检索结果-南通市图书馆

重视并探索兼顾心脑血管病变的联合评估及防控模式在缺血性脑血管病中的应用

在线全文

学校读者我要写书评

暂无评论

中国脑血管病杂志 2018年第12期15卷 617-622页

作者：马欣吉训明首都医科大学宣武医院神经内科北京100053 首都医科大学宣武医院神经外科北京100053

合并冠状动脉病变的缺血性脑血管病(ICVD)患者在临床上较为常见,无论是否存在心肌缺血症状,其心脑血管事件的发生和复发以及死亡风险均较单纯ICVD者显著增加。目前,对ICVD患者心脑血管联合病变的重视程度不足,传统的分科诊治和研究方式... 详细信息

合并冠状动脉病变的缺血性脑血管病(ICVD)患者在临床上较为常见,无论是否存在心肌缺血症状,其心脑血管事件的发生和复发以及死亡风险均较单纯ICVD者显著增加。目前,对ICVD患者心脑血管联合病变的重视程度不足,传统的分科诊治和研究方式难以满足对该类患者的总体防控需求。同时,国内外尚缺乏针对性的筛查及防治规范,也缺少相应的研究数据。因此,需通过加强多学科合作,增进对ICVD患者心脑血管病变的综合评价,兼顾心、脑两个器官及其供血动脉的情况实施诊治及判断预后,以探索规范化和整体化的心脑血管病变联合评估及防控模式。

关键词：脑缺血医师诊疗模式心脑血管病变联合评估心脑血管病变联合防控缺血性脑血管病:专家论坛

Gabapentin inhibits central sensitization during migraine

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2013年第32期8卷 3003-3012页

作者： Yanbo Zhang Guo Shao Wei Zhang Sijie Li jingzhong Niu Dongmei Hu Mingfeng Yang xunming ji Institute of Hypoxia Medicine Xuanwu HospitalCapital Medical University Department of Neurology Affiliated Hospital of Taishan Medical University Biomedical Research Center Baotou Medical College Department of Gastroenterology Second Affiliated Hospital of Baotou Medical College

Peripheral and central sensitizations are phenomena that occur during migraine. The role of gabapentin, a migraine preventive drug, on central sensitization remains unclear. In this study, a rat model of migraine was established by electrical stimulation of the trigeminal ganglion, and the animals were given intragastric gabapentin. Changes in amino acid content in the cerebrospinal fluid and protein kinase C membrane translocation in the spinal trigeminal nucleus were examined to clarify the mechanisms underlying the efficacy of gabapentin in the treatment of central sensiti- zation during migraine. Electrophysiology, liquid chromatography-mass spectrometry and western blot analysis results revealed that gabapentin reduces neuronal excitability in the spinal nucleus in the trigeminal nerve, decreases excitatory amino acid content and inhibits the activation of protein kinase C. This provides evidence that excitatory amino acids and protein kinase C are involved in the formation and maintenance of central sensitization during migraine. Gabapentin inhibits mi- graine by reducing excitatory amino acid content in the cerebrospinal fluid and inhibiting protein kinase C activation.

关键词： neural regeneration migraine protein kinase C excitatory amino acid ionic excitatory amino acidreceptors neurons calcitonin gene-related peptide nitric oxide synthase nuclei of trigeminal nerve glutamic acid gamma-aminobutyric acid grants-supported paper neuroregeneration

A new perspective on changes in vascular function due to hypoxia

在线全文

学校读者我要写书评

暂无评论

Journal of Translational Neuroscience 2024年第3期9卷 1-14页

作者： Mengyuan Guo Weilin Liu Zirui Xu Weihao Li jia Liu xunming ji Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijing 100069China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

This review discusses the functions of blood vessels such as coagulation,regulation,immunity,endocrinology,and nerve conduction from a new perspective and suggests that hypoxia plays a common role in the changes in vascular function in various cardiovascular and cerebrovascular ***,it is oxygen therapy regulation may be a particularly beneficial means by which to regulate vascular function due to its low risk of harm and ease of ***,the authors have identified a link between vascular function and diseases caused by endogenous hypoxia and analyzed it in *** potential effects of hypoxia regulation schemes such as hyperxia,hyperoxic-hypoxia alternations,hypoxia preconditioning,and intermittent hypoxia on vascular function are also discussed,and we present theoretical support for targeted vascular therapy.

