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Journal of Pharmaceutical Analysis 2019年第3期9卷 178-184页

作者： Zhaorui Meng xun gao Haifeng Yu Lan Zhang Xiangyong Yu Longshan Zhao School of Pharmacy Shenyang Pharmaceutical University Shenyang 110016 China Anshan Institute for Food and Drug Control Anshan 114006 China Shenyang Wellwolf Pharmaceutical Science and Technology Co. Ltd Shenyang 110022 China

A simple, rapid, and sensitive gas chromatography-mass spectrometry (GC-MS) method was developed and validated for the simultaneous determination of two fatty acids, methyl hexadecanoate (MH) and methyl stearate (MS), to allow the evaluation of packaging-drug compatibility. The two migrants were quantified in selective ion-monitoring (SIM) mode, with limits of detection (LOD) of 0.0030 μg/mL and 0.0121 μg/mL. Linear calibration curves for MH and MS were obtained in the concentration ranges of 0.1011–5.0570 μg/mL and 0.2015–10.0740 μg/mL, respectively. The developed method was successfully applied to estimate the safety of the injection of recombinant antitumor-antivirus protein (RAAP). The results showed that the possible maximum daily intake was 3.0 ng and 12.1 ng for MH and MS, respectively. As these values were both below the permitted daily exposure, the migrants can be considered as having low safety risk and do not affect the quality of the injection.

关键词： Compatibility Rubber stoppers Injection Fatty acids GC-MS

Synthesis of cis-(±)-2-Hydroxymethyl-5-(Cytosine-1'-yl)-1,3-Oxathiolane (BCH-189)

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Chinese Chemical Letters 2001年第6期12卷 487-488页

作者： Ji Zhen LI Xue Peng QIU Lian xun gao Meng Xian DING Polymer Chemistry Laboratory Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022

The target compound BCH-189 was synthesized with high yield via four steps from benzoyloxy acetylaldehyde and p-dithiane-2,5-diol as starting materials. The synthetic route is preferable to what literature reported.

关键词： Anti-HIV total synthesis BCH-189

Collective modes of type-ⅡWeyl fermions with repulsive S-wave interaction

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Chinese Physics B 2022年第2期31卷 140-143页

作者： xun-gao Wang Yuan Sun Liang Liu Wu-Ming Liu Beijing National Laboratory for Condensed Matter Physics.Institue of Plysics Chinese Academy of SciencesBeijing 100190China School of Physcal Sciences University of Chinese Academy of SciencesBeijing 100190China Key Laboratory of Quantum Optics Shanghai Istiute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Songshan Lake Materials Laboratory Dongguan 523808China

Three-dimensional type-ⅡWeyl fermions possess overtilted cone-like low-energy band *** the closed ellipsoidal Fermi surface for type-ⅠWeyl fermions,the Fermi surface is an open hyperboloid for type-ⅡWeyl *** evaluate the spin and density susceptibility of type-ⅡWeyl fermions with repulsive S-wave interaction by means of Green’s *** obtain the particle–hole continuum along the tilted momentum direction and perpendicular to the tilted momentum direction *** find the zero sound mode in some repulsive interaction strengths by numerically solving the pole equations of the susceptibility within the random-phase approximation.

关键词： Weyl fermions zero sound mode random-phase approximation

Characterization of NDM-5-producing Enterobacteriaceae isolates from retail grass carp(Ctenopharyngodon idella) and evidence of blaNDM-5-bearing IncHI2 plasmid transfer between ducks and fish

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Zoological Research 2022年第2期43卷 255-264页

作者： Lu-Chao Lv Yao-Yao Lu xun gao Wan-Yun He Ming-Yi gao Kai-Bin Mo Jian-Hua Liu College of Veterinary Medicine Key Laboratory of Zoonosis of Ministry of Agricultural and Rural AffairsNational Risk Assessment Laboratory for Antimicrobial Resistant of Microorganisms in AnimalsGuangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety EvaluationSouth China Agricultural UniversityGuangzhouGuangdong 510642China Guangdong Laboratory for Lingnan Modern Agriculture GuangzhouGuangdong 510642China

