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GZMH:用于有丝分裂细胞核检测和分割的乳腺癌病理图像数据集

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中国图象图形学报 2024年第3期29卷 608-619页

作者：汪华登王雪馨黎兵兵刘志鹏许浩潘细朋蓝如师罗笑南广西图像图形与智能处理重点实验室桂林541004 桂林电子科技大学计算机与信息安全学院桂林541004 广东省人民医院赣州医院赣州市立医院病理科赣州341000

目的有丝分裂细胞核计数是乳腺癌诊断和组织学分级的3个重要评分指标之一,基于深度学习的自动检测方法,可以有效辅助医生进行乳腺病理图像有丝分裂细胞核识别和计数。而当前研究中的公开数据集多为竞赛所用,由举办方联合数据提供者挑... 详细信息

目的有丝分裂细胞核计数是乳腺癌诊断和组织学分级的3个重要评分指标之一,基于深度学习的自动检测方法,可以有效辅助医生进行乳腺病理图像有丝分裂细胞核识别和计数。而当前研究中的公开数据集多为竞赛所用,由举办方联合数据提供者挑选而来,与医院临床应用中所使用的数据存在较大的差异,不利于模型性能及泛化能力的测试验证。针对以上问题,本文发布了来自中国赣州市立医院临床环境的数据集GZMH(Ganzhou municipal hospital)。方法整理并公开发布的数据集GZMH包含55幅全视野数字切片(whole slide images, WSIs)临床乳腺癌病理图像,提供了用于有丝分裂细胞核目标检测和语义分割研究的两种标注,并由2名高年资医师对3名初级病理医师的标注进行了复核。5种主流目标检测方法和5种经典分割方法在GZMH数据集上进行了训练和测试,检验它们在临床数据集GZMH上的性能。结果目标检测方法实验结果比较中,SSD(single shot multibox detector)模型取得了最佳的效果,F1分数为0.511;分割方法实验结果比较中,R2U-Net(recurrent rsidual convolutional neural network based on U-Net)性能最佳,F1分数为0.430。所有方法在面对较大规模的临床数据集GZMH时体现的性能都明显低于它们在一些公开数据集上的性能。结论本文所提出的GZMH数据集能够用于有丝分裂目标检测与语义分割研究任务,且此数据集中的图像更加接近实际的应用场景,在推动乳腺病理图像有丝分裂细胞核分割的研究和临床应用方面具有较大的价值。数据集的在线发布地址为:https://***/10.57760/sciencedb.08547。

关键词：乳腺癌病理图像有丝分裂细胞核目标检测语义分割数据集

基于超级电容的智能电能表长寿命后备电源设计

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电测与仪表 2024年第1期61卷 213-218页

作者：王学信郑小平谢正权王亮熊宠巍龙志进威胜信息技术股份有限公司长沙410205 威胜集团有限公司长沙410205 湖南晟和电源科技有限公司长沙410205

智能电能表的进一步发展要求在外部供电电源中断后具有一定时间的远程通信能力,以便电能表数据的备份与停电等重要事件上报。作为常规后备电源的电池与电解电容都存在弊端,前者使用寿命较低,后者容量太小。文章首先用超级电容寿命估计... 详细信息

智能电能表的进一步发展要求在外部供电电源中断后具有一定时间的远程通信能力,以便电能表数据的备份与停电等重要事件上报。作为常规后备电源的电池与电解电容都存在弊端,前者使用寿命较低,后者容量太小。文章首先用超级电容寿命估计理论论述了满足新一代电能表16年设计寿命的可行性,给出了满足寿命要求的超级电容备用电源充电电路设计,并解决了储能电容的待机能力,最后针对微功耗电路难以用常规仪器测量的现实,使用Spice模拟电路仿真工具分析了电路功能,并进行了实际电路试验,验证了电路方案的可行性。文章对市电供电的智能互联仪表设备的备用电源设计具有一定的借鉴意义。

