检索结果-南通市图书馆

闭环靶控深度与中度肌松用于妇科腹腔镜手术效果的比较

在线全文

学校读者我要写书评

暂无评论

中华麻醉学杂志 2024年第6期44卷 710-713页

作者：王刚闫东来马浩南陈旭红谢克亮于泳浩天津市泰达医院麻醉科天津300457 天津医科大学总医院麻醉科天津300052 天津市第五中心医院妇产科天津300450

目的:比较闭环靶控深度与中度肌松用于妇科腹腔镜手术的效果。方法:本研究为前瞻性研究。选取2020年3月至2021年3月于天津医科大学总医院行择期妇科腹腔镜手术患者50例,年龄18~64岁,BMI 18~30 kg/m^(2),ASA分级Ⅰ或Ⅱ级,采用计算机随机... 详细信息

目的:比较闭环靶控深度与中度肌松用于妇科腹腔镜手术的效果。方法:本研究为前瞻性研究。选取2020年3月至2021年3月于天津医科大学总医院行择期妇科腹腔镜手术患者50例,年龄18~64岁,BMI 18~30 kg/m^(2),ASA分级Ⅰ或Ⅱ级,采用计算机随机数字表法分为2组( n=25):TOF闭环靶控中度肌松组(TOF组)和强直刺激后单刺激肌颤搐计数(PTC)闭环靶控深度肌松(PTC组)。2组均采用罗库溴铵闭环靶控输注。TOF组肌松程度目标水平为TOF计数l或2,PTC组肌松程度目标水平为PTC计数1或2。记录术者肌松满意度评分、分级及满意率、平均气腹压、罗库溴铵用量、恢复指数、TOF比值恢复至0.9的时间及气管拔管时间。记录术后腹部VAS评分和补救镇痛药物使用情况,记录术后48 h内患者肩痛、手臂痛、恶心、呕吐以及低氧血症等不良反应的发生情况。结果:与TOF组比较,PTC组术者肌松满意度评分、分级和满意率升高,平均气腹压降低,罗库溴铵总用量及平均用量升高,TOF比值恢复至0.9的时间延长,术后腹部VAS评分和氟比洛芬酯使用率降低( P0.05)。结论:与闭环靶控中度肌松相比,闭环靶控深度肌松为妇科腹腔镜手术提供了更加满意的手术条件,并降低气腹压力及减少相关并发症发生,且不增加术后不良反应的发生。

关键词：药物释放系统神经肌肉阻滞腹腔镜检查

Construction Activity Analysis of Workers Based on Human Posture Estimation Information

在线全文

学校读者我要写书评

暂无评论

Engineering 2024年第2期33卷 225-236页

作者： xuhong Zhou Shuai Li Jiepeng Liu Zhou Wu Yohchia Frank chen School of Civil Engineering Chongqing UniversityChongqing 400044China School of Automation Chongqing UniversityChongqing 400044China Department of Civil Engineering The Pennsylvania State UniversityMiddletownPA 17057USA

Identifying workers’construction activities or behaviors can enable managers to better monitor labor efficiency and construction ***,current activity analysis methods for construction workers rely solely on manual observations and recordings,which consumes considerable time and has high labor *** have focused on monitoring on-site construction activities of ***,when multiple workers are working together,current research cannot accu rately and automatically identify the construction *** research proposes a deep learning framework for the automated analysis of the construction activities of multiple *** this framework,multiple deep neural network models are designed and used to complete worker key point extraction,worker tracking,and worker construction activity *** designed framework was tested at an actual construction site,and activity recognition for multiple workers was performed,indicating the feasibility of the framework for the automated monitoring of work efficiency.

关键词： Pose estimation Activity analysis Object tracking Construction workers Automatic systems

From Acupoints to Mylohyoid: Revealing the Neural Circuitry Basis of Electroacupuncture for Dysphagia

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第1期40卷 139-142页

作者： Xiaoli Da xuhong Jiang Lihong Li Cenglin Xu Zhong chen Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Department of Neurology the First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310003China Department of Acupuncture the Second Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310000China

Acupuncturea representative and historical treatment in traditional Chinese medicine(TCM),has been used to cure diseases for Chinese people in the past *** the late 1990s,acupuncture has been further accepted *** World Health Organization(WHO)proposed Clinical Research Specification for acupuncture in 1995 and the US Food and Drug Administration(FDA)approved acupuncture as a complementary and alternative therapy for various kinds of diseases in 1996,with clinical advantages such as convenience and effectiveness[1].Cumulative evidence has proved that acupuncture could produce different degrees of efficacy for treating various kinds of diseases(such as neuropathic pain,migraine,Parkinson's disease et al.)and alleviate symptoms[2-4].However,unlike its evidence-based efficacies.

