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Discovery of a first-in-class ANXA3 degrader for the treatment of triple-negative breast cancer

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1686-1698页

作者： Yongxi Liang Delin Min Hulin Fan Kunlin Liu Juchuanli Tu xueyan he Bingjie Liu Lu Zhou Suling Liu Xun Sun School of Pharmacy Fudan UniversityShanghai 201203China The Institutes of Integrative Medicine of Fudan University Shanghai 200040China Fudan University Shanghai Cancer Center&Institutes of Biomedical Sciences State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200032China

Triple-negative breast cancer(TNBC)is a nasty disease with extremely high malignancy and poor *** A3(ANXA3)is a potential prognosis biomarker,displaying an excellent correlation of ANXA3 overexpression with patients'poor *** the expression of ANXA3effectively inhibits the proliferation and metastasis of TNBC,suggesting that ANXA3 can be a promising therapeutic target to treat ***,we report a first-in-class ANXA3-targeted small molecule(R)-SL18,which demonstrated excellent anti-proliferative and anti-invasive activities to TNBC cells.(R)-SL18 directly bound to ANXA3 and increased its ubiquitination,thereby inducing ANXA3 degradation with moderate family ***,(R)-SL18 showed a safe and effective therapeutic potency in a high ANXA3-expressing TNBC patient-derived xenograft ***,(R)-SL18 could reduce theβ-catenin level,and accordingly inhibit the Wnt/β-catenin signaling pathway in TNBC ***,our data suggested that targeting degradation of ANXA3 by(R)-SL18 possesses the potential to treat TNBC.

关键词： Annexin A3(ANXA3) Degrader Triple-negative breast cancer Ubiquitination Patient-derived xenograft

Comparison of the Teaching Concepts between Chinese and Americans

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科技信息 2007年第20期 240-240,289页

作者： he xueyan Wang Weiming Nanjing Agricultural University College of Life Science

This paper makes a comparative study on higher education in respect of four aspects in educational system between China and America,in the hope of finding reasons that can be useful to our cultivation in China.

关键词：高等教育教学观念中国美国比较研究原因分析

PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2 pathway

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1828-1841页

作者： Rui Zhang Mengxue Dong Juchuanli Tu Fengkai Li Qiaodan Deng Jiahui Xu xueyan he Jiajun Ding Jie Xia Dandan Sheng Zhaoxia Chang Wei Ma Haonan Dong Yi Zhang Lixing Zhang Lu Zhang Suling Liu Fudan University Shanghai Cancer Center&Institutes of Biomedical Sciences State Key Laboratory of Genetic EngineeringCancer InstitutesKey Laboratory of Breast Cancer in ShanghaiThe Shanghai Key Laboratory of Medical EpigeneticsShanghai Key Laboratory of Radiation OncologyThe International Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyShanghai Medical CollegeFudan UniversityShanghai 200032China Breast Surgery Obstetrics and Gynecology Hospital of Fudan UniversityShanghaiChina Department of Breast and Thyroid Surgery Southwest Hospitalthe First Affiliated Hospital of the Army Military Medical UniversityChongqing 400038China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer MedicineNanjing Medical UniversityNanjing 211166China

Our previous studies have showed that C-C motif chemokine ligand 20(CCL20)advanced tumor progression and enhanced the chemoresistance of cancer cells by positively regulating breast cancer stem cell(BCSC)***,it is unclear whether CCL20 affects breast cancer progression by remodeling the tumor microenvironment(TME).here,we observed that polymorphonuclear myeloid-derived suppressor cells(PMN-MDSCs)were remarkably enriched in TME of CCL20-overexpressing cancer cell orthotopic allograft ***,CCL20 activated the differentiation of granulocyte-monocyte progenitors(GMPs)via its receptor C-C motif chemokine receptor 6(CCR6)leading to the PMN-MDSC ***-MDSCs from CCL20-overexpressing cell orthotopic allograft tumors(CCL20-modulated PMN-MDSCs)secreted amounts of C-X-C motif chemokine ligand 2(CXCL2)and increased ALDH+BCSCs via activating CXCR2/NOTCH1/heY1 signaling ***,C-X-C motif chemokine receptor 2(CXCR2)antagonist SB225002 enhanced the docetaxel(DTX)effects on tumor growth by decreasing BCSCs in CCL20high-expressing *** findings elucidated how CCL20 modulated the TME to promote cancer development,indicating a new therapeutic strategy by interfering with the interaction between PMN-MDSCs and BCSCs in breast cancer,especially in CCL20high-expressing breast cancer.

