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Cluster analysis reveals a homogeneous subgroup of PCOS women with metabolic disturbance associated with adverse reproductive outcomes

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Chinese Medical Journal 2024年第5期137卷 604-612页

作者： Hanxiao Chen Rujun zeng xun zeng Lang Qin The Reproductive Medical Center Department of Obstetrics and GynecologyWest China Second University HospitalSichuan UniversityChengduSichuan 610041China Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education West China Second University HospitalSichuan UniversityChengduSichuan 610041China

Background:Polycystic ovarian syndrome(PCOS)is a heterogeneous and complex reproductive endocrinological disease that could lead to infertility.There were many attempts to classify PCOS but it remains unclear whether there is a specific subgroup of PCOS that is associated with the best or worst reproductive outcomes of assisted reproductive techniques(ART).Methods:Infertile PCOS patients who underwent their first cycle of in vitro fertilization(IVF)in West China Second University Hospital,Sichuan University from January 2019 to December 2021 were included.Basic clinical and laboratory information of each individual were extracted.Unsupervised cluster analysis was performed.Controlled ovarian stimulation parameters and reproductive outcomes were collected and compared between the different clusters of PCOS.Results:Our analysis clustered women with PCOS into"reproductive","metabolic",and"balanced"clusters based on nine traits.Reproductive group was characterized by high levels of testosterone(T),sex hormone-binding globulin(SHBG),follicular stimulation hormone(FSH),luteinizing hormone(LH),and anti-Müllerian hormone(AMH).Metabolic group was characterized by high levels of body mass index(BMI),fasting insulin,and fasting glucose.Balanced group was characterized by low levels of the aforementioned reproductive and metabolic parameters,except for SHBG.Compared with PCOS patients in reproductive and balanced clusters,those in metabolic cluster had lower rates of good quality day 3 embryo and blastocyst formation.Moreover,PCOS patients in the reproductive cluster had greater fresh embryo transfer(ET)cancelation rate and clinical pregnancy rate after fresh ET than metabolic cluster(odds ratio[OR]=3.37,95%confidence interval[CI]:1.77-6.44,and OR=6.19,95%CI:1.58-24.24,respectively).And compared with PCOS of metabolic cluster,PCOS of balanced cluster also had higher chance for fresh ET cancelation(OR=2.83,95%CI:1.26-6.35).Conclusion:Our study suggested that PCOS patients in metabolic cluster may be associated with adverse re

关键词： Polycystic ovarian syndrome Assisted reproductive techniques Clustering analysis Metabolic disturbance Clinical pregnancy

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Systemic autoimmune diseases and recurrent pregnancy loss:research progress in diagnosis and treatment

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Chinese Medical Journal 2021年第17期134卷 2140-2142页

作者： Rui Gao xun zeng Lang Qin Department of Obstetrics and Gynecology The Reproductive Medical CenterWest China Second University HospitalSichuan UniversityChengdu 610041China West China School of Medicine Sichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education West China Second University HospitalSichuan UniversityChengdu 610041China

To the Editor:Recurrent pregnancy loss(RPL)is defined as the loss of two or more pregnancies before 24 weeks of gestation,and it affects about 1%to 2%of couples.[1]The etiology of RPL includes metabolic/endocrinological abnormalities,genetic factors,anatomical factors,immune disorders,thrombophilia,male factors,and psychological factors.[1,2]Systemic autoimmune diseases like antiphospholipid syndrome(APS),[3]undifferentiated connective tissue disease(UCTD),[4]and systemic lupus erythematosus(SLE)[5]have been found to be important causes of RPL in recent years.Understanding the associations between different systemic autoimmune diseases and RPL,as well as being able to provide suitable diagnoses and treatments,is of great significance.

关键词： diagnosis pregnancy treatment Systemic erythematosus lupus

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Effect of grain refinement induced by wire and arc additive manufacture (WAAM) on the corrosion behaviors of AZ31 magnesium alloy in NaCl solution

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Journal of Magnesium and Alloys 2023年第1期11卷 217-229页

作者： Jianwei LI Youmin QIU Junjie YANG Yinying SHENG Yanliang YI xun zeng Lianxi CHEN Fengliang YIN Jiangzhou SU Tiejun ZHANG Xin TONG Bin GUO School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001PR China Beijing Hangxing Machinery Manufacture Limited Corporation Beijing 100013PR China Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou 510632PR China The Third Academy of CASIC Beijing 100074PR China MOE Key Lab of Disaster Forecast and Control in Engineering Jinan UniversityGuangzhou510632P.R.China Institute of Materials and Process Design Helmholtz-Zentrum HereonMax-Planck-Str.121502 GeesthachtGermany School of Materials Science and Hydrogen Energy Foshan UniversityFoshan 528000PR China

