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Differences in the prognostic value of tumor extent of resection among the molecular subgroups of medulloblastoma: A single centre study of 113 cases

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Translational Neuroscience and Clinics 2017年第2期3卷 66-73页

作者： Yuyuan Wang Kay Kawai Li ji Xiong Zhenyu Zhang Yang Wang jian Xu Yin Wang Hokeung ng Ping Zhong Department of Neurosurgery Huashan Hospital Fudan University Department of Anatomical and Cellular Pathology Prince of Wales Hospital the Chinese University of Hong Kong Department of Pathology Huashan Hospital Fudan University Department of Neurosurgery the First Affiliated Hospital of Zhengzhou University Zhengzhou University Department of Radiotherapy Huashan Hospital Fudan University

Medulloblastoma(MB) is one of the most common pediatrics malignant tumors of the central nervous system. Studies in America and Europe have demonstrated significant differences in the prognostic value of medulloblastoma extent among molecular subgroups of medulloblastoma. However, studies focusing on the Chinese population are still lacking. A total of 113 patients with medulloblastoma who underwent surgical resection in Huashan Hospital between January 2002 and December 2013 were included in this study. Histological diagnoses were confirmed by 2 or more pathologists. Immunohistochemistry and CTNNB1 exon 3 mutation analysis were used to determine the different subgroups. Complete or incomplete resection was defined based on surgeons' reports and confirmed by postoperative computer tomography(CT). In this study, we included 113 patients with medulloblastoma(13 with WNT subgroup, 18 with SHH subgroup, and 82 with non-SHH/WNT subgroups) to assess their event-free and overall survival. We identified event-free survival and overall survival benefit for complete resection over incomplete resection. We found that for patients with NON-SHH/WNT medulloblastoma, incomplete resection was significantly associated with progression and overall survival compared with complete resection. To our best knowledge, the present study is the first to demonstrate the prognostic value of tumor extent of resection among the molecular subgroups of 113 medulloblastoma in the Chinese *** prognostic benefit of the increased extent of resection for patients with medulloblastoma is attenuated after the molecular subgroups are taken into account. We still need further study to assess the benefit of surgical resection of small residual portions.

关键词： medulloblastoma molecular subgroups clinical characteristic surgical resection

Isolated Co single atoms in nitrogen-doped graphene for aluminum-sulfur batteries with enhanced kinetic response

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Journal of Energy Chemistry 2022年第4期31卷 354-360页

作者： Zhiqiu Hu Shuai Xie Yue Guo Yadong Ye jing Zhang Song jin Hengxing ji Hefei National Laboratory for Physical Sciences at the Microscale School of Chemistry and Materials ScienceCAS Key Laboratory of Materials for Energy ConversionUniversity of Science and Technology of ChinaHefei 230026AnhuiChina Beijing Synchrotron Radiation Facility(BSRF) Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100864China

Al-S batteries are promising next generation energy storage devices due to their high theoretical energy density(1340 Wh kg^(-1)),low cost,and safe ***,the electrochemical performance of Al-S batteries suffers poor reversibility owing to slow kinetic processes determined by the difficulty of reversible conversion between Al and ***,we proposed a single-atom catalysts comprising Co atoms embedded in a nitrogen-doped graphene(Co ng)as an electrochemical catalyst in the sulfur cathode that renders a reduced discharge-charge voltage hysteresis and improved sulfur utilization in the *** structural and electrochemical analyses suggest that the Co ng facilitated both the formation and oxidation of Al S;during the electrochemical reactions of the sulfur ***,the Co ng-S composite can deliver a considerably reduced voltage hysteresis of 0.76 V and a reversible specific capacity of 1631 m Ah g^(-1) at 0.2 A g^(-1) with a sulfur utilization of more than 97%.

关键词： Single atom Catalyst Graphene Aluminum sulfur battery

Changes and significance of serum troponin in trauma patients: A retrospective study in a level I trauma center

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World Journal of Emergency Medicine 2022年第1期13卷 27-31页

作者： Li-wen Dou Zhe Du ji-hong Zhu Tian-bing Wang Emergency Department Peking University People’s HospitalBeijing 100044China Trauma Center Peking University People’s HospitalBeijing 100044China

BACKGROUND: Elevated troponin I(TnI) is common among trauma patients. TnI is an indicator of myocardial injury, but clinical diagnosis of blunt cardiac injury cannot be based solely on an increase in TnI. Therefore, this study aims to explore the changes and clinical significance of serum TnI in trauma patients. METHODS: The clinical data of consecutive trauma patients admitted to our trauma center between July 1, 2017 and July 31, 2020 were retrospectively analyzed. According to TnI levels within 24 hours of admission, patients were divided into the elevated and normal TnI groups. According to the TnI levels after 7 days of admission, a graph depicting a change in trend was drawn and then analyzed whether TnI was related to in-hospital mortality. RESULTS: A total of 166 patients(69 and 97 cases with elevated and normal TnI, respectively) were included in this study. The average hospital stay, intensive care time, mechanical ventilation time, and in-hospital mortality were higher in the elevated TnI group than in the normal TnI group(Png/mL). Subsequently, it decreased, and then recovered to normal within 7 days. However, 13 patients did not recover. Logistic regression analysis revealed that abnormal TnI at 7 days was independently related to in-hospital mortality. CONCLUSIONS: Trauma patients with elevated TnI levels may have a worse prognosis. Monitoring the changes in serum TnI is important, which can reflect the prognosis better than the TnI measured immediately after admission.

