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Frontiers of Agricultural Science and Engineering 2022年第1期9卷 63-74页

作者： Zhizhi WANG Pu TANG Min SHI Jianhua HUANG Xuexin Chen Institute of Insect Science College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests Zhejiang UniversityHangzhou 310058China Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province Zhejiang UniversityHangzhou 310058China State Key Laboratory of Rice Biology Zhejiang UniversityHangzhou 310058China

There is a growing demand for high-quality agricultural products and morecountries have adopted landscape management by sowing flowering plants inagricultural fields as an important branch of conservation biological control.However, there has been less concern over the interactions and trade-offsbetween floral plants and entomophagous arthropods. This paper reviewprogress in pollen/nectar feeding habits of entomophagous insects includingparasitoids and predators which are important natural enemies of crop pestsin agricultural fields. Factors that influence the preference of different guilds of natural enemies are reviewed to guide the selection of flowering plants inconservation biological control practices. Most studies find that floralresources have positive effects on both biological traits of natural enemies andtheir abundance and diversity, and this is believed to contribute greatly to pestcontrol. Furthermore, the potential impacts of floral resources on crop yieldsare also discussed with an emphasis on a guild of entomophagous insects thatprovides both pest control and pollination services.

关键词： ecosystem services flowering plants natural enemies nectar pollen

Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study

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Frontiers of Medicine 2022年第5期16卷 736-744页

作者： Jiansheng Li Hulei Zhao Yang Xie Jieya Li Qingwei Li Xuexin Chen Weiyu Zhang Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province&Education Ministry of China Henan University of Chinese MedicineZhengzhou 450046China Henan Key Laboratory of Chinese Medicine for Respiratory Disease Henan University of Chinese MedicineZhengzhou 450046China Department of Respiratory Diseases The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450000China Department of Pneumoconiosis Henan Hospital for Occupational DiseasesZhengzhou 450052China Department of Respiratory Diseases Jiaozuo Coal Industry Group Co.Ltd.Central HospitalJiaozuo 454000China Department of Pneumoconiosis Yima Coal Industry Group Co.Ltd.General HospitalYima 472300China

Effective therapy options for pneumoconiosis are lacking.Traditional Chinese medicine(TCM)presents a favorable prospect in the treatment of pneumoconiosis.A pilot study on TCM syndrome differentiation can evaluate the clinical efficacy and safety of TCM and lay a foundation for further clinical research.A double-blind,randomized,and placebo-controlled trial was conducted for 24 weeks,in which 96 patients with pneumoconiosis were randomly divided into the control and treatment groups.Symptomatic treatment was conducted for the two groups.The treatment group was treated with TCM syndrome differentiation,and the control group was treated with placebo.The primary outcomes were the six-minute walking distance(6MWD)and the St.George Respiratory Questionnaire(SGRQ)score.The secondary outcomes were the modified British Medical Research Council Dyspnea Scale(mMRC),Chronic Obstructive Pulmonary Disease Assessment Test(CAT),Hospital Anxiety and Depression Scale(HADS),and pulmonary function.Only 83 patients from the 96 patients with pneumoconiosis finished the study.For the primary outcome,compared with the control groups,the treatment group showed a significantly increased 6MWD(407.90 m vs.499.51 m;95%confidence interval(CI)47.25 to 135.97;P<0.001)and improved SGRQ total score(44.48 vs.25.67;95%CI 27.87 to 9.74;P<0.001).The treatment group also significantly improved compared with the control group on mMRC score(1.4 vs.0.74;95%CI 1.08 to 0.23;P=0.003),CAT score(18.40 vs.14.65;95%CI 7.07 to 0.43;P=0.027),and the total symptom score(7.90 vs.5.14;95%CI 4.40 to 1.12;P<0.001).No serious adverse events occurred.This study showed that TCM syndrome differentiation and treatment had a favorable impact on the exercise endurance and quality of life of patients with pneumoconiosis.

关键词： pneumoconiosis randomized controlled trials traditional Chinese medicine

Review of the genus Latuspina (Hymenoptera Cynipidae), with descriptions of two new species and their host galls

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Zoological Systematics 2016年第1期41卷 82-88页

作者： Yiping Wang Rui Guo Juli Pujade-Villar Shijun Wang Xuexin Chen College of Forest and Biotechnology Zhejiang Agricultural and Forestry University Lin 'an 311300 China Administration Bureau of Zhejiang Qingliangfeng National Nature Reserve Lin 'an 311300 China Depterment of Animal Biology Barcelona University Barcelona 08028 Spain Institute of Insect Sciences College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China

The East Palaearctic genus Latuspina Monzen is reviewed. Four species are recognized： L. acutissima Wang, Pujade-Villar ＆ Guo, sp. nov., L. shaanxinensis Wang, Pujade-Villar ＆ Guo, sp. nov., L. stirps （Monzen） an... 详细信息

关键词： Hymenoptera Cynipini Latuspina new species China.