Additive manufacturing(AM)of Mg alloys has become a promising strategy for producing complex structures,but the corrosion performance of AM Mg components remains unexploited.In this study,wire and arc additive manufacturing(WAAM)was employed to produce single AZ31 layer.The results revealed that the WAAM AZ31 was characterized by significant grain refinement with non-textured crystallographic orientation,similar phase composition and stabilized corrosion performance comparing to the cast AZ31.These varied corrosion behaviors were principally ascribed to the size of grain,where cast AZ31 and WAAM AZ31 were featured by micro galvanic corrosion and intergranular corrosion,respectively.

关键词： AZ31 magnesium alloy Wire and arc additive manufacturing(WAAM) Grain refinement Microstructure Intergranular corrosion

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Molecular Mechanisms of Gut Microbiota-Associated Colorectal Carcinogenesis

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Infectious Microbes & Diseases 2020年第3期2卷 96-106页

作者： Yichang Shao xun zeng State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Zhejiang University School of Medicine HangzhouZhejiangChina

Colorectal cancer(CRC)is the cancer occurring in colon and rectum,and is the fourth leading cause of tumor-associated deaths worldwide.As a multi-etiological cancer,CRC could be induced by genetic and environmental factors,including unhealthy diet,irregular lifestyle,inappropriate inflammatory,and the dysbiosis of gut microbiota.Since immunotherapy has been the most popular cancer therapy nowadays,the relationships among gut microbiota,host immune cells and CRC pathogenesis are widely investigated.Scientists constantly tried to figure out the underlying mechanisms involved to support the further therapeutic studies.In this review,we discuss the component shifts of gut microbiota in CRC patients compared with healthy people,summarize how immune cells participate in protecting host from pathogenic microbes,elaborate the molecular mechanisms involved in gut microbiota-associated carcinogenesis of colonic epithelial cells and look into how gut microbiota influence the CRC therapy.

关键词： gut microbiota colorectal cancer immune cells

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Study on precipitation and transition mechanisms from the magnetic properties of silicon steel during annealing

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International Journal of Minerals,Metallurgy and Materials 2014年第4期21卷 379-387页

作者： Yong-fei Fan Hao Yu Jing Sun Pan Tao Cheng-hao Song xun zeng School of Materials Science and Engineering University of Science and Technology Beijing

Precipitates play an important role in determining the mechanical and magnetic properties of silicon steel. This paper aims to investigate the growth kinetics of precipitates in commercial silicon steel by analyzing its magnetic properties during isothermal annealing at 200℃. The growth of precipitates was studied by optical microscopy, scanning electron microscopy, transmission electron microscopy, and magnetic measurements. In combination with the coercive field and initial susceptibility, this technique offers the advantage of being non-destructive and providing quantitative information about the number, mean radius of precipitates, and fraction of transformation. An ob- served decrease in the number of precipitated particles indicates that the transformation starts from particles of appreciable initial size.

关键词： silicon steel precipitation growth kinetics magnetic properties isothermal annealing

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Effect of electropulsing treatment on static recrystallization behavior of cold-rolled magnesium alloy ZK60 with different reductions

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Journal of Materials Science & Technology 2019年第6期35卷 1113-1120页

作者： Huijun Guo xun zeng Jianfeng Fan Hua Zhang Qiang Zhang Weiguo Li Hongbiao Dong Bingshe Xu Key Laboratory of Interface Science and Engineering in Advanced Materials. Ministry of Education Taiyuan University of Technology Taiyuan 030024China Shanxi Key Laboratory of Advanced Magnesium-Based Materials Taiyuan 030024 China Shanxi Research Center of Advanced Materials Science and Technology Taiyuan 030024 China Department of Engineering University of Leicester Leicester LEI 7RH UK

Effect of electropulsing treatment(EPT) on recrystallization behavior of cold-rolled Mg alloy ZK60 strips was investigated. It was found that EPT significantly improved nucleation rate and migration ability of grain boundaries, leading to accelerated recrystallization of the deformed metals at relatively low temperature. After the recrystallization induced by EPT, the average grain size of 20% rolling reduction samples decreased from 113 um to around 10 um, meanwhile the typical basal-type texture of the coldrolled sample was weakened. EPT was normally accompanied with a thermal and an athermal effects. The athermal effect played a dominated role in increasing nucleation rate, while the thermal effect promoted grain growth. A fewer recrystallized grains originated along the grain boundaries in the 10% reduction samples, while most of the recrystallization took place inside the twins in the 20% reduction samples.

