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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin ren Yingying Sun Zhen-Ni guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

保留反应性软组织联合脱矿牙本质基质应用于拔牙位点保存

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中国组织工程研究 2025年第17期29卷 3557-3565页

作者：戴婕婷任碧晖徐业豪郭水根魏洪武南昌大学附属康复医院江西省南昌市330000

背景:反应性软组织内的干细胞间充质具有促进组织再生的潜力,脱矿牙本质基质具有良好的生物相容性,可以作为位点保存术的支架材料,促进骨细胞的附着、增殖和分化。目的:影像学分析拔牙保留反应性软组织1个月后、行脱矿牙本质基质位点保... 详细信息

背景:反应性软组织内的干细胞间充质具有促进组织再生的潜力,脱矿牙本质基质具有良好的生物相容性,可以作为位点保存术的支架材料,促进骨细胞的附着、增殖和分化。目的:影像学分析拔牙保留反应性软组织1个月后、行脱矿牙本质基质位点保存术后6个月牙槽骨高度和宽度的变化。方法:纳入38例患者共62个拔牙位点,拔除患牙保留反应性软组织1个月后应用脱矿牙本质基质行位点保存术,术前、术后即刻、术后6个月拍摄锥形束CT,分别测量近中骨高度、中央骨高度、远中骨高度、颊侧骨高度、舌侧骨高度、牙槽嵴宽度,根据拔牙后剩余牙槽窝骨壁数量分为一壁骨缺损、二壁骨缺损、三壁骨缺损、四壁骨缺损。比较位点保存术前、术后即刻、术后6个月的骨量变化。结果与结论:①在骨愈合期间无位点发生创口感染;②与位点保存术前比较,术后即刻骨高度、骨宽度明显增加(P0.05);与术后即刻比较,术后6个月骨宽度吸收了(1.253±2.896)mm(P0.05);③位点保存术后即刻、术后6个月4种骨缺损类型的骨高度明显增加(P0.05);术后6个月较术前一壁骨缺损近中骨量增长最少(P<0.05),二壁骨缺损近中骨量增长最多(P<0.05);④结果表明:脱矿牙本质基质应用于位点保存术可有效预防和减缓拔牙术后的牙槽骨吸收,能够在一定程度上重建已发生吸收的牙槽骨轮廓;拔牙术后保留反应性组织应用于脱矿牙本质基质位点保存术中,可实现创口封闭,临床疗效好;脱矿牙本质基质应用于一壁、二壁、三壁、四壁牙槽窝位点保存效果相似,但总体而言,脱矿牙本质基质应用于骨壁完整的拔牙窝时位点保存效果更为优良。

关键词：影像学研究位点保存脱矿牙本质基质反应性软组织骨壁缺损

Fabrication of carbonized spent coffee grounds/graphene nanoplates/cyanate ester composites for superior and highly absorbed electromagnetic interference shielding performance

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Journal of Materials Science & Technology 2022年第7期102卷 123-131页

作者： Zhengzheng guo Penggang ren Zengping Zhang Zhong dai Zhenxia Lu Yanling Jin Fang ren School of Materials Science and Engineering Xi’an University of TechnologyXi’an 710048China The Faculty of Printing Packaging Engineering and Digital Media TechnologyXi’an University of TechnologyXi’an 710048China Key Laboratory for Special Area Highway Engineering of Ministry of Education Chang’an UniversityXi’an 710064China

The conductive polymer composites(CPCs) with highly efficient electromagnetic interference(EMI)shielding effectiveness(SE) are always accompanied with excessive reflectivity, which would cause serious secondary EMI pollution. In this regard, the significant reduction of EMI reflection of CPCs to alleviate secondary pollution is deemed to be very important. Herein, a promising cyanate ester(CE) based composite was successfully fabricated by compounding carbonized spent coffee grounds(C-SCG) and graphene nanosheets(GNSs) via a facile solution blending followed by a hot-pressing method. Benefiting from the porous structure of C-SCG and the layered structure of GNSs, a three-dimensional(3 D)multi-interface conductive network in the CE was easily constructed. The EMI SE of the resultant 9 wt%C-SCG/CE composite(C9) is 15.38 d B and dramatically enhanced to 31.09 d B with the presence of 3 wt% GNSs. The remarkable enhancement is mainly attributed to the formation of the efficient conductive pathways as well as the well-dispersion of the incorporated fillers. Meanwhile, the absorption-dominated shielding mechanism in the prepared composites gets benefit from the synergistic effect of porous C-SCG and lamellar GNSs, which effectively captures and attenuates electromagnetic waves. These encouraging findings extend the practical applications of porous biocarbon materials in EMI shielding field.