Discovery of novel triple targeting G–quadruplex and topoisomerase 1/2 ligands from natural products evodiamine and rutaecarpine

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Chinese Chemical Letters 2023年第4期34卷 203-210页

作者： Haibo Wang xuexin Bai Yahui Huang Yueru chen Guoqiang Dong Tianmiao Ou Shanchao Wu Defeng Xu Chunquan Sheng National&Local Joint Engineering Research Center for High-efficiency Refining and High-quality Utilization of Biomass School of PharmacyChangzhou UniversityChangzhou 213164China Department of Medicinal Chemistry School of PharmacySecond Military Medical UniversityShanghai 200433China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China

Inspired by the indolopyridoquinazoline scaffold of natural products evodiamine and rutaecarpine, novel triple G4 and Top1/2 ligands were rationally designed and synthesized. Systematic structure–activity relationship(SAR) studies led to the discovery of compound 15g, which effectively induced and stabilized G4 and inhibited Top1/2 with potent antitumor activity. Compound 15g represents a valuable chemical tool or lead compound for antitumor drug discovery. This proof-of-concept study also validated the feasibility of using planar natural products scaffold as templates to design new G4 ligands.

关键词： Indolopyridoquinazoline G-quadruplex Topoisomerase Structure-activity relationship Antitumor activity

Preoperative functional MRI localization of language areas in Chinese patients with brain tumors Validation with intraoperative electrocortical mapping

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Neural Regeneration Research 2012年第20期7卷 1563-1569页

作者： Hechun Xia Wei Huang Liang Wu Hui Ma Xiaodong Wang Xuexin Chen Shengyu Sun Xiaoxiong Jia Department of Neurosurgery General Hospital of Ningxia Medical University Yinchuan 750004 Ningxia Hui Autonomous Region China Department of Neurosurgery Hanzhong Central Hospital Hanzhong 723000 Shaanxi Province China

Ten Chinese patients with brain tumors involving language regions were selected. Preoperative functional MRI was performed to locate Broca＇s or Wernicke＇s area, and the cortex that was essential for language function was determined by electrocortical mapping. A site-by-site comparison between functional MRI and electrocortical mapping was performed with the aid of a neuronavigation device. Results showed that the sensitivity and specificity of preoperative functional MRI were 80.0% and 85.0% in Broca＇s area and 66.6% and 85.2% in Wemicke＇s area, respectively. These experimental findings indicate that functional MRI is an accurate, reliable technique with which to identify the location of Wernicke＇s area or Broca＇s area in patients with brain tumors.

关键词： functional MRI brain tumor Chinese language brain mapping intraoperative electrocorticalmapping Wernicke＇s area Broca＇s area regeneration neural regeneration

Tunable microfluidic chip for single-cell deformation study

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Nanotechnology and Precision Engineering 2023年第2期6卷 25-32页

作者： Ruiyun Zhang xuexin Duan Shuaihua Zhang Wenlan Guo chen Sun Ziyu Han College of Precision Instrument and Opto-electronics Engineering Tianjin UniversityTianjin 300072China State Key Laboratory of Precision Measuring Technology and Instruments Tianjin UniversityTianjin 300072China

Microfluidic phenotyping methods have been of vital importance for cellular characterization,especially for evaluating single cells.In order to study the deformability of a single cell,we devised and tested a tunable microfluidic chip-based method.A pneumatic polymer polydimethylsiloxane(PDMS)membrane was designed and fabricated abutting a single-cell trapping structure,so the cell could be squeezed controllably in a lateral direction.Cell contour changes under increasing pressure were recorded,enabling the deformation degree of different types of single cell to be analyzed and compared using computer vision.This provides a new perspective for studying mechanical properties of cells at the single cell level.

关键词： Microfluidics Cell deformation Single cell Computer vision

Efficient collision attacks on smart card implementations of masked AES

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Science China(Information Sciences) 2015年第5期58卷 97-111页

作者： WANG An WANG ZongYue ZHENG xuexin WANG XiaoMei chen Man ZHANG GuoShuang WU LiJi Institute of Microelectronics Tsinghua University Key Laboratory of Cryptologic Technology and Information Security Ministry of EducationShandong University China Academy of Electronics and Information Technology School of Computer and Communication Engineering University of Science and TechnologyBeijing Science and Technology on Communication Security Laboratory

Collision attack is often employed against some cryptographic algorithms such as AES and DES.As a usual countermeasure, masking can resist such attacks to some extent. In CHES 2011, Clavier et al.proposed a collision-correlation attack based on Pearson correlation coefficient against masking. In this paper, a collision distinguisher based on least absolute deviation against masking is proposed. Subsequently, we suggest three other distinguishers based on least square method, least exponent method, and central moment product,respectively. Our experiments and simulations show that in practice, our distinguishers based on least absolute deviation and least square method perform much better than collision-correlation attack and other proposed distinguishers in this paper. We also give four application examples, which show that even if the masks are not reused, new distinguishers are competent to collision attacks.

