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容积弧形动态旋转调强与固定野调强放疗技术在乳腺癌根治术后患者中的剂量学分布特征

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四川解剖学杂志 2024年第2期32卷 17-20页

作者：张敬慧徐文中河南科技大学第一附属医院肿瘤放疗科洛阳471000

目的:探讨乳腺癌根治术后患者开展容积弧形动态旋转调强放疗(VMAT)与固定野调强放疗(iMRT)技术的剂量学分布.方法:选取本院2022年2月至2023年6月收治的60例乳腺癌患者作为研究对象.采用随机数字表法将其分为研究组(n=30,采用VMAT技术)... 详细信息

目的:探讨乳腺癌根治术后患者开展容积弧形动态旋转调强放疗(VMAT)与固定野调强放疗(iMRT)技术的剂量学分布.方法:选取本院2022年2月至2023年6月收治的60例乳腺癌患者作为研究对象.采用随机数字表法将其分为研究组(n=30,采用VMAT技术)和对照组(n=30,采取iMRT技术).对两组患者靶区剂量分布、危及器官剂量分布、体内受照剂量分布及加速器输出机器跳数与治疗时间进行统计学比较.结果:VMAT与iMRT两种技术均符合靶区处方要求,为确保比较的可操作性,将计划靶区95%剂量统一为5000cGy.与对照组比较,研究组患者V100、d98%靶区剂量分布较高,dmean与Ci值较高,d2%、dmax、Hi值较低,差异均有统计学意义(Pd95%比较,差异无统计学意义(P>0.05).与对照组比较,研究组患者健侧乳腺dlcc、dmax、dmean较低,健侧肺V5、dmax较低,患侧肺V20、V30、dmax、dmean较低,心脏V5、V20、V30、dmean较低,肝V5、V50、dmax较低,脊髓dlcc、dmean值较低,差异均有统计学意义(P0.05).与对照组比较,研究组患者V5、V10、V20、V30参数较低,差异均有统计学意义(P0.05).与对照组比较,研究组患者平均机器跳数较少,平均治疗时间缩短,差异均有统计学意义(PiMRT,更有利于确保靶区剂量分布均匀与适形度,减少体内受照与危及器官剂量,加速器输出机器跳数更少,治疗时间更短.

关键词：乳腺癌根治术固定野调强放疗容积弧形动态旋转调强剂量学分布

direct Arylation Polycondensation of Thiophene-Based C−H Monomers

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Chinese Journal of Chemistry 2023年第21期41卷 2908-2924页

作者： xuwen Zhang Yibo Shi Yunfeng deng Yanhou Geng School of Materials Science and Engineering and Tianjin Key Laboratory of Molecular Optoelectronic Science Tianjin Universityand Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin300072 China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhouFujian350207 China

direct arylation polycondensation(dArP)has emerged as an eco-friendly and atom-efficient methodology for the syntheses ofπ-conjugated polymers(CPs).This approach features the direct C—H arylation of an aromatic hydrocarbon with an aryl *** the prevalence of thiophene-containing CPs,achieving efficient and defect-free dArP of thiophene-based C−H monomers is of great *** review presents a mechanistic insight into dArP and describes the development of dArP catalytic systems for varied thiophene-based C−H ***,the control of the primary defects(i.e.,branching and homo-coupling)in thiophene-based dArP is also *** emphasizing the principles behind monomer selection and catalytic system optimization,this review intends to provide a framework for future advancements in the dArP of thiophene-containing CPs.

关键词： Conjugated polymers direct arylation polycondensation Sustainable chemistry Catalytic system Thiophene

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陆域大地电磁基础网规划与展望

地质通报 2024年第4期43卷 489-502页

作者：秦绪文戴意蕴张耀阳肖都方慧裴发根何大双冯斌中国地质调查局北京100037 中国地质科学院地球物理地球化学勘查研究所河北廊坊065000 国家现代地质勘查技术研究中心河北廊坊065000 自然资源部地球物理电磁法探测技术重点实验室河北廊坊065000

阵列式大地电磁测深是区域地球物理调查的重点发展方向之一,对标国外先进水平和国家社会的基础性需求,中国阵列式大地电磁测深工作程度依然较低,缺乏整体规划,开展全国性观测计划亟需提上日程。系统总结了当前区域地球物理学的发展趋势... 详细信息

阵列式大地电磁测深是区域地球物理调查的重点发展方向之一,对标国外先进水平和国家社会的基础性需求,中国阵列式大地电磁测深工作程度依然较低,缺乏整体规划,开展全国性观测计划亟需提上日程。系统总结了当前区域地球物理学的发展趋势及国内外大地电磁网建设现状,提出了合作共建陆域多层级大地电磁基础网和大数据中心的顶层设计和规划布局,并对中国大地电磁基础网未来的重点发展方向进行了展望和思考。相关工作的顺利开展将为中国的区域地球物理调查拓展一项新属性参数,推动构建物性地球、结构地球和地球物理场四维模型,进而变革区域地球物理研究范式和工作模式,支撑中国深地探测走向世界前列。

