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Dynamic intrauterine crosstalk promotes porcine embryo implantation during early pregnancy

Science China(Life Sciences) 2024年第8期67卷 1676-1696页

作者： xupeng zang Shengchen Gu Wenjing Wang Junsong Shi Jianyu Gan Qun Hu Chen Zhou Yue Ding Yanjuan He Lei Jiang Ting Gu Zheng Xu Sixiu Huang Huaqiang Yang Fanming Meng Zicong Li Gengyuan Cai Linjun Hong Zhenfang Wu State Key Laboratory of Swine and Poultry Breeding Industry National Engineering Research Center for Breeding Swine IndustryCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding South China Agricultural UniversityGuangzhou 510642China Yunfu Subcenter of Guangdong Laboratory for Lingnan Modern Agriculture Yunfu 527300China Guangdong Key Laboratory of Animal Breeding and Nutrition Institute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640China Key Laboratory of South China Modern Biological Seed Industry Ministry of Agriculture and Rural AffairsGuangzhou 510520China

Dynamic crosstalk between the embryo and mother is crucial during ***,we comprehensively profile the single-cell transcriptome of pig peri-implantation embryos and corresponding maternal endometrium,identifying 4 different lineages in embryos and 13 cell types in the ***-specific gene expression characterizes 4 distinct trophectoderm subpopulations,showing development from undifferentiated trophectoderm to polar and mural *** expression of genes in different types of endometrial cells illustrates their molecular response to embryos during ***,we developed a novel tool,ExtraCellTalk,generating an overall dynamic map of maternal-foetal crosstalk using uterine luminal proteins as *** cross-species comparisons,we identified a conserved RBP4/STRA6 pathway in which embryonic-derived RBP4 could target the STRA6 receptor on stromal cells to regulate the interaction with other endometrial *** results provide insight into the maternal-foetal crosstalk during embryo implantation and represent a valuable resource for further studies to improve embryo implantation.

关键词： endometrial remodeling ExtraCellTalk implantation maternal-foetal crosstalk trophoblast

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Research on concrete structure defect repair based on three-dimensional printing

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Frontiers of Structural and Civil Engineering 2024年第5期18卷 731-742页

作者： Yang GU Wei LI xupeng YAO Guangjun LIU School of Mechanical Engineering Tongji UniversityShanghai 201804China College of Civil Engineering Tongji UniversityShanghai 200092China Shanghai Engineering Research Center for Safety Intelligent Control of Building Machinery Shanghai 200032China

Quality assurance and maintenance play a crucial role in engineering construction,as they have a significant impact on project *** common issue in concrete structures is the presence of *** enhance the automation level of concrete defect repairs,this study proposes a computer vision-based robotic system,which is based on three-dimensional(3D)printing technology to repair *** system integrates multiple sensors such as light detection and ranging(LiDAR)and *** is utilized to model concrete pipelines and obtain geometric parameters regarding their ***,a convolutional neural network(CNN)is employed with a depth camera to locate defects in concrete ***,a method for coordinate transformation is presented to convert the obtained coordinates into executable ones for a robotic ***,the feasibility of this concrete defect repair method is validated through simulation and experiments.

关键词： concrete defect detection 3D printing deep learning point cloud data

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Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesis

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Engineered Regeneration 2024年第1期5卷 1-10页

作者： Lijun Xie Jiahao Zhang Hangxiang Sun Zehao Chen Wangsiyuan Teng xupeng Chai Cong Wang Xianyan Yang Yifan Li Sanzhong Xu Zhongru Gou Zhaoming Ye Department of Orthopedic Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000PR China Orthopedics Research Institute of Zhejiang University Hangzhou 310000PR China Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou 310000PR China Bio-nanomaterials and Regenerative Medicine Research Division Zhejiang-California International Nanosystem InstituteZhejiang UniversityHangzhou 310058PR China Department of Orthopedics the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003PR China

Mechanically strong magnesium-doped Ca-silicate bioceramic scaffolds have many advantages in repairing large segmental bone *** we combine𝛽-TCP with 6 mol%magnesium-doped calcium silicate(Mg6)at three different ratios(TCP,TCP+15%Mg6,TCP+85%Mg6)to find an appropriate ratio which can exert considerable influence on bone *** this study,the bioceramic scaffolds were assessed for mechanical strength,bioactive ion release,biocompatibility,and osteogenic capacity through in vitro ***,the potential for promoting bone regeneration was investigated through in vivo implantation of porous tube-like *** results showed that the compressive strength increased with the augmentation of Mg6 *** the compressive strength of the TCP+85%Mg6 group reached 38.1±3.8 MPa,three times that of the other two ***,extensive in vivo investigations revealed that the TCP+85%Mg6 bioceramic scaffolds were particularly beneficial for the osteogenic capacity of critical-sized femoral defects(20 mm in length).Altogether,magnesium doping in bioceramic implants is a promising strategy to provide stronger mechanical support and enhance osteogenesis to accelerate the repair of large defects.