关键词： CCL20 CXCR2 breast

Lightweight Underwater Target Detection Using YOLOv8 with Multi-Scale Cross-Channel Attention

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Computers, Materials & Continua 2025年第1期82卷 713-727页

作者： xueyan Ding Xiyu Chen Jiaxin Wang Jianxin Zhang School of Computer Science and Engineering Dalian Minzu UniversityDalian116600China Research Center of Multimodal Information Perception and Intelligent Processing Dalian Minzu UniversityDalian116600China

Underwater target detection is extensively applied in domains such as underwater search and rescue,environmental monitoring,and marine resource *** is crucial in enabling autonomous underwater robot operations and promoting ocean ***,low imaging quality,harsh underwater environments,and obscured objects considerably increase the difficulty of detecting underwater targets,making it difficult for current detection methods to achieve optimal *** order to enhance underwater object perception and improve target detection precision,we propose a lightweight underwater target detection method using You Only Look Once(YOLO)v8 with multi-scale cross-channel attention(MSCCA),named *** the proposed multiscale cross-channel attention module,multi-scale attention(MSA)augments the variety of attentional perception by extracting information from innately diverse sensory *** cross-channel strategy utilizes RepVGGbased channel shuffling(RCS)and one-shot aggregation(OSA)to rearrange feature map channels according to specific *** aggregates all features only once in the final feature mapping,resulting in the extraction of more comprehensive and valuable feature *** experimental results show that the proposed YOLOv8-UOD achieves a mAP50 of 95.67%and FLOPs of 23.8 G on the Underwater Robot Picking Contest 2017(URPC2017)dataset,outperforming other methods in terms of detection precision and computational cost-efficiency.

关键词： Deep learning underwater target detection attention mechanism

利用外部DEM辅助山区SAR立体像对匹配及地形制图

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测绘学报 2013年第3期42卷 425-432页

作者：贺雪艳张路 Timo BALZ 廖明生武汉大学测绘遥感信息工程国家重点实验室湖北武汉430079

SAR立体像对的匹配是利用雷达摄影测量技术提取地形高程信息的关键,匹配精度将直接影响结果 DEM的高程精度。针对山区SAR立体像对匹配过程中同名点选取困难的问题,引入外部粗分辨率DEM作为辅助数据,将该DEM高程转换为视差,为匹配提供初... 详细信息

SAR立体像对的匹配是利用雷达摄影测量技术提取地形高程信息的关键,匹配精度将直接影响结果 DEM的高程精度。针对山区SAR立体像对匹配过程中同名点选取困难的问题,引入外部粗分辨率DEM作为辅助数据,将该DEM高程转换为视差,为匹配提供初值,同时采用金字塔匹配策略,不仅可以缩小搜索范围,提高搜索效率,而且能够减少粗差的产生。试验结果表明,采用外部DEM辅助之后,匹配粗差点数量相对于传统的雷达摄影测量处理结果明显减少,从而有效地提高了高程信息提取重建的精度。

关键词：雷达摄影测量视差模型相关系数金字塔匹配外部DEM

Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： xueyan Zhang Shichao Cheng Chuankai Fu Geping Yin Liguang Wang Yongmin Wu Hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

小于胎龄与适于胎龄早产儿出院后体格生长和神经发育追赶状况

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检验医学与临床 2023年第20期20卷 3009-3014页

作者：何雪雁江西省瑞昌市妇幼保健院儿保科江西瑞昌332200

目的研究小于胎龄(SGA)与适于胎龄(AGA)早产儿出院后早期体格生长和神经发育追赶状况。方法选取2018年1月至2020年12月该院165例早产儿临床资料进行分析,根据出生体质量分为SGA组(56例)和AGA组(109例),另选取该院同期完成随访的足月适... 详细信息