关键词： Trauma Blunt cardiac injury Troponin I Electrocardiography

DWT BASED HMM FOR FACE RECOGNITION

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Journal of Electronics(China) 2007年第6期24卷 835-837页

作者： Shen Linlin ji Zhen Bai Li Xu Chen TI DSPs Lab Faculty of Information Engineering Shenzhen University Shenzhen 518050 China School of Computer Science ＆ Information Technology University of Nottingham NG8 1BB UK Institute of Intelligent Computing Science Shenzhen University Shenzhen 518060 China

A novel Discrete Wavelet Transform (DWT) based Hidden Markov Module (HMM) for face recognition is presented in this letter. To improve the accuracy of HMM based face recognition algorithm, DWT is used to replace Discrete Cosine Transform (DCT) for observation sequence ex- traction. Extensive experiments are conducted on two public databases and the results show that the proposed method can improve the accuracy significantly, especially when the face database is large and only few training images are available.

关键词： Discrete Wavelet Transform (DWT) Hidden Markov Model (HMM) Face recognition

TiN nanocrystal anchored on N-doped graphene as effective sulfur hosts for high-performance lithium-sulfur batteries

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Journal of Energy Chemistry 2021年第3期30卷 16-22页

作者： Wenmiao Chen Hongchang jin Shuai Xie Huanyu Xie Junfa Zhu Hengxing ji Li-Jun Wan Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Materials for Energy ConversionDepartment of Applied ChemistryUniversity of Science and Technology of ChinaHefei 230026AnhuiChina National Synchrotron Radiation Laboratory and Collaborative Innovation Center of Suzhou Nano Science and Technology University of Science and Technology of ChinaHefei 230029AnhuiChina CAS Key Laboratory of Molecular Nanostructure and Nanotechnology Institute of ChemistryChinese Academy of SciencesBeijing 100190China

Lithium-sulfur(Li-S)batteries have become prospective candidates for next-generation energy storage owing to the high energy density and low ***,the sluggish kinetics of the electrochemical reaction and shuttle effect result in a rapid capacity ***,a titanium nitride nanocrystal/Ndoped graphene(TiN@ng)composite is developed to host elemental *** TiN nanoparticles decorated on graphene sheets attract Li polysulfides(LiPSx)and catalyze the electrochemical reduction and oxidation of LiPSx in the discharge and charge processes,*** two effects effectively restrain the dissolution of the LiPSx and accelerate the electrochemical reactions,thereby,alleviating the shuttle *** a result,the cathode composed of TiN@ng/S delivers a remarkable reversible capacity(1390 mA h g^(-1) at 0.1 C)and excellent cycling performance(730 mA h g^(-1) after 300 cycles).We believe that this work can bring some inspiration for designing high-performance Li-S batteries.

关键词： Titanium nitride Nitrogen-doped graphene Catalysis effects Adsorption capability Lithium-sulfur batteries

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国外图书馆社交媒体研究热点分析及启示

图书馆学研究 2019年第2期 12-17,82页

作者：刘竟张禄芬崔欣卉江苏大学图书馆江苏大学科技信息研究所

基于R语言开发的Bibliometrix软件包,对WOS中近10年图书馆社交媒体相关文献进行了聚类分析,并从图书馆员认知与态度、图书馆社交媒体用户使用行为、社交媒体发布内容主题及服务等方面,对国外图书馆社交媒体的研究热点进行了归纳分析,进... 详细信息

基于R语言开发的Bibliometrix软件包,对WOS中近10年图书馆社交媒体相关文献进行了聚类分析,并从图书馆员认知与态度、图书馆社交媒体用户使用行为、社交媒体发布内容主题及服务等方面,对国外图书馆社交媒体的研究热点进行了归纳分析,进而得出充分挖掘社交媒体平台功能、整体规划发布内容,保护用户隐私、加强用户需求及信息行为的研究,重视基于社交媒体的图书馆社区建设及服务等启示和建议。

关键词：社交媒体图书馆研究热点

Ultralow detection limit of giant magnetoresistance biosensor using Fe3O4–graphene composite nanoparticle label

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Chinese Physics B 2017年第1期26卷 151-155页