关键词：区域地球物理大地电磁测深深地探测基础网建设观测监测体系数据库

Enhancement　of　Supercontinuum　Spectrum　Generation　in　adispersion-decreasing　Fibre　with　a　Concave　dispersion　Profile

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Chinese Physics Letters 2004年第6期21卷 1089-1092页

作者： xuwen-Cheng JiNWei XUYong-Zhao CUiHu LiUSong-Hao instituteofQuantumElectronics SouthChinaNormalUniversityGuangzhou510631

A new approach is proposed to enhance supercontinuum (SC) spectrum generation in A dispersion-decreasing optical fibre with a new dispersion profile. The chromatic dispersion d(λ, z) is a concave function of wavelengths and has no zero-dispersion wavelengths over the whole or part of the fibre as d(λ, z) is positive. A flatter and much broader spectrum can be produced based on the scheme. The general criteria parameters are obtained for characterizing SC shapes in the optical fibres.

关键词： Optical fibers

2020—2022年江苏省无锡市预防接种异常反应保险补偿分析

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上海预防医学 2024年第8期36卷 814-822页

作者：杨旭王玲玲王旭雯无锡市疾病预防控制中心(南京医科大学附属无锡疾病预防控制中心)免疫规划科

【目的】分析江苏省无锡市预防接种异常反应保险补偿实施情况。【方法】收集2020—2022年无锡市预防接种异常反应基础保险和商业补充保险补偿个案信息，进行描述性流行病学分析。【结果】实施预防接种异常反应保险补偿期间共补偿病例2 ... 详细信息

【目的】分析江苏省无锡市预防接种异常反应保险补偿实施情况。【方法】收集2020—2022年无锡市预防接种异常反应基础保险和商业补充保险补偿个案信息，进行描述性流行病学分析。【结果】实施预防接种异常反应保险补偿期间共补偿病例2 272例，补偿金额525.59万元，平均每例补偿0.23万元，基础保险补偿例数和金额分别占0.62%、10.72%，补充保险补偿例数和金额分别占99.43%、89.28%。基础保险中残疾、三级损害补偿分别占63.18%、88.71%，补充保险中四级及以下损害补偿占96.52%。补充保险补偿率高于基础保险。保险补偿0～岁组最多，国家免疫规划（EPi）疫苗补偿例数、金额最多分别占70.11%、73.84%。基础保险中卡介苗（BCG）补偿例数最多；补充保险中EPi疫苗补偿例数前3位为麻腮风联合减毒活疫苗、乙型肝炎疫苗、无细胞百白破联合疫苗，非EPi疫苗前3位为13价肺炎球菌多糖结合疫苗、吸附无细胞百白破灭活脊髓灰质炎和b型流感嗜血杆菌联合疫苗、肠道病毒71型灭活疫苗。基础保险中血小板减少性紫癜（症）、BCG局部脓肿补偿例数均占21.43%，补充保险中呼吸系统疾病补偿例数占77.47%。受种者报案至提交补偿材料（d）、提交补偿材料至补偿款支付（≤14 d）的时间间隔，基础保险分别占71.43%、57.14%，补充保险分别占90.22%、86.23%。【结论】无锡市预防接种异常反应商业补充保险较大程度地弥补了基础保险在补偿范围和效率等方面的不足，建议进一步推广低龄儿童商业补偿保险、加强商业补充保险补偿监管。

关键词：疫苗预防接种异常反应基础保险补充保险补偿

Yonarolide A, an unprecedented furanobutenolide-containing norcembranoid derivative formed by photoinduced.intramolecular[2+2] cycload.ition

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Chinese Chemical Letters 2023年第2期34卷 420-424页

作者： Yeqing du Ligong Yao xuwen Li Yuewei Guo School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China drug discovery Shandong Laboratory Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China

Eight polycyclic furanobutenolide-containing norcembrane diterpenoids featuring C19 frameworks(1–8)were rapidly recognized and.isolated from the Hainan soft coral Sinularia sp. by the HSQC-based small molecule accurate recognition technology. Yonarolide A(1a), featuring an unprecedented 5/6/4/4/7 pentacyclic ring skeleton, was surprisingly obtained as a transformed product by leaving compound 1 under indoor natural light, and was further proved to be a [2 + 2] cycload.ition product of 1 by photochemical reaction. The absolute stereochemistry of 1a and the three known norcembrane diterpenoids 1, 4, and7 were determined by using X-ray diffraction(XRd) analyses. Further, with the aid of XRd analysis, the structure of scabrolide B(2), which was previously reported of possessing 5/6/7 tricyclic skeleton, was firmly revised as 2a with the rare inelegane skeleton featured by the highly oxygenated 5/7/6 tricyclic carbocycle.

