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Identification of hyper-methylated tumor suppressor genes-based diagnostic panel for esophageal squamous cell carcinoma(ESCC) in a Chinese Han population

Identification of hyper-methylated tumor suppressor genes-ba...

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2017中国长三角遗传学大会

作者： Chenji Wang Weilin Pu Dunmei Zhao Sidi Chen Yinghui Zhou Zhenglei He xulong feng Ying Wang Caihua Li Li Jin Shicheng Guo Jiucun Wang Minghua Wang Department of Biochemistry and Molecular Biology Medical CollegeSoochow University State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and DevelopmentSchool of Life SciencesFudan University Ministry of Education Key Laboratory of Contemporary Anthropology School of Life SciencesFudan University

Background:DNA methylation-based biomarkers were suggested to be promising for early cancer ***,DNA methylation-based biomarkers for esophageal squamous cell carcinoma(ESCC),especially in Chinese Han populations have not been identified and evaluated ***:Candidate tumor suppressor genes(N=65) were selected through literature searching and four public high-throughput DNA methylation microarray datasets including 136 samples totally were collected for initial *** bisulfite sequencing was applied in an independent cohort of 94 pairs of ESCC and normal tissues from a Chinese Han population for eventual ***:ADHFE1,EOMES,SALL1 and TFPI2 were identified and validated in the ESCC samples from a Chinese Han *** four candidate regions were validated to be significantly hypermethylated in ESCC samples(ADHFE1,p = 1.70×10;EOMES,p = 2.90×10;SALLl,p = 3.90×10;TFPI2,p = 3.40 × 10).Logistic regression based prediction model shown a robust ESCC classification performance(Sensitivity = 66%,Specificity = 87%,AUC = 0.81).Moreover,advanced classification method had better performances(random forest and naive Bayes).Interestingly,the diagnostic performance could be improved in non-alcohol use subgroup(AUC = 0.84).Conclusion:Methylation panels of ADHFEl,EOMES,SALL1 and TFPI2 could be an effective methylation-based assay for ESCC diagnosis.

关键词： Esophageal squamous cell carcinoma DNA methylation Biomarker Diagnosis Targeted bisulfite sequencing

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Fast Parallel Algorithm for Slicing STL Based on Pipeline

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Chinese Journal of Mechanical Engineering 2016年第3期29卷 549-555页

作者： MA xulong LIN feng YAO Bo Key Laboratory for Advanced Materials Processing Technology Ministry of Education of China Tsinghua University Department of Mechanical Engineering Army Aviation Institute of PLA

In Additive Manufacturing field, the current researches of data processing mainly focus on a slicing process of large STL files or complicated CAD models. To improve the efficiency and reduce the slicing time, a parallel algorithm has great advantages. However, traditional algorithms can＇t make full use of multi-core CPU hardware resources. In the paper, a fast parallel algorithm is presented to speed up data processing. A pipeline mode is adopted to design the parallel algorithm. And the complexity of the pipeline algorithm is analyzed theoretically. To evaluate the performance of the new algorithm, effects of threads number and layers number are investigated by a serial of experiments. The experimental results show that the threads number and layers number are two remarkable factors to the speedup ratio. The tendency of speedup versus threads number reveals a positive relationship which greatly agrees with the Amdahl＇s law, and the tendency of speedup versus layers number also keeps a positive relationship agreeing with Gustafson＇s law. The new algorithm uses topological information to compute contours with a parallel method of speedup. Another parallel algorithm based on data parallel is used in experiments to show that pipeline parallel mode is more efficient. A case study at last shows a suspending performance of the new parallel algorithm. Compared with the serial slicing algorithm, the new pipeline parallel algorithm can make full use of the multi-core CPU hardware, accelerate the slicing process, and compared with the data parallel slicing algorithm, the new slicing algorithm in this paper adopts a pipeline parallel model, and a much higher speedup ratio and efficiency is achieved.