关键词： blood vessel function hypoxia hypoxia regulation vascular disease vascular intervention

远隔缺血适应在缺血性脑血管疾病中的应用研究进展

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国脑血管病杂志 2019年第4期16卷 213-217页

作者：赵童马欣吉训明首都医科大学宣武医院神经内科北京100053 首都医科大学宣武医院神经外科北京100053

远隔缺血适应(RIC)是一种新的缺血适应方式,通过远隔器官短暂的缺血-再灌注,以保护靶器官持续缺血性损伤,其常用方式是通过前臂的缺血(即骨骼肌缺血)为靶器官提供缺血保护,现已逐渐应用于缺血性心脑血管疾病的临床研究。RIC可降低缺血... 详细信息

远隔缺血适应(RIC)是一种新的缺血适应方式,通过远隔器官短暂的缺血-再灌注,以保护靶器官持续缺血性损伤,其常用方式是通过前臂的缺血(即骨骼肌缺血)为靶器官提供缺血保护,现已逐渐应用于缺血性心脑血管疾病的临床研究。RIC可降低缺血性脑血管疾病的发生率,改善缺血性脑血管疾病的预后,但有部分研究结果未提示有效。作者通过复习文献,对RIC的可能机制及其应用研究进行综述,以期为临床应用提供帮助。

关键词：缺血预处理脑缺血再灌注损伤综述

脑梗死患者急性期血清泛素羧基末端水解酶-1及神经胶质原纤维酸性蛋白水平的变化

在线全文

学校读者我要写书评

暂无评论

中国脑血管病杂志 2016年第7期13卷 337-342页

作者：李娜任长虹吉训明北京市仁和医院神经内科 102600 首都医科大学宣武医院低氧医学研究所

目的探讨泛素羧基末端水解酶-1（UCH-L1）、神经胶质原纤维酸性蛋白（GFAP）在脑梗死急性期水平的变化。方法回顾性纳入2011年3月至2012年6月于首都医科大学宣武医院神经内科门诊、急诊和卒中筛查工程基地及北京市仁和医院神经内科病房... 详细信息

目的探讨泛素羧基末端水解酶-1（UCH-L1）、神经胶质原纤维酸性蛋白（GFAP）在脑梗死急性期水平的变化。方法回顾性纳入2011年3月至2012年6月于首都医科大学宣武医院神经内科门诊、急诊和卒中筛查工程基地及北京市仁和医院神经内科病房就诊的早期脑梗死患者95例作为脑梗死组,并选择同期在体检中心接受体检的61名非卒中对象作为对照组。测定脑梗死组及脑梗死发病不同时间组（发病〈12 h组和发病12-24 h组）及美国国立卫生研究院卒中量表（NIHSS）不同评分组（NIHSS 0-4分组和NIHSS 5-19分组）和对照组人群的血清UCH-L1、GFAP水平并进行各组间比较。构建受试者工作特征（ROC）曲线,获取相关参数在脑梗死诊断中的阳性与阴性的临界值及诊断敏感度与特异度。结果脑梗死组血清UCH-L1、GFAP均高于对照组[0.13（0.09,0.21）μg/L比0.05（0.02,0.13）μg/L,0.030（0.008,0.130）μg/L比0.004（0.004,0.020）μg/L;Z值分别为3.62、4.95,均P〈0.01];NIHSS评分5-19分组血清UCH-L1、GFAP水平高于NIHSS评分0-4分组[0.12（0.08,0.21）比0.09（0.08,0.18）,0.07（0.01,0.11）比0.04（0.01,0.10）;均P〈0.05]。发病12-24 h组血清UCH-L1、GFAP水平与发病〈12 h组差异无统计学意义[0.12（0.08,0.21）μg/L比0.09（0.08,0.18）μg/L,0.030（0.010,0.110）μg/L比0.040（0.008,0.100）μg/L;均P〉0.05]。UCH-L1、GFAP诊断急性脑梗死的ROC曲线分析结果显示,当血清UCH-L1≥0.18μg/L时,UCH-L1的敏感度、特异度分别为68%、74%;当血清GFAP≥0.11μg/L时,GFAP的敏感度和特异度分别为70%、86%;UCH-L1、GFAP诊断脑梗死的ROC曲线下面积分别为0.64及0.71。结论血清UCH-L1、GFAP水平在脑梗死急性期时有明显变化。血清UCH-L1、GFAP水平与卒中的严重程度可能具有一定相关性。

关键词：脑梗死泛素羧基末端水解酶-1 神经胶质原纤维酸性蛋白

在线全文

学校读者我要写书评

暂无评论

颅内动脉狭窄的血管内支架治疗

上海医学 2006年第12期29卷 849-851页

作者：江宗华吉训明江西赣州市人民医院神经内科 341000 首都医科大学定宣武医院神经科

目的评价症状性颅内动脉狭窄血管内支架置入治疗的疗效、安全性和操作技术。方法17例局限性颅内血管狭窄患者出现与血管狭窄有关的神经功能障碍,内科抗凝、抗血小板治疗无效。采用经皮支架辅助血管成形术,使狭窄血管扩张。术后3个月进... 详细信息