关键词： medicine(TCM) acupuncture Acupuncture

Multistep continuous flow synthesis of Erlotinib

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第4期35卷 371-375页

作者： Hui Jin Qin Cai Peiwen Liu Yan chen Derong Wang Weiping Zhu Yufang Xu xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

Erlotinib is an orally administered, highly effective, specific epidermal growth factor receptor tyrosine kinase inhibitor, used to treat non-small cell lung cancer and pancreatic cancer. The traditional synthetic methods for Erlotinib exhibit long reaction time and safety concern. Herein, we describe a novel five-step route for the synthesis of Erlotinib in flow. These five steps comprise etherification, nitration, reduction,addition and cyclization reactions. All steps were optimized and converted to continuous flow process,which drastically reduces the reaction time and considerably improves the process safety as well as the total yield. Enabled by five continuous flow units, Erlotinib is efficiently afforded with an E-factor of 38,an overall yield of 83%, and a total residence time of 25.1 min. Majority steps in this process have been optimized for quantitative conversion, which offers the possibility of telescoping the entire process.

关键词： Erlotinib Continuous flow synthesis Microchannel flow reactor Process optimization Continuous nitration Continuous hydrogenation

A laser light scattering study of the interaction between human serum albumin and ampicillin sodium

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2006年第4期49卷 332-337页

作者： WANG Weiping TANG Jianghong PENG xuhong HU Zhide chen Xingguo Department of Chemistry Lanzhou University Lanzhou 730000 China Department of Chemistry Lanzhou University Lanzhou 730000 China Department of Chemistry Lanzhou University Lanzhou 730000 China Department of Chemistry Lanzhou University Lanzhou 730000 China Department of Chemistry Lanzhou University Lanzhou 730000 China

The complexes formed by the interaction of human serum albumin and ampicillin sodium in aqueous solutions were investigated at 25 ± 0.1℃, ionic strength I = 0.085 mol·kg-1, pH 4.9, 5.8 and 7.4. The results of static light scattering have suggested that at pH 7.4, 5.8, 4.9, the molecular weight of the protein/drug complexes is 210,000 g·mol-1, 418,000 g·mol-1, 448,000 g·mol-1, re- spectively. The z-average root-mean-square radius of gyration and the second virial coefficients de- crease with pH decreasing. Dynamic light scattering provides information on diffusion coefficient and particle distributions of protein/drug complexes under different conditions, which suggests a broad hydrodynamic diameter range of scatters. The diffusion coefficients of the systems change with am- picillin sodium concentration and pH changing.

关键词： human serum albumin (HSA), ampicillin sodium (AMP), dynamic light scattering (DLS), static light scattering (SLS).

Change Laws of Flake's Temperature during Making a Diamond Film by DC-PJ

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 1999年第2期13卷 97-102页

作者： xuhong chen Lihe Zhao Fanxiu Lu(Mechanical Engineering School, University of Science and Technology Beijing, Beijing 100083, China) Mechanical Engineering School University of Science and Technology Beijing Beijing 100083 China

When making a diamond film by direct current plasma jet, a kind piece of flake is used as a base body Which the film can beattached to. The flake's temperature is unstable. Therefore, some experiments and constructed mathematical models, which were solvedby computer, were done. The results show that the flake's temperature is influenced by many factors and the mains are plasma jet powerand vacuum pressure. Through adjusting the two parameters, the flake's temperature can be accurately controlled, furthermore, diamondfilms' quality would be improved. Lowering sediment platform's temperature has a little effect to the flake's temperature at present technology conditions.

关键词： CVD (Chemical Vapor Deposition) plasma, impact heat transfer

Distribution of phosphorylated Elk-1 in rat brain after Y-maze active avoidance training in a temporal manner

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2006年第3期1卷 193-196页

作者： xuhong chen Siyun Shu Zhenjiang Liang Xinmin Bao Lixue chen Yongming Wu Research Room of Neurobiology. Second Affiliated Hospital of Southern Medical University. Guangzhou 510282 Guangdong Province China Department of Otolaryngology Shenzhen Children＇s Hospital Shenzhen 518026 Guengdong Province China

