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A review on phospholipids and their main applications in drug delivery systems

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Asian Journal of Pharmaceutical Sciences 2015年第2期10卷 81-98页

作者： Jing Li xuling wang Ting Zhang Chunling wang Zhenjun Huang Xiang Luo Yihui Deng School of Pharmacy Shenyang Pharmaceutical UniversityNo.103Wenhua RoadShenyang 110016China

Phospholipids have the characteristics of excellent biocompatibility and a especial *** unique properties make phospholipids most appropriate to be employed as important pharmaceutical excipients and they have a very wide range of applications in drug delivery *** aim of this review is to summarize phospholipids and some of their related applications in drug delivery systems,and highlight the relationship between the properties and applications,and the effect of the species of phospholipids on the efficiency of drug *** refer to some relevant literatures,starting from the structures,main sources and properties of phospholipids to introduce their applications in drug delivery *** present article focuses on introducing five types of carriers based on phospholipids,including liposomes,intravenous lipid emulsions,micelles,drug-phospholipids complexes and cochleates.

关键词： Phospholipids Biocompatibility Amphiphilicity Drug delivery systems

Analysis of the Immune Response by Standardized Whole‑Blood Stimulation with Metabolism Modulation

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Phenomics 2024年第1期4卷 81-89页

作者： Jialin Zhao xuling Han Helian Li Yali Luo Yan Fang Yun wang Jian Gao Yiran Zhao Jingxuan Han Feng Qian State Key Laboratory of Genetic Engineering ShanghaiPublic Health Clinical CenterHuman PhenomeInstituteZhangjiang Fudan International InnovationCenter and School of Life SciencesFudan UniversityShanghai 200438China Ministry of Education Key Laboratory of ContemporaryAnthropology School of Life SciencesFudan UniversityShanghai 200438China Institute of Immunophenome International Human PhenomeInstitutes(Shanghai)Shanghai 200433China

The immune system defends the body from infection and plays a vital role in a wide range of health *** afects a series of physiological processes,including those linked to the function of human immune *** metabolism modulates immune cell activation and cytokine *** the relationship between metabolism and immune response has important implications for the development of immune-based ***,the deployment of large-scale functional assays to investigate the metabolic regulation of immune response has been limited by the lack of standardized ***,we present a protocol for the analysis of immune response using standardized whole-blood stimulation with metabolism *** immune stimuli including pattern recognition receptor(PRR)ligands and microbial stimuli were incubated with fresh human whole *** metabolic inhibitors were used to modulate metabolic status in the immune *** variable immune responses after metabolic interventions were *** described in detail the main steps involved in the whole-blood stimulation and cytokines quantifcation,namely,collection and treatment of whole blood,preparation of samples and controls,cytokines detection,and stimulation with metabolic *** metabolic inhibitors for anabolic pathways and catabolic pathways exert selective efects on the production of cytokines from immune *** addition to a robust and accurate assessment of immune response in cohort studies,the standardized whole-blood stimulation with metabolic regulation might provide new insights for modulating immunity.

关键词： Immune response Whole blood stimulation Cytokines Immunometabolism

Effects of complement inhibition on the ABC phenomenon in rats

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Asian Journal of Pharmaceutical Sciences 2017年第3期12卷 250-258页

作者： Lirong wang Yuqing Su xuling wang Kaifan Liang Mengyang Liu Wenya Tang Yanzhi Song Xinrong Liu Yihui Deng Shenyang Pharmaceutical University

Researchers reported that intravenously injected PEGylated colloidal drug carriers lose their long-circulating characteristic and accumulated extensively in liver when they are administrated twice in the same animal with certain intervals. This phenomenon was referred to as the 'accelerated blood clearance(ABC) phenomenon'. Some former studies had found that complement-mediated phagocytosis, activated by antigen–antibody complex, was responsible for inducing the phenomenon. According to the theory, we have used cobra venom factor to deplete complement in vivo and to investigate the effect of complement inhibition on the ABC phenomenon. Rats were administered by injection of cobra venom factor solution to build up the model of complement exhaustion/inhibition, and the effect of the inhibition of complement on ABC phenomenon was carried out. It seemed that inhibition of complement didn’t affect the pharmacokinetic of the first infection. By contrast, in rats of which complement had been depleted, the second dose of PEGylated nanoemulsions showed enhanced circulation time compared with normal rats in a complement inhibition-independent manner, but the ABC phenomenon was not completely eliminated. It indicated that complement inhibition could certainly weaken the accelerated clearance;meanwhile, there were other factors causing the ABC *** findings provide novel insights into the attenuating of ABC phenomenon and lay foundation for further study of immune mechanism.

关键词： ABC phenomenon PEGylated nanoemulsions Complement inhibition Cobra venom factor

Mixed PEGylated surfactant modifying system decrease the accelerated blood clearance phenomenon of nanoemulsions in rats

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Asian Journal of Pharmaceutical Sciences 2017年第1期12卷 28-36页

作者： Yuqing Su Wenya Tang Yanzhi Song Chunling wang Qingjing Tian xuling wang Jingjing Quan Buoqun Li Shaoning wang Yihui Deng School of Pharmacy Shenyang Pharmaceutical University103Wenhua RoadShenyang 110016China Beijing Sihuan-Pharm Company China School of Pharmaceutical Engineering Shenyang Pharmaceutical University103Wenhua RoadShenyang 110016China