We aimed to characterize NDM-5-producing Enterobacteriaceae from aquatic products in Guangzhou,China.A total of 196 intestinal samples of grass carp collected in 2019 were screened for carbapenemase *** of bla_(NDM-5) positive isolates and plasmids was determined by antimicrobial susceptibility testing,conjugation experiments,Illumina HiSeq,and Nanopore *** Citrobacter freundii and six Escherichia coli strains recovered from seven intestinal samples were verified as bla_(NDM-5) carriers(3.57%,7/196).The bla_(NDM-5) genes were located on the lncX3(n=5),lncHI2(n=1),or lncHI2-lncF(n=1)*** bla_(NDM-5)-bearing plasmids were transferred by conjugation at frequencies of~10^(-4)-10^(-6).Based on sequence analysis,the lncHI2 plasmid pHNBYF33-1 was similar to other bla_(NDM-5)-carrying lncHI2 plasmids deposited in GenBank from Guangdong *** all lncHI2 plasmids,bla_(NDM-5)was embedded in a novel transposon,Tn7057(IS3000-△ISAba125-IS5-△ISAba125-bla_(NDM-5)-bleMBL-trpF-tat-△dct-IS26-△umuD-△ISKox3-IS3000),which was identical to the genetic structure surrounding bla_(NDM-5)found in some IncX3 *** lncHI2-lncF hybrid plasmid pHNTH9F11-1 was formed by homologous recombination of the bla_(NDM-5)-carrying lncHI2 plasmid and a heavy-metal-resistant IncF plasmid through△Tn1721 To the best of our knowledge,this is the first report on the characterization of bla_(NDM-5)-bearing plasmids in fish in *** lncHI2 plasmid pHNBYF33-1 may be transmitted from ducks,considering the common duck-fish freshwater aquaculture system in ***7051 is likely responsible for the transfer of bla_(NDM-5) from lncX3 to lncHI2 plasmids in Enterobacteriaceae,resulting in the expansion of transmission vectors of bla_(NDM-5).

关键词： bla_(NDM-5) Enterobacteriaceae Plasmid Fish Carbapenemase

Slack-Nibbling Battery-Aware Task Scheduling

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Wuhan University Journal of Natural Sciences 2009年第3期14卷 229-234页

作者： gao xun CAO Yang LIAO Weihui LI Geyang School of Electronic Information Wuhan University' Wuhan430072 Hubei China State Key Laboratory of Software Engineering WuhanUniversity Wuhan 430072 Hubei China

Dynamic voltage scaling （DVS） is an efficient approach to maximize the battery life of portable devices. A novel overall planning strategy （OPS II） balancing slack supply and demand for DVS is proposed. An OPS II-based slack-nibbling overall planning strategy （SNOPS） algorithm is also proposed, which iteratively nibbles slacks for appropriate tasks selected by an overall planning dynamic priority function to perform DVS until the slack is exhausted and an optimum voltage setting is obtained. For a high-load task set, SNOPS manages to recover battery overload while maintaining schedulability. For random variable-load task sets, SNOPS achieves a saving of 29.51% battery capacity on average, the suboptimal gap is 27.84% narrower than that of our previously proposed OPS-based algorithm, and 92.10% narrower than that of the algorithm proposed by Chowdhury et al. Results indicate that OPS n manages to save battery to various extents while maintaining schedulability, and demonstrates good load compatibility and close-to-optimal performance on average.

关键词： battery optimization low power task scheduling dynamic voltage scaling slack

A Compound Prescheduling Algorithm for Real-Time Tasks’ Battery-Aware Scheduling

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Wuhan University Journal of Natural Sciences 2009年第3期14卷 235-240页

作者： CAO Yang gao xun LIAO Weihui LI Geyang School of Electronic Information Wuhan UniversityWuhan 430072 Hubei China State Key Laboratory of Software Engineering WuhanUniversity Wuhan 430072 Hubei China

To minimize battery consumption for portable devices, the prescheduling policy of battery-aware scheduling was improved by optimizing slack distribution. A battery-aware compound task scheduling （BACTS） algorithm considering various aspects including task deadline, current and execution time was proposed and evaluated with the previously prevailing earliest deadline first （EDF） algorithm. The results indicate the proposed BACTS algorithm manages to figure out a feasible schedule （if available） in battery-aware task scheduling even for disorganized connected task graphs beyond the solving ability of EDF. Its schedule achieves better performance with lower charge consumption after prescheduling, and also lower or equal optimum charge consumption after voltage scaling.

关键词： scheduling algorithm battery dynamic voltage scaling slack

Effect of the target positions on the rapid identification of aluminum alloys by using filament-induced breakdown spectroscopy combined with machine learning

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Chinese Physics B 2022年第5期31卷 379-385页

作者： Xiaoguang Li Xuetong Lu Yong Zhang Shaozhong Song Zuoqiang Hao xun gao School of Electrical Information Changchun Guanghua UniversityChangchun 130033China School of Physics Changchun University of TechnologyChangchun 130600China School of Information Engineering Jilin Engineering Normal UniversityChangchun 130052China School of Physics and Electronic Sciences Shandong Normal UniversityJinan 250358China

