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AI-Based Advanced Approaches and Dry Eye Disease Detection Based on Multi-Source Evidence:Cases,Applications,Issues,and Future Directions

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Big Data Mining and Analytics 2024年第2期7卷 445-484页

作者： Mini Han wang Lumin Xing Yi Pan Feng Gu Junbin Fang Xiangrong Yu Chi Pui Pang Kelvin Kam-Lung Chong Carol Yim-Lui Cheung xulin Liao Xiaoxiao Fang Jie Yang Ruoyu Zhou Xiaoshu Zhou Fengling wang Wenjian Liu Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University/The First Affiliated Hospital of Faculty of Medicine Macao University of Science and Technology) Zhuhai 519000China Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong 999077China Faculty of Data Science City University of MacaoMacao 999078China Zhuhai Institute of Advanced Technology Chinese Academy of Sciences Zhuhai 519000China Perspective Technology Group Zhuhai 519000China First Affiliated Hospital of Shandong First Medical University Shandong Provincial Qianfoshan Hospital Jinan 250000China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518000China College of Staten Island The City University of New YorkNY 10314USA Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510000China Zhuhai Aier Eye Hospital Zhuhai 519000China College of Artificial Intelligence Chongqing Industry and Trade PolytechnicChongqing 400000China Centre for Science and Technology Exchange and Cooperation between China and Portuguese-Speaking Countries Zhuhai 519000China School of Artificial Intelligence Hezhou UniversityHezhou 542899China

This study explores the potential of Artificial Intelligence(AI)in early screening and prognosis of Dry Eye Disease(DED),aiming to enhance the accuracy of therapeutic approaches for eye-care *** the promising opportunities,challenges such as diverse diagnostic evidence,complex etiology,and interdisciplinary knowledge integration impede the interpretability,reliability,and applicability of AI-based DED detection *** research conducts a comprehensive review of datasets,diagnostic evidence,and standards,as well as advanced algorithms in AI-based DED detection over the past five *** DED diagnostic methods are categorized into three groups based on their relationship with AI techniques:(1)those with ground truth and/or comparable standards,(2)potential AI-based methods with significant advantages,and(3)supplementary methods for AI-based DED *** study proposes suggested DED detection standards,the combination of multiple diagnostic evidence,and future research directions to guide further ***,the research contributes to the advancement of ophthalmic disease detection by providing insights into knowledge foundations,advanced methods,challenges,and potential future perspectives,emphasizing the significant role of AI in both academic and practical aspects of ophthalmology.

关键词： Artificial Intelligence(AI) ophthalmology Dry Eye Disease(DED)detection multi-source evidence

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10 Gb/s classical secure key distribution based on temporal steganography and private chaotic phase scrambling

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Photonics Research 2024年第2期12卷 321-330页

作者： ZHENSEN GAO ZHITAO DENG LIHONG ZHANG xulin GAO YUEHUA AN ANBANG wang SONGNIAN FU ZHAOHUI LI YUNCAI wang YUWEN QIN School of Information Engineering Guangdong University of TechnologyGuangzhou 510006China Pengcheng Laboratory Shenzhen 518062China Key Laboratory of Photonic Technology for Integrated Communication and Sensing Ministry of EducationGuangzhou 510006China School of Optoelectronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou 510665China School of Electrical and Information Technology Sun Yat-sen UniversityGuangzhou 510006China

Secure distribution of high-speed digital encryption/decryption keys over a classical fiber channel is strongly pursued for realizing perfect secrecy communication ***,it is still challenging to achieve a secret key rate in the order of tens of gigabits per second to be comparable with the bit rate of commercial fiber-optic *** this paper,we propose and experimentally demonstrate a novel solution for high-speed secure key distribution based on temporal steganography and private chaotic phase scrambling in the classical physical *** encryption key is temporally concealed into the background noise in the time domain and randomly phase scrambled bit-by-bit by a private chaotic signal,which provides two layers of enhanced security to guarantee the privacy of key distribution while providing a high secret key *** experimentally achieved a record classical secret key rate of 10 Gb/s with a bit error rate lower than the hard-decision forward error correction(HD-FEC)over a 40 km standard single mode *** proposed solution holds great promise for achieving high-speed key distribution in the classical fiber channel by combining steganographic transmission and chaotic scrambling.

