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Chinese Chemical Letters 2023年第2期34卷 420-424页

作者： Yeqing Du ligong Yao xuwen li Yuewei Guo School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Drug Discovery Shandong Laboratory Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China

Eight polycyclic furanobutenolide-containing norcembrane diterpenoids featuring C19 frameworks(1–8)were rapidly recognized and isolated from the Hainan soft coral Sinularia sp. by the HSQC-based small molecule accurate recognition technology. Yonarolide A(1a), featuring an unprecedented 5/6/4/4/7 pentacyclic ring skeleton, was surprisingly obtained as a transformed product by leaving compound 1 under indoor natural light, and was further proved to be a [2 + 2] cycloaddition product of 1 by photochemical reaction. The absolute stereochemistry of 1a and the three known norcembrane diterpenoids 1, 4, and7 were determined by using X-ray diffraction(XRD) analyses. Further, with the aid of XRD analysis, the structure of scabrolide B(2), which was previously reported of possessing 5/6/7 tricyclic skeleton, was firmly revised as 2a with the rare inelegane skeleton featured by the highly oxygenated 5/7/6 tricyclic carbocycle.

关键词： Soft coral Sinularia Norcembranoid Photocycloaddition SMART method

Nanomaterials with dual immunomodulatory functions for synergistic therapy of breast cancer brain metastases

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Bioactive Materials 2023年第9期27卷 474-487页

作者： Zhenhao Zhao Chufeng li Yiwen Zhang Chao li Yongchao Chu xuwen li Peixin liu Hongyi Chen Yu Wang Boyu Su Qinjun Chen Tao Sun Chen Jiang Department of Pharmaceutics School of PharmacyFudan UniversityKey Laboratory of Smart Drug DeliveryMinistry of EducationState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceShanghai201203China

A long-standing paucity of effective therapies results in the poor outcomes of triple-negative breast cancer brain metastases.Immunotherapy has made progress in the treatment of tumors,but limited by the non-immunogenicity of tumors and strong immunosuppressive environment,patients with TNBC brain metastases have not yet benefited from immunotherapy.Dual immunoregulatory strategies with enhanced immune activation and reversal of the immunosuppressive microenvironment provide new therapeutic options for patients.Here,we propose a cocktail-like therapeutic strategy of microenvironment regulation-chemotherapy-immune synergistic sensitization and construct reduction-sensitive immune microenvironment regulation nanomaterials(SIL@T).SIL@T modified with targeting peptide penetrates the BBB and is subsequently internalized into metastatic breast cancer cells,releasing silybin and oxaliplatin responsively in the cells.SIL@T preferentially accumulates at the metastatic site and can significantly prolong the survival period of model animals.Mechanistic studies have shown that SIL@T can effectively induce immunogenic cell death of metastatic cells,activate immune responses and increase infiltration of CD8+T cells.Meanwhile,the activation of STAT3 in the metastatic foci is attenuated and the immunosuppressive microenvironment is reversed.This study demonstrates that SIL@T with dual immunomodulatory functions provides a promising immune synergistic therapy strategy for breast cancer brain metastases.

关键词： Breast cancer brain metastases Drug delivery Immunogenic cell death Microenvironmental regulation STAT3

低共熔溶剂双水相萃取-UPLC法检测吸烟者尿液中杂环胺类化合物

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高等学校化学学报 2024年第3期45卷 47-54页

作者：李敏贺姗姗王宏宇庄家莹金永日李绪文郑州轻工业大学食品与生物工程学院郑州450001 吉林大学化学学院长春130012

为评估香烟烟气中杂环胺的暴露水平,建立了一种基于低共熔溶剂/无机盐双水相萃取-UPLC法测定吸烟者尿液中5种杂环胺(IQ,IQ[4,5-b],Harman,Norharman和Phe-P-1)的方法.制备了7种以氯化胆碱(ChCl)为氢键受体的低共熔溶剂,并对其进行了表征... 详细信息

