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Synthesis and Characterization of Novel Acetohydroxyacid Synthase Inhibitors

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Chemical Research in Chinese Universities 2006年第5期22卷 593-597页

作者： gao Fei-fei LI Yao-xian zhang Suo-qin zhang Guang-liang College of Chemistry Jilin University Changchun 130021 P. R. China

A novel kind of acetohydroxyacid synthase（AHAS） inhibitors, arylsulfonylaminocarbonyl-2-thiohydantoins, was synthesized based on biorational design. The structures of these compounds were confirmed by IR, MS, NMR, and elemental analysis. The results of the preliminary activity tests indicate that most of the arylsulfonylamidecarbonyl-5- methyl-2-thiohydantoins have a higher biological activity than those without 5-methyl substituent.

关键词： Sulfonylaminocarbonyl-2-thiohydantoin Sulfonylurea Acetohydroxyacid synthase, Herbicidal activity

Novel TiC/Ti Open Cellular Foams Prepared by a Modified Sponge-coating Method Using High Frequency Induction Heating Process

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Journal of Materials Science & Technology 2013年第4期29卷 339-343页

作者： Yong gao Xingxiang Xu Zhenming Yang Junqi zhang Chunhai Jiang Jinsong zhang Institute of Metal Research Chinese Academy of Sciences

A new kind of open cellular foam material with three dimensionally interconnected TiC/Ti struts was prepared by a two-step sponge-coating and high frequency induction heating process. The microstructure, composition and compression strength of the prepared TiC/Ti foam materials were characterized. It was confirmed that the incorporation of Ti into TiC resulted in an inter-bonded Ti-TiC-Ti layered structure in the struts, which enhanced the plasticity of the composite foam materials.

关键词： TiC/Ti foams Composite Sintering Porosity Mechanical properties

Effects of grazing disturbance of spatial distribution pattern and interspecies relationship of two desert shrubs

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Journal of Forestry Research 2022年第2期33卷 507-518页

作者： Lei zhang Yong gao Jinrong Li Chao zhang Minyu Li Zhao Hu Xiangxin Cui College of Desert Science and Engineering Inner Mongolia Agricultural UniversityHohhot 010019People’s Republic of China Institute of Water Resources for Pastoral Area of the Ministry of Water Resources Hohhot 010020People’s Republic of China Institute of Forestry Monitoring and Planning of Inner Mongolia Autonomous Region Hohhot 010020People’s Republic of China School of Soil and Water Conservation Beijing Forestry UniversityBeijing 100083People’s Republic of China

Grazing significantly affects the distribution,growth,and productivity of *** this study,we evalu-ated the effects of grazing disturbance on the spatial distri-bution patterns and interspecific relationships of two desert shrubs,Ammopiptanthus mongolicus and Sarcozygium *** types of grazing conditions were considered,including enclosed area(EA),seasonal rotational grazing area(SRGA),and grazing area(GA)(100 m×100 m),in the West Ordos Nature Reserve of Inner Mongolia,*** results showed that *** and *** populations were uniformly distributed at a small scale,and the distribution in EA and SRGA became gradually *** GA,*** population showed aggregated distribution but *** population showed random distribution at a small scale. Moreover, both A. mongolicus and S. xanthoxylon populations at the 5-7 m scale showed random distribution. At the small and intermediate scales, the two species showed positive interspecific relationships of GA. However, no interspecific relationship was noted between the two species in EA and SRGA. A significant positive relationship (P < 0.01) was noted between the two species at 2-9 m and a negative relationship (P < 0.01) at 13-17 m scales in GA. Positive relationship (P < 0.01) was noted between the two species at 6-13 m scales and a sig-nificant negative relationship (P < 0.01) at 14-24 m scales in SRGA. The two species of desert shrubs showed posi-tive interspecific relationships at the small scale, and they showed negative relationships as the interspecific compe-tition intensified in the presence of grazing disturbance. When the grazing intensity exceeds a certain threshold, the interspecific relationships become weak. Therefore, moder-ate grazing would facilitate interspecific competition and species succession, whereas excessive grazing would disrupt natural competition causing desertification ultimately.