关键词： chaotic distribution phase

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基于二次受力的隧道套拱加固损伤衬砌模型试验

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四川大学学报（工程科学版） 2015年第3期47卷 21-28页

作者：刘学增王煦霖何本国桑运龙同济大学测绘与地理信息学院上海200092 中铁第一勘察设计院集团有限公司陕西西安710043 同济大学土木信息技术教育部工程研究中心上海200092 上海同岩土木工程科技有限公司上海200092

松动荷载引起损伤衬砌失稳是不良地层隧道运营期间关键的科学问题。针对此问题,研制了双车道公路隧道带缝衬砌套拱加固模型试验加载装置,可对衬砌结构任意位置施加松动荷载,在损伤衬砌受力同时进行套拱加固,解决了衬砌加固二次受力的"瓶... 详细信息

松动荷载引起损伤衬砌失稳是不良地层隧道运营期间关键的科学问题。针对此问题,研制了双车道公路隧道带缝衬砌套拱加固模型试验加载装置,可对衬砌结构任意位置施加松动荷载,在损伤衬砌受力同时进行套拱加固,解决了衬砌加固二次受力的"瓶颈"问题;开展1∶10模型试验,研究了松动荷载作用下损伤衬砌套拱加固补强效果,对比变形特性、力学响应及破坏模式。结果表明:衬砌结构刚度随荷载增加而退化,套拱加固有效修复受损衬砌,整体结构刚度明显增大,损伤严重衬砌经套拱加固后承载力仍可提高1倍;原衬砌结构破坏位置为拱顶、拱肩和边墙;套拱加固带缝衬砌构件关键控制截面为拱顶和墙脚,拱顶易发生大偏心压弯破坏,建议加强拱顶纵向配筋,提高抗拉承载力;墙脚出现斜裂缝,属于压剪破坏,应增设墙脚箍筋,以提高抗剪承载力。

关键词：隧道损伤衬砌二次受力套拱加固失稳模式

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柔性连接隧道在正断层黏滑错动下的变形特征

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岩石力学与工程学报 2013年第S2期32卷 3545-3551页

作者：刘学增林亮伦王煦霖李昕同济大学土木信息技术教育部工程研究中心上海200092 重庆市建筑科学研究院重庆400015 同济大学土木工程学院上海200092

针对穿越60°倾角活动正断层情况,隧道采取节段长度为0.5D(D为隧道洞径)、节段间柔性连接的隧道抗断措施;并对柔性连接隧道在正断层黏滑错动作用下的受力、变形特征进行模型试验研究。试验结果表明:在距离土体主破裂面1D范围内,柔性连... 详细信息

针对穿越60°倾角活动正断层情况,隧道采取节段长度为0.5D(D为隧道洞径)、节段间柔性连接的隧道抗断措施;并对柔性连接隧道在正断层黏滑错动作用下的受力、变形特征进行模型试验研究。试验结果表明:在距离土体主破裂面1D范围内,柔性连接隧道衬砌结构的纵向、环向应变变化较大。柔性连接隧道的主要破坏形式为节段间转动和错台,隧道节段连接处发生2处转角为33°和28°的转动破坏,破坏范围为2.5D。在相同条件下,与未采取抗断设计的完整隧道相比:柔性连接隧道衬砌结构纵向应变要小于完整隧道应变,其破坏范围也小于完整隧道的破坏范围。

关键词：隧道工程正断层黏滑错动柔性连接变形特征

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A Prospective Cohort Study of Antimony Exposure and Cognitive Impairment in Older Adults—China,2017–2021

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China CDC weekly 2024年第23期6卷 537-541,I0001-I0007页

作者： Yidan Qiu Saisai Ji Chen Chen Jinhui Zhou Jun wang Bing Wu Yuan Wei Fangyu Li xulin Zheng Lanjing Xu Zheng Zhang Feng Zhao Guangdi Chen John SJi Yuebin Lyu Shilu Tong Xiaoming Shi Department of Big Data in Health Science School of Public HealthZhejiang UniversityHangzhou CityZhejiang ProvinceChina China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Center for Global Health School of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of Epidemiology and Biostatistics School of Public HealthJilin UniversityChangchun CityJilin ProvinceChina School of Public Health China Medical UniversityShenyang CityLiaoning ProvinceChina Institute of Environmental Health School of Public Healthand Bioelectromagnetics LaboratorySchool of MedicineZhejiang UniversityHangzhou CityZhejiang ProvinceChina Environmental Research Center Duke Kunshan UniversityKunshan CityJiangsu ProvinceChina Nicholas School of the Environment Duke UniversityDurhamNCUSA School of Public Health Institute of Environment and Population HealthAnhui Medical UniversityHefei CityAnhui ProvinceChina School of Public Health and Social Work Queensland University of TechnologyBrisbaneAustralia

