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Phase-field lattice-Boltzmann study on fully coupled thermal-solute-convection dendrite growth of Al-Cu alloy

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China Foundry 2024年第2期21卷 125-136页

作者： Yin-qi qiu Meng-wu Wu xun-peng Qin Shou-mei Xiong Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Longzhong Laboratory Xiangyang 441000HubeiChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

Dendrite growth is a complex liquid-solid phase transition process involving multiple physical factors.A phase-field lattice-Boltzmann method was developed to simulate the two-and three-dimension dendrite growth of Al-Cu alloy.The effect of fully coupled thermal-solute-convection interaction on the dendrite growth was investigated by incorporating a parallel-adaptive mesh refinement algorithm into the numerical model.By accurately reproducing the latent heat release,solute diffusion and convective transport behaviors at the liquidsolid interface,the interaction mechanism among thermal-solute-convection transport as well as their coupling effects on the dendrite growth dynamics were discussed.The simulation results show that the release of latent heat slows down the dendrite growth rate,and both natural and forced convection disrupt the symmetrical growth of dendrites.Their combination makes the growth of dendrites more complex,capturing important physical aspects such as recalescence,dendrite tip splitting,dendrite tilting,dendrite remelting,and solute plume in the simulation case.Based on the robustness and powerful ability of the numerical model,the formation mechanisms of these physical aspects were revealed.

关键词： simulation phase field dendrite growth thermal-solute-convection interaction

Highly Stable sp^(2) Carbon-Conjugated Porous Organic Cages

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CCS Chemistry 2024年第1期6卷 149-156页

作者： Fenglei qiu xun Chen Wenjing Wang Kongzhao Su Daqiang Yuan State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002 College of Chemistry Fuzhou UniversityFuzhouFujian 350116 University of the Chinese Academy of Sciences Beijing 100049

The high-yield synthesis of ultrastable porous organic cages(POCs)by facile methods is highly desirable but challenging.Inspired by highly stable sp^(2) carbon-conjugated(C=C)covalent organic frameworks,we used rational design and synthesized the first family of sp^(2) carbon-linked POCs(sp^(2)c-POCs)with triangular prism shapes by a one-step Knoevenagel reaction that is a high yield[2+3]condensation reaction.The stability of sp^(2)c-POC was demonstrated under strenuous conditions involving for example concentrated HCl or saturated NaOH solution.sp^(2)c-POC was used as a robust adsorbent for efficient separation of CO_(2)/CH_(4) or CO_(2)/N_(2) mixtures.In view of their facile synthesis and unique properties,we expect widespread use of these sp^(2) C=C linkages in the development of POC materials.

关键词： porous organic cages Knoevenagel condensation sp^(2)C=C linkage exceptional chemical stability gas adsorption and separation properties

Corrosion behavior of pure metals(Ni and Ti)and alloys(316H SS and GH3535)in liquid GaInSn

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Nuclear Science and Techniques 2024年第3期35卷 70-83页

作者： Jian-Hui Yu Hong-Xia Xu Xiang-Xi Ye Bin Leng Han-xun qiu Xing-Tai Zhou School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China

In this study,the interactions between a Ga-based liquid metal,GaInSn,and several metal materials,including pure metals(Ni and Ti)and alloys(316H stainless steel(SS)and GH3535),at 650℃were investigated.The aim was to evaluate the corrosion performance and select a suitable candidate material for use as a molten salt manometer diaphragm in thermal energy storage systems.The results indicated that the alloys(316H SS and GH3535)exhibited less corrosion than pure metals(Ni and Ti)in liquid GaInSn.Ga-rich binary intermetallic compounds were found to form on the surfaces of all the tested metal materials exposed to liquid GaInSn,as a result of the decomposition of liquid GaInSn and its reaction with the constituent elements of the metal materials.The corrosion mechanism for all the tested materials exposed to liquid GaInSn was also investigated and proposed,which may aid in selecting the optimal candidate material when liquid GaInSn is used as the pressure-sensing medium.

关键词： Metal materials Liquid GaInSn Corrosion Intermetallic compounds Thermal energy storage systems

Enhanced service stability and thermoelectric performance in CuSebased composites

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Science China Materials 2024年

作者： Pengfei qiu xun Shi State Key Laboratory of High Performance Ceramics and Superfine Microstructure Chinese Academy of Sciences Shanghai Institute of Ceramics

Thermoelectric (TE) materials can directly convert the industrial waste heat into useful electricity based on the Seebeck effect,providing a promising way to tackle the environmental pollution and global energy crisis [1]. In the past several decades, many new high-performance TE materials have been discovered to enrich the TE family. Among them, Cu2-δSe-based TE materials,which are in line with the “phonon-liquid electron-crystal”concept, have sparked widespread interest due to the high TE figure-of-merit (ZT) and the combination of elements that are nontoxic and earth-abundant [2]. In 2012, Liu et al.