目的评价症状性颅内动脉狭窄血管内支架置入治疗的疗效、安全性和操作技术。方法17例局限性颅内血管狭窄患者出现与血管狭窄有关的神经功能障碍,内科抗凝、抗血小板治疗无效。采用经皮支架辅助血管成形术,使狭窄血管扩张。术后3个月进行经颅彩色多普勒检查和(或)数字减影血管造影检查及临床症状随访。结果17例患者血管内支架均成功置人,血管狭窄率从术前的平均83％降至术后的5％。均无与手术相关的颅内出血发生。短期内(3个月)随访未见再狭窄,没有短暂性脑缺血发作或脑卒中发生,临床症状改善。结论经皮血管内支架置入术是治疗症状性颅内动脉狭窄安全、有效的手段。

关键词：颅内动脉狭窄支架

m TOR cell signaling pathway contributes to the protective effects of ischemic postconditioning against stroke

在线全文

学校读者我要写书评

暂无评论

m TOR cell signaling pathway contributes to the protective e...

Perspectives on potential neuroprotective role of albumin in acute ischemic stroke

长三角地区神经科学论坛2016暨第八次会员代表大会

作者：谢嵘 Peng Wang Michelle Cheng Robert Sapolsky xunming ji Heng Zhao Department of Neurosurgery Huashan Hospital Fudan University Departments of Neurosurgery Stanford University Departments of Neurosurgery Stanford University Department of Neurosurgery Xuanwu Hospital Capital Medical School Departments of Biological Sciences Stanford University

＜正＞Introduction:Ischemic postconditioning（IPost C）provides protective effect against focal ischemia and improves neurological *** the m TOR pathway is protective or detrimental in brain injury induced by stroke is controversial,and whether it is involved in the protective effects of ischemic postconditioning against stroke has not been *** report that m TOR contributes to neuronal survival in vitro,in a neuronal culture,as well as in vivo,in stroke brains receiving IPostC.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Translational Neuroscience 2023年第2期8卷 1-6页

作者： Yuanyuan Liu Xiao Dong Xuehong Chu Ran Meng Chuanhui Li Chen Zhou Chuanjie Wu xunming ji Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurology and Stroke Center Xuanwu HospitalCapital Medical UniversityBeijing 100053China China-America Institute of Neuroscience and Beijing Institute of Geriatrics Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing 100069China

Albumin is the most abundant protein in plasma and is synthesized primarily in the *** has a variety of biological roles,such as increasing colloid osmotic pressure, and performing antioxidant, anti-inflam-matory,and substance transportation *** studies have confirmed that albumin has neuroprotective effects and it has been used in the treatment of cerebral edema and increased intracranial *** this review we focus on the neuroprotective effects of albumin in ischemic stroke,such as the reduction of cerebral edema, antioxidant effects, protection of neuronal cell membranes, and increased cerebral blood flow. In addition, we summarize preclinical and clinical studies of albumin in ischemic stroke. We believe that the neuroprotective role of albumin should be re-investigated in the era of reperfusion therapy.

关键词： albumin acute ischemic stroke neuro-protection reperfusion therapy

基于恒河猴脑卒中模型的低温自体血靶向回输系统

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

科学通报 2024年第31期69卷 4521-4522页

作者：徐率立吴迪侯武刚吉训明首都医科大学北京脑重大疾病研究院北京100069 首都医科大学宣武医院神经外科北京100053 空军军医大学西京医院麻醉与围术期医学科西安710000

几十年来,急性缺血性卒中一直位于我国致死、致残性疾病前列,给患者家庭及社会带来沉重负担[1].其病理特点是血栓阻塞脑血管,形成局部脑组织缺氧.对于急性缺血性卒中,主流的治疗方式是以静脉溶栓及血管内机械取栓术为代表的血管再通疗法... 详细信息

几十年来,急性缺血性卒中一直位于我国致死、致残性疾病前列,给患者家庭及社会带来沉重负担[1].其病理特点是血栓阻塞脑血管,形成局部脑组织缺氧.对于急性缺血性卒中,主流的治疗方式是以静脉溶栓及血管内机械取栓术为代表的血管再通疗法[2].但是,仍有50%左右接受再通患者预后仍然较差,究其原因,在于未能得到及时的血管再通以及继发缺血再灌注损伤[3].

关键词：急性缺血性卒中脑组织缺氧致残性疾病血管再通血栓阻塞自体血静脉溶栓缺血再灌注损伤