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免疫炎症反应和内皮祖细胞在肉鸡肺血管丛样病变形成中的作用（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第1期18卷 59-69页

作者： xun tan Fan-guo JUAN Ali Q.SHAH Department of Veterinary Medicine College of Animal Sciences Zhejiang University Hangzhou 310058 China

目的:肺血管丛样病变是重度肺动脉高压(PAH)病人的特征病变,病变血管周围常伴有单个核细胞浸润。肺血管丛样病变在常用实验动物上难以复制,但可在肉鸡(一种生长快速的肉用型鸡)肺脏中自发形成。内皮祖细胞(EPCs)在组织再生和血管修复过... 详细信息

目的:肺血管丛样病变是重度肺动脉高压(PAH)病人的特征病变,病变血管周围常伴有单个核细胞浸润。肺血管丛样病变在常用实验动物上难以复制,但可在肉鸡(一种生长快速的肉用型鸡)肺脏中自发形成。内皮祖细胞(EPCs)在组织再生和血管修复过程中发挥重要作用。本研究以肉鸡为模型,探讨EPCs与肺血管丛样病变形成之间的关系。创新点:证实EPCs参与了肺血管丛样病变的形成过程,并揭示了导致EPCs功能障碍的免疫学机制。方法:采集1~4周龄肉鸡肺组织,常规石蜡切片,观察肺血管丛样病变的形成情况;采用免疫组化法检测EPCs表面标志CD133和VEGFR-2的表达以及肝细胞生长因子(HGF)的表达;分离培养晚期EPCs,建立EPCs/淋巴细胞共培养体系,并在共培养体系中添加20 ng/ml HGF,观察EPCs增殖、凋亡和体外管样结构形成的变化。结论:在不同周龄的肉鸡肺组织中均可观察到处于不同发展阶段的肺血管丛样病变(图1)。早期的丛样病变主要由EPCs(CD133^+和VEGFR-2^+细胞)构成,HGF在病变实体中高表达(图2)。淋巴细胞共培养显著促进EPCs凋亡(图5),并能阻断HGF诱导的EPCs存活和体外管样结构形成(图6)。综上所述,肺血管丛样病变的形成可能与局部免疫炎症反应诱导EPCs凋亡并下调EPCs对促血管生成因子的反应性有关。

关键词：丛样病变内皮祖细胞免疫反应肝细胞生长因子肉鸡

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一种宽延时范围的压控延时线电路

中国集成电路 2024年第6期33卷 61-66,89页

作者：吴贵洲谭勋琼白创长沙理工大学物理与电子科学学院

为改善压控延时线(voltage control delay line,VCDL)的延时性能,用于满足延时锁相环(delay locked loop,DLL)在不同频率时钟下的工作需求,设计并实现了一种宽延时范围的压控延时线电路。该电路通过在偏置电路增加多条配置路径生成宽范... 详细信息

为改善压控延时线(voltage control delay line,VCDL)的延时性能,用于满足延时锁相环(delay locked loop,DLL)在不同频率时钟下的工作需求,设计并实现了一种宽延时范围的压控延时线电路。该电路通过在偏置电路增加多条配置路径生成宽范围输出电流,增大基本延时单元充放电电流的范围;通过在基本延迟单元增加一个可选电容负载,进一步拓宽延迟时间范围。基于40nm CMOS工艺和1.1 V电源电压进行仿真,VCDL所占物理版图面积为0.004mm2。版图后仿真结果表明该VCDL能提供2.2~391ns的延迟,使得DLL可以工作在3~400MHz的输入频率范围。通过引入可配置结构的VCDL,为宽锁定范围的DLL系统提供了新的解决思路。

关键词：压控延时线延时性能延时锁相环延时时间范围可配置

Multi-Axis Attention With Convolution Parallel Block for Organoid Segmentation

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1295-1297页

作者： Pengwei Hu xun Deng Feng tan Lun Hu Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of SciencesUrumqi 830011 University of Chinese Academy of Sciences Beijing 100049 Xinjiang Laboratory of Minority Speech and Language Information Processing Urumqi 830011China Merck KGaA Darmstadt 64293Germany

Dear Editor,This letter presents an organoid segmentation model based on multi-axis attention with convolution parallel *** adeptly captures dynamic dependencies within bright-field microscopy images,improving global ... 详细信息

关键词： letter convolution organo

Perspective on new cell-free DNA technologies for early cancer detection

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Cancer Biology & Medicine 2024年第2期21卷 139-143页

作者： Jie Li xun Lan Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China MOE Key Laboratory of Bioinformatics Tsinghua UniversityBeijing 100084China Tsinghua-Peking Joint Center for Life Sciences Tsinghua UniversityBeijing 100084China

High cancer heterogeneity and aggressiveness are major factors contributing to the poor prognosis of patients with advanced cancer~(1-5).Early detection of cancer can significantly improve the prognosis of patients with early-stage cancer after standard treatment.Although traditional cancer detection technologies,such as endoscopy for gastrointestinal cancer,mammography for breast cancer。

关键词： prognosis cancer patients

Assessment of tree-ring mercury radial translocation and age effect in Masson pine:Implications for historical atmospheric mercury reconstruction

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Journal of Environmental Sciences 2024年第4期138卷 266-276页

作者： Xu Liu xun Wang Dingyong Wang College of Resources and Environment Southwest UniversityChongqing 400715China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

