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民治水电站水轮机进水阀选择研究

水力发电 2005年第6期31卷 51-53页

作者：田迅牛文彬成都勘测设计研究院四川成都610072 中国水利水电建设工程咨询公司北京100011

长期以来,我国水电站水轮机进水阀选择蝴蝶阀或球阀通常以200m水头为界。民治水电站最大水头238.46m,随着新规范的出台,水轮机进水阀型式采用蝴蝶阀还是球阀还需仔细斟酌。通过对两种阀型进行技术经济比较、设计制造难度与可行性分析,... 详细信息

长期以来,我国水电站水轮机进水阀选择蝴蝶阀或球阀通常以200m水头为界。民治水电站最大水头238.46m,随着新规范的出台,水轮机进水阀型式采用蝴蝶阀还是球阀还需仔细斟酌。通过对两种阀型进行技术经济比较、设计制造难度与可行性分析,认为民治水电站水轮机进水阀采用蝴蝶阀是完全可行的。

关键词：水轮机进水阀型式选择民治水电站

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并行密钥隔离聚合签名

电子学报 2015年第5期43卷 1035-1040页

作者：赵慧艳于佳李朦寻甜甜赵华伟舒明雷青岛大学信息工程学院山东青岛266071 山东省科学院山东省计算机网络重点实验室山东济南250014

为了应对聚合签名中的密钥泄露问题,将并行密钥隔离机制扩展到聚合签名系统中,给出了并行密钥隔离聚合签名的概念.在给出的形式化定义和安全模型的基础上,提出了第一个并行密钥隔离聚合签名方案,并在随机预言模型下证明了方案的安全性.... 详细信息

为了应对聚合签名中的密钥泄露问题,将并行密钥隔离机制扩展到聚合签名系统中,给出了并行密钥隔离聚合签名的概念.在给出的形式化定义和安全模型的基础上,提出了第一个并行密钥隔离聚合签名方案,并在随机预言模型下证明了方案的安全性.所提出的方案满足密钥隔离性、强密钥隔离性和安全密钥更新等性质,特别在签名验证方面具有较高的效率.引入的两个协助器交替帮助用户进行临时私钥更新,增强了系统防御密钥泄露的能力.

关键词：密钥隔离并行性聚合签名随机预言模型

干旱和灌溉条件下少花蒺藜草分株生物量分配特征

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草业科学 2011年第2期28卷 185-188页

作者：张志新田迅兰州大学草地农业科技学院甘肃草原生态研究所甘肃兰州730020 内蒙古民族大学生命科学学院内蒙古通辽028043

调查了生长在科尔沁沙地干旱、灌溉2个条件下的少花蒺藜草(Cenchrus pauci florus)分蘖丛。对分株高度、分株生物量以及根、茎、叶、穗、叶鞘等构件生物量进行了定量统计分析。结果显示,灌溉条件下,植株高度为41.2 cm,明显高于干旱条件... 详细信息

调查了生长在科尔沁沙地干旱、灌溉2个条件下的少花蒺藜草(Cenchrus pauci florus)分蘖丛。对分株高度、分株生物量以及根、茎、叶、穗、叶鞘等构件生物量进行了定量统计分析。结果显示,灌溉条件下,植株高度为41.2 cm,明显高于干旱条件的33.7 cm。灌溉条件下果穗生物量是干旱环境下的1.8倍。2种条件下,根生物量、茎生物量、叶片生物量、叶鞘生物量均与分株生物量呈极显著的正相关(P<0.01),并符合y=axb幂函数的变化规律;根生物量、茎生物量、叶片生物量、叶鞘生物量之间呈显著的正相关(P<0.05),并符合y=ax+b线性函数的变化规律。随着分株生物量的增加,灌溉条件下各构件的生物量增长速度均高于干旱条件下的。分析认为,在生物量分配上干旱条件下少花蒺藜草表现出存活对策,灌溉条件下表现出竞争和繁殖生长对策。

关键词：少花蒺藜草分株异速增长生物量分配生长可塑性

Risk assessment and triage strategy of cervical cancer primary screening on HPV integration status:5-year follow-up of a prospective cohort study

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Journal of the National Cancer Center

Journal of the National Cancer Center 2024年第4期4卷 311-317页

作者： xun tian Danhui Weng Ye Chen Yi Wang Xiao Li Xin Wang Chen Cao Danni Gong Zhen Zeng Qiongyan Wu Xueqian Wang Peng Wu Lu Fan Qinghua Zhang Hui Wang Zheng Hu Xiaodong Cheng Ding Ma Department of Gynecological Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina National Clinical Research Center for Obstetrics and Gynecology Cancer Biology Research Center(Key Laboratory of the Ministry of Education)Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Obstetrics and Gynecology Academician expert workstationThe Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Gynecology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Obstetrics and Gynecology The Affiliated Panyu Central Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Gynecologic Oncology Women’s HospitalSchool of MedicineZhejiang UniversityHangzhouChina Department of Gynecology and Obstetrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Maternal and Child Health and Family Planning Service Center of Longyou County QuzhouChina Department of Gynecologic Oncology Zhongnan Hospital of Wuhan UniversityWuhanChina

