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The position of tree shrews in the mammalian tree:Comparing multi-gene analyses with phylogenomic results leaves monophyly of Euarchonta doubtful

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Integrative Zoology 2015年第2期10卷 186-198页

作者： xuming zhou Fengming SUN Shixia XU Guang YANG Ming LI Key laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing China University of Chinese Academy of Sciences Beijing China CUHK-BGI Innovation Institute of Trans-omics Chinese University of Hong KongShatinNew TerritoriesHong KongChina BGI-Shenzhen ShenzhenChina Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life SciencesNanjing Normal UniversityNanjingChina

The well-accepted Euarchonta grandorder is a pruned version of Archonta nested within the Euarchontoglires(or Supraprimates)*** present,it includes tree shrews(Scandentia),flying lemurs(Dermoptera)and primates(Primates).Here,a phylogenomic dataset containing 1912 exons from 22 representative mammals was compiled to investigate the phylogenetic relationships within this *** analyses and hypothesis testing suggested that tree shrews can be classified as a sister group to Primates or to Glires or even as a basal clade within *** analyses of both modified and original previously published datasets found that the phylogenetic position of tree shrews is *** also found that two of three exonic indels reported as synapomorphies of Euarchonta in a previous study do not unambiguously support the monophyly of such a ***,the monophyly of both Euarchonta and Sundatheria(Dermoptera+Scandentia)are *** dating and divergence rate analyses suggested that the ancestor of Euarchontoglires experienced a rapid divergence,which may cause the unresolved position of tree shrews even using the whole genomic data.

关键词： Euarchonta Euarchontoglires phylogenomics tree shrews

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输水管道基础处理及镇墩对安全的影响分析

人民珠江 2024年第S1期45卷 166-169页

作者：高杰周旭明唐亚萍广东中灏勘察设计咨询有限公司云南分公司云南红河661100 红河哈尼族彝族自治州水利水电工程地质勘察咨询规划研究院云南红河661100

管道线路布置应与工程区域的相关规划相协调,并符合工程总体布置要求,考虑地形、地质、环境、水力学、施工、交通、运行管理、建设征占地、既有地面地下设施等因素,经技术经济比较后确定。特别管道基础对管道的安全稳定运行非常重要,在... 详细信息

管道线路布置应与工程区域的相关规划相协调,并符合工程总体布置要求,考虑地形、地质、环境、水力学、施工、交通、运行管理、建设征占地、既有地面地下设施等因素,经技术经济比较后确定。特别管道基础对管道的安全稳定运行非常重要,在管道铺设过程中,往往会遇到多种地质条件,如软基、地下水、澎胀土等。一般要求管道和镇、支墩置于坚实稳定的硬基之上,对置于软基之上也是可行的,但须采取一定的措施保证其承载能力和正常运行要求。

关键词：水利水电工程基础处理镇墩输水管道管线运行

方形基坑尺寸效应对长短桩围护结构支护效果的影响

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土木与环境工程学报（中英文） 2024年第2期46卷 33-41页

作者：周旭明詹刚毅石钰锋占宇飞徐长节蒋亚龙华东交通大学江西省岩土工程基础设施安全与控制重点实验室南昌330013 中铁上海设计院集团有限公司上海200070 华东交通大学江西建筑设计院有限公司南昌330013

为研究方形基坑尺寸效应对长短桩围护结构支护效果的影响,以某桥梁承台基坑为依托,采用数值分析手段,通过现场实测对选用参数进行验证,依托选用参数拟定不同平面尺寸计算工况,通过地层应力与桩后土压力变化分析其尺寸效应;通过对比长短... 详细信息

