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Retreatment with peginterferon and ribavirin in chronic hepatitis C

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World Journal of Gastroenterology 2015年第6期21卷 1994-1999页

作者： Yong Min Jo Sung Wook Lee Sang Young Han Yang Hyun Baek Soo Young Kim Woo Jae Kim ji Hye Ahn ji Young Lee Department of Internal Medicine Dong-A University School of Medicine

The development of boceprevir and telaprevir was a major step forward in the treatment of chronic hepatitis *** addition,the treatment of these infections has been recently revolutionized by the approval of sofosbuvir and ***,there are several challenges associated with the application of noveldrugs,such as new and more frequent adverse events,new drug interactions,and excessively high treatment *** additional concern is viral *** considerations highlight the fact that direct-acting antiviral agents are not a panacea and may not be the best option for all patients who are in need of *** retrospective study revealed that the sustained virologic response was not significantly reduced following peginterferon and ribavirin retreatment compared with the new *** suggest that patients who experience relapse shortly after completing treatment with peginterferon and ribavirin have a reasonable chance of achieving a sustained virologic response when retreated with these drugs alone.

关键词： Chronic hepatitis C Direct-acting antiviral agents

Two new aristolane sesquiterpenes from Laurencia similis

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Chinese Chemical Letters 2007年第2期18卷 178-180页

作者： Nai Yun ji Xiao Ming Li Lan Ping Ding Bin Gui Wang Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China

Two new aristolane sesquiterpenes, namely, aristolan-10-ol-9-one and aristolan-8-en-1-one, were isolated from the red alga Laurencia similis. Their structures were established on the basis of various NMR spectroscopic... 详细信息

关键词： Laurencia similis Aristolane Aristolan-10-ol-9-one Aristolan-8-en-1-one

T300A polymorphism of ATG16L1 and susceptibility to inflammatory bowel diseases:A meta-analysis

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World Journal of Gastroenterology 2010年第10期16卷 1258-1266页

作者： Cheng, jia-Fei Ning, Yue-ji Zhang, Wei Lu, Zong-Hai Lin, Lin Nanjing Med Univ Dept Gastroenterol Affiliated Hosp 1 Nanjing 210029 Jiangsu Prov Peoples R China

AIM:To evaluate the association of the autophagy- related 16-like 1 (ATG16L1 ) T300A polymorphism (rs2241880) with predisposition to inflammatory bowel diseases (IBD) by means of ***: Publications addressing the relationship between rs2241880/T300A polymorphism of ATG16L1 and Crohn's disease (CD) and ulcerative colitis (UC) were selected from the MEDLINE and EMBASE data-bases. To make direct comparisons between the data collected in these studies, the individual authors were contacted when necessary to generate a standardized set of data from these studies. From these data, odds ratio (OR) with 95% confidence interval (CI) were ***: Twenty-five studies of CD were analyzed, 14 of which involved cases of UC. The variant G allele of ATG16L1 was positively associated with CD (OR=1.32, 95% CI: 1.26-1.39, P<0.00001) and UC (OR =1.06, 95% CI:1.01-1.10, P=0.02). For child-onset IBD, a higher G allele frequency was found for cases of CD (OR=1.35, 95% CI: 1.16-1.57, P=0.0001) than for cases of UC (OR = 0.98, 95% CI: 0.81-1.19, P = 0.84) relative to ***: The ATG16L1 T300A polymorphism contributes to susceptibility to CD and UC in adults, but different in children, which implicates a role for autophagy in the pathogenesis of IBD.

关键词： ATG16L1 Inflammatory bowel diseases Crohn’s disease Ulcerative colitis Meta-analysis

New classification of the anatomic variations of cystic artery during laparoscopic cholecystectomy

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World Journal of Gastroenterology 2007年第42期13卷 5629-5634页

作者： You-Ming Ding Bin Wang Wei-Xing Wang Ping Wang ji-Shen Yan Department of Hepatobiliary & Laparoscopic Surgery Renmin Hospital of Wuhan University Wuhan 430060 HubeiProvince China

AIM： To investigate the anatomic variations in the cystic artery by laparoscopy, and to provide a new classification system for the guidance of laparoscopic ***： Six hundred patients treated with laparoscopic cholecystectomy from June 2005 to May 2006 were studied retrospectively, The laparoscope of 30° （Stryker, American） was applied, Anatomic structures of cystic artery and conditions of Calot＇s triangle under laparoscope were recorded respectively,RESULTS： Laparoscopy has revealed there are many anatomic variations of the cystic artery that occur frequently. Based on our experience with 600 laparoscopic cholecystectomies, we present a new classification of anatomic variations of the cystic artery, which can be divided into three groups：（1） Calot＇s triangle type, found in 513 patients （85.5%）; （2） outside Calot＇s triangle, found in 78 patients （13%）; （3） compound type, observed in 9 patients （1.5%）.CONCLUSION： Our classification of the anatomic variations of the cystic artery uncontrollable cystic artery extrahepatic bile duct injury. will be useful for decreasing hemorrhage, and avoiding extrahepatic bile duct injury.