What is already known about this topic?Antimony(Sb)has been identified as a new neurotoxicant that impacts neurological functions in animal ***,its effects on the human population remain *** is added by this report?The study reveals that there is an association between exposure to Sb and a higher incidence of cognitive impairment in older *** dose-response curve demonstrates that the risk of cognitive impairment consistently increased with higher levels of Sb exposure without a discernible *** are the implications for public health practice?Reducing exposure to Sb may have a beneficial effect in delaying or preventing the onset of cognitive *** intervention has the potential to significantly decrease the disease burden associated with cognitive impairment,ultimately contributing to social development.

关键词： Antimony development. exposure

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异形高耸建筑专用塔机结构的设计与建模研究

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机械管理开发 2019年第12期34卷 5-7页

作者：汪许林广东庞源工程机械有限公司

对异形高耸建筑专用塔机结构设计内容进行总结,并从SIEMENS N X技术、同步建模技术、异形专用塔机结构静力分析和模态分析四方面,论述了异形高耸建筑专用塔机的结构设计与建模研究。开展有效的异形专用塔机结构建模操作,并通过同步建模... 详细信息

对异形高耸建筑专用塔机结构设计内容进行总结,并从SIEMENS N X技术、同步建模技术、异形专用塔机结构静力分析和模态分析四方面,论述了异形高耸建筑专用塔机的结构设计与建模研究。开展有效的异形专用塔机结构建模操作,并通过同步建模技术应用,可以实现对模型内容的有效修改,从而为后续工作执行创造有利条件。

关键词：塔机结构设计建模模态分析

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Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial

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Chinese Journal of Cancer Research 2017年第2期29卷 144-148页

作者： Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao xulin wang Pin Liang Xinxin wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji Department of Gastrointestinal Surgery the First Affiliated Hospital of Dalian Medical University Dalian 116011 China Deparunent of General Surgery Chinese People's Liberation Army General Hospital Beijing 100853 China Department of Abdominal Surgery Zhejiang Cancer Hospital Hangzhou 310022 China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Center of Gastrointestinal Surgery Peking University Cancer Hospital & Institute Beijing 100142 China Department of General Surgery Peking University First Hospital Beijing 100034 China Department of Gastrointestinal Surgery Peking University People's Hospital Beijing 100044 China Department of General Surgery Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of General Surgery Beijing Hospital Beijing 100730 China Department of General Surgery Xuanwu Hospital Capital Medical University Beijing 100053 China Department of General Surgery Qilu Hospital of Shandong University Jinan 250012 China Department of General Surgery Nanjing General Hospital Nanjing 210002 China Department of Gastrointestinal Surgery the First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 China Department of Oncology Zhongnan Hospital of Wuhan University Wuhan 430071 China Department of Medical Oncology Zhejiang Cancer Hospital Hangzhou 310022 China Department of Medical Oncology the First Affiliated Hospital of Dalian Medical University Dalian 116011 China Department of Chemotherapy Qilu Hospital of Shandong University Jinan 250012 China

Background： The ACTS-GC study had shown postoperative adiuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer. Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision. Methods： We have commenced a randomized phase III trial in December 2016 to evaluate S-I plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer. A total of 564 patients will be accrued from 13 Chinese institutions in two years. The primary endpoint is 3-year relapse-free survival. The secondary endpoints are 5-year overall survival, proportion of patients who complete the postoperative chemotherapy and incidence of adverse events. Ethic and dissemination： The trial has been approved by the institutional review board of each participating institution and it was activated on December, 2016. The enrollment will be finished in December, 2018. Patient＇s follow-up will be ended until December, 2023. Trial registration： ***, identifier： NCT02867839. Registered on August 4, 2016.

