检索结果-南通市图书馆

Integrins as attractive targets for cancer therapeutics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第9期11卷 2726-2737页

作者： Meng Li Ying Wang Mengwei Li xuezhen wu Sarra Setrerrahmane Hanmei Xu National Institutes for Food and Drug Control Beijing 102629China State Key Laboratory of Natural Medicines Ministry of Educationthe Engineering Research Center of Synthetic Polypeptide Drug Discovery and Evaluation of Jiangsu ProvinceDepartment of Marine PharmacyChina Pharmaceutical University Nanjing 211198ChinaAffiliated Hospital of Chifeng CollegeInner Mongolia Autonomous Region 024005China

Integrins are transmembrane receptors that have been implicated in the biology of various human physiological and pathological *** molecules facilitate cell-extracellular matrix and cell-cell interactions,and they have been implicated in fibrosis,inflammation,thrombosis,and tumor *** role of integrins in tumor progression makes them promising targets for cancer treatment,and certain integrin antagonists,such as antibodies and synthetic peptides,have been effectively utilized in the clinic for cancer ***,we discuss the evidence and knowledge on the contribution of integrins to cancer ***,we summarize the clinical attempts targeting this family in anti-cancer therapy development.

关键词： Integrins Extracellular matrix Tumor progression Targeted drug Antagonists Clinical trial

Research progress and prospect of interaction between rock engineering and geo-environments

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2015年第6期7卷 722-723页

作者： Yujing Jiang xuezhen wu State Key Laboratory of Mining Disaster Prevention and Control Shandong University of Science and Technology Graduate School of Engineering Nagasaki University

In recent years, a large number of geotechnical engineering projectshave been completed or under construction in China, such asthe Three Gorges Dam Project, Expressway Network Plan, South-to-North Water Diversion Project, West-to-East Gas Pipeline Project,etc. （Wang, 2003; Li, 2010; Huang, 2011; She and Lin, 2014）. Theconstruction of large-scale geotechnical engineering not onlybrings huge economic benefits, but also causes large interferenceto the lithosphere and hydrosphere that we rely on for survival（Wang et al., 2005）. This paper focuses on the interaction mechanismof rock engineering and geo-environments in the fields of urbanunderground space utilization, natural gas hydrate exploitationand high-level radioactive waste disposal.

关键词： Research progress and prospect of interaction between rock engineering and geo-environments rock

A new deformable cable for rock support in high stress tunnel:Steel pipe shrinkable energy-absorbing cable

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2024年第8期34卷 1083-1093页

作者： xuezhen wu Mingzhu Zhao Qing Ye Yujing Jiang Tao Deng Hanfang Zheng Gang Wang Zhenchang Guan College of Civil Engineering Fuzhou UniversityFuzhou 350108China School of Engineering Nagasaki UniversityNagasaki 852-8521Japan Key Laboratory of Underground Engineering Fujian University of TechnologyFuzhou 350118China

High stress in surrounding rock will lead to serious problems,e.g.,rock burst in hard rock and large deformation in soft *** applied support system under high in-situ stress conditions should be able to carry high load and also accommodate large deformation without experiencing severe *** this paper,a specially designed energy-absorbing component for rock bolt and cable that can solve the above problems was *** energy-absorbing component can provide support resistance by plastic deformation of the metal including constraint annulus and compression *** practical engineering,two forms were *** was installed in the surrounding rock by reaming,and the other was installed directly outside the surrounding *** the dilation of the surrounding rock,the relative displacement of constraint annulus and compression pipe occurs,resulting in deformation *** resistance is transmitted to the rock bolt or cable,providing support *** lab test and numerical simulation showed that the energy-absorbing component can perfectly achieve the large deformation effect,the deformation amount is as high as 694 mm,and the bearing capacity is stable at 367 *** field application tests were carried out in the mining roadway of Xinjulong coal mine,and the results showed that the new type of cable can ensure itself not to break under the condition of large deformation of the surrounding *** energy-absorbing component has the superiorities of performing large constant resistance and controllable deformation to effectively control the unpredictable disasters such as large deformation in soft rock and rock burst in hard rock encountered in deep strata.