为评估香烟烟气中杂环胺的暴露水平,建立了一种基于低共熔溶剂/无机盐双水相萃取-UPLC法测定吸烟者尿液中5种杂环胺(IQ,IQ[4,5-b],Harman,Norharman和Phe-P-1)的方法.制备了7种以氯化胆碱(ChCl)为氢键受体的低共熔溶剂,并对其进行了表征;系统考察了影响萃取效率的主要参数,并将该方法与其它方法进行了对比研究.结果表明,在最佳提取条件下,杂环胺(HAAs)的回收率为81.9%~106.2%,日内和日间精密度分别低于2.9%和3.2%,检出限和定量限分别为0.020~0.097 ng/g和0.19~0.39 ng/g.该方法具有操作简单、环境友好及单样品成本低等特点,为尿液中杂环胺的检测提供了一种新方法,在生物样品检测领域具有良好的开发与应用价值.

关键词：杂环胺低共熔溶剂双水相萃取尿液

Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects

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Acta Pharmaceutica Sinica B 2019年第2期9卷 237-257页

作者： Qihao Wu Bastien Nay Min Yang Yeke Ni Hong Wang ligong Yao xuwen li State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences College of Pharmaceutical Science Zhejiang University of Technology Laboratoire de Synthèse Organique UMR 7652 CNRS Ecole Polytechnique Université Paris-Saclay

Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated Stelletta sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018.

关键词： Marine natural products Stelletta sponge Isolation Total synthesis Biological activity Marine drug leads

The exploration of N6-deoxyadenosine methylation in mammalian genomes

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Protein & Cell 2021年第10期12卷 756-768页

作者： xuwen li Zijian Zhang Xinlong Luo Jacob Schrier Andrew D.Yang Tao P.Wu Department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Medical Scientist Training Program Baylor College of MedicineHoustonTX 77030USA Huffington Center on Aging Baylor College of MedicineHoustonTX 77030USA Dan L Duncan Comprehensive Cancer Center Baylor College of MedicineHoustonTX 77030USA

N^(6)-methyladenine(N^(6)-mA,m^(6)dA,or 6mA),a prevalent DNA modification in prokaryotes,has recently been identified in higher eukaryotes,including mammals.Although 6mA has been well-studied in prokaryotes,the function and regulatory mechanism of 6mA in eukaryotes are still poorly understood.Recent studies indicate that 6mA can serve as an epigenetic mark and play critical roles in various biological processes,from transposable-element suppression to environmental stress response.Here,we review the significant advances in methodology for 6mA detection and major progress in understanding the regulation and function of this non-canonical DNA methylation in eukaryotes,predominantly mammals.

关键词： DNA N^(6)-methyladenine(6mA) mammalian DNA modification norvcanonical mammalian DNA methylation

Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry

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Chinese Chemical Letters 2021年第1期32卷 271-276页

作者： Yufen li Songwei li Cristina Cuadrado Chenglong Gao Qihao Wu Xiaolu li Tao Pang Antonio Hernandez Daranas Yuewei Guo xuwen li State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China Instituto de Productos Naturalesy Agrobiologi’a Consejo Superior de Investigaciones Científicas(IPNA-CSIC)La Laguna 38206Spain Jiangsu Key Laboratory of Drug Screening State Key Laboratory of Natural MedicinesJiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesChina Pharmaceutical UniversityNanjing210009 China

Five novel biscembranoids,ximaolides H-L(1-5),along with four known related compounds(6-9) were isolated from the Hainan soft coral Sarcophyton tortuosum.The structures of the new compounds were determined by extensive spectroscopic analysis,quantum chemical calculations,and/or by comparing their CD spectra with those of the known compounds.Compounds 1 and 2 are the first examples of biscembranoids bearing a 1,35-bridged lactone moiety,4 is the first biscembranoid comprising an uncommon oxetane ring,and 5 represents the first 36-peroxyl biscembranoid.Ximaolides Ⅰ(2),K(4) and F(9) exhibited interesting anti-inflammatory activity by the inhibition of LPS-induced TNF-α protein release in RAW264.7 macrophages.