为研究方形基坑尺寸效应对长短桩围护结构支护效果的影响,以某桥梁承台基坑为依托,采用数值分析手段,通过现场实测对选用参数进行验证,依托选用参数拟定不同平面尺寸计算工况,通过地层应力与桩后土压力变化分析其尺寸效应;通过对比长短桩围护结构与等长桩围护结构的变形受力差异,探明尺寸效应对长短桩围护结构支护效果的影响。结果表明:当方形基坑尺寸较小时,在坑边一定距离处会形成连续、封闭的“类圆形”拱区域,存在与圆形基坑中环箍效应相似的“类环箍效应”,算例表明该效应在边长大于18.0 m后环箍断开,效应消失;当拱区域封闭为环箍时,围护结构桩后土压力显著降低,当其不封闭时,土压力增长,坑边中部桩后土压力增长量大于坑角处;长短桩围护结构的支护效果在尺寸效应越强的方形基坑中降低越少,基坑的尺寸效应对其变形及稳定有利,算例中边长小于等于14.4 m的基坑可充分利用其尺寸效应,采用长短桩代替等长桩围护,做到绿色环保。

关键词：长短桩围护结构基坑尺寸效应支护效果

Editorial: Welcome Message from Editor-in-Chief, xuming Mo

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Congenital Heart Disease 2024年第1期19卷 1-3页

作者： xuming Mo Department of Cardiothoracic Surgery Children’s Hospital of Nanjing Medical UniversityNanjing210008China

1 Introduction The release of the most recent volume of Congenital Heart Disease(CHD)(Issue 19,Volume 1,2024)coincides with my assumption of the role of Co-Editor-In-Chief for CHD.I would like to express my appreciation to CHD for providing me with the opportunity to use the Editorial page.I took on this responsibility on November 18,2023.I would like to take this opportunity to share reflections and convey my *** in 2006,CHD stands as the pioneering professional periodical exclusively dedicated to the exploration and treatment of congenital cardiac abnormalities across all age *** paramount goal is to elevate the scholarly and educational dimension of CHD,driven by an unwavering commitment to provide optimal,holistic cardiac care to patients spanning infancy to *** commitment remains steadfast,with a focus on community service,research,and education quality,regardless of the patient’s financial situation.

关键词： cardiac education release

Water Extract of Rice False Smut Balls Activates Nrf2/HO-1 and Apoptosis Pathways,Causing Liver Injury

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Rice science 2023年第5期30卷 473-485,I0025-I0028页

作者： ZHANG Guomei LI Han LIU Shanshan zhou xuming LU Mingyang TANG Liang SUN Lihua School of Public Health(Food Science and Engineering) Hangzhou Medical CollegeHangzhou 310013China

Ustiloxins are vital cyclopeptide mycotoxins originally isolated from rice false smut balls that form in rice spikelets infected by the fungal pathogen Ustilaginoidea *** toxicity of the water extract of rice false smut balls(RBWE) remains to be *** have shown that RBWE may be toxic to animals,but toxicological evidence is still *** this study,we found that the IC50 values of RBWE to BNL CL.2 cells at 24 and 48 h were 40.02 and 30.11 μg/m L,respectively,with positive correlations with dose toxicity and time *** treatment with RBWE,the number of BNL CL.2 cells decreased significantly,and the morphology of BNL CL.2 cells showed atrophy and wall *** induced DNA presynthesis phase arrest of BNL CL.2 cells,increased the proportion of apoptotic cells and inhibited cell *** up-regulated reactive oxygen species(ROS) levels and lowered mitochondrial membrane ***,Western blot and q RT-PCR results suggested that RBWE exerted the above effects by promoting the Nrf2/HO-1 and caspase-induced apoptosis pathways in vitro and in *** contents of alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,and total bile acids in the serum of mice from Institute of Cancer were significantly up-regulated by *** the same time,RBWE can lead to increases in ROS and malondialdehyde contents,decreases in contents of oxidized glutathione,glutathione and reduced glutathione,as well as decrease in catalase and superoxide dismutase activities in mouse liver tissues,demonstrating that oxidative stress occurred in ***,liver damage was further detected by haematoxylin-eosin staining and electron microscopy to verify the damage to the mice caused by *** general,RBWE may cause hepatotoxicity in vivo and in vitro via the apoptosis pathway,which provides a reference for hepatotoxicity and its mechanism of action.

