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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo Le Tong Jianhong Dong Ziwei fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

收肌管阻滞不同输注方式对全膝关节置换术后镇痛的效果

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临床与病理杂志 2021年第7期41卷 1610-1615页

作者：袁栋欣李庆辉尹翔宇范雪艳李欣王春光保定市第一中心医院麻醉科河北保定071000

目的:观察收肌管阻滞不同输注方式用于全膝关节置换术后的镇痛效果。方法:拟行全膝关节置换术患者60例,美国麻醉医师学会(American Society of Anesthesiologists,ASA)Ⅱ或Ⅲ级,年龄65~77岁,随机分为2组(n=30):程序间歇式输注组(P组)和... 详细信息

目的:观察收肌管阻滞不同输注方式用于全膝关节置换术后的镇痛效果。方法:拟行全膝关节置换术患者60例,美国麻醉医师学会(American Society of Anesthesiologists,ASA)Ⅱ或Ⅲ级,年龄65~77岁,随机分为2组(n=30):程序间歇式输注组(P组)和恒速输注组(C组)。术毕给予负荷剂量0.2%罗哌卡因10 mL,并连接患者自控神经阻滞镇痛泵。P组程序间歇输注,单次自动给药剂量为10 mL,间歇时间为2 h。C组持续输注,背景剂量为5 mL/h。两组患者单次按压剂量为5 mL,锁定时间为30 min。当视觉模拟评分(Visual Analogue Scale,VAS)>4时,按压镇痛泵。若30 min后无缓解,皮下注射盐酸羟考酮5 mg,进行镇痛补救。分别于术后4、8、24、48和72 h时评估患者疼痛程度及患肢股四头肌肌力,并记录术后1~3 d患者步行距离。记录术后72 h内镇痛补救情况、患者满意度评分及不良反应发生情况。结果:与C组比较,P组患者8~48 h动态VAS评分降低(P0.05)。结论:程序间歇式输注收肌管阻滞可有效用于全膝关节置换术后镇痛,抑制动态痛效果优于恒速输注方式。

关键词：程序间歇式输注恒速输注收肌管阻滞全膝关节置换术

Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

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World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding Yuan-Yuan fang Wen-Jie fan Chen-Yu Zhang Shao-Fei Wang Jing Hu Wei Han Qiao Mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics

Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing Cao Chenglin Cai Guangming Wang Min Zhou Luying Peng Yantao fan Qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

Targeting STAT3 with SH-4-54 suppresses stemness and chemoresistance in cancer stem-like cells derived from colorectal cancer

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World Journal of Clinical Oncology 2025年第2期16卷 63-75页

作者： Xu-fan Zhang Qian Chen Qin Jiang Qiong-Ying Hu Department of Nuclear Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Laboratory Medicine Hospital of Mianyang Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Department of Laboratory Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Over the years,the numbers of treatment options for colorectal cancer(CRC)have increased,leading to notable improvements in the overall survival of CRC *** therapy may initially yield positive results,the development of drug resistance can result in treatment failure and cancer *** resistance is often attributed to the presence of cancer stem cells(CSCs).These CSCs not only contribute to therapeutic resistance but also play crucial roles in the initiation and development of tumor *** To investigate the antitumor effects of SH-4-54,which are mediated by targeting CSCs relative to treatment *** CSCs were enriched by culturing CRC cells in serum-free *** of stemness and IL-6/JAK2/STAT3 signaling were detected by Western *** of CSC malignancy,including proliferation,invasion,and tumor formation,were *** In this study,we employed SH-4-54,which exhibits anticancer activity in solid tumors through targeting the SH2 domain of both the signal transducer and activator of transcription(STAT)3 and the STAT5,and evaluated its effects on stemness and chemoresistance in colorectal *** expected,SH-4-54 treatment inhibited the phosphorylation of STAT3(p-STAT3)and decreased the percentage of ALDH1A1-positive CRC *** addition of SH-4-54 dissociated colorectal spheroids and decreased the expression of stemness markers,including ALDH1A1,CD44 and ***-4-54 treatment decreased IL-6/JAK2/STAT3 signaling by inhibiting p-STAT3 and thus inhibited spheroid formation by SW480 and LoVo ***,SH-4-54 treatment inhibited indicators of malignancy,including cell proliferation,invasion,and tumor formation,in CSCs in vitro and in ***,SH-4-54 treatment significantly increased chemosensitivity to *** Taken together,these results indicate that SH-4-54 is a promising molecule that exerts antitumor effects on colorectal CSCs by inhibiting STAT3 signaling.