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Differential expression profile of circular RNAs in mouse peritoneum with peritoneal fibrosis and the potential regulatory role of novel_circ_0007527

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Genes & Diseases 2024年第3期11卷 59-62页

作者： Yingfeng Shi Yan Hu Hui Chen Jinqing Li Min Tao xun Zhou Qin Zhong Andong qiu Shougang Zhuang Na Liu Department of Nephrology Shanghai East HospitalTongji University School of MedicineShanghai 200120China School of Life Science and Technology Advanced Institute of Translational MedicineTongji UniversityShanghai 200092China Department of Medicine Rhode Island Hospital and Alpert Medical SchoolBrown UniversityProvidenceRI 02912USA

CircRNAs,a novel type of endogenous non-coding RNAs(ncRNAs),are typically produced by back-splicing from exons of protein-coding genes,which are characterized by a covalently closed structure with neither 5'to 3'polarity nor a poly(A)tail.'On the one hand,circRNAs are involved in the regulation of a variety of important biological processes,such as apoptosis,proliferation,migration,and inflammatory responses.'On the other hand,the relationship between circRNAs and several fibrotic diseases has been reported.2 However.

关键词： endogenous peritoneal diseases

Importance of oxygen-containing functionalities and pore structures of biochar in catalyzing pyrolysis of homologous poplar

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Chinese Journal of Chemical Engineering 2024年第1期65卷 200-211页

作者： Li qiu Chao Li Shu Zhang Shuang Wang Bin Li Zhenhua Cui Yonggui Tang Obid Tursunov xun Hu School of Material Science and Engineering University of JinanJinan 250022China Joint International Research Laboratory of Biomass Energy and Materials College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013China Shandong BASAN Graphite New Material Plant Zibo 255311China Department of Power Supply and Renewable Energy Sources National Research University TIIAMETashkent 100000Uzbekistan

Biochar and bio-oil are produced simultaneously in one pyrolysis process,and they inevitably contact and may interact,influencing the composition of bio-oil and modifying the structure of biochar.In this sense,biochar is an inherent catalyst for pyrolysis.In this study,in order to investigate the influence of functionalities and pore structures of biochar on its capability for catalyzing the conversion of homologous volatiles in bio-oil,three char catalysts(600C,800C,and 800AC)produced via pyrolysis of poplar wood at 600 or 800℃or activated at 800℃,were used for catalyzing pyrolysis of homologous poplar wood at 600℃,respectively.The results indicated that the 600C catalyst was more active than 800C and 800AC for catalyzing cracking of volatiles to form more gas(yield increase by 40.2%)and aromatization of volatiles to form more light or heavy phenolics,due to its abundant oxygen-containing functionalities acting as active sites.The developed pores of the 800AC showed no such catalytic effect but could trap some volatiles and allow their further conversion via sufficient aromatization.Nevertheless,the interaction with the volatiles consumed oxygen on 600C(decrease by 50%),enhancing the aromatic degree and increasing thermal stability.The dominance of deposition of carbonaceous material of a very aromatic nature over 800C and 800AC resulted in net weight gain and blocked micropores but formed additional macropores.The in situ diffuse reflectance infrared Fourier transform spectroscopy characterization of the catalytic pyrolysis indicated superior activity of 600C for removal of -OH,while conversion of the intermediates bearing C=O was enhanced over all the char catalysts.

关键词： Poplar wood Catalytic pyrolysis Char catalyst Volatile-char interaction Bio-oil

Fibroblast growth factor 21(FGF21) attenuates tacrolimus-induced hepatic lipid accumulation through transcription factor EB(TFEB)-regulated lipophagy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第6期24卷 485-495页

作者： Zhensheng ZHANG Li XU xun qiu Xinyu YANG Zhengxing LIAN Xuyong WEI Di LU Xiao XU Zhejiang University School of Medicine Hangzhou 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Hangzhou 310006China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Institute of Organ Transplantation Zhejiang UniversityHangzhou 310003China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Westlake Laboratory of Life Sciences and Biomedicine Hangzhou 310024China

Tacrolimus(TAC),also called FK506,is one of the classical immunosuppressants to prevent allograft rejection after liver transplantation.However,it has been proved to be associated with post-transplant hyperlipemia.The mechanism behind this is unknown,and it is urgent to explore preventive strategies for hyperlipemia after transplantation.Therefore,we established a hyperlipemia mouse model to investigate the mechanism,by injecting TAC intraperitoneally for eight weeks.After TAC treatment,the mice developed hyperlipemia(manifested as elevated triglyceride(TG)and low-density lipoprotein cholesterol(LDL-c),as well as decreased high-density lipoprotein cholesterol(HDL-c)).Accumulation of lipid droplets was observed in the liver.In addition to lipid accumulation,TAC induced inhibition of the autophagy-lysosome pathway(microtubule-associated protein 1light chain 3β(LC3B)II/I and LC3B II/actin ratios,transcription factor EB(TFEB),protein 62(P62),and lysosomal-associated membrane protein 1(LAMP1))and downregulation of fibroblast growth factor 21(FGF21)in vivo.Overexpression of FGF21may reverse TAC-induced TG accumulation.In this mouse model,the recombinant FGF21 protein ameliorated hepatic lipid accumulation and hyperlipemia through repair of the autophagy-lysosome pathway.We conclude that TAC downregulates FGF21and thus exacerbates lipid accumulation by impairing the autophagy-lysosome pathway.Recombinant FGF21 protein treatment could therefore reverse TAC-caused lipid accumulation and hypertriglyceridemia by enhancing autophagy.