关键词：超级电容智能电能表仪表电源设计寿命电路仿真

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黄河下游淤背区保水层施工方案研究

水利规划与设计 2024年第9期 139-142页

作者：党同均王学新宋广增山东黄河勘测设计研究院有限公司山东济南250013 济南黄河河务局天桥黄河河务局山东济南250031 济南大学水利与环境学院山东济南250022

针对黄河下游淤背区壤土保水层施工过程中土料难找、施工不便及成本过高等问题,采用膨润土代替壤土作为保水材料,通过室内掺入比渗透试验、现场试验、模拟试验,研究得出黄河下游淤背区保水层施工方案。实验结果表明膨润土可改良砂土的... 详细信息

针对黄河下游淤背区壤土保水层施工过程中土料难找、施工不便及成本过高等问题,采用膨润土代替壤土作为保水材料,通过室内掺入比渗透试验、现场试验、模拟试验,研究得出黄河下游淤背区保水层施工方案。实验结果表明膨润土可改良砂土的保水性,对混合膨润土保水层、薄铺膨润土保水层、壤土保水层、无保水层4个试验段土壤含水率进行监测对比,混合膨润土保水层方案保水效果最好,按最佳厚度与埋设深度施工,可显著提高土壤含水率,有利于种植树株的生长。

关键词：淤背区膨润土改良砂土保水黄河下游

Modeling and Simulation of Lithium Vacuum Evaporation Process Using COMSOL Multiphysics

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Journal of Thermal Science 2024年第1期33卷 86-100页

作者： LIAN xuexin ZHONG Dawen Beijing Key Laboratory of Passive Nuclear Power Safety and Technology North China Electric Power UniversityBeijing 102206China

Based on the COMSOL Multiphysics simulation software,this study carried out modeling and numerical simulation for the evaporation process of liquid metal lithium in the vacuum free molecular flow *** motion of lithium atoms in the evaporation process was analyzed through a succession of *** on the available experimental values of the saturated vapor pressure of liquid metal lithium,the relationship between saturated vapor pressure and temperature of liquid lithium in the range of 600 K-900 K was obtained.A two-dimensional symmetric model(3.5 mm×20 mm) was established to simulate the transient evaporation process of liquid lithium at wall temperatures of 750 K,780 K,800 K,810 K,825 K,and 850 K,*** effects of temperature,the evaporation coefficient,back pressure,and length-to-diameter ratio on the evaporation process were studied;the variation trends and reasons of the molecular flux and the pressure during the evaporation process were *** the same time,the evaporation process under variable wall temperature conditions was *** research made the evaporation process of liquid lithium in vacuum molecular flow clearer,and provided theoretical support for the space reactor and nuclear fusion related fields.

关键词： free molecular flow saturated vapor pressure vacuum evaporation liquid lithium metal

孕早中期阻塞性睡眠呼吸暂停患者生命质量的现状及影响因素分析

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北京医学 2024年第6期46卷 443-448页

作者：范辰辰宋伟王雪昕赵友萍刘晓巍高红首都医科大学附属北京妇产医院/北京妇幼保健院围产医学部 100026 首都医科大学附属北京妇产医院/北京妇幼保健院内科 100026

目的探讨阻塞性睡眠呼吸暂停(obstructive sleep apnea, OSA)对妊娠期女性生命质量(quality of life, QOL)的影响。方法选取2020年9月至2022年3月首都医科大学附属北京妇产医院单胎孕早中期妊娠女性,根据睡眠呼吸暂停低通气指数(apnea... 详细信息