关键词： Cystic artery Laparoscopic cholecystectomy Bile duct injury Calot's triangle

Sleeve Design of Permanent-magnet Machine for Low Rotor Losses

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Chinese Journal of Electrical Engineering 2020年第4期6卷 86-96页

作者： Junqiang Zheng Wenxiang Zhao jinghua ji jihong Zhu Christopher H.T.Lee School of Electrical and Information Engineering Jiangsu UniversityZhenjiang 212013China Department of Computer Science and Technology Tsinghua UniversityBeijing 100000China School of Electrical and Electronic Engineering Nanyang Technological University639798Singapore

In this study,a novel rotor sleeve for permanent-magnet(PM)machines equipped with fractional-slot concentrated-windings(FSCW)is *** the newly designed rotor sleeve,the rotor eddy-current(EC)losses are significantly reduced,and the torque density of the machine is ***,the rotor EC losses of a surface-mounted PM machine with the sleeve are ***,the sleeve EC barriers and PM segmentation technologies for the suppression of the rotor EC losses are ***,an FSCW PM machine with the newly designed sleeve is proposed and optimized for a given set of *** electromagnetic and mechanical performances are evaluated by the finite element method(FEM).Finally,three assembling methods are presented and assessed comprehensively in terms of their merits and drawbacks.

关键词： Permanent-magnet machine rotor losses sleeve eddy-current concentrated-windings

Preparation of polymeric microspheres with high content of sulphonate groups

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Chinese Chemical Letters 2010年第2期21卷 234-236页

作者： Chen, Yun Shen Wang, ji Shuai Hou, Zhao Sheng Kan, Cheng You Tsinghua Univ Dept Chem Engn Beijing 100084 Peoples R China Tsinghua Univ Key Lab Adv Mat Minist Educ Beijing 100084 Peoples R China

Poly(styrene-co-sodium styrene sulphonate)(P(St-NaSS)) latex particles were prepared using the mixture of ethanol and water as continuous phase in the presence of surfactant by dispersion--emulsion combined *** influence of recipes on polymerization process as well as the content of sulphonate group in the purified products was *** showed that the copolymerization could be performed *** the mole ratio of NaSS/St/divinyl benzene(DVB) was 25/75/2 and the weight ratio ...

关键词： Styrene Sodium styrene sulphonate Microspheres Polymerization

Bridging therapy and direct mechanical thrombectomy in the treatment of cardiogenic cerebral infarction with anterior circulation macrovascular occlusion

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World Journal of Clinical Cases 2021年第27期9卷 8051-8060页

作者： Hong-Ju Ding Cong Ma Fu-Ping Ye ji-Fang Zhang Department of Emergency Qingdao Jiaozhou Central HospitalQingdao 266300Shandong ProvinceChina Department of Neurology Qingdao Jiaozhou Central HospitalQingdao 266300Shandong ProvinceChina Department of Gastrointestinal Surgery Qingdao Jiaozhou Central HospitalQingdao 266300Shandong ProvinceChina Department of Neurosurgery Qingdao Municipal HospitalSchool of MedicineQingdao UniversityQingdao 266071Shandong ProvinceChina

BACKGROUND Intravenous thrombolysis is an important treatment for cerebral ***,it is difficult to achieve good results if the patient is complicated with anterior circulation macrovascular *** addition,the vascular recanalization rate is low,so mechanical thrombectomy,that is,bridging therapy,is needed AIM To investigate the efficacy and safety of bridging therapy and direct mechanical thrombectomy in the treatment of cardiogenic cerebral infarction with anterior circulation macrovascular *** Ninety-six patients in our hospital with cardiogenic cerebral infarction with anterior circulation macrovascular occlusion from January 2017 to July 2020 were divided into a direct thrombectomy group(n=48)and a bridging group(n=48).Direct mechanical thrombectomy was performed in the direct thrombectomy group,and bridging therapy was used in the bridging treatment *** were performed for the treatment data of the two groups(from admission to imaging examination,from admission to arterial puncture,from arterial puncture to vascular recanalization,and from admission to vascular recanalization),vascular recanalization rate,National Institutes of Health Stroke Scale(NIHSS)and Glasgow Coma Scale(GCS)scores before and after treatment,prognosis and incidence of adverse *** In the direct thrombectomy group,the time from admission to imaging examination was 24.32±8.61 min,from admission to arterial puncture was 95.56±37.55 min,from arterial puncture to vascular recanalization was 54.29±21.38 min,and from admission to revascularization was 156.88±45.51 min,and the corresponding times in the bridging treatment group were 25.38±9.33 min,100.45±39.30 min,58.14±25.56 min,and 161.23±51.15 min;there were no significant differences between groups(P=0.564,0.535,0.426,and 0.661,respectively).There was no significant difference in the recanalization rate between the direct thrombectomy group(79.17%)and the bridging group(75.00%)(P=0.627)