关键词： Soft coral Sinularia Norcembranoid Photocycload.ition SMART method

The exploration of N6-deoxyadenosine methylation in mammalian genomes

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Protein & Cell 2021年第10期12卷 756-768页

作者： xuwen Li Zijian Zhang Xinlong Luo Jacob Schrier Andrew d.Yang Tao P.Wu department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Medical Scientist Training Program Baylor College of MedicineHoustonTX 77030USA Huffington Center on Aging Baylor College of MedicineHoustonTX 77030USA dan L duncan Comprehensive Cancer Center Baylor College of MedicineHoustonTX 77030USA

N^(6)-methyladenine(N^(6)-mA,m^(6)dA,or 6mA),a prevalent dNA modification in prokaryotes,has recently been identified.in higher eukaryotes,including *** 6mA has been well-studied.in prokaryotes,the function and regulatory mechanism of 6mA in eukaryotes are still poorly *** studies indicate that 6mA can serve as an epigenetic mark and play critical roles in various biological processes,from transposable-element suppression to environmental stress ***,we review the significant advances in methodology for 6mA detection and major progress in understanding the regulation and function of this non-canonical dNA methylation in eukaryotes,predominantly mammals.

关键词： dNA N^(6)-methyladenine(6mA) mammalian dNA modification norvcanonical mammalian dNA methylation

Growth responses of Picea mongolica seed.ings to defoliation rate

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Journal of Environmental Sciences 2005年第2期17卷 232-236页

作者： ZOUChun-jing HANShi-jie QiShu-yan xuwen-duo Lidao-tang CollegeofLifeScience＆Biotechnology ShanghaiJiaotongUniversityShanghai200030China／／InstituteofAppliedEcologyChineseAcademyofSciencesShenyang110016China instituteofAppliedEcology ChineseAcademyofSciencesShenyang110016China NormalCollege ShenyangUniversityShenyang110016China CollegeofLifeScience＆Biotechnology ShanghaiJiaotongUniversityShanghai200030China

Picea mongolica W. d. Xu. is an endemic species in China. The spruce forest is only found.in semi-arid habitat in inner Mongolia Autonomous Region of China. Based on the simulative defoliation experiment, it was proved that Picea mongolica seed.ings had the compensatory and overcompensatory effects under the certain defoliation rate. The results of variance analysis on growth indexes showed that in PM Ⅰ(natural regeneration seed.ings under Picea mongolica forest), the differences of H 1(height in June 23) and H 2(height in September 3) were extremely significant, and the difference of d(diameter at the breast height) were not significant. in PM Ⅱ(artificial regeneration seed.ings under Betula platyphylla Suk. forest), the difference of H 1 was significant, the difference of H 2 was not significant, and the difference of d was extremely significant. The regression equations were established and the compensatory and overcompensatory points were obtained. in PM Ⅰ, the compensatory points of H 1, H 2, and d were 0.7628, 0.7436, 0.5725, and the overcompensatory points were 0.6056, 0.5802 and 0.2909 respectively. in PM Ⅱ, the compensatory points of H 1, H 2, and d are 0.5012, 0.3421, 0.2488, and the overcompensatory points are 0.4137, 0.2633 and 0.0747 respectively. These results suggested that the induction of compensatory growth mechanisms in spruce seed.ings required a threshold level of defoliation, and the insects in Picea mongolica forest could be controlled.in a certain degree.

关键词： Picea mongolica W. d. Xu. compensate overcompensate growth defoliation rate

Cloning and Characterization of the fecC Gene Necessary for Optimal Growth under iron-deficiency Conditions in the Cyanobacterium Anabaena sp. PCC7120

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Wuhan University Journal of Natural Sciences 2004年第4期9卷 498-502页

作者： xuwen-liang LiUYong-ding ZHANGCheng-cai LiJuan CollegeofLifeSciences CentralChinaNormalUniversityWuhan430079HubeiChina instituteofHydrobiology ChineseAcademyofSciencesWuhan430072HubeiChina CollegeofLifeSciencesandTechnology HuazhongAgriculturalUniversityWuhan430070HubeiChina CollegeofLifeSciences CentralChinaNormalUniversityWuhan430079HubeiChina

ThefecC gene encoding a putative iron (iii) dicitrate transporter was cloned from nitrogen-fixing cyanobacteriumAnabaena sp. PCC 7120, and.inactivated. The mutant grows normally in medium with NO 3 ? , NH 4 + or without combined nitrogen. But in iron-deficient medium, the mutant grows slowly. Photosynthetic properties were compared between the mutant and the wildtype strain, the content of photosynthetic pigments in the mutant is lower than that of the wild-type. The results of RT-PCR experiments show that thefecC gene is expressed under iron-deficient conditions, but is not expressed under iron-replete conditions. These results revealed thatfecC gene product is required for optimal growth under iron-deficient conditions inAnabaena sp. PCC 7120. Key words Anabaena sp. PCC 7120 - fecC - iron deficiency - photosynthetic properties - expression CLC number Q 933 Foundation item: Supported by the National Natural Sciences Foundation of China (30070154), the Frontier Science Projects Program of the institute of Hydrobiology, the Chinese Academy of Sciences (220316), State Key Project on Cyanobacterial Bloom Control in Lake dianchi (K99-05-35-01)Biography: XU Wen-liang (1974-), male, Ph. d, research direction: molecular genetics of cyanobacteria.

关键词： Anabaena sp. PCC 7120 fecC iron deficiency photosynthetic properties expression