关键词： additive manufacturing STL model slicing algorithm data parallel pipeline parallel

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Surface crack evolution patterns in freeze-thaw damage of fissured rock bodies

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Journal of Mountain Science 2024年第9期21卷 3094-3107页

作者： KANG Zhiqiang WANG Zhilei SHAO Luhang feng Jiangjiang YAO xulong College of Mining Engineering North China University of Science and TechnologyTangshan 063200China Green Intelligent Mining Technology Innovation Center of Hebei Province North China University of Science and TechnologyTangshan 063210China Luannan Macheng Mining Co. Ltd.Shougang Group Co.LtdLuannan CountyTangshan 063500China

To explore the effects of freeze‒thaw cycles on the mechanical properties and crack evolution of fissured sandstone,biaxial compression experiments were carried out on sandstone subjected to freeze‒thaw cycles to characterize the changes in the physical and mechanical properties of fissured sandstone caused by freeze‒thaw *** crack evolution and crack change process on the surface of the fissured sandstone were recorded and analysed in detail via digital image technology(DIC).Numerical simulation was used to reveal the expansion process and damage mode of fine-scale cracks under the action of freeze‒thaw cycles,and the simulation results were compared and analysed with the experimental data to verify the reliability of the numerical *** results show that the mass loss,porosity,peak stress and elastic modulus all increase with increasing number of freeze‒thaw *** an increase in the number of freeze‒thaw cycles,a substantial change in displacement occurs around the prefabricated cracks,and a stress concentration appears at the crack *** new cracks continue to sprout at the tips of the prefabricated cracks until the microcracks gradually penetrate into the main cracks,the displacement cloud becomes obviously discontinuous,and the contours of the displacement field in the crack fracture damage area simply intersect with the prefabricated cracks to form an obvious *** damage patterns of the fractured sandstone after freeze‒thaw cycles clearly differ,forming a symmetrical"L"-shaped damage pattern at zero freeze‒thaw cycles,a symmetrical"V"-shaped damage pattern at 10 freeze‒thaw cycles,and a"V"-shaped damage pattern at 20 freeze‒thaw *** 20 freeze‒thaw cycles,a"V"-shaped destruction pattern and"L"-shaped destruction pattern are formed;after 30 freeze‒thaw cycles,an"N"-shaped destruction pattern is *** shows that the failure mode of fractured sandstone gradually becomes more complicated with an increasing number of freeze‒t

关键词： Freeze‒thaw cycles Fissured sandstone Particle flow software Rock mechanics Crack extension pattern DIC technique

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整合素αV基因多态位点rs11902171与肺癌易感性的关联研究

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南通大学学报（医学版） 2016年第5期36卷 373-377页

作者：张雅娟何正磊张苹王辰骥冯旭龙王明华苏州卫生职业技术学院医学技术学院苏州215009 苏州大学基础医学与生物科学学院

目的：探究整合素αV（integrinαV,ITGAV）基因3’UT R区的单核苷酸多态位点（single nucleotide polymorphism,SNP）rs11902171（G/C）与中国人群肺癌遗传易感性的关系。方法：采用病例-对照研究设计,随机选取481例肺癌患者和560例... 详细信息

目的：探究整合素αV（integrinαV,ITGAV）基因3’UT R区的单核苷酸多态位点（single nucleotide polymorphism,SNP）rs11902171（G/C）与中国人群肺癌遗传易感性的关系。方法：采用病例-对照研究设计,随机选取481例肺癌患者和560例健康人群对照,收集外周血样本后抽提基因组DNA,用高分辨率熔解曲线（high resolution melting,HRM）方法对rs11902171（G/C）位点进行基因分型,采用SPSS 19.0软件对分型数据进行统计分析。结果：rs11902171位点分型后得到GG和GC两种基因型。在对照组中的分布频率分别为GG基因型89.8%、GC基因型10.2%,在病例组中的分布频率分别为GG基因型80.2%、GC基因型19.8%,两组间的基因型分布频率差异有统计学意义（P〈0.001）,且GC基因型相对于GG基因型能显著增加中国人群的肺癌遗传易感性（OR=2.18,95%CI：1.53~3.12）。根据吸烟及饮酒等因素分层分析显示,GC基因型除了饮酒组外,在其他组（〉或≤60岁年龄组;男性或女性组;非饮酒组;吸烟或非吸烟组）均能显著增加肺癌易感性（均P〈0.05）。结论：ITGAV基因的SNP位点rs11902171（G/C）与中国人群肺癌遗传易感性具有显著的相关性。

关键词：整合素αV 单核苷酸多态性肺癌易感性高分辨率熔解曲线

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Fault Tolerant Control Method for Three-Level Photovoltaic Inverter Based on Redundant Voltage Space Vector 36

Fault Tolerant Control Method for Three-Level Photovoltaic I...