关键词： SH-4-54 Colorectal cancer Cancer stem-like cells Stemness Chemosensitivity

低月桂烯柠檬香茅和食材柠檬香茅的引种对比试验

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饲料博览 2022年第3期32卷 48-52,55页

作者：黄俊葵杨启晟范雪雁吴柱月邱磊李冬郁黄志娟广西壮族自治区畜牧研究所/广西家畜遗传改良重点实验室南宁530001

香茅草具有广泛的应用价值,为了筛选出优良的香茅草品种用于畜禽养殖,从广西防城港市防城区引进两个香茅草品种:低月桂烯柠檬香茅和食材柠檬香茅,在相同的环境条件下种植,进行相同的管护,生长一段时间后,分别进行营养成分和生长性能指... 详细信息

香茅草具有广泛的应用价值,为了筛选出优良的香茅草品种用于畜禽养殖,从广西防城港市防城区引进两个香茅草品种:低月桂烯柠檬香茅和食材柠檬香茅,在相同的环境条件下种植,进行相同的管护,生长一段时间后,分别进行营养成分和生长性能指标的测定与分析。结果表明:低月桂烯柠檬香茅的粗蛋白、粗纤维含量明显高于食材柠檬香茅,粗脂肪含量两者相当;低月桂烯柠檬香茅的株高、冠幅、新芽长度大于食材柠檬香茅;低月桂烯柠檬香茅的产量和分蘖数比食材柠檬香茅高。说明低月桂烯柠檬香茅蛋白质含量较高,产量相对也高,更适合饲喂畜禽。

关键词：香茅草功效成分分析产量筛选

Tackling the microlensing wave effects of strong lensing gravitational waves with TAAH

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 257-258页

作者： Zuhui fan South-Western Institute for Astronomy Research Yunnan University

The rapid development of gravitational wave（GW） observations since their first detection in 2015 [1] has opened a completely new window for exploring the Universe. Consequently, astronomical research has entered the multimessenger era, allowing us to use different tracers to view the cosmos from various perspectives. Among others, the appealing application of gravitational wave events from compact binary mergers is that they can act as standard sirens to determine absolute cosmic distances entirely independent of standard candles. This approach is one of the most promising means to solve the current H0tension problem.

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习近平文化思想科学体系阐释论纲

新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 16-33,F0002页

作者：范玉刚山东大学文艺美学研究中心山东济南250100 南方科技大学全球城市文明典范研究院广东深圳518055

习近平文化思想是逻辑自恰、相互贯通、结构完整并集时代性、系统性、原创性于一体的开放性科学体系。深刻把握和领会习近平文化思想的核心要义与主导逻辑,需要建构具有有效性的理论阐释框架。文本通过提炼五个重大学术命题,即坚持党对... 详细信息

习近平文化思想是逻辑自恰、相互贯通、结构完整并集时代性、系统性、原创性于一体的开放性科学体系。深刻把握和领会习近平文化思想的核心要义与主导逻辑,需要建构具有有效性的理论阐释框架。文本通过提炼五个重大学术命题,即坚持党对文化工作的全面领导和巩固党的文化领导权,坚定文化自信、建设社会主义文化强国,在不断健全文化体系中增强国家文化软实力,以“两个结合”特别是“第二个结合”引领中华文明发展,在文明互鉴中增强中华文明的传播力影响力,以此为四梁八柱构建阐释习近平文化思想科学体系的理论框架。

关键词：习近平文化思想科学体系文化基本理论重大学术命题理论框架

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang fan Yang Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis