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应用高压冷冻-冷冻置换技术研究受Potyvirus侵染的寄主细胞超微结构

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电子显微学报 2010年第2期29卷 146-151页

作者：郑瑛洪健祝建陈集双浙江理工大学生物工程研究所浙江杭州310018 浙江大学分析测试中心浙江杭州310029 同济大学生命科学与医学工程研究院上海200092

应用高压冷冻-冷冻置换技术(HPF-FS)制备了马铃薯Y病毒属的小西葫芦黄花叶病毒(ZYMV)和大豆花叶病毒(SMV)侵染寄主植物叶细胞的超薄切片样品,并与传统化学固定方法进行比较。透射电镜观察结果显示:病毒粒子和内含体的形态分布在两种方... 详细信息

应用高压冷冻-冷冻置换技术(HPF-FS)制备了马铃薯Y病毒属的小西葫芦黄花叶病毒(ZYMV)和大豆花叶病毒(SMV)侵染寄主植物叶细胞的超薄切片样品,并与传统化学固定方法进行比较。透射电镜观察结果显示:病毒粒子和内含体的形态分布在两种方法处理的样品中无明显差异,但高压冷冻样品的细胞超微结构精细,细胞壁与细胞质之间边界清晰,质膜平滑而完整,细胞基质丰富;细胞核和叶绿体、线粒体等形态饱满,高尔基体潴泡结构及分泌小泡清晰,在ZYMV感染细胞的叶绿体中观察到囊泡结构。而化学处理的样品普遍存在细胞结构的收缩和变形,特别是质膜褶皱,与细胞壁分离,叶绿体呈梭形,片层结构发生改变,高尔基体潴泡结构及分泌小泡相当少见。实验结果有利于正确区别病毒所引起的细胞病理变化和化学处理而产生的人工假象。

关键词：高压冷冻-冷冻置换小西葫芦黄花叶病毒大豆花叶病毒超微结构

规范化分级治疗对哮喘患者生活质量的影响探讨

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中国卫生产业 2016年第24期13卷 140-141,187页

作者：冀长城黑龙江省第二医院呼吸内科黑龙江哈尔滨150001

目的探讨规范化分级治疗对哮喘患者生活质量的影响。方法在医院2014年1月—2015年2月期间诊治的哮喘患者中抽取60例作研究对象,对其应用规范化分级治疗,对比该组患者治疗前后的生活质量与肺功能指标变化。结果相较于治疗前,该组患者治... 详细信息

目的探讨规范化分级治疗对哮喘患者生活质量的影响。方法在医院2014年1月—2015年2月期间诊治的哮喘患者中抽取60例作研究对象,对其应用规范化分级治疗,对比该组患者治疗前后的生活质量与肺功能指标变化。结果相较于治疗前,该组患者治疗后的社会功能、情感职能、精神健康、精力、一般健康状况、躯体疼痛、生理职能和生理机能评分均明显升高(P<0.01),且治疗后的FEV1、PEF高于治疗前(P<0.05)。结论规范化分级治疗可对哮喘患者生活质量产生正面影响,并能改善其肺功能,值得借鉴。

关键词：规范化分级治疗哮喘生活质量

Study on the Strategy of International Publicity Translation in Our Country from the Perspective of National Image

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International Journal of Technology Management 2016年第5期 31-33页

作者： Yinping ji Sias International University Xinzhe ngHenan451150 China

Along with the advent of the age of globalization, our country and international community are becoming more closely, and comprehensive national strength and infl uence is also greatly growing. Strengthening external propaganda has become a strategic task in the current development of our country. The translation work has been paid more and more attention, and it has an important role in shaping the image of our country. But from the current point of view, there are still some common problems. In this paper, from the perspective of the national image, we analyze the relationship between foreign publicity translation strategies and national image, and we also analyze the status quo of the translation of foreign propaganda in China, then we put forward the strategy of publicity translation.

关键词： external-propaganda translation national image relationship present situation strategy

Plasmakinetic enucleation of prostate versus 160-W laser photoselective vaporization for the treatment of benign prostatic hyperplasia

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Asian Journal of Andrology 2017年第1期19卷 15-19页

作者： Si-Jun Wang Xiao-Nan Mu ji Chen Xun-Bo jin Shi-Bao Zhang Long-Yang Zhang Department of Urology Jinan Central Hospital Affiliated to Shandong University Jinan 250013 P.R. China Department of Concerning Foreign Affairs Jinan Central Hospital Affiliated to Shandong University Jinan 250013 P.R. China Department of Minimally Invasive Urology Provincial Hospital Affiliated to Shandong UniversityJinan 250021 P.R. China.