目的探讨阻塞性睡眠呼吸暂停(obstructive sleep apnea, OSA)对妊娠期女性生命质量(quality of life, QOL)的影响。方法选取2020年9月至2022年3月首都医科大学附属北京妇产医院单胎孕早中期妊娠女性,根据睡眠呼吸暂停低通气指数(apnea hypopnea index, AHI),采用SF-36简明健康调查量表(简称SF-36量表)评估QOL。比较SF-36量表总分及各维度得分与睡眠监测各参数、BMI、年龄之间的相关性。结果共纳入单胎孕早中期妊娠女性171例,年龄25~45岁,平均(34.0±3.9)岁。SF-36总分与非快速眼动期(non rapid eye movement, NREM)呼吸暂停最大时长呈负相关,躯体疼痛与NREM期呼吸暂停平均时长呈负相关,精力与最长氧减时间呈负相关。年龄对QOL影响不明显,但BMI与生理机能维度得分呈负相关。结论 OSA对妊娠期女性QOL均存在一定影响,肥胖能显著影响妊娠期OSA患者的QOL,临床医生在关注母婴并发症和结局的同时,更应关注其身心健康,并提供相应生活方式指导和心理干预;与AHI相比,呼吸暂停低通气持续时间对妊娠期OSA女性QOL影响更大,临床上可将AHI、最低血氧饱和度程度、呼吸暂停低通气持续时间综合考虑,为OSA患者评估提供一种新思路。

关键词：阻塞性睡眠呼吸暂停生命质量妊娠孕早中期多导睡眠监测 SF-36量表肥胖

Advances in microfluidic-based DNA methylation analysis

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Nanotechnology and Precision Engineering 2024年第1期7卷 116-134页

作者： Jiwen Li Tiechuan Li xuexin Duan State Key Laboratory of Precision Measuring Technology and Instruments Tianjin UniversityTianjin 300072China

DNA methylation has been extensively investigated in recent years,not least because of its known relationship with various *** in analytical methods can greatly increase the relevance of DNA methylation studies to both clinical medicine and scientiﬁc ***ﬂu-idic chips are excellent carriers for molecular analysis,and their use can provide improvements from multiple ***-chip molecular analysis has received extensive attention owing to its advantages of portability,high throughput,low cost,and high efﬁ*** recent years,the use of novel microﬂuidic chips for DNA methylation analysis has been widely reported and has shown obvious superiority to conventional *** this review,weﬁrst focus on DNA methylation and its ***,we discuss advanced microﬂuidic-based methods for DNA methylation analysis and describe the great progress that has been made in recent ***,we summarize the advantages that microﬂuidic technology brings to DNA methylation analysis and describe several challenges and perspectives for on-chip DNA methylation *** review should help researchers improve their understanding and make progress in developing microﬂuidic-based methods for DNA methylation analysis.

关键词： Microﬂuidic chip DNA methylation analysis Molecular analysis High throughput Low cost

Freeze-induced acceleration of iodide oxidation and consequent iodination of dissolved organic matter to form organoiodine compounds

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Journal of Environmental Sciences 2024年第10期144卷 67-75页

作者： xuexin Gong Mei He Zhineng Hao Rusong Zhao Jingfu Liu School of Resources and Environment Yangtze UniversityWuhan 430100China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Qilu University of Technology(Shandong Academy of Sciences) Shandong Analysis and Test CenterKey Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong ProvinceJinan 250014China Institute of Environment and Health Jianghan UniversityWuhan 430056China

Freeze-induced acceleration of I–oxidation and the consequent iodination of dissolved organic matter(DOM)contribute to the formation of organoiodine compounds(OICs)in cold *** formed OICs may be a potentially important source of risk and are very closely with the environment and human ***,we investigated the acceleration effects of the freeze process on I–oxidation and the formation of *** comparison to reactive iodine species(RIS)formed in aqueous solutions,I–oxidation and RIS formation were greatly enhanced in frozen solution and were affected by pH,and the content of I–and ***-thaw process further promoted I–oxidation and the concentration of RIS reached 45.7μmol/L after 6 freeze-thaw *** consequent products of DOM iodination were greatly promoted in terms of both concentration and *** total content of OICs ranged from 0.02 to 2.83μmol/L under various *** 183–1197 OICs were detected by Fourier transform ion cyclotron resonance mass spectrometry,and more than 96.2%contained one or two iodine *** OICs had aromatic structures and were formed via substitution and addition *** findings reveal an important formation pathway for OICs and shed light on the biogeochemical cycling of iodine in the natural aquatic environment.