关键词： Energy-absorbing cable Numerical simulation Lab test Load capacity Ultimate displacement

Dissolution Kinetics of Magnesitic-Dolomite and Magnesite-Chrome Refractories in Secondary Steelmaking Slags

在线全文

学校读者我要写书评

暂无评论

China's Refractories 2007年第1期16卷 3-10页

作者： CHEN Zhaoyou wu xuezhen YE Fangbao Sinosteel Luoyang Institute of Refractories Research Luoyang 471039 China

Dissolution kinetics of magnesitic-dolomite and magnesite-chrome refractories in secondary steelmaking slags was studied by means of the rotating cylinder method under forced convection. Materials investigated include four magnesitic-dolomite samples（MgO content 40% to 93%）and two magnesite-chrome samples （co-clinkered and semi-rebonded）.Synthetic slags simulative of VOD and AOD slags with varying basicity （0.6-2.68） are *** experiments are carried out in Ar atmosphere at different temperatures （1 600 ℃-1 750 ℃） and revolution speeds （200 r·min^-1 to 500 r·min^-1）.The microstructure of specimens （before and after slag tests） are studied by optical microscopy, SEM and EPMA. Based on our experimental results the mechanism and kinetics of the dissolution process are discussed.

关键词： Magnesitic-dolomite Magnesite-chrome dissolution kinetics Corrosion mechanism secondary steelmaking slag

在线全文

学校读者我要写书评

暂无评论

国际金融危机的原因分析及警示

现代经济探讨 2009年第5期 26-29页

作者：吴学臻庞世伟工程兵指挥学院社科部

引发国际金融危机的因素很复杂,既有体制、政策层面的原因,又有基本制度方面的深层次根源。汲取西方国家引发危机的深刻教训,推进改革发展,要求我们必须坚持和巩固中国特色社会主义基本经济制度,决不能踏入私有化的歧途;必须坚持走共同... 详细信息

引发国际金融危机的因素很复杂,既有体制、政策层面的原因,又有基本制度方面的深层次根源。汲取西方国家引发危机的深刻教训,推进改革发展,要求我们必须坚持和巩固中国特色社会主义基本经济制度,决不能踏入私有化的歧途;必须坚持走共同富裕的道路,坚决防止收入差距持续扩大;必须正确处理虚拟经济与实体经济关系,防范和化解金融风险;必须重视节制资本,防止资本侵害公众利益、危害经济安全;必须处理好储蓄与消费的关系,促使消费、投资、出口协调拉动经济增长。

关键词：国际金融危机原因警示

剪切荷载下岩体结构面-浆体-锚杆相互作用机理宏细观研究

在线全文

学校读者我要写书评

暂无评论

中南大学学报（自然科学版） 2015年第6期46卷 2207-2215页

作者：王刚袁康蒋宇静吴学震山东科技大学矿山灾害预防控制省部共建国家重点实验室培育基地山东青岛266590 山东科技大学山东省土木工程防灾减灾重点实验室山东青岛266590 山东省矿山灾害预防控制重点实验室山东青岛266590

基于PFC中FISH语言,采用双线性锚杆本构模型对岩体加锚节理面在剪切荷载作用下的力学行为进行数值模拟研究,通过变化锚杆刚度和浆体强度,深入研究岩体结构面-浆体-锚杆相互作用下锚固体系宏细观力学响应。结果表明:加锚节理面的力学响... 详细信息

基于PFC中FISH语言,采用双线性锚杆本构模型对岩体加锚节理面在剪切荷载作用下的力学行为进行数值模拟研究,通过变化锚杆刚度和浆体强度,深入研究岩体结构面-浆体-锚杆相互作用下锚固体系宏细观力学响应。结果表明:加锚节理面的力学响应与锚固结构的力学性质密切相关。锚杆刚度越大,节理面宏观抗剪强度越高;随着锚杆刚度的增加,岩体和浆体中的裂纹也越来越多,锚杆对浆体和岩体的损伤逐渐增加。岩体结构面-浆体-锚杆相互作用,裂纹的产生首先起于节理面上和锚杆与节理面交叉处,随着剪切位移的不断增加,节理面上的裂纹在接触力集中的地方继续产生,而在锚杆周围则由锚杆与节理面交叉处向锚杆两端继续扩展,且裂纹集中在锚固体系的受压侧,主要为由"压致拉"机理导致的张拉裂纹。浆体的强度过小或过大都可能导致锚固体系中裂纹数量的增多,且裂纹以张拉裂纹为主。当浆体强度较低时,裂纹主要集中在浆体中,而当浆体强度较高时,裂纹主要集中在岩体中。因此,在对节理岩体进行加固的过程中,应综合考虑节理面宏观上的抗剪强度和细观上锚固体系的损伤,以实现锚固体系的宏细观耦合支护。分析结论对于节理岩体的锚固支护设计具有参照价值。