Objective:We investigated the relation between man papillomavirus(HPV)integration status and the immediate risk of cervical intraepithelial neoplasia(CIN),as well as the triage strategy based on HPV integration ***:4086 women aged 20 to 65 years in China were enrolled in 2015 for a prospective,population-based,clinical observational study to evaluate the triage performance of HPV *** exfoliated cells were collected for HPV testing and cytologic *** high-risk HPV was positive,HPV integration test was performed at baseline,2-year and 5-year ***:At baseline,HPV integration was positively correlated with the severity of cervical pathology,ranging from 5.0%(15/301)in normal diagnosis,6.9%(4/58)in CIN1,31.0%(9/29)in CIN2,70%(14/20)in CIN3,and 100%(2/2)in cervical cancer(P<0.001).Compared with cytology,HPV integration exhibits comparable sensitivity and negative predictive value for the diagnosis of CIN3+,higher specificity(92.8%[90.2%-95.4%]vs.75.5%[71.2%-79.8%],P<0.001)and higher positive predictive value(36.4%[22.1%-50.6%]vs.15.2%[8.5%-21.8%],P<0.001).HPV integration testing strategy yielded a significantly lower colposcopy referral rate than cytology strategy(10.7%[44/410]vs.27.3%[112/410],P<0.001).The HPV integration-negative group exhibited the lowest immediate risk for CIN3+(1.6%)and accounted for the largest proportion of the total population(89.3%),when compared with the normal cytology group(risk,1.7%;proportion,72.7%).Conclusion:As a key molecular basis for the development of cervical cancer,HPV integration might be a promising triage strategy for HPV-positive patients.

关键词： Human papillomavirus Cervical cancer screening HPV integration Colposcopy Cervical intraepithelial neoplasia

HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer

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Journal of Genetics and Genomics 2020年第8期47卷 435-448页

作者： Canhui Cao Ping Hong Xingyu Huang Da Lin Gang Cao Liming Wang Bei Feng Ping Wu Hui Shen Qian Xu Ci Ren Yifan Meng Wenhua Zhi Ruidi Yu Juncheng Wei Wencheng Ding xun tian Qinghua Zhang Wei Li Qinglei Gao Gang Chen Kezhen Li Wing-Kin Sung Zheng Hu Hui Wang Guoliang Li Peng Wu Department of Gynecologic Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Cancer Biology Research Center(Key Laboratory of the Ministry of Education) Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan430070China Agricultural Bioinformatics Key Laboratory of Hubei Province Hubei Engineering Technology Research Center of Agricultural Big DataCollege of InformaticsHuazhong Agricultural UniversityWuhan430070China State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan430070China Bio-Medical Center Huazhong Agricultural UniversityWuhan430070China College of Veterinary Medicine Huazhong Agricultural UniversityWuhan430070China Department of Obstetrics and Gynecology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Obstetrics and Gynecology Key Laboratory for Molecular Diagnosis of Hubei ProvinceThe Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430010China Department of Computational and Systems Biology Genome Institute of SingaporeSingapore Department of Gynecological Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510080China

Integration of human papillomavirus(HPV)DNA into the human genome is a reputed key driver of cervical ***,the effects of HPV integration on chromatin structural organization and gene expression are largely *** studied a cohort of 61 samples and identified an integration hot spot in the CCDC106 gene on chromosome *** then selected fresh cancer tissue that contained the unique integration loci at CCDC106 with no HPV episomal DNA and performed whole-genome,RNA,chromatin immunoprecipitation and high-throughput chromosome conformation capture(Hi-C)sequencing to identify the mechanisms of HPV integration in cervical *** analyses indicated that chromosome 19 exhibited significant genomic variation and differential expression densities,with correlation found between three-dimensional(3D)structural change and gene ***,HPV integration divided one topologically associated domain(TAD)into two smaller TADs and hijacked an enhancer from PEG3 to CCDC106,with a decrease in PEG3 expression and an increase in CCDC106 *** expression dysregulation was further confirmed using 10 samples from our cohort,which exhibited the same HPV-CCDC106 *** summary,we found that HPV-CCDC106 integration altered local chromosome architecture and hijacked an enhancer via 3D genome structure ***,this study provides insight into the 3D structural mechanism underlying HPV integration in cervical carcinogenesis.

