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Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys

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Journal of Materials Science & Technology 2021年第36期95卷 237-248页

作者： Ling Ren Xiaohe Xu Hui Liu Ke Yang xun qi Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China Department of Ophthalmology Shengjing Hospital of China Medical University36 Sanhao StreetShenyang 110001China School of Materials Science and Engineering University of Science and Technology of China96 Jinzhai RoadHefei 230026China Key Laboratory of Diagnostic Imaging and Interventional Radiology of Liaoning Province Department of RadiologyThe First Affiliated Hospital of China Medical University155 Nanjing Bei StreetShenyang 110001China

To reduce the risk of implant-associated infections,we previously designed and developed a series of medical copper(Cu)-bearing titanium alloys that release Cu ions and hence play an antibacterial ***,both excessive and deficient Cu levels adversely affect human health;therefore,the aim of the present study was to comprehensively evaluate the short-and long-term biosafety of Cu-bearing titanium alloys(Ti6 Al4V-Cu and Ti-Cu)both in vitro and in ***,the predominant kinetic mechanism of Cu ions release and its effect on biosafety were also *** results indicate that the biocompatibility of the Cu-bearing titanium alloys meets the requirements of ISO standards and the Cu ion release kinetics display a good correlation over the entire time period in the normal zero-order model with an almost constant release *** release rate maintained at a parts per billion level safe for humans;consequently,we can conclude that our Cu-bearing titanium alloys have satisfactory biocompatibility.

关键词： Cu ions Kinetic Biocompatibility Titanium

Effects of the duration of expressions on the recognition of microexpressions

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第3期13卷 221-230页

作者： xun-bing SHEN qi wu Xiao-lan FU State Key Laboratory of Brain and Cognitive Science Institute of Psychology Chinese Academy of Sciences Beijing 100101 China

Objective: The purpose of this study was to investigate the effects of the duration of expressions on the recognition of microexpressions, which are closely related to deception. Methods: In two experiments, participants were briefly (from 20 to 300 ms) shown one of six basic expressions and then were asked to identify the expression. Results: The results showed that the participants' performance in recognition of microexpressions increased with the duration of the expressions, reaching a turning point at 200 ms before levelling off. The results also indicated that practice could improve the participants' performance. Conclusions: The results of this study suggest that the proper upper limit of the duration of microexpressions might be around 1/5 of a second and confirmed that the ability to recognize microexpressions can be enhanced with practice.

关键词： Duration of expressions Microexpressions Microexpression training tool (METT)

A voltage resonance-based single-ended online fault location algorithm for DC distribution networks

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Science China(Technological Sciences) 2016年第5期59卷 721-729页

作者： JIA Ke LI Meng BI Tian Shu YANG qi xun State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power University

A novel single-ended online fault location algorithm is investigated for DC distribution networks. The proposed algorithm calculates the fault distance based on the characteristics of the voltage resonance. The Prony's method is introduced to extract the characteristics. A novel method is proposed to solve the pseudo dual-root problem in the calculation process. The multiple data windows are adopted to enhance the robustness of the proposed algorithm. An index is proposed to evaluate the accuracy and validity of the results derived from the various data windows. The performances of the proposed algorithm in different fault scenarios were evaluated using the PSCAD/EMTDC simulations. The results show that the algorithm can locate the faults with transient resistance using the 1.6 ms data of the DC-side voltage after a fault inception and offers a good precision.

关键词： protection fault location DC distribution VSC voltage resonance Prony's method

Osteogenesis stimulation by copper-containing 316L stainless steel via activation of akt cell signaling pathway and Runx2 upregulation

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Journal of Materials Science & Technology 2019年第11期35卷 2727-2733页

作者： Yonghui Yuan Shujing Jin xun qi Xudong Chen Wei Zhang Ke Yang Hongshan Zhong Key Laboratory of Diagnostic Imaging and Interventional Radiology of Liaoning Province Department of RadiologyThe First Affiliated Hospital of China Medical UniversityShenyang 110001China Research and Academic Department Cancer Hospital of China Medical University Liaoning Cancer Hospital&InstituteShenyang 110042China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China First Affiliated Hospital of Southern University of Science and Technology Shenzhen People's Hospital&Shenzhen Interventional Medical Engineering Research and Development CenterShenzhen 518020China

As a metallic orthopedic implant,316L stainless steel(316L SS)is used extensively for its good resistance to corrosion and mechanical ***,it takes a long time to achieve osseointegration between 316L SS and adjacent tissues due to its bio-inert ***,the aim is to improve the bio-adaption of 316L SS.A good approach is to add elements to materials to improve their osteogenic capabilities by the appropriate release of *** copper-containing 316L stainless steel(316L-Cu SS)was investigated in this work,where Cu is an essential trace element that can stimulates *** was found that 316L-Cu SS was bio-safe and did not affect the proliferation of co-cultured osteoblasts in comparison with 316L *** increased cell apoptosis on day 1 but inhibited it on day 3,which cooperates with new bone formation *** extend themselves more quickly and in a better manner on the surface of 316L-Cu SS,wheneven more pseudopodia are ***,the gene expression of alkaline phosphatase,collagen I and runt-related transcription factor 2(Runx2)in osteoblasts cultured with 316L-Cu SS was significantly ***2 protein expression increased,and osteogenesis was stimulated by 316L-Cu SS via an Akt cell signaling *** conclusion,316L-Cu SS stimulates osteogenesis through activation of the Akt cell signaling pathway and the upregulation of ***,316L-Cu SS is a promising material that may be used in surgical implants to stimulate osteogenesis.