关键词： Carbonized spent coffee grounds Graphene nanosheets Electromagnetic interference shielding Low reflection

Morphological Mechanism and Experimental Verification of Self-healing of Basalt-fiber Modified Water-soaked Asphalt

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期 171-186页

作者：肖敏敏董金勇 LI Chunyan guo Xu ren Jianguo School of Urban Construction and Safety Engineering Shanghai Institute of Technology

This study investigates the mechanism of action of representative molecules of basalt fibers on the healing of water-soaked *** parameters,morphological characteristics,interfacial healing energy,and interfacial healing strength were analyzed using molecular dynamics and macroscopic tests under different time,temperature,and water conditions to evaluate the specific states and critical conditions involved in *** results indicate that basalt-fiber molecules can induce rearrangement and a combination of water-soaked asphalt at the healing *** groups with different bonding states increase the interfacial adsorption capacity of water-soaked *** interaction between basalt fiber molecules and water molecules leads to a "hoop" phenomenon,while aromatics-2 molecules exhibit a "ring band aggregation" *** former reduces the miscibility of water and asphalt molecules,while the latter causes slow diffusion of the ***,a micro-macro dual-scale comparison of interfacial healing strength was conducted at temperatures of 297.15 and 312.15 K to identify the strength transition point and critical temperature of 299.4 K during the self-healing process of basalt-fiber modified water-soaked asphalt.

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Natural tea-leaf-derived, ternary-doped 3D porous carbon as a high-performance electrocatalyst for the oxygen reduction reaction

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Nano Research 2016年第5期9卷 1244-1255页

作者： Zhaoyan guo Zhen Xiao Guangyuan ren guozheng Xiao Ying Zhu Liming dai Lei Jiang Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education School of Chemistry and Environment Beihang University Beijing 100191 China Department of Macromolecular Science and Engineering Case Western Reserve University Cleveland 10900 USA Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

To commercialize fuel cells and metal-air batteries, cost-effective, highly active catalysts for the oxygen reduction reaction （ORR） must be developed. Herein, we describe the development of low-cost, heteroatom （N, P, Fe） ternary-doped, porous carbons （HDPC）. These materials are prepared by one-step pyrolysis of natural tea leaves treated with an iron salt, without any chemical and physical activation. The natural structure of the tea leaves provide a 3D hierarchical porous structure after carbonization. Moreover, heteroatom containing organic compounds in tea leaves act as precursors to functionalize the resultant carbon frameworks. In addition, we found that the polyphenols present in tea leaves act as ligands, reacting with Fe ions to form coordination compounds; these complexes acted as the precursors for Fe and N active sites. After pyrolysis, the as-prepared HDPC electrocatalysts, especially HDPC-800 （pyrolyzed at 800℃）, had more positive onsets, half-wave potentials, and higher catalytic activities for the ORR, which proceeds via a direct four-electron reaction pathway in alkaline media, similar to commercial Pt/C catalysts. Furthermore, HDPC-X also showed enhanced durability and better tolerance to methanol crossover and CO poisoning effects in comparison to commercial Pt/C, making them promising alternatives for state-of-the-art ORR electrocatalysts for electrochemical energy conversion. The method used here provides valuable guidelines for the design of high-performance ORR electrocatalysts from natural sources at the industrial scale.

关键词： green tea leaves oxygen reduction catalysts,heteroatoms doped hierarchically porous carbon,synergistic effect

Segmental Kinematic Coupling of the Human Spinal Column during Locomotion

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Journal of Bionic Engineering 2008年第4期5卷 328-334页

作者： guo-ru Zhao Lei ren Lu-quan ren John R. Hutchinson Li-mei Tian Jian S. dai Key Laboratory for Terrain-Machine Bionics Engineering （Ministry of Education China） Jilin University Changchun 130022 P. R. China School of Physical Science and Engineering King＇s College of London University of London London WC2R 2LS UK Structure and Motion Laboratory Department of Veterinary Basic Sciences The Royal Veterinary College University of London Hertfordshire AL9 7TA UK

As one of the most important daily motor activities, human locomotion has been investigated intensively in recent decades. The locomotor functions and mechanics of human lower limbs have become relatively well understood. However, so far our understanding of the motions and functional contributions of the human spine during locomotion is still very poor and simultaneous in-vivo limb and spinal column motion data are scarce. The objective of this study is to investigate the delicate in-vivo kinematic coupling between different functional regions of the human spinal column during locomotion as a stepping stone to explore the locomotor function of the human spine complex. A novel infrared reflective marker cluster system was constrncted using stereophotogrammetry techniques to record the 3D in-vivo geometric shape of the spinal column and the segmental position and orientation of each functional spinal region simultaneously. Gait measurements of normal walking were conducted. The preliminary results show that the spinal column shape changes periodically in the frontal plane during locomotion. The segmental motions of different spinal functional regions appear to be strongly coupled, indicating some synergistic strategy may be employed by the human spinal column to facilitate locomotion. In contrast to traditional medical imaging-based methods, the proposed technique can be used to investigate the dynamic characteristics of the spinal column, hence providing more insight into the functional biomechanics of the human spine.