关键词： Cervical cancer HPV integration Fusion gene Hi-C Enhancer TAD

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学科信息门户的知识组织

图书馆论坛 2006年第3期26卷 178-180页

作者：唐家玉谢明龙训田桂林工学院图书馆广西桂林541004 桂林旅游高等专科学校图书馆广西桂林541004 广西工学院图书馆广西柳州545006

从学科信息门户的含义及类型入手,论述了学科信息门户知识组织体系的原则及知识组织的内容:分类法、主题法和分类主题一体化。

关键词：学科信息门户图书馆知识组织

盐酸酸洗水活化法一步制备磁性活性炭（英文）

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新型炭材料 2018年第4期33卷 303-309页

作者：王芳党艳秋田勋 Steven Harrington 马雷马彦青滨州学院化学与安全学院、滨州市材料重点实验室山东滨州256600 天津大学精密仪器与光电子工程学院天津300072 天津大学天津纳米颗粒与纳米系统国际研究中心天津300072

以盐酸酸洗水为活化剂,玉米芯为为碳源,通过简单一步法制备出一种新型磁性活性炭。详细研究了该材料不同条件下甲基橙的吸附性能。结果表明,973 K活化1 h所得磁性活性炭具有较大的比表面积(784.76 m^2/g),298 K甲基橙的吸附量高达555.56... 详细信息

以盐酸酸洗水为活化剂,玉米芯为为碳源,通过简单一步法制备出一种新型磁性活性炭。详细研究了该材料不同条件下甲基橙的吸附性能。结果表明,973 K活化1 h所得磁性活性炭具有较大的比表面积(784.76 m^2/g),298 K甲基橙的吸附量高达555.56 mg/g。此外,磁性活性炭含有赤铁矿和磁铁矿易于从染料废水中分离。

关键词：玉米芯碳质材料酸洗水甲基橙

科尔沁沙地不同地区少花蒺藜草种子库与种子活力结构特征

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中国草地学报 2015年第6期37卷 85-90页

作者：田迅张志新陈艳东内蒙古民族大学生命科学学院内蒙古通辽028043 草地农业系统国家重点实验室/兰州大学草地农业科技学院甘肃兰州730020

通过野外调查取样与室内试验相结合,对科尔沁沙地5个不同生境样地少花蒺藜草种子库数量特征与刺苞生活力结构特征进行了分析。结果表明:不同样地间种子库大小差异显著,高林屯样地刺苞总数和未萌发刺苞数显著高于其他样地(P<0.05),巴胡... 详细信息

通过野外调查取样与室内试验相结合,对科尔沁沙地5个不同生境样地少花蒺藜草种子库数量特征与刺苞生活力结构特征进行了分析。结果表明:不同样地间种子库大小差异显著,高林屯样地刺苞总数和未萌发刺苞数显著高于其他样地(P<0.05),巴胡塔样地已萌发刺苞数最高。高林屯样地未萌发刺苞0种子的比例达77%,其他样地以2粒种子为主。所有样地未萌发刺苞内较大的种子(呈芒型)和较小的种子(呈心形)均有活性且比例最高(67%),而已萌发刺苞以较大的种子和较小的种子均萌发(36%)为主要类型。

关键词：少花蒺藜草种子库刺苞生活力

Anti-HIF-1α-pEGFP重组质粒的构建及表达

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中国组织化学与细胞化学杂志 2010年第4期19卷 401-404页

作者：宋毓平田训敖启林湖北省武汉市东湖医院皮肤科武汉430074 湖北省武汉市中心医院妇产科武汉430014 华中科技大学同济医学院附属同济医院病理研究所同济医学院病理学系武汉430030

目的构建EGFP-HIF-1α反义重组质粒,转染人宫颈癌Hela细胞,用以探讨HIF-1α蛋白在宫颈癌的生长、转移中的作用。方法应用基因重组技术构建EGFP-HIF-1α反义重组质粒,通过脂质体介导将其转染入Hela细胞,倒置荧光显微镜观察转染效果,Weste... 详细信息

目的构建EGFP-HIF-1α反义重组质粒,转染人宫颈癌Hela细胞,用以探讨HIF-1α蛋白在宫颈癌的生长、转移中的作用。方法应用基因重组技术构建EGFP-HIF-1α反义重组质粒,通过脂质体介导将其转染入Hela细胞,倒置荧光显微镜观察转染效果,Western blot检测HIF-1α蛋白的表达。结果酶切鉴定结果显示含EGFP-HIF-1α反义重组质粒构建成功,并能在Hela细胞中封闭HIF-1α蛋白的表达。结果 EGFP-HIF-1α反义重组质粒构建及转染成功,封闭Hela细胞中HIF-1α蛋白的表达,为进一步研究HIF-1α蛋白在宫颈癌的生长、转移中的作用提供试验基础。

关键词： HIF-1α基因重组质粒基因转染基因表达