The tree ring has been regarded as an emerging archive to reconstruct historical atmospheric mercury(Hg)trends,but with the large knowledge gaps in the reliability.In this study,we comprehensively evaluated the Hg source,radial translocation and age effect of Masson pine(Pinus massoniana)tree ring at Mt.Jinyun in Chongqing,to assess the suitability of such tree ring as the archive of atmospheric Hg.Results showed that distinct variabilities among Masson pine tree-ring Hg concentration profiles.The Hg concentration significantly increased along with stem height(P<0.05),indicating the Hg in tree rings mainly derived from foliage uptake atmospheric Hg.We found a distinct age effect that the tree ring of young trees had the higher Hg concentration.Besides,we used the advection-diffusion model to demonstrate how Hg concentration shifted by the advection or/and diffusion in tree rings.The modeling results showed that the advection induced radial translocation during the young growth period of tree was a plausible mechanism to result in the tree-ring Hg record largely different from the trend of anthropogenic Hg emissions in Chongqing.We finally suggest that in further Hg dendrochemistry,better discarding the tree-ring Hg profile of the young growth period to reduce impacts of the radial translocation and age effect.

关键词： Masson pine Tree-ring mercury Radial translocation Tree age effect

Persistence of gentamicin residues in milk after the intramammary treatment of lactating cows for mastitis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第4期10卷 280-284页

作者： xun tan Ye-wen JIANG Yi-jun HUANG Song-hua HU Department of Veterinary Medicine Zhejiang University Hangzhou 310029 China

This study was designed to investigate persistence of gentamicin residues in milk after the intramammary treatment of lactating cows for mastitis. Milk samples were collected at a 1-d interval after the last administration from 34 individual cows that had received intramammary infusions of gentamicin. The doses and treatment times evaluated in this study represented those that have been applied by veterinarians in practice. The tetrazolium chloride assay was used to determine whether there were significant residues of the antibiotic in the samples. Persistence of detectable drug residues in milk from 33 cows (28 cows, ≤6 infusions at ≤0.7 g gentamicin; and 5 cows, 2 infusions at 0.8 g gentamicin) did not exceed 5 d; but 1 cow (5 infusions at 0.8 g gentamicin) had detectable residues in its milk for 9 d. Our results suggest that a 5-d milk withdrawal period might be insufficient to secure the clearance of the contamination of gentamicin, because treatment times and dosages contribute to the antibiotic clearance. A larger scale of samples are needed for further investigations.

关键词：抗生素残留庆大霉素治疗时间乳房炎哺乳期奶牛牛奶样品收集

Regeneration of the heart:f rom molecular mechanisms to clinical therapeutics

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Military Medical Research 2024年第1期11卷 80-97页

作者： Qian-Yun Guo Jia-Qi Yang xun-xun Feng Yu-Jie Zhou Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Beijing Institute of Heart Lung and Blood Vessel DiseaseClinical Center for Coronary Heart DiseaseDepartment of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar formation.These changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health burden.Military personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military medicine.So far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart regeneration.In the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury.Insights have emerged from studies in animal models and early clinical trials.Clinical interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart disease.In this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.

关键词： Heart regeneration Cardiac disease Therapeutics Signaling mechanisms

Superior compound coatings prepared by low-temperature vanadium-nitrocarburizing duplex treatment

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Rare Metals 2024年第4期43卷 1828-1835页

作者： Gen Jin Fang-Fang Xu xun-xun Hu Yue Xu School of Chemistry Beihang University Guobiao (Beijing) Testing and Certification Co. Ltd School of Materials Science and Engineering Beihang University

Superior compound coatings were prepared on CK45 steel surface by vanadium-nitrocarburizing duplex treatment in low-temperature salt bath.In this study,the microhardness,the phase constitution and the compositional distribution in the coatings prepared under different conditions were systematically characterized.The results indicated that the reactions among activated vanadium,carbon and nitrogen atoms occurred on the steel surface,leading to the formation of compound coatings composed of outermost and compound layers.The mechanism for the formation of compound layer as well as the growth kinetics of the layer was also discussed.Upon the duplex treatment,the wear and corrosion resistances of steel surface were significantly improved.It was found that the growth kinetics of compound layer obeyed the parabolic law,with the activation energy of 122.82 kJ·mol-1.

关键词： Vanadium-nitrocarburizing duplex treatment Compound coatings Microstructure Formation mechanism Growth kinetics

Role of the portal system in liver regeneration:From molecular mechanisms to clinical management

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Liver Research 2024年第1期8卷 1-10页

作者： Hanzhi Xu xun Qiu Zhoucheng Wang Kai Wang Yawen tan Fengqiang Gao Marcos Vinicius Perini Xiao Xu Zhejiang University School of Medicine HangzhouZhejiangChina Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province HangzhouZhejiangChina Department of Surgery University of MelbourneAustin HealthHeidelbergVictoriaAustralia

The liver has a strong regenerative capacity that ensures patient recovery after hepatectomy and liver transplantation.The portal system plays a crucial role in the dual blood supply to the liver,making it a significant factor in hepatic function.Several surgical strategies,such as portal vein ligation,associating liver partition and portal vein ligation for staged hepatectomy,and dual vein embolization,have high-lighted the portal system's importance in liver regeneration.Following hepatectomy or liver trans-plantation,the hemodynamic properties of the portal system change dramatically,triggering regeneration via shear stress and the induction of hypoxia.However,excessive portal hyperperfusion can harm the liver and negatively affect patient outcomes.Furthermore,as the importance of the gut-liver axis has gradually been revealed,the effect of metabolites and cytokines from gut microbes carried by portal blood on liver regeneration has been acknowledged.From these perspectives,this review outlines the molecular mechanisms of the portal system's role in liver regeneration and summarizes therapeutic strategies based on the portal system intervention to promote liver regeneration.

关键词： Portal system Liver regeneration Hemodynamic properties Gut microbiota Therapeutic strategies