To evaluate the safety and efficacy of plasmakinetic enucleation of the prostate （PKEP） for the treatment of symptomatic benign prostatic hyperplasia （BPH） compared with 160-W lithium triboride laser photoselective vaporization of the prostate （PVP）. From February 2011 to July 2012, a prospective nonrandomized study was performed. One-hundred one patients underwent PKEP, and 110 underwent PVP. No severe intraoperative complications were recorded, and none of the patients in either group required a blood transfusion. Shorter catheterization time （38.14 ± 23.64 h vs 72.54 ± 28.38 h, P 〈 0.001） and hospitalization （2.32 ± 1.25 days vs 4.07±1.23 days, P 〈 0.001） were recorded in the PVP group. At 12-month postoperatively, the PKEP group had a maintained and statistically improvement in International Prostate Symptom Score （IPSS）（4.07 ±2.07 vs 5.00 ±2.10; P〈 0.001）, quality of life （QoL）（1.08 ± 0.72 vs 1.35 ± 0.72; P= 0.007）, maximal urinary flow rate （Qmax）（24.75±5.87 ml s^-1 vs 22.03 ±5.04 ml s^-1; P 〈 0.001）, postvoid residual urine volume （PVR）（14,29 ± 6,97 ml vs 17.00±6.11 ml; P = 0,001）, and prostate-specific antigen （PSA） value （0.78 ±0.57 ng ml^-1 vs 1.27 ±1.07 ng ml^-1; P 〈 0.001）. Both PKEP and PVP relieve low urinary tract symptoms （LUTS） due to BPH with low complication rates. PKEP can completely remove prostatic adenoma while the total amount of tissue removed by PVP is less than that can be removed by PKER Based on our study of the follow-up, PKEP provides better postoperative outcomes than PVP.

关键词： electrosurgery laser therapy prostate prostatic hyperplasia transurethral resection of prostate

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Movers and Shapers

Beijing Review 2019年第28期62卷 32-35页

作者： ji jing 不详

In an exhibition area of the World Economic Forum's (WEF) Annual Meeti ng of the New Cham pions in China's northeastern coastal city of Dalian, a robot was performing a surgical operation on a rose. The volunteers in the booth invited visitors to have a go at running the machine, which was developed by U.S. company Intuitive Surgical and has been used in 6 million successful surgeries worldwide. Over 110,000 of these were done in China, which has around 80 such robots in use in hospitals.

关键词： Movers Shapers Innovation technology

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析消费者网上购买决策的形成及影响诸因素

消费经济 2005年第2期21卷 82-85,81页

作者：周一骑焦观生南开大学周恩来政府管理学院天津300071

网上交易是消费者与生产厂商“一对一”的信息交流,具有互动性,大大缩短了二者间的距离,改变了原有消费的模式。为此,本文分析了消费者网上购买决策的形成以及影响消费者网上购买决策和购买行为的诸因素。

关键词：网上购买购买决策购买行为消费者权益网上消费者中国

Occurrence and risk assessment of typical PPCPs and biodegradation pathway of ribavirin in wastewater treatment plants

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Environmental Science and Ecotechnology 2022年第3期11卷 74-82页

作者： Qixin Liu Xuan Feng Ning Chen Fei Shen Haichuan Zhang Shuo Wang Zhiya Sheng ji Li jiangsu Key Laboratory of Anaerobic Biotechnology School of Environment and Civil EngineeringJiangnan UniversityWuxi214122China Laboratory of Instrumental Analysis Jiangsu Wuxi Environmental Monitoring CenterWuxi214121China jiangsu Engineering Laboratory for Biomass Energy and Carbon Reduction Technology Jiangnan UniversityWuxi214122China jiangsu College of Water Treatment Technology and Material Collaborative Innovation Center Suzhou215009China Department of Civil and Environmental Engineering University of AlbertaEdmontonT6G 2W2Canada

A large number of pharmaceuticals and personal care products(PPCPs)persist in wastewater,and the consumption of PPCPs for COVID-19 control and prevention has sharply increased during the *** study investigated the occurrence,removal efficiency,and risk assessment of six typical PPCPs commonly used in China in two wastewater treatment plants(WWTPs).Ribavirin(RBV)is an effective pharmaceutical for severely ill patients with COVID-19,and the possible biodegradation pathway of RBV by activated sludge was *** experimental results showed that PPCPs were detected in two WWTPs with a detection rate of 100%and concentrations ranging between 612 and 2323 ng L^(-1).The detection frequency and concentrations of RBV were substantially higher,with a maximum concentration of 314 ng L^(-1).Relatively high pollution loads were found for the following PPCPs from influent:ibuprofen>ranitidine hydrochloride>RBV>ampicillin sodium>clozapine>*** removal efficiency of PPCPs was closely related to adsorption and biodegradation in activated sludge,and the moving bed biofilm reactor(MBBR)had a higher removal capacity than the anoxic-anaerobic-anoxicoxic(AAAO)*** removal efficiencies of sulfamethoxazole,ampicillin sodium,ibuprofen,and clozapine ranged from 92.21%to 97.86%in MBBR process and were relatively low,from 61.82%to 97.62%in AAAO process,and the removal of RBV and ranitidine hydrochloride were lower than 42.96%in both MBBR and AAAO *** discrepancy in removal efficiency is caused by temperature,hydrophilicity,and hydrophobicity of the compound,and acidity and *** transformation products of RBV in activated sludge were detected and identified,and the biodegradation process of RBV could be speculated as follows:first breaks into TCONH_(2) and an oxygen-containing five-membered heterocyclic ring under the nucleosidase reaction,and then TCONH_(2) is finally formed into TCOOH through amide *** ecological risks