关键词： power analysis attack collision attack least absolute deviation least square method masking

Rheological and Sintering Properties of Two Kinds of Corundum-spinel Micropowders

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China's Refractories 2022年第4期31卷 7-11页

作者： WANG Jingran chen Xinming KE Changming ZHANG Jinhua LIU xuexin LI Wen The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China Hubei Smile New Material Co. Ltd.Hong’an 438400China

For the proper use of micropowders in castables,slurries and fired samples were prepared with two kinds of corundumspinel micropowders(D and G).The effects of the solid content and disperser WSM-R1 on the rheological properties of the slurries were studied.The sintering properties and the slag corrosion resistance of the fired samples were also researched.The results show that:the slurries all show pseudoplastic rheological characteristics.With the same solid content,the slurry with micropowder G has higher initial viscosity than that with micropowder D.Disperser WSM-R1 significantly reduces the initial viscosity of the two slurries and plays a more obvious dispersing effect on the slurry with micropowder G.The fired sample with micropowder G has higher bulk density,lower apparent porosity and better corrosion resistance than that with micropowder D.

关键词： corundum-spinel micropowder rheological property sintering property slag corrosion resistance

Monitoring forest dynamics in Africa during 2000- 2020 using a remotely sensed fractional tree cover dataset

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International Journal of Digital Earth 2023年第1期16卷 2212-2232页

作者： xuexin Wei Yang Liu Lin Qi Jilong chen Guoqin Wang Linxiu Zhang Ronggao Liu Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijingPeople’s Republic of China College of Resources and Environment University of Chinese Academy of SciencesBeijingPeople’s Republic of China United Nations Environment Programme-International Ecosystem Management Partnership BeijingPeople’s Republic of China

Africa is covered with extensive woodlands,savannas and rainforests.The tree cover of these biomes has been undergoing substantial changes in recent decades.However,the dynamics of forests in Africa are currently unclear,particularly in the woodlands and savanna areas covered by sparse trees.Here,we assessed the spatio-temporal trend of African forests from 2000 to 2020,using a 250-m resolution fractional tree cover product that can capture the variation of forest density in the widespread mixed vegetation landscapes of the continent.The tree cover trends,interannual change and hotspots of forest gain and loss were evaluated.Results showed that the African forest area increased at a rate of 3.59 million ha/year over the study period,reaching 589 million ha in 2020.Considerable forest gain and loss both occurred in Africa.The net change rate in woodlands’forest area was the fastest(2.28 million ha/year),followed by rainforests(0.80 million ha/year)and savannas(0.34 million ha/year).Hotspots of forest gain were concentrated in the north belt of woodlands and savannas,while forest loss primarily clustered in East and South Africa.This work would help African countries to monitor forest change and promote forest management to achieve the Sustainable Development Goals.

关键词： Forest gain forest loss tree cover Africa spatio-temporal dynamic

Transcription-wide impact by RESCUE-induced off-target single-nucleotide variants in mammalian cells

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Journal of Molecular Cell Biology 2023年第2期15卷 17-28页

作者： Guo Li Xiaoning Zhu Yihan Wang Hongru Ma Yuzhe Wang Hanyu Wu Xiangyang Li Yiling Wang Jianen Gao Xuexin Chen Xingxu Huang Yuan Yao Xiaoxiang Hu College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311200China State Key Laboratory of Agrobiotechnology College of Biological SciencesChina Agricultural UniversityBeĳing 100193China National Research Institute for Family Planning Beĳing 100081China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Institute of Insect Sciences College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China Zhejiang Lab Hangzhou 311121China

RNA base editing is a promising tool in precise molecular therapy. Currently, there are two widely used RNA base editors, REPAIRand RESCUE. REPAIR only facilitates A-to-I conversions, while RESCUE performs both A-to-I and C-to-U conversions. Thus, RESCUEcan generate twice the number of mutations compared to REPAIR. However, transcription-wide impact due to RESCUE-induced offtarget single-nucleotide variants (SNVs) is not fully appreciated. Therefore, to determine the off-target effects of RESCUE-mediatedediting, we employed transcription-wide sequencing on cells edited by RESCUE. The SNVs showed different off-target effects onmRNA, circRNA, lncRNA, and miRNA expression patterns and their interacting networks. Our results illustrate the transcriptionwide impact of RESCUE-induced off-target SNVs and highlight the need for careful characterization of the off-target impact by thisediting platform.

关键词： transcription-wide off-target SNV RESCUE RNA