关键词： Soft coral Sarcophyton tortuosum Biscembranoid Stereochemistry Anti-inflammatory

南疆地区图木舒克市主城区园林树木调查及评价

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绿色科技 2024年第9期26卷 1-6页

作者：宁阳阳李许文广州园林建筑规划设计研究总院有限公司广州市建筑集团有限责任公司广州市名卉景观科技发展有限公司新疆前昆工程建设集团有限责任公司

为摸清南疆地区图木舒克市主城区园林树木应用情况，在分析以往资料的基础上，选择图木舒克市主城区3类绿地类型进行调查。结果表明：图木舒克主城区现有木本园林植物112种，隶属于31科58属，其中乔木65种，灌木47种；在观赏特性上，有... 详细信息

为摸清南疆地区图木舒克市主城区园林树木应用情况，在分析以往资料的基础上，选择图木舒克市主城区3类绿地类型进行调查。结果表明：图木舒克主城区现有木本园林植物112种，隶属于31科58属，其中乔木65种，灌木47种；在观赏特性上，有观花植物、观形植物、观色植物、观果植物；应用频率高的植物种类较少；绝大部分乔灌木生长状况良好。针对树种种植间距密集、植物景观单一、植物材料缺乏本土特性、植物养护不当等问题提出针对性建议。

关键词：园林树木调查与评价图木舒克市

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股骨颈动力交叉钉系统与空心螺钉固定治疗65~75岁年龄段患者股骨颈骨折的效果比较

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中华创伤骨科杂志 2024年第3期26卷 228-233页

作者：张成栋王开李绪文王天瑞刘国明杜现法叶发刚扈延龄青岛大学附属医院创伤外科青岛266000

目的比较股骨颈动力交叉钉系统(FNS)与空心螺钉(CCS)固定治疗65~75岁年龄段患者股骨颈骨折的临床效果。方法回顾性分析2015年1月至2022年9月期间青岛大学附属医院创伤外科收治的39例65~75岁年龄段股骨颈骨折患者资料。按内固定方式不同... 详细信息

目的比较股骨颈动力交叉钉系统(FNS)与空心螺钉(CCS)固定治疗65~75岁年龄段患者股骨颈骨折的临床效果。方法回顾性分析2015年1月至2022年9月期间青岛大学附属医院创伤外科收治的39例65~75岁年龄段股骨颈骨折患者资料。按内固定方式不同分为两组:FNS组18例,男8例,女10例;年龄(71.1±2.8)岁;采用FNS固定治疗。CCS组21例,男7例,女14例;年龄(70.1±2.9)岁;采用CCS固定治疗。比较两组患者的术中透视次数、手术时间、术中出血量、住院费用、骨折愈合时间、内固定失败情况,以及术后1年髋关节Harris评分、颈干角变化、股骨颈短缩程度。结果两组患者术前一般资料及随访时间比较差异均无统计学意义(P>0.05),具有可比性。FNS组患者的术中透视次数[(15.1±2.3)次]显著少于CCS组患者[(19.5±3.5)次]、手术时间[(49.2±5.2) min]显著短于CCS组患者[(62.4±11.2)min],术中出血量[(74.2±15.6) mL]、住院费用[(39 928.7±1 438.3)元]显著多于CCS组患者[(53.1±17.3)mL、(23 527.9±2 126.3)元],差异均有统计学意义(P0.05)。FNS组患者术后1年颈干角减小角度(2.65°±1.66°)、股骨颈短缩程度[(3.9±1.3)mm]均显著小于CCS组患者[4.18°±2.13°、(6.3±2.5)mm],髋关节Harris评分[(82.2±7.2)分]显著高于CCS组患者[(76.4±5.9)分],差异均有统计学意义(P0.05)。结论与CCS比较,FNS固定治疗65~75岁年龄段患者股骨颈骨折的疗效更好,但也要考虑内固定失败的发生风险。