关键词： Mg alloys Recrystallization Athermal effect Twins

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Dynamic tensile properties and microstructural evolution of extruded EW75 magnesium alloy at high strain rates

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Journal of Magnesium and Alloys 2020年第3期8卷 849-859页

作者： Jincheng Yu Bo Song Dabiao Xia xun zeng Yuanding Huang Norbert Hort Pingli Mao Zheng Liu School of Mechanical Technique Wuxi Institute of TechnologyWuxi 214121China School of Materials and Energy Southwest UniversityChongqing 404100China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China MagIC-Magnesium Innovation Centre Helmholtz-Zentrum GeesthachtGeesthacht 21502Germany School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

The dynamic tensile properties and microstructural evolution of an extruded EW75 magnesium alloy deformed at ambient temperature and different high strain rates(from 1000 to 3000 s^(-1))along extrusion direction(ED)were investigated by Split Hopkinson Tension Bar(SHTB).The corresponding deformation mechanisms,texture evolution and microstructure changes were analyzed by optical microscope(OM),electron backscatter diffraction(EBSD)and transmission electron microscope(TEM).The results show that the extruded EW75 magnesium alloy along ED exhibits a conventional positive strain rate sensitivity that the dynamic flow stresses increase with in creasing strain rate.Texture measurements show that after dynamic tension,the initial weak texture of extruded EW75 magnesium alloy tansforms to a relatively strong//ED texture with increasing strain rates.The microstructural analysis demonstrates that dislocation motion are main deformatin mode to accommodate dynamic tensile deformation at high strain rates.In addition,the interactions of dislocation-dislocation and dislocation-second phase lead to the in crease of flow stress and strain hardening with increasing strain rate.

关键词： EW75 magnesium alloy High strain rates Split Hopkinson test Texture Microstructure

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Effects of Occupational Noise on the Hearing Ability of Outpatient Clinic Nurses in Different Classes of Hospitals in Guangzhou

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International Journal of Clinical Medicine 2020年第4期11卷 154-162页

作者： Donglan Liu xun zeng Li Wang Outpatient Clinic of Internal Medicine Department The First Affiliated Hospital Sun Yat-sen University Guangzhou China Department of Healthcare The First Affiliated Hospital Sun Yat-sen University Guangzhou China

Background: Occupational noise can induce hearing impairment. Work-related hearing impairment has become a growing threat to medical practitioners who feel anxious about occupational noise exposure and its health outcomes or even experience auditory dysesthesia (including drumming, distending pain in the ears, and otalgia) after long-term exposure to a noisy work environment. Objective: To investigate the effects of occupational noise on the hearing ability of outpatient clinic nurses in Grade III, Level A and Grade II, Level A hospitals in Guangzhou. Methods: During June 2019, noise monitoring was performed by quantifying the noise levels at four measuring points (reception, waiting area, hallway, blood-sampling room) in five Grade III, Level A and five Grade II, Level A hospitals, in Guangzhou, four times a day (8 AM, 10 AM, 2 PM, and 4 PM) for 19 working days, using a professional noise measuring application for smartphones. The measurements were verified and used to create a database in Excel. Data analysis was conducted using SPSS22.0, and questionnaires were distributed to nurses who had been working at outpatient clinics for five years and above to assess the impacts of occupational noise exposure on the hearing ability. Results: In the Grade III, Level A hospitals, the sound levels at the four measuring points during the specific time periods were 4.92 - 6.75 dB above the permissible limit of 55 dB and were all significantly higher than the sound levels at the outpatient clinics of the Grade II, Level A hospitals (P Conclusions: Exposure to excess noise can lead to auditory dysesthesia in outpatient clinic nurses. Compared to those from Grade II, Level A hospitals, outpatient clinic nurses from Grade III, Level A hospitals are at higher risk of auditory dysesthesia. The noise levels at outpatient clinics should be closely monitored, and effective measures should be taken to reduce occupational noise exposure. Outpatient clinic nurses should enhance protective measures and receive preventive health exams o