关键词： water extract rice false smut ball ustiloxin liver injury Nrf2/HO-1 pathway apoptosis pathway

Apoptotic and nonapoptotic function of caspase 7 in spermatogenesis

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Asian Journal of Andrology 2017年第1期19卷 47-51页

作者： Bin Lei xuming zhou Daojun Lv Bo Wan Huayan Wu Liren Zhong Fangpeng Shu Xiangming Mao Department of Urology Nanfang Hospital Southern Medical University Guangzhou Guangdong Province China Department of Urology Peking University Shenzhen Hospital Shenzhen PKU-HKUST Medical Center Shenzhen Guangdong Province China.

Recent studies have reported that caspase 7 has an apoptotic and nonapoptotic function. However, the relationship between caspase 7 and spermatogenesis remains unknown. This study aimed to investigate the possible function of caspase 7 during normal and abnormal spermatogenesis. The cleaved form of caspase 7 was detected in testis tissues at different postpartum times （5-14 weeks） by qRT-PCR, Western blot and immunohistochemistry （IHC）. Then, the mice models of spermatogenic dysfunction were obtained by busulfan （30 mg kg-1） to further evaluate the potential function and mechanism of caspase 7. qRT-PCR and Western blot results showed that caspase 7 expression was gradually elevated from 5 to 14 weeks, which was not connected with apoptosis. IHC results revealed that caspase 7 was mainly located in spermatogenic cells and Leydig cells. In addition, spermatogenic dysfunction induced by busulfan gradually enhanced the apoptosis and elevated the expression of caspase 3, caspase 6, and caspase 9, but decreased the expression of caspase 7 in spermatogenic cells. However, when spermatogenic cells were mostly disappeared at the fourth week after busulfan treatment, caspase 7 expression in Leydig cells was significantly increased and positively correlated with the expression of caspase 3, caspase 6, and caspase 9. Therefore, these results indicate that caspase 7 has a nonapoptic function that participates in normal spermatogenesis, but also displays apoptotic function in spermatogenic dysfunction.

关键词： apoptosis caspase 7 caspases spermatogenesis spermatogenic dysfunction

Population genomic analysis reveals distinct demographics and recent adaptation in the black flying fox(Pteropus alecto)

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遗传学报:英文版 2023年第8期50卷 554-562页

作者： Haopeng He Hechuan Yang Randy Foo Wharton Chan Feng Zhu Yunsong Liu xuming zhou Liang Ma Lin-Fa Wang Weiwei Zhai Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Programme in Emerging Infectious Diseases Duke-NUS Medical SchoolSingapore 169857Singapore Singhealth Duke-NUS Global Health Institute Singapore 169857Singapore Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China

As the only mammalian group capable of powered flight,bats have many unique biological *** comparative genomic studies in bats have focused on long-term ***,the microevolutionary processes driving recent evolution are largely *** resequencing data from 50 black flying foxes(Pteropus alecto),one of the model species for bats,we find that black flying fox has much higher genetic diversity and lower levels of linkage disequilibrium than most of the mammalian *** inference reveals strong population fluctuations(>100 fold)coinciding with multiple historical events including the last glacial change and Toba super eruption,suggesting that the black flying fox is a very resilient species with strong recovery *** long-term adaptation in the black flying fox is enriched in metabolic genes,recent adaptation in the black flying fox has a unique landscape where recently selected genes are not strongly enriched in any functional *** demographic history and mode of adaptation suggest that black flying fox might be a well-adapted species with strong evolutionary *** together,this study unravels a vibrant landscape of recent evolution for the black flying fox and sheds light on several unique evolutionary processes for bats comparing to other mammalian groups.

关键词： Bats The black flying fox Microevolution Population fluctuations Toba eruption