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A two-step correction of a congenital alar cleft in an adult patient:A case report

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Chinese Journal Of Plastic and Reconstructive Surgery 2023年第4期5卷 182-184页

作者： Yinmin Wang Shikun Cao Jun Yang xusong luo Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Plastic Surgery Second Affiliated Hospital of Soochow UniversitySuzhou 215004JiangsuChina

This report describes a two-step surgical correction of an isolated left-sided congenital alar cleft in a 21-year-old male patient presenting with a 9×6.5 mm^(2)-sized cleft.Malformations of the alar structure and displacement of the lower lateral cartilage were observed.All flaps survived,and the patient was completely satisfied with the surgical results.This surgical treatment is simple and reliable,can greatly improve the nasal appearance of patients with alar clefts,and may be an alternative to the current surgical treatment.

关键词： Alar cleft Tessier cleft number 2 Rotation flaps A two-step surgical treatment

A combined therapy for the repair of alar defects that consists of a modified spiral flap and postoperative nasal stent

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Chinese Journal Of Plastic and Reconstructive Surgery 2022年第4期4卷 154-157页

作者： Yinmin Wang Cheng Huang Youcong Ning Rui Jin Jun Yang Lin Lu xusong luo Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Plastic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China The First People’s Hospital of the Lancang Lahu Autonomous County Puer 665699YunnanChina

Background: The repair of alar defects is challenging in clinics. Although skin grafts and nasolabial flaps are reliable, they can cause secondary post-surgical deformities.Methods: In this report, we describe an alar spiral advancement flap with a subcutaneous pedicle combined with postoperative nasal stent therapy for the repair of alar defects.Results: All cases showed slight asymmetry immediately after surgery, but at a median follow-up of 24 months, no cases of dissatisfaction with the nose shape or abnormal respiratory function were found. Almost all incision scars subsided within 12 months. In addition, all flaps that were dissected and rotated during the surgeries healed, and no signs of necrosis or development of vascular compromise were observed.Conclusion: Our preliminary experience suggests that the alar spiral flap followed by nasal stent therapy provides stable recovery of appearance and function for alar defects during follow-ups and shows promise for future therapies.

关键词： Nasal alar defects Flap transposition Spiral flap Nasal stent Nasal subunits

Frozen bean curd-inspired xenogeneic acellular dermal matrix with triple pretreatment approach of freeze–thaw,laser drilling and ADSCs pre-culture for promoting early vascularization and integration

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Regenerative Biomaterials 2022年第1期9卷 687-703页

作者： Xing Huang Zhu Zhu Lin Lu Rui Jin Di Sun xusong luo Department of Plastic and Reconstructive Surgery Shanghai 9th People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011PR China Shanghai Key Lab of Tissue Engineering Shanghai 9th People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011PR China

Xenogeneic acellular dermal matrix(ADM)is widely used in clinical practice given its good biocompatibility and biomechanical properties.Yet,its dense structure remains a hindrance.Incorporation of laser drilling and pre-culture with Adipose-derived stem cells(ADSCs)have been attempted to promote early vascularization and integration,but the results were not ideal.Inspired by the manufacturing procedure of frozen bean curd,we proposed a freeze–thaw treatment to enhance the porosity of ADM.We found that the ADM treated with-80℃3Rt-30℃3R had the largest disorder of stratified plane arrangement(deviation angle 28.6%)and the largest porosity(96%),making it an optimal approach.Human umbilical vein endothelial cells on freeze–thaw treated ADM demonstrated increased expression in Tie-2 and CD105 genes,proliferation,and tube formation in vitro compared with those on ADM.Combining freeze–thaw with laser drilling and pre-culture with ADSCs,such tri-treatment improved the gene expression of proangiogenic factors including IGF-1,EGF and vascular endothelial growth factor,promoted tube formation,increased cell infiltration and accelerated vascularization soon after implantation.Overall,freeze–thaw is an effective method for optimizing the internal structure of ADM,and tri-treatments may yield clinical significance by promoting early cell infiltration,vascularization and integration with surrounding tissues.