关键词： Bioceramic tubes Mg-doped calcium silicate Porous structural stability Large segmental bone defects Digital light processing

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哺乳动物乳腺发育调控机制的研究进展

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畜牧与兽医 2022年第1期54卷 137-143页

作者：王雯竞吴霄臧旭鹏吴珍芳李紫聪华南农业大学动物科学学院/国家生猪种业工程技术研究中心广东广州510642 广东温氏食品集团股份有限公司广东云浮527400

乳腺是哺乳动物特有器官之一,其发育可分为胚胎期、青春期、妊娠期、哺乳期和退化期共5个阶段,发育过程主要受激素、生长因子及细胞因子等调控。乳腺发育主要在出生后,青春期经生长激素(growth hormone,GH)、雌激素(estrogen,E)和胰岛... 详细信息

乳腺是哺乳动物特有器官之一,其发育可分为胚胎期、青春期、妊娠期、哺乳期和退化期共5个阶段,发育过程主要受激素、生长因子及细胞因子等调控。乳腺发育主要在出生后,青春期经生长激素(growth hormone,GH)、雌激素(estrogen,E)和胰岛素样生长因子1(insulin-like growth factor 1,IGF1)等调控启动分支形态发生;妊娠期及哺乳期由孕激素(progesterone,P)和催乳素(prolactin,PRL)共同作用产生腺泡并分泌乳汁;退化期则由断奶启动退化过程,腺体重塑至妊娠前状态。乳腺功能主要是通过产生和分泌乳汁以维持初生幼畜正常发育,研究乳腺发育调控机制对畜牧生产具有重要意义。本文以小鼠为例介绍其乳腺发育过程及发育调控机制,并阐述研究乳腺发育及人工调控乳腺发育对畜牧生产的深刻意义,为后期进一步研究乳腺发育和初乳形成提供一定理论参考。

关键词：哺乳动物乳腺调控机制初乳

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Clinical significance,molecular characterization,and immune microenvironment analysis of coagulation-related genes in clear cell renal cell carcinoma

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Cancer Innovation 2024年第1期3卷 29-49页

作者： Weihao Chen xupeng Zhao Yongliang Lu Hanfeng Wang Xiyou Wang Yi Wang Chen Liang Zhuomin Jia Wei Ma Department of Urology The Third Medical Center of PLA General HospitalBeijingChina School of Medicine Nankai UniversityTianjinChina Medical Service Department The PLA General HospitalBeijingChina Senior Department of Otolaryngology-Head&Neck Surgery The Sixth Medical Center of PLA General HospitalBeijingChina

Background:Numerous studies have revealed a tight connection between tumor development and the coagulation ***,the effects of coagulation on the prognosis and tumor microenvironment(TME)of clear cell renal cell carcinoma(ccRCC)remain poorly ***:We employed the consensus clustering method to characterize distinct molecular subtypes associated with coagulation ***quently,we examined variations in the overall survival(OS),genomic profiles,and TME characteristics between these *** develop a prognostic coagulation-related risk score(CRRS)model,we utilized the least absolute shrinkage and selection operator Cox regression and stepwise multivariate Cox regression *** also created a nomogram to aid in the clinical application of the risk score,evaluating the relationships between the CRRS and the immune microenvironment,responsiveness to immunotherapy,and targeted *** clinical significance of PLAUR and its biological function in ccRCC were also further ***:There were significant differences in clinical features,prognostic stratification,genomic variation,and TME characteristics between the two coagulation-related *** established and validated a CRRS using six coagulation-related genes that can be employed as an effective indicator of risk stratification and prognosis estimation for ccRCC *** variations in survival outcomes were observed between the high-and low-risk *** nomogram was proficient in predicting the 1-,3-,and 5-year ***,the CRRS emerged as a novel tool for evaluating the clinical effectiveness of immunotherapy and targeted treatments in ***,we confirmed upregulated PLAUR expression in ccRCC samples that was significantly correlated with poor patient *** knockdown notably inhibited ccRCC cell proliferation and ***:Our data suggested that CRRS may be employed as a reliable predictive biomarker that can pro