作者： jie Xu ji-qing jiao Qiang Li Shan-dong Li College of Physics Key Laboratory of Photonics Materials and Technology in Universities of Shandong and Laboratory of Fiber Materials and Modem Textile the Growing Base for State Key Laboratory Qingdao University Qingdao 266071 China School of Chemical Science and Engineering Qingdao University Qingdao 266071 China National Laboratory of Solid State Microstructures Nanjing University Nanjing 210093 China

A special Fe3O4nanoparticles–graphene（Fe3O4–GN） composite as a magnetic label was employed for biodetection using giant magnetoresistance（GMR） sensors with a Wheatstone bridge. The Fe3O4–GN composite exhibits a strong ferromagnetic behavior with the saturation magnetization MS of approximately 48 emu/g, coercivity HC of 200 Oe, and remanence Mr of 8.3 emu/g, leading to a large magnetic fringing field. However, the Fe3O4 nanoparticles do not aggregate together, which can be attributed to the pinning and separating effects of graphene sheet to the magnetic particles. The Fe3O4–GN composite is especially suitable for biodetection as a promising magnetic label since it combines two advantages of large fringing field and no aggregation. As a result, the concentration x dependence of voltage difference ｜？V｜ between detecting and reference sensors undergoes the relationship of ｜？V｜ = 240.5 lgx ＋ 515.2 with an ultralow detection limit of 10 ng/mL（very close to the calculated limit of 7 ng/mL） and a wide detection range of 4 orders.

关键词： giant magnetoresistance biosensors magnetic label Fe3O4–graphene composite lowest detection limit

Waist Circumference Reference Values for Screening Cardiovascular Risk Factors in Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2010年第1期23卷 21-31页

作者： GUAN-SHEng MA CHEng-YE ji JUN MA jiE MI R1TA YT SLIng FEng XIOng WEI-LI YAN XIAO-QI HU YAN-PIng LI SOng-M1ng DU HOng-YUN FAng AND J1ng-XIOng jiAng National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing100050 China Institute of Child and Adolescent Health Peking gniversi07 Health Science Center Beijing100191 China Capital Institute of Pediatrics Beijing 100020 China Department of Paediatrics TheChinese University of Hong Kong Hong Kong Special Administrative Re'on China The Children's Hospital of Chongqing Medical University Chongqing 400014 China School of Public Health Xinjiang Medical University Wulumuqi 830011 Xinjiang China National Center for Women and Childre's Health Chinese Center for Disease Control and Prevention Beijing 100013 China

Objectives To explore the optimal threshold values of waist circumference （WC） for detecting cardiovascular （CV） risk factors among Chinese children and adolescents. Methods Association of WC with CV risk factors was studied among 65 898 children aged 7-18 years whose data were pooled from nine previous studies in China. CV risk factors in this study included hypertension （blood pressure above 95 percentile levels）, dyslipidemia （with one or more of the following three indexes： TG ≥ 1.7 mmol/L, TC ≥ 5.18 mmol/L, and HDL-C ≤ 1.04 mmol/L） and elevated glucose level （fasting plasma glucose ≥5.6 mmol/L）. Receive-operating characteristic analysis （ROC） and logistic regression were employed to derive optimal age- and sex-specific waist circumference references for predicting CV risk factors. Results A slight increasing trend of CV risk factors was observed starting from the 75th percentile of waist circumference in the study population, while a remarkable increasing trend occurred from the 90th percentile. The optimal waist circumference thresholds for predicting high blood pressures were at the 75th percentile for both boys and girls, which was at the 90th percentiles for detecting at least two of the above three CV risk factors. In comparison with children with waist circumference below the 75th percentile, the odds ratio of two CV risk factors doubled among children with waist circumference between the 75th and the 90th percentile, and increased by 6 times among children with waist circumference above the 90th percentile. The trend of high blood pressure increasing with waist circumference remained significant after having been stratified by BMI category. Conclusion The 75th and the 90th percentiles of WC are the optimal cut-off points for predicting an increased and a substantially increased risk of CV factors in Chinese children and adolescents, respectively.

关键词： Waist circumference Cardiovascular disease risk factor China

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着舰环境对舰载机着舰的影响分析

科技创新与应用 2019年第16期9卷 20-21页

作者：焦晓辉王鹏中国飞行试验研究院，陕西西安 710089

相比常规陆基飞机降落来说,舰载机着舰面临着更加复杂的着舰环境,着舰的要求要苛刻得多,难度要大得多,影响着舰安全的因素也多得多。文章通过分析舰载机着舰过程中面临的主要环境因素对安全着舰的影响及缓解措施,有助于降低舰载机着舰风... 详细信息

相比常规陆基飞机降落来说,舰载机着舰面临着更加复杂的着舰环境,着舰的要求要苛刻得多,难度要大得多,影响着舰安全的因素也多得多。文章通过分析舰载机着舰过程中面临的主要环境因素对安全着舰的影响及缓解措施,有助于降低舰载机着舰风险,提高着舰成功率。

关键词：舰载机着舰环境着舰安全