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第36届中国控制会议

作者： xulong Zhang feng Wang Wen Ji Shuyun Qiao Yanjing Cao Department of Information and Electrical Engineering Xuzhou University of Technology

ISBN: (纸本)9781538629185

Power devices short circuit or open circuit fault can have serious impact on the reliability of the photovoltaic inverter system during the operational *** the basis of analysis of the fault characteristics and types with neutral point clamped three-level photovoltaic inverter as the research object,fault diagnosis logic is *** tolerant control strategy for three-level photovoltaic inverter based on redundant space vectors is *** changes of photovoltaic inverter space vector are analyzed before and after the fault occurs,photovoltaic inverter will maintain fault-tolerant operation by utilizing the redundant voltage space *** and experiment verify the feasibility and effectiveness of the proposed fault tolerant control method and the proposed method has a good fault tolerant performance.

关键词： Photovoltaic inverter fault tolerant control three-level redundant voltage space vector

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NF-κB1基因多态位点rs4648127与胃癌易感性的研究

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南通大学学报（医学版） 2017年第2期37卷 96-100页

作者：蒋骅付霖廖蔼东何正磊王辰骥冯旭龙赵敦梅毛旭华乔国洪江苏省苏州市相城区第二人民医院消化内科苏州215143 苏州大学基础医学与生物科学学院生物化学与分子生物学江苏省宜兴市人民医院检验科

目的:探讨位于核因子κB1(nuclear factor kappa subunit 1,NF-κB1)基因内含子区的多态性位点rs4648127与中国人群胃癌易感性的关联。方法:采用病例-对照研究,以363例胃癌患者和506例年龄、性别相匹配的健康对照者作为研究对象,用高分... 详细信息

目的:探讨位于核因子κB1(nuclear factor kappa subunit 1,NF-κB1)基因内含子区的多态性位点rs4648127与中国人群胃癌易感性的关联。方法:采用病例-对照研究,以363例胃癌患者和506例年龄、性别相匹配的健康对照者作为研究对象,用高分辨率熔解曲线(high resolution melting,HRM)方法对rs4648127多态位点进行基因分型,最后通过SPSS 19.0统计分析软件对分型数据进行统计分析。结果:rs4648127位点的突变基因型CT与胃癌易感性有显著的相关性(P=0.005,OR=0.45,95%CI=0.25~0.79)。根据吸烟及饮酒等因素分层分析显示,在年龄组、性别组、非吸烟组及非饮酒状态组中均体现出CT基因型能够显著降低胃癌易感性风险(P<0.05)。结论:NF-κB1多态性位点rs4648127能够显著降低中国人群胃癌易感性。

关键词：胃癌核因子κB1 单核苷酸多态性易感性高分辨率熔解曲线

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基于OpenMP的快速并行分层算法

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计算机辅助设计与图形学学报 2015年第4期27卷 747-753页

作者：马旭龙林峰清华大学机械工程系先进成型制造教育部重点实验室北京100084

为了充分利用现有的多核CPU计算资源,提出一种基于OpenMP框架的快速并行分层算法,并对其性能进行讨论.该算法利用模型自然分组特征建立拓扑关系分组,使得模型拓扑数据结构的建立时间缩短;在此基础上,采用基于OpenMP的多线程计算,将拓扑... 详细信息

为了充分利用现有的多核CPU计算资源,提出一种基于OpenMP框架的快速并行分层算法,并对其性能进行讨论.该算法利用模型自然分组特征建立拓扑关系分组,使得模型拓扑数据结构的建立时间缩短;在此基础上,采用基于OpenMP的多线程计算,将拓扑结构的建立过程和求取层片轮廓的过程并行化计算,可以取得接近CPU核数的加速比,因此分层时间明显降低.对于复杂三维模型的超大STL文件进行分层处理,实例计算表明文中算法是一种高效且易于实现的方法.