关键词： clear cell renal cell carcinoma coagulation immunotherapy risk score tumor immune microenvironment

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PDGFR in PDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis ina Temporal Manner

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Research 2024年第1期2023卷 33-48页

作者： Fangqian Wang Yuxiao Ye Zengjie Zhang Wangsiyuan Teng Hangxiang Sun xupeng Chai Xingzhi Zhou Jiayu Chen Haochen Mou Yinwang Eloy Xiaoqiang Jin Liang Chen Zhenxuan Shao Yan Wu Yue Shen An Liu Peng Lin Jianwei Wang Xiaohua Yu Zhaoming Ye Department of Orthopedic Surgery the Second Affiliated HospitalZhejang University School of MedicineHangzhou CityZhejiang ProvincePR China Orthopedics Research Institute of Zhejang University Hangzhou CityZhejiang ProvincePR China Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou CityZhejiang ProvincePR China School of Material Science and Engineering University of New South WalesSydney 2052Australia

Platelet-derived growth factor-BB(PDGF-BB)/platelet-derived growth factor receptor-β(PDGFR-β)pathway is conventionally considered as an important pathway to promote osteogenesis;however,recent study suggested its role during osteogenesis to be *** the differential functions of this pathway during 3 stages of bone healing,we hypothesized that temporal inhibition of PDGF-BB/PDGFR-βpathway could shift the proliferation/differentiation balance of skeletal stem and progenitor cells,toward osteogenic lineage,which leads to improved bone *** first validated that inhibition of PDGFR-βat late stage of osteogenic induction effectively enhanced differentiation toward *** effect was also replicated invivo by showing accelerated bone formation when block PDGFR-βpathway at late stage of critical bone defect healing mediated using ***,we found that such PDGFR-βinhibitor-initiated bone healing was also effective in the absence of scaffold implantation when administrated ***,timely inhibition of PDGFR-βblocked extracellular regulated protein kinase 1/2 pathway,which shift proliferation/differentiation balance of skeletal stem and progenitor cell to osteogenic lineage by upregulating osteogenesis-related products of Smad to induce *** study offered updated understanding of the use of PDGFR-βpathway and provides new insight routes of action and novel therapeutic methods in the field of bone repair.

关键词： healing sized implantation

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自适应广义酉变换近似消息传递算法

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清华大学学报（自然科学版） 2024年第4期64卷 700-711页

作者：雷旭鹏杨健徐孟怀朱江龚旻浙江大学海洋学院舟山316021 中国运载火箭技术研究院北京100076

信号/参数经过线性变换,再经过逐位非线性变换得到测量值的过程可以抽象为广义线性模型。广义近似消息传递算法是处理广义线性模型的一种Bayes方法,通过引入信号的稀疏先验分布,利用似然函数和先验分布得到后验均值和后验方差。然而,当... 详细信息

信号/参数经过线性变换,再经过逐位非线性变换得到测量值的过程可以抽象为广义线性模型。广义近似消息传递算法是处理广义线性模型的一种Bayes方法,通过引入信号的稀疏先验分布,利用似然函数和先验分布得到后验均值和后验方差。然而,当测量矩阵的元素不服从次Gauss分布时,广义近似消息传递算法性能会急剧恶化。通过奇异值分解,广义酉变换近似消息传递算法消除了测量矩阵的相关性,在包括相关测量矩阵的各类测量矩阵中表现出更强的鲁棒性。然而,经过足够多次迭代后,广义酉变换近似消息传递算法的信号重构误差在平衡点附近振荡;且随着测量矩阵相关性的增加,广义酉变换近似消息传递算法性能开始恶化。为了进一步提高广义酉变换近似消息传递算法的稳健性、改善算法准确性,该文提出自适应广义酉变换近似消息传递算法。该算法通过构造目标函数并自适应选择合适的步长,使得广义酉变换近似消息传递算法能够收敛到平衡点,从而获得更好的性能。大量的数值仿真实验结果验证了自适应广义酉变换近似消息传递算法的有效性。

关键词：广义线性模型压缩感知酉变换近似消息传递自适应算法

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基于关键特征增强机制的3D人脸识别

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电子科技大学学报 2024年第2期53卷 252-258页

作者：王奇钱伟中雷航王旭鹏电子科技大学信息与软件工程学院成都610054 喀什地区电子信息产业技术研究院喀什844000

3D人脸识别是计算机视觉领域的重要组成部分,Pointnet依靠深度学习解决了点云的无序性,实现了3D点云的全局特征提取,但由于点云数据缺乏细节纹理,仅靠全局特征很难实现复杂情况下的人脸识别。针对以上问题,基于Pointnet提出了一种局部... 详细信息