关键词： Osteogenesis Cu addition Stainless steel Cell signaling pathway Bone

Evolution,progress,and prospects of research on transjugular intrahepatic portosystemic shunt applications

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Journal of Interventional Medicine 2021年第2期4卷 57-61页

作者： Peng Wang xun qi Ke Xu Department of Radiology The First Affiliated Hospital of China Medical UniversityShenyangChina

Transjugular intrahepatic portosystemic shun(TIPS)is an effective procedure for the treatment of portal hypertension complications such as esophagogastric variceal bleeding and refractory *** date,its use by many experts and scholars at home and abroad has benefitted countless *** order to further promote the development and innovation of TIPS in China,this paper briefly reviews the development process of TIPS at home and abroad,objectively analyzes the bottlenecks and breakthrough achievements in the development of TIPS,and discusses the application status and research progress of TIPS technology for different ***,we provide an outlook about the development and application of TIPS in China.

关键词： TIPS Application situation Research progress Prospect

Preparation of Sulphur-containing Aromatic Amines by Reduction of the Corresponding Aromatic Nitro Compounds with Hydrazine Hydrate over Iron Oxide Hydroxide Catalyst

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Chinese Chemical Letters 2006年第8期17卷 1045-1047页

作者： qi xun SHI Rong Wen LU Zhu Xia ZHANG De Feng ZHAO State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012

Sulphur-containing aromatic nitro compounds were rapidly reduced to the corresponding amines in high yields by employing hydrazine hydrate as a hydrogen donor in the presence of iron oxide hydroxide catalyst. It was worth noting that the catalyst exhibited extremely high activity. The reduction could be completed within 20-50 min and the yields were up to 97-99 %.

关键词： Iron oxide hydroxide catalyst hydrazine hydrate sulphur-containing aromatic nitro compounds reduction.

Reduction of Sulphur-containing Aromatic Nitro Compounds with Hydrazine Hydrate over Iron(III) Oxide-MgO Catalyst

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Chinese Chemical Letters 2006年第4期17卷 441-443页

作者： qi xun SHI Rong Wen LU Zhu Xia ZHANG De Feng ZHAO State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012

Sulphur-containing aromatic amines were prepared efficiently in good to excellent yields by reduction of the corresponding sulphur-containing aromatic nitro compounds with hydrazine hydrate in the presence of iron（Ⅲ） oxide-MgO catalyst. The catalyst exhibited high activity and stability for the reduction of sulphur-containing aromatic nitro compounds. The yields of sulphur-containing aromatic amines were up to 91-99 % at 355 K after reduction for 1-4 h over this catalyst.

关键词： Iron(Ⅲ) oxide-MgO catalyst hydrazine hydrate sulphur-containing aromatic nitro compounds reduction.

Ivor Lewis subtotal esophagectomy with two-field lymphadenectomy for squamous cell carcinoma of the lower thoracic esophagus

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World Journal of Gastroenterology 2008年第32期14卷 5084-5089页

作者： Jie Wu Ying Chai Xing-Ming Zhou qi-xun Chen Fu-Lai Yan Department of Thoracicoabdominal Surgery Zhejiang Cancer Hospital Hangzhou 310022 Zhejiang Province China Department of Thoracic Surgery 2nd Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 Zhejiang Province China

AIM： To evaluate the clinical outcome of Ivor Lewis subtotal esophagectomy with two-field lymphadenectomy for patients with squamous cell carcinoma of the lower thoracic esophagus. METHODS： From January 1998 to December 2001, 73 patients with lower thoracic esophageal carcinoma underwent Ivor-Lewis subtotal esophagectomy with two-field lymphadenectomy. Clinicopathological information, postoperative complications, mortality and long term survival of all these patients were analyzed retrospectively. RESULTS： The operative morbidity and mortality was 15.1% and the mortality was 2.7%. Lymph node metastases were found in 52 patients （71.2%）. Nodal metastases to the upper, middle, lower mediastini and upper abdomen were found in 13 （17.8%）, 15 （20.5%）, 30 （41.1%）, and 25 （34.2%） patients, respectively. Postoperative staging was as follows： stage Ⅰ in 5 patients, stage Ⅱ in 34 patients, stage Ⅲ in 32 patients, and stage Ⅳ in 2 patients, respectively. The overall 5-year survival rate was 23.3%. For NO and N1 patients, the 5-year survival rate was 38.1% and 17.3%, respectively （X^2 = 22.65, P 〈 0.01）. The 5-year survival rate for patients in stages Ⅱ a, Ⅱ b and Ⅲ was 31.2%, 27.8% and 12.5%, repsectively （X^2 = 29.18, P 〈 0.01）. CONCLUSION： Ivor Lewis subtotal esophagectomy with two-field （total mediastinum） lymphadenectomy is a safe and appropriate operation for squamous cell carcinoma of the lower thoracic esophagus.

关键词： Esophageal neoplasm Ivor Lewis approach Two-field lymphadenectomy

A New Stilbene Tetramer from Caragana rosea

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Chinese Chemical Letters 2003年第10期14卷 1048-1050页

作者： Guo xun YANG, Chang qi HU School of Pharmacy, Fudan University, Shanghai 200032 School of Pharmacy Fudan University Shanghai 200032 China

Cararosinol A, a new stilbene tetramer, was isolated from Caragana rosea. Its structure has been established on the basis of spectroscopic evidence.

关键词： Caragana rosea Leguminase stilbene tetramer.