关键词： biomechanics spinal cofumn human locomotion in-vivo segmental kinematics motion analysis stereophotogrammetry kinematic coupling

Ultralong Organic Phosphorescence Modulation of Aromatic Carbonyls and Multi-Component Systems

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Chinese Journal of Chemistry 2022年第16期40卷 1987-2000页

作者： Chunguang ren Zhengshuo Wang Tianjie Wang Jiayi guo Yifeng dai Hua Yuan Yeqiang Tan State Key Laboratory of Bio-Fibers and Eco-Textiles&Institute of Marine Biobased Materials&Collage of Materials Science and Engineering Qingdao UniversityQingdaoShandong266071 China

Aromatic carbonyls have evoked sustained attention in the field of room-temperature phosphorescence(RTP).The introduction of carbonyl groups is a general way to achieve RTP for their effective intersystem crossing(ISC)by improving spin-orbit coupling(SOC).With further molecular design and processing strategies,aromatic carbonyls materials with multi-functional and high efficiency ultralong organic phosphorescence(UOP)can be *** review summarizes the mechanism of aromatic carbonyls with UOP in pure aromatic carbonyls and their multi-component *** detailed strategies for improving UOP performance are further *** summary and outlook are presented to expound on the advances and lack of aromatic *** development directions and requirements are also put forward.

关键词： Arynes Carbonyl ligands Ultralong organic phosphorescence Molecular design Processing strategy

A bio-inspired Co304-polypyrrole-graphene complex as an efficient oxygen reduction catalyst in one-step ball milling

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Nano Research 2015年第11期8卷 3461-3471页

作者： Guangyuan ren Yunan Li Zhaoyan guo guozheng Xiao Ying Zhu Liming dai Lei Jiang Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education School of Chemistry and Environment Beihang University Beijing 116023 China School of Chemistry Biology and Materials Science East China Institute of Technology Nanchang 330013 China Department of Macromolecular Science and Engineering Case Western Reserve University Cleveland Ohio 44106 USA

The development of non-precious metal-based electrocatalysts has attracted much research attention because of their high oxygen reduction reaction （ORR） activities, low cost, and good durability. By one-step in-situ ball milling of graphite, pyrrole, and cobalt salt without resorting to high-temperature annealing, we developed a general and facile strategy to synthesize bio-inspired cobalt oxide and polypyrrole coupled with a graphene nanosheet （Co3O4-PPy/GN） complex. Herein, the exfoliation of graphite and polymerization of pyrrole occurred simultaneously during the ball milling process. Meanwhile, the Co3O4 and Co-Nx ORR active sites were generated from the oxidized cobalt ion, cobalt-PPy, and the newly exfoliated graphene nanosheets via strong π-π stacking interactions. The resultant Co3O4-PPy/GN catalysts showed efficient electrocatalytic performances for ORRs in an alkaline medium with a positive onset and reduction potentials of -0.102 and -0.196 V （vs. Ag/AgCl）, as well as a high diffusion-limited current density （4.471 mA·cm^-2）, which was comparable to that of a Pt/C catalyst （4.941 mA·cm^-2）. Compared to Pt/C, Co3O4-PPy/GN catalysts displayed better long-term stability, methanol tolerance, and anti-CO-poisoning effects, which are of great significance for the design and development of advanced non-precious metal electrocatalysts.

关键词： graphene cobalt-polypyrrole oxygen reduction reaction electrocatalysts ball milling

Selection of treatment modalities for Budd-Chiari Syndrome in China:A preliminary survey of published literature

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World Journal of Gastroenterology 2014年第30期20卷 10628-10636页

作者： Xing-Shun Qi Wei-Rong ren dai-Ming Fan guo-Hong Han Xijing Hospital of Digestive Diseases Fourth Military Medical University Department of Gastroenterology General Hospital of Shenyang Military Area Department of Gastroenterology No.463 Hospital of Chinese PLA

AIM: To evaluate the frequency of use of various treatment modalities for Budd-Chiari syndrome (BCS) in China by conducting a preliminary survey of relevant literature.

关键词： Budd-Chiari syndrome Treatment Surgery Percutaneous recanalization Transjugular intrahepatic portosystemic shunt