关键词： Extending point pattern analysis Grazing Interspecific relationships Unmanned aerial vehicle(UAV)

The promoting effect of interstitial hydrogen on the oxygen reduction performance of PtPd alloy nanotubes for fuel cells

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Nano Research 2023年第2期16卷 2366-2372页

作者： Tingting Chao Xuan Luo Mengzhao Zhu Yanmin Hu Yida zhang Yunteng Qu Hantao Peng Xiaoshuang Shen Xusheng Zheng Liang zhang xun Hong Center of Advanced Nanocatalysis(CAN) Department of Applied ChemistryUniversity of Science and Technology of ChinaHefei 230026China Country Center for Combustion Energy and School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China National Synchrotron Radiation Laboratory(NSRL) University of Science and Technology of ChinaHefei 230029China Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China School of Physical Science and Technology Yangzhou UniversityYangzhou 225002China

Highly efficient and stable oxygen reduction reaction(ORR)electrocatalysts are remarkably important but challenging for advancing the large-scale commercialization of practical proton exchange membrane fuel cells(PEMFCs).In this work,we report that the introduction of interstitial hydrogen atoms into PtPd nanotubes can significantly promote ORR performance without scarifying the *** enhanced mass activity was 8.8 times higher than that of commercial Pt/*** accelerated durability test showed negligible activity attenuation after 30,000 ***,H2/O2 fuel cell tests further verified the excellent activity of PtPd-H nanotubes with a maximum power density of 1.32 W·cm^(−2),superior to that of commercial Pt/C(1.16 W·cm^(−2)).Density functional theory calculations demonstrated the incorporation of hydrogen atoms gives rise to the broadening of Pt d-band and the downshift of d-band center,which consequently leads to the weaker intermediates binding and enhanced ORR activity.

关键词： hydrogen atoms incorporation alloy d-band structure regulation oxygen reduction reaction fuel cell

Acoustic wireless communication based on parameter modulation and complex Lorenz chaotic systems with complex parameters and parametric attractors

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Chinese Physics B 2021年第8期30卷 248-259页

作者： Fang-Fang zhang Rui gao Jian Liu Department of Control Science and Engineering Shandong UniversityJinan 250061China Department of Electrical Engineering and Automation Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China School of Mathematical Sciences University of JinanJinan 250022China

As the competition for marine resources is increasingly fierce,the security of underwater acoustic communication has attracted a great deal of *** information and location of the communicating platform can be leaked during the traditional underwater acoustic communication *** to the unique advantages of chaos communication,we put forward a novel communication scheme using complex parameter modulation and the complex Lorenz ***,we design a feedback controller and parameter update laws in a complex-variable form with rigorous mathematical proofs(while many previous references on the real-variable form were only special cases in which the imaginary part was zero),which can be realized in practical engineering;then we design a new communication scheme employing parameter *** main parameter spaces of the complex Lorenz system are discussed,then they are adopted in our communication *** also find that there exist parametric attractors in the complex Lorenz *** make numerical simulations in two channels for digital signals and the simulations verify our conclusions.

关键词： parameter modulation identification chaotic system acoustic wireless communication

骨料种类对铁水包用Al_(2) O_(3)-SiC-C砖性能的影响

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耐火材料 2024年第1期58卷 19-24页

作者：高东升聂建华蔡曼菲梁永和张晓存武汉科技大学省部共建耐火材料与冶金国家重点实验室湖北武汉430081

骨料作为耐火材料的重要组成部分,决定着材料的各项性能。分别以粒度均为5~3、3~1和≤1 mm的高铝矾土、电熔棕刚玉、板状刚玉为骨料,以电熔白刚玉(≤0.045 mm)、SiC(≤0.075 mm)、活性α-Al_(2)O_(3)微粉(≤0.045 mm)和鳞片石墨(≤0.15 ... 详细信息