关键词：颗粒流岩石节理面锚杆直剪试验宏细观耦合

在线全文

学校读者我要写书评

暂无评论

经济型宽带DTMB地面数字电视覆盖系统

电子测量与仪器学报 2018年第6期32卷 199-204页

作者：伍学珍陈伟广西水利电力职业技术学院桂林爱威电子设备有限公司

本研究所设计的经济型宽带DTMB地面数字电视覆盖系统,采用自主先进的国标地面数字电视DTMB国际技术标准,其核心技术为TDS-OFDM和LDPC技术。设计的数字电视地面无线传输系统在抗干扰能力、接收性能、传输速率和容量等实测均表现优异,系统... 详细信息

本研究所设计的经济型宽带DTMB地面数字电视覆盖系统,采用自主先进的国标地面数字电视DTMB国际技术标准,其核心技术为TDS-OFDM和LDPC技术。设计的数字电视地面无线传输系统在抗干扰能力、接收性能、传输速率和容量等实测均表现优异,系统以1个500 W室外防雨型宽带发射机基站为主,天线安装于120 m铁塔的平台上,在40 km内相对平坦的地区能够覆盖90%以上的地方,用户终端可通过7单元室外天线或5单元室内天线接收后,经AVS+数字电视机顶盒收看电视,并在东盟及非洲地区,满足客户需求并推广应用了中国DTMB标准。

关键词：地面数字电视 DTMB 国际标准宽带发射机

在线全文

学校读者我要写书评

暂无评论

地铁盾构施工对上跨桩板结构的扰动机制研究

华中科技大学学报（自然科学版） 2021年第7期49卷 24-30页

作者：曹洋林育睿张二望吴学震福州大学土木工程学院福建福州350108

针对浅埋施工条件下盾构下穿桩板结构的开挖扰动问题展开研究.依托滨海软弱土层地铁盾构隧道开挖工程,结合现场原位测试和数值动态仿真,分别针对开挖顶进和盾尾注浆两个扰动阶段,分析近场和远场结构部件的受力变形规律,阐明扰动机制.结... 详细信息

针对浅埋施工条件下盾构下穿桩板结构的开挖扰动问题展开研究.依托滨海软弱土层地铁盾构隧道开挖工程,结合现场原位测试和数值动态仿真,分别针对开挖顶进和盾尾注浆两个扰动阶段,分析近场和远场结构部件的受力变形规律,阐明扰动机制.结果表明:盾构开挖顶进阶段,顶推力对周围土体的放射挤压引起桩身横向弯曲及顶板抬升,刀盘驶过目标桩1.00D(D为开挖洞径)时,近场桩身变形达到最大;盾尾注浆阶段,在注浆层硬化前,顶板及近场桩身随土体出现回弹变形,并于刀盘驶过目标断面约3.00D后趋于稳定,此时顶板出现沉降槽;距离开挖空间1.00D的远场桩身先后受到顶推力的外扩挤压,以及隧道上部地层回弹沉降的横向推动作用,弯曲变形逐步增大,未表现出回弹变形.

关键词：盾构开挖桩板结构软弱土层原位测试数值仿真

座标法计算既有线改建的拨量及第二线设计的线间距

在线全文

学校读者我要写书评

暂无评论

西南交通大学学报 1984年第2期 26-34页

作者：吴学镇

本文认为用角图法或渐伸线法计算既有线改建的拨量及第二线的线间距存在某些不可避免的缺陷,提出采用直角座标进行计算的方法。

关键词：拨量既有线改建整正既有曲线线间距股道间距座标二线