目的研究小于胎龄(SGA)与适于胎龄(AGA)早产儿出院后早期体格生长和神经发育追赶状况。方法选取2018年1月至2020年12月该院165例早产儿临床资料进行分析,根据出生体质量分为SGA组(56例)和AGA组(109例),另选取该院同期完成随访的足月适龄新生儿92例作为对照组,3组新生儿出院后定期进行门诊随访,定期测量身长、体质量和头围等指标,并计算Z评分和ΔZ评估体格生长情况。采用《0~6岁小儿神经心理发育诊断量表》计算发育商(DQ),评估神经发育情况,比较各组不同校正月龄体格生长和神经发育情况。结果3组新生儿身长、头围均变化均存在交互效应(P3~6、>6~9和>9~12月龄时3组新生儿身长、体质量、头围ΔZ评分变化存在时间效应(P<0.001);3组新生儿身长、体质量、头围ΔZ评分均存在组间效应(P<0.001);3组新生儿身长、体质量、头围ΔZ评分均存在交互效应(P<0.001)。SGA组校正1、3、6、9月龄时《0~6岁小儿神经心理发育诊断量表》的大运动、精细动作、认知功能、语言和社会行为DQ均明显低于AGA组和对照组,差异均有统计学意义(P<0.05);AGA组校正1、3、6月龄时大运动、精细动作、认知功能和社交行为DQ均明显低于对照组,差异均有统计学意义(P<0.05)。结论SGA和AGA早产儿1岁以内均存在追赶生长现象,其中AGA早产儿生长潜能较SGA早产儿具有明显优势。

关键词：早产儿小于胎龄儿适于胎龄儿体格生长神经发育追赶生长

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大肠杆菌培养过程动态模型的参数优化和估计

化工进展 2013年第S1期32卷 179-186页

作者：何雪艳王彦洪伟荣浙江大学化工机械研究所浙江杭州310027 热力学过程环境和自然材料过程研究所Freiberg工业大学德国09596

研究基于密度培养的大肠杆菌培养过程的非线性动态优化模型,描述和验证了大肠杆菌培养过程的动态DAE模型方程。用最小二乘法建立目标函数,并建立了完整的优化问题模型,拟合实验观察值,分析得到大肠杆菌培养过程模型中的关键不确定参数... 详细信息

研究基于密度培养的大肠杆菌培养过程的非线性动态优化模型,描述和验证了大肠杆菌培养过程的动态DAE模型方程。用最小二乘法建立目标函数,并建立了完整的优化问题模型,拟合实验观察值,分析得到大肠杆菌培养过程模型中的关键不确定参数。通过原对偶内点法的优化算法求解该动态优化问题,得到参数优化估计值,建立了准确的大肠杆菌培养过程动态模型。

关键词：动态过程优化原对偶内点法参数估计大肠杆菌

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基于曲率指导的B样条飞机进气道几何设计

计算机辅助设计与图形学学报 2023年第12期35卷 1822-1832页

作者：魏明强何雪滟吴梦郭延文谭慧俊南京航空航天大学计算机科学与技术学院南京210016 南京大学计算机软件新技术国家重点实验室南京210023 南京理工大学数学与统计学院南京210094 南京航空航天大学能源与动力学院南京210016

进气道能够捕获来流,按一定流量、流速和畸变向发动机供气.作为飞机推进系统的起始部件,进气道直接影响飞机发动机的工作效率、性能和安全性.针对进气道自由曲面构型的特点,提出基于曲率指导的B样条进气道几何设计方法.首先给定控制点... 详细信息

进气道能够捕获来流,按一定流量、流速和畸变向发动机供气.作为飞机推进系统的起始部件,进气道直接影响飞机发动机的工作效率、性能和安全性.针对进气道自由曲面构型的特点,提出基于曲率指导的B样条进气道几何设计方法.首先给定控制点、节点数据,构造C2光滑约束的B样条关键截线,避免产生台阶效应而影响进气道性能;其次将计算过渡截线的离散点坐标,转化为利用过渡截线导数值反求所对应的B样条曲线,减小在复原曲线过程中计算离散点带来的累积误差;最后将上述B样条曲线拟合为B样条张量积曲面结构,减少格式转换造成的信息损失.该方法已集成在某型号进气道建模系统中,可快速、交互式地完成由任意进气口截线到出气口截线的光滑过渡.实验结果表明,建模得到的进气道曲面结构精确性较高、通用性较好,一定程度上减少了对国外相关CAD航空工业软件的依赖,可以为后续基于数值优化的几何设计与流体仿真一体化提供技术支撑.

关键词：飞机进气道几何建模曲率指导 B样条曲面拟合

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