关键词： COVID-19 pandemic Ribavirin(RBV) Mass balance Pollution load estimation Risk assessment Biodegradation pathway

Development and validation of a prediction model for microvascular invasion in hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第14期26卷 1647-1659页

作者： Lin Wang Yue-Xinzi jin Ya-Zhou ji Yuan Mu Shi-Chang Zhang Shi-Yang Pan Department of Laboratory Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina National Key Clinical Department of Laboratory Medicine Jiangsu Province HospitalNanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Microvascular invasion(MVI)is an important prognostic factor affecting early recurrence and overall survival in hepatocellular carcinoma(HCC)patients after hepatectomy and liver transplantation,but it can be determined only in surgical *** preoperative prediction of MVI is conducive to clinical *** To develop and validate a preoperative prediction model for MVI in patients with *** Data from 454 patients with HCC who underwent hepatectomy at the First Affiliated Hospital of Nanjing Medical University between May 2016 and October 2019 were retrospectively ***,the patients were nonrandomly split into a training cohort and a validation *** regression analysis was used to identify variables significantly associated with MVI that were then included in the *** evaluated the discrimination and calibration ability of the nomogram by using R *** MVI was confirmed in 209(46.0%)patients by a pathological *** logistic regression analysis identified four risk factors independently associated with MVI:Tumor size[odds ratio(OR)=1.195;95%confidence interval(CI):1.107–1.290;Png/mL,OR=1.955;95%CI:1.055–3.624;P=0.033;>400 ng/mL,OR=3.476;95%CI:1.950–6.195;Png and validation cohorts,*** calibration curves showed good agreement between the predicted risk by the nomogram and real *** We have developed and validated a preoperative prediction model for MVI in patients with *** model could aid physicians in clinical treatment decision making.

关键词： Microvascular invasion Nomogram Hepatocellular carcinoma Discrimination and calibration Neutrophils Early recurrence

Predictors for malignant potential and deep submucosal invasion in colorectal laterally spreading tumors

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World Journal of Gastrointestinal Oncology 2022年第7期14卷 1337-1347页

作者： Xiao-Wen Hao Peng Li Yong-Jun Wang Ming ji Shu-Tian Zhang Hai-Yun Shi National Clinical Research Centre for Digestive Disease Beijing Digestive Disease CentreBeijing Key Laboratory for Precancerous Lesion of Digestive DiseaseBeijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Colorectal laterally spreading tumors(LSTs)with malignant potential require en bloc resection by endoscopic submucosal dissection(ESD),but lesions with deep submucosal invasion(SMI)are endoscopically *** To investigate the factors associated with high-grade dysplasia(HGD)/carcinoma and deep SMI in colorectal *** The endoscopic and histological results of consecutive patients who underwent ESD for colorectal LSTs in our hospital from June 2013 to March 2019 were retrospectively *** characteristics of LST subtypes were *** factors for HGD/carcinoma and deep SMI(invasion depth≥1000μm)were determined using multivariate logistic *** A total of 323 patients with 341 colorectal LSTs were *** the four subtypes,non-granular pseudodepressed(ng-PD)LSTs(85.5%)had the highest rate of HGD/carcinoma,followed by the granular nodular mixed(G-NM)(77.0%),granular homogenous(29.5%),and non-granular flat elevated(24.2%)*** SMI occurred commonly in ng-PD LSTs(12.9%).In the adjusted multivariate analysis,ng-PD[odds ratio(OR=16.8,Png sign(OR=3.3,P=0.024)were independently associated with HGD/*** ng-PD subtype(OR=13.3,Png-PD and G-NM LSTs are removed en bloc through *** their substantial risk for deep SMI,surgery needs to be considered for ng-PD LSTs located in the rectosigmoid,especially those with positive nonlifting signs.

关键词： Colorectal laterally spreading tumors Subtype Deep submucosal invasion Endoscopic submucosal dissection