关键词： Bridging therapy Direct mechanical thrombectomy Cardiogenic cerebral infarction Anterior circulation macrovascular occlusion

Influence of Operating Conditions on the Removal Cd Ions from Aqueous Media by Adsorption Using Chlamydomonas Reinhardtii

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Chinese Journal of Population,Resources and Environment 2010年第2期8卷 93-96页

作者： jiang Yongbin Zhu Yi ji Hongbing Resource Environmental and GIS Key Laboratory of Beijing City College of Resource Environment and Tourism Capital Normal University Beijing 100048 China College of Food Science and Nutritional Engineering China Agriculture University Beijing 100083 China

Chlamydomonas reinhardtii(***) was used to study adsorption of cadmium(Cd) from aqueous media within various experimental *** showed that the adsorption process was very fast,with most of the adsorption occurring within 30 min of contact time and the equilibrium state was reached in about 60 *** adsorption ability of the algae increases with the increasing adsorptions sites on *** adsorption was observed at the initial Cd concentration of 100 mg/L and pH 6.0. The adsorption was markedly inhibited in the presence of calcium and magnesium ions at 10 mM and the Cd removal efficiency was reduced by 16.54%and 14.99%*** study would be a finding of note with regard to practical wastewater treatment.

关键词： C. reinhardtii cadmium adsorption wastewater

Antigen presenting cells may be able to distinguish between normal and radiatedSchistosoma japonicum cercaria:anin vitro observation

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The Journal of Biomedical Research 2010年第4期24卷 285-291页

作者： Guixia Tang Minjun ji HaiweiWu Guanling Wu Department of Pathogen Biology and Immunology Nanjing Medical University Nanjing 210029 Jiangsu Province China jiangsu Provinee Key Laboratory of Modern Pathogen Biology Nanjing 210029 Jiangsu Province China

Objective： To observe the discrepancies of responses induced by Schistosoma japonicum （S. japonicum） normal cercaria antigen （NCA） and ultraviolet （UV） -radiation-attenuated cercaria antigen （UVACA） in an in vitro system. Methods： S. japonicum cercariae were collected and UVACA and NCA were prepared. Mouse macro- phage model cells （RAW 264.7） were treated with medium, NCA （40 μg/mL） or UVACA （40 μg/mL） in the presence or absence of recombinant mouse interferon gamma （rmIFN-γ; 4 ng/mL） for 48 h. Cell surface staining and flow cytometry were used to assess the major histocompatibility complex （MHC） Ⅱ expression, and data were expressed as mean fluorescence intensities （MFI）. Interleukin （IL） -10, IL-6 and prostaglandin E2 （PGE2） in cell culture supernatant were evaluated by commercial enzyme-linked immunosorbent assays. Results： NCA significantly suppressed IFN-7-induced MHC Ⅱ expression on RAW 264.7 cells. In the presence of 1FN-7, NCA significantly promoted IL-6, IL-10 and PGE2 secretion from RAW 264.7 cells. In the presence of IFN-γ, UVACA significantly promoted IL-10 but not IL-6 and PGE2 secretion from RAW 264.7 cells and showed no effect on IFN-γ-induced MHC Ⅱ expression. Compared with UVACA, NCA significantly suppressed IFN-γ-induced MHC Ⅱ expression and significantly promoted IL-6, PGE2 and IL-10 secretion from RAW 264.7 cells. Conclusion： RAW 264.7 cells respond differently to NCA and UVACA. NCA can significantly suppress IFN-γ-induced MHC Ⅱ expression and significantly promote IL-6, IL-10 and PGE2 secretion from RAW 264.7 cells compared with UVACA.

关键词： Schistosoma japonicum ultraviolet-radiation-attenuated cercaria RAW 264.7 cells normal cercaria,major histocompatibility complex Ⅱ