关键词： Noise Outpatient Clinic Nurse Auditory Dysesthesia Survey

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体外受精/卵胞浆内单精子注射⁃胚胎移植术后单胎妊娠早产的危险因素分析

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中国计划生育和妇产科 2024年第2期16卷 24-28页

作者：刘慧敏高睿曾珣张琼陈明丽刘秀美秦朗四川大学华西第二医院生殖医学中心四川成都610041 四川大学华西第二医院出生缺陷与相关妇儿疾病教育部重点实验室四川成都610041 资阳市妇幼保健院妇产科四川资阳641300

目的探究接受体外受精/卵胞浆内单精子注射⁃胚胎移植(in⁃vitro fertilization/intracytoplasmic sperm injection⁃embryo transfer,IVF/ICSI⁃ET)助孕后单胎妊娠早产的独立危险因素。方法采用巢式病例对照研究设计,纳入2014年1月至2022年12月于四川大学华西第二医院行IVF/ICSI⁃ET助孕后单胎妊娠并分娩的患者3079例,收集社会人口学资料、IVF/ICSI⁃ET临床资料和孕期并发症资料,随防至分娩。根据分娩孕周将其分为早产组(240例)和足月产组(2839例),采用单因素分析筛选差异变量,将后者纳入多因素Logistic回归分析筛选早产的独立危险因素。结果女方吸烟史(OR=3.416,95%CI:1.429⁃8.165,P=0.006)、大月份流产史(OR=3.451,95%CI:1.559⁃7.636,P=0.002)、前置胎盘(OR=7.035,95%CI:3.874⁃12.775,P<0.001)、胎盘早剥(OR=3.859,95%CI:1.429⁃10.426,P=0.008)、妊娠期高血压(OR=5.560,95%CI:3.136⁃9.858,P<0.001)及妊娠期肝内胆汁淤积症(OR=2.780,95%CI:1.335⁃5.793,P=0.006)是IVF/ICSI⁃ET助孕后患者发生早产的独立危险因素。结论对于接受IVF/ICSI⁃ET助孕后单胎妊娠的患者,有吸烟史、大月份流产史、合并妊娠期高血压、前置胎盘、胎盘早剥及妊娠期肝内胆汁淤积症者发生早产的风险较高,应予以充分关注。

关键词：体外受精/卵细胞胞浆内单精子注射⁃胚胎移植单胎妊娠早产危险因素

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Effect of Precipitation on Intergranular Corrosion Resistance of 430 Ferritic Stainless Steel

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Journal of Iron and Steel Research(International) 2015年第11期22卷 1062-1068页

作者： xun-zeng HUANG Dan WANG Yi-tao YANG School of Materials Science and Engineering Shanghai University

With Nb-Ti-stabilized 430 ferritic stainless steel（NTS430FSS） and SUS 430 ferritic stainless steel（SUS430FSS） as experimental materials, the influence of precipitation on intergranular corrosion resistance was investigated. A series of aging treatment were carried out. The free-exposure corrosion test and double loop electrochemical potentiokinetic reactivation（DL-EPR） test with a scan rate of 1.67 m V/s at 26 °C were applied to evaluate the intergranular corrosion（IGC） resistance. Metallographic observation, scanning electron microscope（SEM）, transmission electron microscope（TEM） with energy dispersive spectroscopy（EDS） and X-ray diffraction（XRD） analysis were conducted. The results show that IGC occurred in SUS430 FSS aged above 700 °C, while it occurred in NTS430 FSS as the temperature was improved to 1 050 °C. The critical degree of sensitization Ir/Ia reaches 0.305 in SUS430 FSS, which is higher than that of NTS430 FSS, i.e. 0.010, aged at 950 °C for 2 h. The TEM, EDS and XRD results show that a large amount of Cr23C6 precipitates with size of 60 nm×22 nm are located at the SUS430 FSS grain boundaries as chains. With the addition of Nb and Ti and reduction of C, the amount of precipitates reduces significantly in NTS430 FSS. A majority of Cr23C6 were replaced by Ti C and Nb C. Only a small amount of spherical Ti C（R=186 nm） and square Ti N（312 nm×192 nm） with Nb and Cr adsorbed are left along grain boundaries. Due to the dual stabilization of Nb and Ti, the precipitation of Cr23C6 is restrained, the chromium depleted region is avoided and accordingly the resistance to the intergranular corrosion is improved.

关键词： 430 ferritic stainless steel intergranular corrosion double-loop electrochemical potentiokinetic reactivation carbonitride extraction precipitation

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