关键词：增材制造 STL分层 OpenMP框架并行分层算法

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激光微熔覆沉积成形工艺参数对TC4钛合金沉积组织的影响

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稀有金属材料与工程 2016年第2期45卷 439-444页

作者：姚波林峰马旭龙清华大学先进成形制造教育部重点实验室北京100084 陆军航空兵学院北京101123

通过改变激光微熔覆沉积制造过程中的激光功率和扫描速度,研究了成形工艺参数对TC4合金组织和显微硬度的影响。结果表明:激光微熔覆沉积组织可以为贯穿整个熔覆层的外延生长的柱状晶,也可能下部晶粒延续着前一层的柱状晶生长,最上部为... 详细信息

通过改变激光微熔覆沉积制造过程中的激光功率和扫描速度,研究了成形工艺参数对TC4合金组织和显微硬度的影响。结果表明:激光微熔覆沉积组织可以为贯穿整个熔覆层的外延生长的柱状晶,也可能下部晶粒延续着前一层的柱状晶生长,最上部为快速凝固的枝晶薄层。宏观上存在明暗2个组织区域,当P/V值小于40 W·s·mm^(-1)时,成形试样的显微组织顶部区域为明区,下部为暗区。2个区域的组织都为细长针状马氏体,明区组织更细密。同时,明区的硬度要比暗区高,并且随着激光功率的增加或扫描速度的减小,顶部明区的宽度增加,而明区和暗区的硬度都呈下降趋势。反之为暗区在上,明区在下。此时,明区的组织仍然是细针状的马氏体组织。暗区是由于发生了固溶时效处理,细针状马氏体组织粗化,同时暗区的硬度要高于明区的硬度。

关键词：激光微熔覆 TC4 工艺参数显微组织显微硬度

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End-Permian conodont fauna from Dongpan section:Correlation between the deep-and shallow-water facies

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Science China Earth Sciences 2008年第11期51卷 1611-1622页

作者： GenMing Luo (1) (2) xulong Lai (1) (2) QingLai feng (1) (3) HaiShui Jiang (1) (2) Paul Wignall (4) KeXin Zhang (1) (3) YaDong Sun (2) Jun Wu (1) (2) School of Earth and Environment University of Leeds LS2 9JT Leeds UK

This paper systematically investigated the conodonts from the uppermost Permian to the Lower Triassic at the Dongpan Section, Southern Guangxi, South China, and obtained abundant Late Permian conodonts from the syndepositional limestone lenses of beds 3 and 5-2 at this section. One genus and eight species of conodont P1 element including one new species, Neogondolella dongpanensis sp. nov., have been identified. The feature of conodont fauna indicates that conodonts collected from beds 3 and 5 at the Dongpan Section belong to the Neogondolella yini conodont zone, and correspond to bed 24 at the Meishan Section. Based on these conodont data, we suggest that the Neoalbaillella optima radiolarian zone at the Dongpan Section at least extended to the upper part of the N. yini conodont zone.

关键词： Dongpan Section end-Permian conodont fauna biostratigraphic correlation

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改进保留非线性算法在介损测量应用中的研究

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高电压技术 2005年第3期31卷 39-40页

作者：袁旭龙冯小华邵阳学院邵阳422000 武汉大学电气工程学院武汉430072

摘针对高阶正弦拟合法中迭代所用的运算时间和计算精度之间的矛盾制约该法用于介损测量的问题。提出一种快速收敛潮流算法—改进保留非线性算法,使介损的数字化测量中,在 tanδ<0. 000 3 时,计算时间<10ms。在满足介损在线监测的同时,... 详细信息

摘针对高阶正弦拟合法中迭代所用的运算时间和计算精度之间的矛盾制约该法用于介损测量的问题。提出一种快速收敛潮流算法—改进保留非线性算法,使介损的数字化测量中,在 tanδ<0. 000 3 时,计算时间<10ms。在满足介损在线监测的同时,还可以实时检测系统频率,为同步采样提供了一条新途径。

关键词：介损损耗高阶正弦拟合法改进保留非线性法修正理想采样频率

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