The accelerated blood clearance(ABC) phenomenon which is induced by repeated injection of poly(ethylene glycol)(PEG)-coated colloidal carriers gives clinical challenge to the promising drug delivery system. It is necessary to decrease this unexpected immunological response.A novel 4-arm poly(ethylene glycol-5000)4-cholesteryl methyl amide(4-arm PEG5000-CHMA)has been synthesized. The structure of 4-arm PEG5000-CHMA was confirmed by IR and 1H-NMR spectrum. The pharmacokinetics of the tocopheryl nicotinate(TN)-loaded nanoemulsions modified with 4-arm PEG5000-CHMA or/and 1, 2-distearoyl-Sn-glycero-3-phosphoethanolamine-n-[methoxy(poly-ethyleneglycol)-2000](mPEG2000-DSPE) have been studied. Furthermore, the ABC phenomenon has been detailed investigated in rats by TN-loaded nanoemulsions modified with 4-arm PEG5000-CHMA and mPEG2000-DSPE(CPNE). The plasma levels of TN and anti-PEG IgM antibody were determined by HPLC and ELISA, *** circulation time of the CPNEs were comparable to the mPEG2000-DSPE coated nanoemulsions. Moreover, the ABC phenomenon can be decreased by CPNEs. This study designs a method to decrease the ABC phenomenon and develops a clinical promising nanoemulsion for therapeutic or imaging purpose.

关键词： Accelerated blood clearance(ABC) phenomenon Repeated administration 4-arm PEG5000-CHMA Anti-PEG IgM

社区“全专联合”综合干预高血压合并焦虑抑郁患者的效果评价

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上海医药 2022年第20期43卷 55-59页

作者：王徐玲上海市黄浦区瑞金二路街道社区卫生服务中心全科上海200020

目的:分析社区全科和专科医师联合(全专联合)综合干预高血压合并焦虑抑郁患者的效果。方法:选取2019年12月至2021年5月于上海瑞金二路街道社区卫生服务中心就诊的高血压合并焦虑、抑郁患者246例,根据随机数字表法将患者分为观察组123例... 详细信息

目的:分析社区全科和专科医师联合(全专联合)综合干预高血压合并焦虑抑郁患者的效果。方法:选取2019年12月至2021年5月于上海瑞金二路街道社区卫生服务中心就诊的高血压合并焦虑、抑郁患者246例,根据随机数字表法将患者分为观察组123例和对照组123例。观察组中有男性57例,女性66例,平均年龄(61.80±8.32)岁;对照组中由男性61例,女性62例,平均年龄(60.65±8.49)岁。对观察组患者进行社区“全专联合”综合干预,对照组患者在社区接受常规内科降压治疗。比较两组患者干预前后的血压、焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分以及生活质量评分。结果:干预前两组患者的收缩压、舒张压、SAS评分、SDS评分以及各项生活质量评分差异均无统计学意义(均P> 0.05),干预后观察组收缩压、SAS及SDS评分均低于对照组,降压有效率高于对照组(87.80%比72.36%),各项生活质量评分也高于对照组,差异均有统计学意义(均P <0.05)。结论:社区“全专联合”综合干预可有效降低高血压合并焦虑、抑郁患者的血压,改善其焦虑、抑郁状态和生活质量。

关键词：高血压焦虑抑郁 “全专联合” 综合干预

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化学教学的探究性有利于加强师生交往

齐齐哈尔师范高等专科学校学报 2009年第1期 147-148页

作者：王绪玲齐齐哈尔市民族中学黑龙江齐齐哈尔161006

培养学生的科学素养离不开科学的学习过程,科学的核心是探究,教育的重要目标是促进学生的发展,要让受教育者在参与科学的过程中,学习"亲历科学"的探究思想和方法。

关键词：科学探究交往教学模式课程

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基于XML与JAVA的遗留数据集成

科技广场 2007年第9期 105-108页

作者：王绪玲景德镇市商业职工中等专业学校江西景德镇333000

遗留数据是数据挖掘重要的数据源之一,但采用传统的技术难以有效地集成它。本文提出了基于XML结合JAVA技术集成遗留数据的方法,并通过具体示例介绍实现过程,同时说明了该方法的可行性。

关键词：遗留数据数据挖掘 XML JAVA

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回扫:多行文本阅读中必不可少的眼动

心理科学 2024年第3期47卷 581-589页

作者：高晓雷王丹慧李旭玲曾蔓高蕾西藏大学高原脑科学研究中心拉萨850000

回扫是读者的注视点从文本上一行行末到下一行行首的眼动,在多行文本阅读中非常重要且必不可少。目前,回扫的相关研究较少,且主要集中于回扫起跳位置、回扫目标选择、回扫的精确性、与回扫相邻的注视四个方面。本文先简单介绍回扫研究... 详细信息

回扫是读者的注视点从文本上一行行末到下一行行首的眼动,在多行文本阅读中非常重要且必不可少。目前,回扫的相关研究较少,且主要集中于回扫起跳位置、回扫目标选择、回扫的精确性、与回扫相邻的注视四个方面。本文先简单介绍回扫研究中常用的眼动指标,再详细介绍回扫的四个方面的研究,最后提出未来的研究设想:关注其他文字与文字系统的回扫、考察二语阅读中的回扫、探究行末注视是否受行末注视词词汇特征的影响、探讨回扫过程中预视的缺失对词汇加工的影响以帮助我们理解边界范式中的“预视效益”,完善现有模型以适应回扫。

关键词：阅读回扫眼动

宝丰县农民专业合作社发展特点、问题及对策建议

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安徽农学通报 2010年第16期16卷 7-7,33页

作者：王旭玲宝丰县农业局河南宝丰467400

通过对宝丰县农民专业合作社的调查,分析了宝丰县农民专业合作社发展的基本状况、特点和存在的问题,提出了进一步发展完善农民专业合作社的对策建议。

关键词：农业农民专业合作社对策建议宝丰县

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