关键词： freeze-thaw xenogeneic acellular dermal matrix vascularization early integration

A systematic review of the treatment of lower eyelid retraction and our attempt of a dermal-orbicularis oculi suspension flap

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Chinese Journal Of Plastic and Reconstructive Surgery 2022年第1期4卷 38-43页

作者： Yi Ding Xing Huang Lin Lu Rui Jin Di Sun Jun Yang xusong luo Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Lower eyelid retraction describes the inferior displacement of the lower eyelid with or without inversion or ectropion.Based on the causes of lower eyelid retraction,we divided the forming factors of lower eyelid retraction into three categories:(1)change in the balance of forces associated with the lower eyelid margin;(2)excessive loss of lower eyelid volume;(3)changes in the relative position of the eyeball and lower lid margin.In this review,the corresponding treatment methods are elaborated on individually for the above three forming factors.We also reported,for the first time,a new treatment for lower eyelid retraction.We created a dermal-orbicularis oculi suspension flap on the lateral side of the canthus and suspended it upward and inward on the dense connective tissue over the lateral bony surface of the orbital rim.The longest follow-up time was one year,and the results were satisfactory.

关键词： Lower eyelid retraction Dermal-orbicularis oculi suspension flap Orbicularis retaining ligament

Biomaterials for tarsal plate reconstruction and our innovative work

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Chinese Journal Of Plastic and Reconstructive Surgery 2021年第3期3卷 150-154页

作者： Xing Huang Yi Ding Lin Lu Rui Jin Sun Di Jun Yang xusong luo Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Large tarsal plate defect reconstruction is one of the most challenging tasks for plastic surgeons.Based on our practical work and literature review,the techniques and postoperative results of the preserved sclera,ear cartilage,and acellular dermal matrix(ADM)as tarsal plate substitutes were investigated.Two cases were reviewed.Case 1 was a 22-year-old female who had total loss of the right lower eyelid.Ear cartilage(23 mm25 mm)was implanted under the expanded skin during the forehead skin-expanding procedure to form a skin-cartilageexpander capsule compound structure for lower eyelid reconstruction.Case 2 was a 7-year-old boy with a unilateral divided nevus.The lid and conjunctiva of the lower eyelid were invaded.A piece of ADM(12 mm4 mm)was used to repair the tarsal plate defect(12 mm3 mm).The conjunctiva of ADM was covered by itself.An orbicularis oculi myocutaneous flap was used for anterior lamella reconstruction.In case 1,the compound tissue survived and supported the lower eyelid,the lid margin was clear,and the structure was complete over a 1-year follow-up.The aesthetic appearance of the eyelid improved after depilation.It is the first clinical research on the expander capsule as eyelid conjunctiva.In case 2,the conjunctiva completely covered the superior ADM,and the transplant merged with the surrounding tissues without complications after 5 months.The preserved sclera has the longest application history as a tarsal plate substitute.However,it should be preserved in an eye bank and transplanted with conjunctiva repair.Ear cartilage is an autologous tissue that requires conjunctival reconstruction.Our clinical practice was the first to prove the possibility of the expander capsule as eyelid conjunctiva.It is feasible to prefabricate the skin-tarsal conjunctiva complex during the skin expansion procedure.Allogeneic ADM is a common clinical material with advantages of good biological histocompatibility,supportive strength,conjunctivalization,and not requiring donor site surgery.Plastic surgeons are fami

关键词： Tarsal plate reconstruction Ear cartilage Preserved sclera Acellular dermal matrix Conjunctival repair Expander capsule

基于模糊控制的疏浚泥射水抽真空装置真空度可调设计

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排灌机械工程学报 2017年第12期35卷 1048-1053页

作者：冯旭松向清江吉锋骆寅南水北调东线江苏水源有限责任公司江苏南京210029 江苏省泵站工程技术研究中心江苏南京210029 江苏大学国家水泵及系统工程技术研究中心江苏镇江212013

基于变频调速方法改变射流泵喷嘴处的喷射强度,从而改变抽真空能力,实现射流泵抽真空装置的真空度可调.以MSP430F149单片机为主控模块设计了控制系统的硬件,并采用模糊控制的方法实现离心泵转速控制,在搭建的试验台上开展了真空度可调试... 详细信息

基于变频调速方法改变射流泵喷嘴处的喷射强度,从而改变抽真空能力,实现射流泵抽真空装置的真空度可调.以MSP430F149单片机为主控模块设计了控制系统的硬件,并采用模糊控制的方法实现离心泵转速控制,在搭建的试验台上开展了真空度可调试验.结果表明:所设计的射流泵尺寸结构不变时,真空度随离心泵转速提高(或者射流泵工作水流量的增大)而增大;射流泵抽真空试验装置真空度调节范围在0~92 kPa,真空度控制精度在5 kPa以内,达到稳定的设定值所需要的实际时间在25 s以内;试验结果表明模糊控制的方法具有自适应强的特点,装置能获得稳定可靠的真空度控制.对比闸阀调节真空度的方法,变频形式具有节能的优点,真空度可调的特性也将在井点降水等其他抽真空领域中获得应用.