BACKGROUND： Elk-1 mRNA distributes extensively in the neurons of mice, rat and human brains, and the Elk-1 expression may be correlated with the synaptic plasticity, learning and memory. OBJECTIVE： To observe the distribution of phosphorylated Elk-1 （pEIk-1） in whole brain of rats received Y-maze active avoidance training and the changes of pEIk-1 expression at different time points after training. DESIGN ： A randomized controlled study SETTING ： Research Room of Neurobiology, the Second Affiliated Hospital of Southern Medical University MATERIALS ： Fifty-five male clean-degree SD rats of 3-4 months old, weighing 200-250 g, were provided by the Experimental Animal Center of Southem Medical University. The rabbit anti-monoclonal pEIk-1 antibody was purchased from Cell Signal Transduction Company, and ABC kit from Vector Company. METHODS ： The experiments were carried out in the Research Room of Neurobiology, Second Affiliated Hospital of Southern Medical University from September 2004 to February 2005. ① Grouping： The rats were randomly divided into training group （n = 25）, sham-training group （n = 25） and normal control group （n = 5）, and the training and sham-training groups were observed at 0, 1, 3, 6 and 24 hours after training, which represented the five phases in the process of leaming and memory. ② Y-maze training： The rats were preconditioned in the electrical Y-maze apparatus, 20 minutes a day for 3 days continuously, and training began from the 4^th day. In the training group, the rats were trained with the combination of light and electddty. Each rat repeated for 60 times in each training, and the correct times were recorded, those correct for less than 25 times were taken as unqualified, and excluded from the training group, and supplemented by other rats in time. In the sham-training group, there was no fixed correlation between the application of light and electricity. The rats in the normal contrel group were given not any training. ③Detection of pEIk-

关键词： Distribution of phosphorylated Elk-1 in rat brain after Y-maze active avoidance training in a temporal manner

CFRP板纵向加固RC柱在水平低周循环荷载下的力学性能研究与应用

在线全文

学校读者我要写书评

暂无评论

湖南大学学报（自然科学版） 2024年第7期51卷 148-163页

作者：强旭红陈岩松姜旭谭成同济大学土木工程学院上海200092

开发了一种纵向粘贴CFRP(Carbon Fiber Reinforced Polymer,碳纤维增强复合材料)板的RC(Reinforced Concrete,钢筋混凝土)柱抗弯加固系统,该加固系统由纵向粘贴在柱表面的预制CFRP板和防止柱底CFRP板脱粘的混凝土加厚层组成.为研究纵向... 详细信息

开发了一种纵向粘贴CFRP(Carbon Fiber Reinforced Polymer,碳纤维增强复合材料)板的RC(Reinforced Concrete,钢筋混凝土)柱抗弯加固系统,该加固系统由纵向粘贴在柱表面的预制CFRP板和防止柱底CFRP板脱粘的混凝土加厚层组成.为研究纵向粘贴CFRP板对RC柱的抗弯性能影响,设计并开展了5根足尺矩形RC柱的水平低周循环加载试验.研究结果表明:粘贴CFRP板加固能有效延缓柱的开裂;柱的破坏模式得到明显改善;相较于未加固柱子,粘贴1层CFRP板和2层CFRP板加固的RC柱极限承载力分别提高了15.1%和17.4%;加固后柱的抗弯承载力和刚度得到提高,但增加CFRP板的层数对极限强度和刚度没有显著影响,反而会降低柱的延性,相较于仅采用增大柱底截面的方式加固的对照柱,粘贴1层CFRP板和2层CFRP板加固的试验柱的延性系数分别降低16.2%和35.1%;试验过程中,由于柱与基础节点承载力的限制,CFRP的最大应变仅达到极限应变的24%,抗拉强度未得到充分发挥.该加固方法已在某医院加固工程中得到应用,跟踪研究表明,加固后柱子的抗弯承载力有明显提升,加固方法得到工程业界的认可.

关键词：钢筋混凝土柱抗弯加固水平低周循环加载碳纤维增强复合材料板纵向粘贴

维普期刊数据库博看期刊

“国之所需、吾志所向”——纪念创新药物开拓者蒋华良院士

在线全文

学校读者我要写书评

暂无评论

中国科学：生命科学 2024年第2期54卷 357-363页

作者：陈国强钱旭红海南医学院/海南医学科学院海南571199 上海交通大学医学院附属仁济医院肿瘤系统医学全国重点实验室上海200127 华东师范大学化学和分子工程学院上海200241 华东理工大学药学院上海200237

蒋华良,著名药学家,中国科学院院士、中国民主同盟盟员、中国科学院上海药物研究所原所长、研究员,临港实验室首任主任、华东理工大学药学院首任院长、上海科技大学科道书院原院长.蒋华良1965年1月10日生于江苏武进. 1995年获上海药物... 详细信息

蒋华良,著名药学家,中国科学院院士、中国民主同盟盟员、中国科学院上海药物研究所原所长、研究员,临港实验室首任主任、华东理工大学药学院首任院长、上海科技大学科道书院原院长.蒋华良1965年1月10日生于江苏武进. 1995年获上海药物研究所博士学位,后留所工作,历任副研究员、研究员、副所长、所长、学术委员会主任等职. 2017年当选为中国科学院院士. 1998年加入中国民主同盟.曾任中国人民政治协商会议第十一届、第十二届全国委员会委员,民盟第十届中央委员会委员、民盟第十二届、第十三届中央委员会常务委员.

关键词：中国科学院院士原所长上海药物研究所中国民主同盟创新药物博士学位药学家副所长