关键词： Freeze process Dissolved organic matter(DOM) Iodination Organoiodine compounds(OICs) Ultrahigh resolution mass spectrometry

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伐桩高度对猴耳环人工药材林萌芽更新的影响

福建林业科技 2024年第2期51卷 61-65页

作者：闫晶晶王雪鑫李梅金文云陈祖旭范春节黄世能中国地质调查局西安矿产资源调查中心陕西西安710100 北京海开控股(集团)股份有限公司北京100094 中国林业科学研究院热带林业研究所、国家林业和草原局重点实验室广东广州510520 广州草木蕃环境科技有限公司广东广州510520

为探究不同伐桩高度对猴耳环人工林萌芽更新与生物量积累的影响,于2016年惠州市惠阳区良井镇前锋村,以480 d的猴耳环人工纯林为研究对象,分别采用30、60、90、120 cm的伐桩高度进行采伐,以去枝留顶和去枝截顶2种方式为对照,分析不同伐... 详细信息

为探究不同伐桩高度对猴耳环人工林萌芽更新与生物量积累的影响,于2016年惠州市惠阳区良井镇前锋村,以480 d的猴耳环人工纯林为研究对象,分别采用30、60、90、120 cm的伐桩高度进行采伐,以去枝留顶和去枝截顶2种方式为对照,分析不同伐桩高度对伐桩萌芽率、存活率、萌条数、萌条生长和生物量等的影响。结果表明:伐桩高度120 cm的萌芽点数和萌条数量最多,伐桩高度90 cm的萌条长度和萌条生物量最大,与对照相比,伐桩高度对萌芽率和存活率没有显著影响,但对萌芽点数、萌条数、萌条基径、长度和生物量影响显著;伐桩的萌条数、基径、长度和生物量均随伐桩高度的增加呈现先增加后减少的趋势。总体而言,4种伐桩高度中,90、120 cm的伐桩在萌条数量、基径、长度和生物量方面萌芽更新效果最好。伐桩高度90~120 cm是猴耳环人工药材林适宜的采伐高度,可获得较大的萌芽林生物量。

关键词：猴耳环伐桩高度萌芽更新生物量

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Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3432-3456页

作者： Xueqiang Peng Jianjun Fang Chuyuan Lou Liang Yang Shaobo Shan Zixian wang Yutong Chen Hangyu Li xuexin Li Department of General Surgery The Fourth Affiliated HospitalChina Medical UniversityShenyang 110032China Department of Ophthalmology Xi’an People’s Hospital(Xi’an Fourth Hospital)Xi’an 710004China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 10050China Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhou 510060China Department of Pathology Medical CollegeJinan UniversityGuangzhou 510632China Department of Physiology and Pharmacology Karolinska InstitutetStockholm SE-17177Sweden

The advent of cancer immunotherapy has imparted a transformative impact on cancer treatment paradigms by harnessing the power of the immune ***,the challenge of practical and precise targeting of malignant cells *** address this,engineered nanoparticles(NPs)have emerged as a promising solution for enhancing targeted drug delivery in immunotherapeutic interventions,owing to their small size,low immunogenicity,and ease of surface *** comprehensive review delves into contemporary research at the nexus of NP engineering and immunotherapy,encompassing an extensive spectrum of NP morphologies and strategies tailored toward optimizing tumor targeting and augmenting therapeutic ***,it underscores the mechanisms that NPs leverage to bypass the numerous obstacles encountered in immunotherapeutic regimens and probes into the combined potential of NPs when co-administered with both established and novel immunotherapeutic ***,the review evaluates the existing limitations of NPs as drug delivery platforms in immunotherapy,which could shape the path for future advancements in this promising field.

关键词： Engineered nanoparticles Cancer immunotherapy Drug delivery Bloodebrain barrier Tumor-barrier Nanomedicine Nanomaterial Cancer