3D人脸识别是计算机视觉领域的重要组成部分,Pointnet依靠深度学习解决了点云的无序性,实现了3D点云的全局特征提取,但由于点云数据缺乏细节纹理,仅靠全局特征很难实现复杂情况下的人脸识别。针对以上问题,基于Pointnet提出了一种局部特征描述子,用于描述点云局部空间的几何特征,并引入关键特征增强机制,通过特征概率分布增强人脸关键信息,该机制能减少不必要特征对任务的干扰,有效提升模型的准确率。在公共数据集CASIA-3D、Lock3DFace、Bosphorus上进行实验测试,结果表明该方法能很好地应对表情变化、部分遮挡以及头部姿态的干扰,在弱光环境下其准确率高于RP-Net 1.1%,并具有良好的实时性。

关键词： 3D人脸识别深度学习局部特征描述子特征增强点云数据

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基于视觉自注意力模型与轨迹滤波器的篮球战术识别

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电子与信息学报 2024年第2期46卷 615-623页

作者：许国良沈刚梁旭鹏雒江涛重庆邮电大学通信与信息工程学院重庆400065 重庆邮电大学体育学院重庆400065

通过机器学习分析球员轨迹数据获得进攻或防守战术,是篮球视频内容理解的关键组成部分。传统机器学习方法需要人为设定特征变量,灵活性大大降低,因此如何自动获取可用于战术识别的特征信息成为关键问题。为此,该文基于美国职业篮球联赛(... 详细信息

通过机器学习分析球员轨迹数据获得进攻或防守战术,是篮球视频内容理解的关键组成部分。传统机器学习方法需要人为设定特征变量,灵活性大大降低,因此如何自动获取可用于战术识别的特征信息成为关键问题。为此,该文基于美国职业篮球联赛(NBA)比赛中球员轨迹数据设计了一个篮球战术识别模型(TacViT),该模型以视觉自注意力模型(ViT)作为主干网络,利用多头注意力模块提取丰富的全局轨迹特征信息,同时并入轨迹滤波器来加强球场线与球员轨迹之间的特征信息交互,增强球员位置特征表示,其中轨迹滤波器以对数线性复杂度学习频域中的长期空间相关性。该文将运动视觉系统(SportVU)的序列数据转化为轨迹图,自建篮球战术数据集(PlayersTrack),在该数据集上的实验表明,TacViT的准确率达到了82.5%,相对未做更改的视觉自注意力S模型(ViT-S),精度上提升了16.7%。

关键词：篮球战术识别球员轨迹轨迹滤波器对数线性复杂度多头注意力

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何谓与何为:中华传统廉洁文化的“两创”方略

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长白学刊 2024年第2期 29-46页

作者：余绪鹏上海应用技术大学马克思主义学院上海201418

推动中华优秀传统文化创造性转化和创新性发展是习近平文化思想的重大贡献。中华传统廉洁文化是中华优秀传统文化的重要组成部分,是中国古代以来形成并代代相传的价值观念和行为规范,主张廉洁自律、廉洁从政、廉洁为民。中华传统廉洁文... 详细信息

推动中华优秀传统文化创造性转化和创新性发展是习近平文化思想的重大贡献。中华传统廉洁文化是中华优秀传统文化的重要组成部分,是中国古代以来形成并代代相传的价值观念和行为规范,主张廉洁自律、廉洁从政、廉洁为民。中华传统廉洁文化的创造性转化和创新性发展,是推进“第二个结合”的现实需要,也是中国式现代化的必然要求。创造性转化是指文化的现代转型,创新性发展是指对文化的提升和超越,两者各有侧重,却又融合贯通,被统称为“两创”方略。中华传统廉洁文化的“两创”包含形式、内容和功能三个方面的转化与发展。在“两创”的基本原则上,必须坚持马克思主义文化观的指导,必须坚持中国共产党对文化工作的领导,必须坚持社会主义核心价值观的引领,必须坚持服务于新时代党风廉政建设。在主要方法上要做到批判与继承相结合、理论阐释与实践运用相结合、问题导向与目标导向相结合、民族性与国际化相结合。在实践路径上,现阶段需要加强阵地建设、创新话语表达、优化传播载体、推进科技赋能。

关键词：习近平文化思想中华传统廉洁文化创造性转化创新性发展党风廉政建设科技赋能

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