关键词：股骨颈骨折骨折固定术,内骨钉股骨颈动力交叉钉系统老年人

“哨兵-2”卫星影像及C2RCC算法在太湖冬春季水色分析中的应用

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中国环境监测 2024年第3期40卷 271-282页

作者：李旭文张悦姜晟王甜甜崔嘉宇纪轩禹陈冰魏玉强陈栋江苏省环境监测中心江苏省太湖水质监测中心站江苏南京210019 南京信息工程大学遥感与测绘工程学院江苏南京210044

利用太湖2019—2022年冬春季“哨兵-2”卫星10 m分辨率的MSI影像和SNAP软件C2RCC(Case 2 Regional CoastColour)模块,以适合浑浊、富营养程度较高、光学复杂的“二类水体”的C2X-nets为模式,开展太湖叶绿素a、总悬浮物浓度、透明度等水... 详细信息

利用太湖2019—2022年冬春季“哨兵-2”卫星10 m分辨率的MSI影像和SNAP软件C2RCC(Case 2 Regional CoastColour)模块,以适合浑浊、富营养程度较高、光学复杂的“二类水体”的C2X-nets为模式,开展太湖叶绿素a、总悬浮物浓度、透明度等水色参数反演。结果表明:冬春季太湖各湖区叶绿素a浓度处于较低水平,但4月中旬起有明显抬升;太湖西部沿岸区、南部沿岸区和湖心区总悬浮物浓度较高,表明这些湖区易受风浪影响,造成沉积物再悬浮;太湖东部沿岸区、北部湖湾及东太湖遥感反演的水体清澈度较高,可能与这些湖区冬春季沉水植物菹草的分布有关,菹草生长对水质有较好的净化效果。总体来看,基于C2X-nets模式的C2RCC反演算法从较高分辨率卫星遥感影像中提取的水色信息,能有效反映太湖冬春季水色指标的空间分布特征,可为湖体生态状况及动态变化的长期监测评估提供有价值的参考。

关键词：哨兵-2 遥感 C2RCC算法水色反演太湖

Temporal assembly patterns of microbial communities in three parallel bioreactors treating low-concentration coking wastewater with differing carbon source concentrations

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Journal of Environmental Sciences 2024年第3期137卷 455-468页

作者： Weijia li Yu Xia Na li Jie Chang Jing liu Pei Wang xuwen He School of Chemical and Environmental Engineering China University of Mining and Technology-BeijingBeijing 100083China

Carbon source is an important factor of biological treatment systems, the effects of which on their temporal community assembly patterns are not sufficiently understood currently.In this study, the temporal dynamics and driving mechanisms of the communities in three parallel bioreactors for low-concentration coking wastewater(CWW) treatment with differing carbon source concentrations(S0 with no glucose addition, S1 with 200 mg/L glucose addition and S2 with 400 mg/L glucose addition) were comprehensively studied. Highthroughput sequencing and bioinformatics analyses including network analysis and Infer Community Assembly Mechanisms by Phylogenetic bin-based null model(iCAMP) were used. The communities of three systems showed turnover rates of 0.0029~0.0034 every 15days. Network analysis results showed that the S0 network showed higher positive correlation proportion(71.43%) and clustering coefficient(0.33), suggesting that carbon source shortage in S0 promoted interactions and cooperation of microbes. The neutral community model analysis showed that the immigration rate increased from 0.5247 in S0 to 0.6478in S2. The iCAMP analysis results showed that drift(45.89%) and homogeneous selection(31.68%) dominated in driving the assembly of all the investigated microbial communities.The contribution of homogeneous selection increased with the increase of carbon source concentrations, from 27.92% in S0 to 36.08% in S2. The OTUs participating in aerobic respiration and tricarboxylic acid(TCA) cycle were abundant among the bins mainly affected by deterministic processes, while those related to the metabolism of refractory organic pollutants in CWW such as alkanes, benzenes and phenols were abundant in the bins dominated by stochastic processes.

关键词： Coking wastewater treatment Temporal dynamics Network analysis Deterministic processes Stochastic processes