骨料作为耐火材料的重要组成部分,决定着材料的各项性能。分别以粒度均为5~3、3~1和≤1 mm的高铝矾土、电熔棕刚玉、板状刚玉为骨料,以电熔白刚玉(≤0.045 mm)、SiC(≤0.075 mm)、活性α-Al_(2)O_(3)微粉(≤0.045 mm)和鳞片石墨(≤0.15 mm)等为基质,以热固性酚醛树脂为结合剂制备了Al_(2)O_(3)-SiC-C砖,研究了骨料种类(高铝矾土、电熔棕刚玉、板状刚玉)对Al_(2)O_(3)-SiC-C砖常温力学性能、高温力学性能和抗渣性能的影响。结果表明:以板状刚玉为骨料时,由于其较高的致密度和较低的杂质含量,使得Al_(2)O_(3)-SiC-C砖具有最优的高温力学性能和抗渣性能;以高铝矾土为骨料时,由于其较高的气孔率和杂质含量,导致试样高温力学性能和抗渣性最差。

关键词：高铝矾土电熔棕刚玉板状刚玉 Al_(2)O_(3)-SiC-C砖

人脐带间充质干细胞对糖尿病肾病大鼠肠道屏障功能的调节作用

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中国组织工程研究 2024年第19期28卷 2967-2973页

作者：吴雅茹米焱魏凯悦高和平张丁予王彩丽内蒙古科技大学包头医学院内蒙古自治区包头市014000 内蒙古科技大学包头医学院第一附属医院肾内科内蒙古自治区包头市014000

背景:糖尿病肾病是引起终末期肾病的重要原因,其中肠道屏障损伤在糖尿病肾病的发生发展中起到了重要作用。目的:观察人脐带间充质干细胞对糖尿病肾病大鼠肠道屏障的保护作用。方法:30只8周龄雄性SD大鼠随机分配至健康对照组、模型组和... 详细信息

背景:糖尿病肾病是引起终末期肾病的重要原因,其中肠道屏障损伤在糖尿病肾病的发生发展中起到了重要作用。目的:观察人脐带间充质干细胞对糖尿病肾病大鼠肠道屏障的保护作用。方法:30只8周龄雄性SD大鼠随机分配至健康对照组、模型组和人脐带间充质干细胞组,每组10只。人脐带间充质干细胞组大鼠在糖尿病肾病成模后经尾静脉注射1×106个人脐带间充质干细胞,每周1次,连续4周,健康对照组和模型组大鼠在相同时间注射等体积PBS。末次注射后1周,光镜下观察肾脏和结肠组织形态学改变情况,免疫组化法检测大鼠结肠组织中ZO-1和Occludin的表达;ELISA法检测大鼠血清D-乳酸和脂多糖水平。此外,还利用活体成像系统观察DiR染料标记的人脐带间充质干细胞在大鼠体内的示踪分布,以及应用免疫组化法检测结肠组织中人源性间充质干细胞表面标志抗原CD44和CD90的表达。结果与结论:①与模型组比较,人脐带间充质干细胞移植显著抑制了糖尿病肾病大鼠尿素氮、血肌酐、24 h尿蛋白水平和尿白蛋白/肌酐比值的增加(均P<0.05);②在糖尿病肾病大鼠结肠中发现了人源间充质干细胞表面标志物CD44和CD90的表达;③与健康对照组相比,模型组大鼠结肠组织中紧密连接蛋白Occludin与ZO-1蛋白表达水平显著减少,而人脐带间充质干细胞治疗后显著提高了Occludin和ZO-1的表达;④与模型组比较,人脐带间充质干细胞移植后显著降低了糖尿病肾病大鼠血清D-乳酸和脂多糖水平;⑤结果提示,人脐带间充质干细胞可能通过增强糖尿病肾病大鼠肠道紧密连接蛋白的表达来保护肠道屏障功能。