Filament-induced breakdown spectroscopy(FIBS)combined with machine learning algorithms was used to identify five aluminum *** study the effect of the distance between focusing lens and target surface on the identification accuracy of aluminum alloys,principal component analysis(PCA)combined with support vector machine(SVM)and Knearest neighbor(KNN)was *** intensity and intensity ratio of fifteen lines of six elements(Fe,Si,Mg,Cu,Zn,and Mn)in the FIBS spectrum were *** distances between the focusing lens and the target surface in the pre-filament,filament,and post-filament were 958 mm,976 mm,and 1000 mm,*** source data set was fifteen spectral line intensity ratios,and the cumulative interpretation rates of PC1,PC2,and PC3 were 97.22%,98.17%,and 95.31%,*** first three PCs obtained by PCA were the input variables of SVM and *** identification accuracy of the different positions of focusing lens and target surface was obtained,and the identification accuracy of SVM and KNN in the filament was 100%and 90%,*** source data set of the filament was obtained by PCA for the first three PCs,which were randomly selected as the training set and test set of SVM and KNN in 3:*** identification accuracy of SVM and KNN was 97.5%and 92.5%,*** research results can provide a reference for the identification of aluminum alloys by FIBS.

关键词： filament-induced breakdown spectroscopy(FIBS) principal component analysis(PCA) support vector machine(SVM) K-nearest neighbor(KNN) aluminum alloys identification

Energy Balance Routing Protocol for Wireless Sensor Networks Based on Fuzzy Next-Hop Selection

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Wuhan University Journal of Natural Sciences 2009年第2期14卷 148-152页

作者： LI Geyang CAO Yang gao xun TANG Juan School of Electronic Information Wuhan University Wuhan 430072 Hubei China State Key Laboratory of Software Engineering Wuhan University Wuhan 430072 Hubei China

The implementation of energy balanced routing is an effective way to prolong the lifetime of wireless sensor networks （WSNs）. To balance energy consumption, fuzzy next-hop selecting strategy was designed： nodes of different gradients are fuzzily classified into relevant levels; each level has a chance to provide a node with maximum residual energy as the next-hop. Based on the above strategy and directed diffusion （DD）, fuzzy next-hop selection based energy balance （FNSEB） routing protocol was proposed. The simulation results showed that FNSEB utilized the limited energy more thoroughly and rationally, decreased the average energy consumption and prolonged the lifetime of WSNs.

关键词： wireless sensor networks (WSNs) energy balanced routing fuzzy next-hop selection gradient directed diffusion (DD)

Time-resolved spectroscopy of collinear femtosecond and nanosecond dual-pulse laser-induced Cu plasmas

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Plasma Science and Technology 2021年第11期23卷 121-127页

作者： Qiuyun WANG Hongxia QI Xiangyu ZENG Anmin CHEN xun gao Mingxing JIN Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012People's Republic of China School of Science Changchun University of Science and TechnologyChangchun 130022People's Republic of China

In this paper,we investigate the time-resolved spectroscopy of collinear femtosecond(fs)and nanosecond(ns)dual-pulse(DP)laser-induced plasmas.A copper target was used as an experimental sample,and the fs laser was considered as the time zero reference *** interpulse delay between fs and ns laser beams was 3μ***,we compared the time-resolved peak intensities of Cu(I)lines from Cu plasmas induced by fs+ns and ns+fs DP lasers with collinear *** results showed that compared with the ns+fs DP,the fs+ns DP laser-induced Cu plasmas had stronger peak intensities and longer ***,we calculated time-resolved plasma temperatures using the Boltzmann plot with three spectral lines at Cu(I)510.55,515.32 and 521.82 *** addition,time-resolved electron densities were calculated based on Stark broadening with Cu(I)line at 521.82 *** was found that compared with ns+fs DP,the plasma temperatures and electron densities of the Cu plasmas induced by fs+ns DP laser were ***,we observed images of ablation craters under the two experimental conditions and found that the fs+ns DP laser-produced stronger ablation,which corresponded to stronger plasma emission.

关键词： laser-induced breakdown spectroscopy fs+ns and ns+fs dual-pulse time-resolved spectroscopy plasma temperature electron density

Collective modes of Weyl fermions with repulsive S-wave interaction

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Chinese Physics B 2020年第11期29卷 146-150页

作者： xun-gao Wang Huan-Yu Wang Jiang-Min Zhang Wu-Ming Liu Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Fujian Provincial Key Laboratory of Quantum Manipulation New Energy Materials College of Physics and Energy Fujian Normal UniversityFuzhou 350007China Fujian Provincial Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient Devices Xiamen 361005China Songshan Lake Materials Laboratory Dongguan 523808China

We calculate the spin and density susceptibility ofWeyl fermions with repulsive S-wave interaction in ultracold *** fermions have a linear dispersion,which is qualitatively different from the parabolic dispersion of conventional *** find that there are different collective modes for the different strengths of repulsive interaction by solving the poles equations of the susceptibility in the random-phase *** the long-wavelength limit,the sound velocity and the energy gaps vary with the different strengths of the interaction in the zero sound mode and the gapped modes,*** particle-hole continuum is obtained as well,where the imaginary part of the susceptibility is nonzero.

关键词： ultracold gases collective modes random-phase approximation