关键词： Autophagy Fibroblast growth factor 21(FGF21) Lipid Lipophagy Lysosome Tacrolimus Transcription factor EB(TFEB)

Synergistic strategy of surface-induced spinel structure and F doping to improve the electrochemical performance of Li-rich cathodes

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Progress in Natural Science:Materials International 2024年第3期34卷 524-531页

作者： Yuezhen Wang Ningbo Qin xun Yuan Shiming qiu Fangli Ji Ruirui Tuo Tingfeng Guan Cheng Yang Jiang Zhu Miao Ge Hui Wang Yan Cheng Zhaozhe Yu Guangxi Key Laboratory of Manufacturing Systems and Advanced Manufacturing Technology Guilin University of Electronic Technology Guangxi Institute of Science and Technology Development Co. Ltd. Guangxi CNGR New Energy Science & Technology Co. Ltd. Guangxi Key Laboratory for High-value Utilization of Manganese Resources Guangxi Minzu Normal University

Li-rich Mn-based materials provide higher capacity than commercial NCM layered materials due to the synergistic redox effect of cations and anions. However, lattice straining and structural collapse caused by the irreversible oxygen release at high voltage range during cycling, which results in severe capacity and voltage decay. Herein, a synergistic strategy of surface-induced spinel structure and F doping is provided to improve the structural stability. The surface spinel structure helps to reduce the structural collapse caused by electrolyte corrosion on the cathode and effectively inhibits voltage decay resulted from structural evolution. The stronger Mn-F bonds are formed by F doping to inhibit migration of transition metal(TM) and induce the uniform deposition of Li F to form the thinner and more stable CEI on the cathode. Accordingly, the designed cathode(LMNO-NF) shows remarkable cycling performance with the capacity retention of 86.68 % and voltage retention of 96.6 % for 200 cycles at 1C,higher than pristine material(68.76 % and 85.75 %). Therefore, this simple dual-modification strategy of one-step synthesis is promising for solving the structural evolution and voltage decay of Li-rich Mn-based cathode materials effectively, achieving further commercialization.

关键词： F doping High cycling stability Li-rich Mn-Based cathode Surface-induced spinel structure Synergistic strategy

Aspirin in hepatocellular carcinoma:Is it an out-of-date or promising treatment?

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iLIVER 2022年第1期1卷 55-64页

作者： xun qiu Fengqiang Gao Kai Wang Zhensheng Zhang Chuxiao Shao Xiao Xu Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryAffiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou310006China Westlake Laboratory of Life Sciences and Biomedicine Hangzhou310024China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou310003China Institute of Organ Transplantation Zhejiang UniversityHangzhou310003China Department of Hepatobiliary and Pancreatic Surgery Affiliated Lishui HospitalZhejiang University School of MedicineLishui323000China

Hepatocellular carcinoma(HCC)is one of the most aggressive human malignancies with a dismal survival rate.Few strategies can effectively prevent the occurrence of HCC.Although immunotherapy has significantly improved HCC-related survival in recent years,this systemic therapy is very expensive and lays a heavy burden on most HCC patients.Aspirin,which is currently one of the most widely used medications in analgesic and cardiovascular diseases,is reported to have anti-tumor effects on HCC.Most importantly,long-term administration of low-dose aspirin does not significantly increase the risk of gastrointestinal bleeding.Owing to its costeffectiveness and wide use,aspirin can be easily applied as an HCC treatment and is affordable for a wide range of patients.Therefore,deeper understanding and more attention are needed to extend the frontline of aspirin's preventive and therapeutic potential into cancer research and management.In this review,we discuss the preventive effect of aspirin on HCC in the context of different etiological factors,including hepatitis B or hepatitis C virus infection,non-alcoholic fatty liver disease,and alcohol-associated liver disease.The therapeutic role of aspirin in resectable or unresectable HCC management is also discussed.Furthermore,the mechanisms underlying the anti-cancer effects of aspirin on HCC are fully reviewed and discussed in the following two aspects:the effect of aspirin on multi-oncogenic signaling pathways in HCC(e.g.,AMPK,Wnt/β-catenin,NF-κB)and aspirinmediated immunometabolic responses in liver diseases.These findings indicate aspirin is a promising agent for populations at risk and HCC patients to prevent or treat HCC.

关键词： Hepatocellular carcinoma Aspirin Chemoprevention Cancer therapy Oncogenic signaling Immunometabolic response