关键词：人脐带间充质干细胞糖尿病肾病肠道屏障 ZO-1 Occludin

Acceleration of the particulate organic matter hydrolysis by start-up stage recovery and its original microbial mechanism

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Frontiers of Environmental Science & Engineering 2021年第1期15卷 175-184页

作者： Yanqing Duan Aijuan Zhou Xiuping Yue Zhichun zhang Yanjuan gao Yanhong Luo Xiao zhang College of Environmental Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi Engineer Research Institute of Sludge Disposition and Resources Taiyuan University of TechnologyTaiyuan 030024China School of Environment and Safety Engineering North University of ChinaTaiyuan 030051China

To address the availability of carbon sources for denitrification,the accelerated hydrolysis of the most abundant but low-availability fraction of particulate organic matter(POM)was *** sieves with different pore sizes were used as primary pretreatment at the start-up-stage of the biological process to separate some POM from the liquid *** changes in soluble carbohydrates and proteins were monitored to investigate the hydrolysis performance of the sieved POM,with waste activated sludge(WAS)as the control *** results showed that an average of 35%POM could be entrapped before filtrate mat *** addition,benefiting from the high polysaccharides concentration,as well as the high availability due to the relatively loose physical structure,a 23%hydrolysis efficiency of POM was obtained,in contrast to that of WAS(3.4%),with a hydrolysis constant of 0.39 h^(−1).The prominent performance was also attributed to the unique microbial communities having been domesticated at a lower temperature,especially the cellulose-degrading bacteria Paraclostridium and psychrophile Psychrobacter,making up 6.94%and 2.56%,***,the potential benefits and application of improved POM hydrolysis by start-up stage recovery via mesh sieves combined with anaerobic fermentation were evaluated,including selective POM entrapment,alleviation of blockage and wear,and a reduction in aeration *** the proposed strategy,carbon availability for biological nutrient removal(BNR)processes is anticipated to be improved more economically than that can be achieved by primary clarifier elimination.

关键词： Particulate organic matter(POM) Hydrolysis Microbial community Mass balance

Hallmark guided identification and characterization of a novel immune-relevant signature for prognostication of recurrence in stageⅠ-Ⅲlung adenocarcinoma

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Genes & Diseases 2023年第4期10卷 1657-1674页

作者： Yongqiang zhang Zhao Yang Yuqin Tang Chengbin Guo Danni Lin d Linling Cheng xun Hu Kang zhang Gen Li West China School of Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhouGuangdong 510620China State Key Laboratory of Southwestern Chinese Medicine Resources School of Basic Medical SciencesChengdu University of Traditional Chinese MedicineChengduSichuan 611137China Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacao 999078China Clinical Research Center The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310003China Biorepository State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China

The high risk of postoperative mortality in lung adenocarcinoma(LUAD)patients is principally driven by cancer recurrence and low response rates to adjuvant ***,A combined cohort containing 1,026 stageⅠ-Ⅲpatients was divided into the learning(n Z 678)and validation datasets(n Z 348).The former was used to establish a 16-mRNA risk signature for recurrence prediction with multiple statistical algorithms,which was verified in the valida-tion *** and multivariate analyses confirmed it as an independent indicator for both recurrence-free survival(RFS)and overall survival(OS).Distinct molecular characteristics between the two groups including genomic alterations,and hallmark pathways were compre-hensively ***,the classifier was tightly linked to immune infiltrations,high-lighting the critical role of immune surveillance in prolonging survival for ***,the classifier was a valuable predictor for therapeutic responses in patients,and the low-risk group was more likely to yield clinical benefits from immunotherapy.A transcription factor regulato-ry proteineprotein interaction network(TF-PPI-network)was constructed via weighted gene co-expression network analysis(WGCNA)concerning the hub genes of the *** con-structed multidimensional nomogram dramatically increased the predictive ***-fore,our signature provides a forceful basis for individualized LUAD management with promising potential implications.

关键词： Immune infiltration Lung adenocarcinoma Nomogram Recurrence Risk signature