关键词： Locally advanced gastric cancer S-1 plus oxaliplatin randomized phase HI trial

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Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections

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Bone Research 2024年第2期12卷 270-288页

作者： Leilei Qin Shuhao Yang Chen Zhao Jianye Yang Feilong Li Zhenghao Xu Yaji Yang Haotian Zhou Kainan Li Chengdong Xiong Wei Huang Ning Hu xulin Hu Department of Orthopaedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Orthopedic Laboratory of Chongqing Medical University Chongqing 400016China Clinical Medical College and Affiliated Hospital of Chengdu University Chengdu UniversityChengduSichuan 610081China University of Chinese Academy of Sciences Bei Jing 101408China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China

Osteomyelitis is a devastating disease caused by microbial infection in deep bone *** high recurrence rate and impaired restoration of bone deficiencies are major challenges in *** have evolved numerous mechanisms to effectively evade host intrinsic and adaptive immune attacks to persistently localize in the host,such as drug-resistant bacteria,biofilms,persister cells,intracellular bacteria,and small colony variants(SCVs).Moreover,microbial-mediated dysregulation of the bone immune microenvironment impedes the bone regeneration process,leading to impaired bone defect *** advances in surgical strategies and drug applications for the treatment of bone infections within the last decade,challenges remain in clinical *** development and application of tissue engineering materials have provided new strategies for the treatment of bone infections,but a comprehensive review of their research progress is *** review discusses the critical pathogenic mechanisms of microbes in the skeletal system and their immunomodulatory effects on bone regeneration,and highlights the prospects and challenges for the application of tissue engineering technologies in the treatment of bone *** will inform the development and translation of antimicrobial and bone repair tissue engineering materials for the management of bone infections.

关键词： impaired infections treatment

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嗜酸粒细胞性食管炎研究进展

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胃肠病学 2015年第7期20卷 435-438页

作者：杨涛莲王振江王绪霖天津中医药大学 300193 天津医科大学总医院消化科

嗜酸粒细胞性食管炎(Eo E)是以食管壁全层嗜酸粒细胞浸润为病理特征的慢性免疫性炎性疾病,临床表现无特异性,发病机制尚未明确,诊断需结合临床、内镜、组织病理学等多方面因素。治疗方法主要包括饮食、药物和手术等。本文就Eo E的研究... 详细信息

嗜酸粒细胞性食管炎(Eo E)是以食管壁全层嗜酸粒细胞浸润为病理特征的慢性免疫性炎性疾病,临床表现无特异性,发病机制尚未明确,诊断需结合临床、内镜、组织病理学等多方面因素。治疗方法主要包括饮食、药物和手术等。本文就Eo E的研究进展作一综述。

关键词：嗜酸性食管炎发病机制诊断治疗

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国内强筋小麦品种及配麦的面包加工性能研究

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麦类作物学报 2023年第3期43卷 359-367页

作者：杜亚飞王旭琳吴桂玲刘锐金沙河集团产业技术研究院/河北省谷物食品加工技术创新中心河北邢台054100 农业农村部食物与营养发展研究所北京100081

为通过合理配麦提升国内优质强筋小麦的面包加工性能,对11种主栽强筋小麦品种进行理化、面团流变学检测及烘焙评价,筛选出综合品质较优、特点不同且互补的三个品种,分析其不同比例配麦对面粉理化特性和面包品质的影响。结果表明,新麦26... 详细信息

为通过合理配麦提升国内优质强筋小麦的面包加工性能,对11种主栽强筋小麦品种进行理化、面团流变学检测及烘焙评价,筛选出综合品质较优、特点不同且互补的三个品种,分析其不同比例配麦对面粉理化特性和面包品质的影响。结果表明,新麦26和师栾02-1具有良好的面包烘焙品质;配麦可有效均衡小麦品质特性,提高烘焙品质。新麦26、师栾02-1和西农979搭配后,3种配麦样品的形成时间、稳定时间均高于单个品种和对照,面包感官评分均显著高于西农979;配麦3的面包感官评分显著高于师栾02-1。由此可见,国内不同品种的优质强筋小麦合理搭配,可有效弥补单个品种的品质缺陷,提升其面包加工性能、适用性和综合效益,满足市场对面包专用粉的需求。

关键词：优质强筋麦配麦面包感官评价

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