,进一步阐述其作为生物医用材料的应用特点,着重围绕UCNPs在生物监测、细胞与小动物活体内的生物成像,如肿瘤疾病的治疗等生物医用领域的最新研究成果展开重点论述。指出目前研究仍主要存在UCNPs制备方法较为单一、发光效率不佳等问题,生物成像也仅限于小鼠等小型动物。最后论述UCNPs应用于生物医用领域的最新发展动态。

关键词：稀土掺杂纳米材料上转换发光效率生物成像生物医用

DQCT复合堵漏止水体系在桥隧通道缝隙堵漏中的应用

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中国建筑防水 2019年第12期 40-43页

作者：刘世波卢士军李树青杨巍朱旭阳刘建国傅庆志北京立高立德工程技术有限公司北京100141 北京公联洁达公路养护工程有限公司北京100070 北京市政路桥管理养护集团有限公司北京100054

分析了桥隧通道缝隙渗漏病害的原因,详细阐述了DQCT材料复合堵漏体系的工作机理、材料性能及其在桥隧渗漏病害治理中的优势,并简介了已经发展成型的施工工艺。该体系采用聚酯纤维棉和丙烯酸盐凝胶体充满缝隙,形成三维空间的全充满完整... 详细信息

分析了桥隧通道缝隙渗漏病害的原因,详细阐述了DQCT材料复合堵漏体系的工作机理、材料性能及其在桥隧渗漏病害治理中的优势,并简介了已经发展成型的施工工艺。该体系采用聚酯纤维棉和丙烯酸盐凝胶体充满缝隙,形成三维空间的全充满完整弹性堵漏防水体系,具备良好的堵漏防水效果,且耐久性好。

关键词：桥隧通道缝隙渗漏水复合堵漏体系聚酯纤维棉丙烯酸盐凝胶体施工工艺

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浴缸水温控制的最优注水方案研究

电子测试 2018年第19期29卷 5-8,11页

作者：李若韬张文瑜李南廷肖绪洋重庆文理学院重庆402160

浴缸是人们日常生活中必不可少的一种生活用具。基于流体流动和热量传递的原理,本文研究了水经热水器加热后再输送至浴缸过程中水温的控制模型以及浴缸热水温度分布状态。理论推导得到了浴缸中水的传导传热和对流传热的传递方程,通过联... 详细信息

浴缸是人们日常生活中必不可少的一种生活用具。基于流体流动和热量传递的原理,本文研究了水经热水器加热后再输送至浴缸过程中水温的控制模型以及浴缸热水温度分布状态。理论推导得到了浴缸中水的传导传热和对流传热的传递方程,通过联系人体皮肤与外界环境的热量交换方程,获得单位时间内应注入浴缸的热水量体积为:Q_V=∫Ω(T)(t/T+U·▽t-λ/cp·▽~2t+ηA_f/cpV·(T_(water)-T_(outside)-XA_P/cpV·(T_(average)-T_(outside)))dV/T_(hotwater)-T_(water)。给定边界条件,以C语言程序得到近似数值解并利用Matlab绘制浴缸内水的温度场分布图,最后将三维温度场简化为一维温度场,求得热水流量数值8.227×10^(-3)m^3/s,符合实际情况。

关键词：浴缸热传导方程 Matlab 高斯-赛德尔迭代法傅里叶导数