关键词：射流泵变频调速模糊控制真空度可调疏浚泥

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精氨酸对大鼠深Ⅱ度烧伤的治疗作用

华西医科大学学报 1999年第2期30卷 198-201页

作者：岑瑛罗旭松任林森刘晓雪华西医科大学附属第一医院烧伤整形科

为研究精氨酸对烧伤的治疗作用，将精氨酸用于２０％ＴＢＳＡ深Ⅱ度烧伤大鼠的随机对照实验，伤后定时进行创面愈合情况、细胞免疫水平及氮平衡的各项指标的检测。结果显示：实验组创面愈合情况好于对照组，细胞免疫水平的恢复比对照组... 详细信息

为研究精氨酸对烧伤的治疗作用，将精氨酸用于２０％ＴＢＳＡ深Ⅱ度烧伤大鼠的随机对照实验，伤后定时进行创面愈合情况、细胞免疫水平及氮平衡的各项指标的检测。结果显示：实验组创面愈合情况好于对照组，细胞免疫水平的恢复比对照组快，并取得了正氮平衡。由此提示：大鼠烧伤后补充外源性精氨酸可产生促进创面愈合，减轻伤后免疫抑制及增进蛋白质合成的有益效果。

关键词：精氨酸烧伤动物实验药物疗法

脱细胞真皮基质在组织工程与再生医学中的应用

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组织工程与重建外科杂志 2020年第1期16卷 65-66页

作者：黄成罗旭松上海交通大学医学院附属第九人民医院整复外科上海市200011

脱细胞真皮基质是通过物理、化学方法将皮肤组织的表皮细胞及真皮层内的细胞成分去除,并保留了正常胶原三维结构及基底膜的真皮支架。脱细胞真皮基质具有低抗原性、良好的组织相容性和稳定的理化性质,是一种理想的生物材料。本文就脱细... 详细信息

脱细胞真皮基质是通过物理、化学方法将皮肤组织的表皮细胞及真皮层内的细胞成分去除,并保留了正常胶原三维结构及基底膜的真皮支架。脱细胞真皮基质具有低抗原性、良好的组织相容性和稳定的理化性质,是一种理想的生物材料。本文就脱细胞真皮基质在组织工程与再生医学中的应用进行综述。

关键词：脱细胞真皮基质组织工程再生医学

眶隔-睑板与眼轮匝肌-睑板双重固定的重睑切开术

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组织工程与重建外科 2021年第4期17卷 327-330页

作者：任红利黄幸罗旭松川北医学院附属医院整形美容烧伤外科四川省南充市637000 上海交通大学医学院附属第九人民医院整复外科上海市200011

目的观察眶隔-睑板与眼轮匝肌-睑板双重固定的重睑切开术应用于上睑臃肿患者的效果。方法回顾性分析53名上睑臃肿的单睑患者,在去除部分肥厚的眼轮匝肌后脂肪、眶隔脂肪及增厚的眶隔后,采用眶隔-睑板和眼轮匝肌-睑板的双重内固定方式,... 详细信息

目的观察眶隔-睑板与眼轮匝肌-睑板双重固定的重睑切开术应用于上睑臃肿患者的效果。方法回顾性分析53名上睑臃肿的单睑患者,在去除部分肥厚的眼轮匝肌后脂肪、眶隔脂肪及增厚的眶隔后,采用眶隔-睑板和眼轮匝肌-睑板的双重内固定方式,达到去除患者上睑多余组织、恢复患者眶隔止点位置的目的。手术切口采用切口下缘皮肤眼轮匝肌-睑板-切口上缘皮肤眼轮匝肌缝合关闭。结果本组53例患者(共106侧),术后随访6~24个月,平均8.7个月。所有患者手术切口均一期愈合,无切口感染及瘢痕增生发生。53例患者中3例重睑变浅,0例复发。将本方法应用于上睑臃肿患者后,单睑复发率明显低于不加内固定的重睑术和Park法重睑术(P<0.05)。结论对于上睑臃肿的单睑患者,尤其是东亚人群,采用眶隔-睑板与眼轮匝肌-睑板双重固定的重睑切开术可获得更持久稳定的重睑形态,单睑复发率明显降低,值得临床推广应用。

关键词：上睑臃肿双重内固定眶隔重睑切开