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Food Science and Human Wellness 2023年第4期12卷 1212-1223页

作者： Changhui Du Zhenjie Li Jing Zhang Ni Yin Lirong Tang Jie Li Jingyin Sun Xiaoqing Yu Wei chen Hang Xiao Xian Wu xuexiang chen School of Public Health Guangzhou Medical UniversityGuangzhou 510642China Department of Information Systems and Analytics Miami UniversityOxford 45056USA Department of Food Science University of MassachusettsAmherst 01003USA Department of Kinesiology Nutritionand HealthMiami UniversityOxford 45056USA

Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease(IBD).Carnosic acid(CA)is a major antioxidant component of rosemary and sage.Herein,we investigated the protective effects of dietary CA on dextran sodium sulfate(DSS)-induced colitis mouse model with an emphasis on its impact on the composition and metabolic function of gut microbiota.We found that CA effectively attenuated DSS-stimulated colitis in mice,as evidenced by reduced disease activity index(DAI),and systemic and colonic inflammation.Additionally,CA restored microbial diversity and improved the composition of gut microbiota in DSS-treated mice.Moreover,Spearman’s correlation coefficient showed a significant correlation between the fecal metabolites and the gut microbiota species.Changes in gut microbiota and the correlated metabolites might partially explain CA’s anti-inflammatory effects against colitis.Future clinical trials are needed to determine the therapeutic effects and mechanisms of CA on IBD in humans.

关键词： Carnosic acid Inflammatory bowel diseases Colitis Gut microbiota Metabolites

Ancient water wells reveal a prolonged drought in the lower Yellow River area about 2800 years ago

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Science Bulletin 2018年第20期63卷 1324-1327页

作者： Shiyong Yu xuexiang chen Xiuling Liu Zhen Fang Junfeng Guo Senyang Zhan Hui Fang Fahu chen School of Geography Geomaticsand PlanningJiangsu Normal UniversityXuzhou 221116China Joint International Research Laboratory for Environmental and Social Archaeology 5handong Universityfinan 250100China Jinan Municipal Institute of Archaeology jinan 250062China Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100101China

Proxy records from the North Atlantic realm reveal that large and rapid cooling known as the Bond events continued into the Holocene [1],repeatedly punctuating what is conventionally thought to have been a relatively stable climate.Given that the Holocene is the most recent interglacial period that has spurred the development of modern societies,scrutinizing climate variabil- ity during this period is important not only for predicting the trend of future climate changes,but also for better understanding the driving forces behind the rise and fall of ancient civilizations.

关键词： water wells drought Yellow River area

一株香猪源乳酸菌的分离鉴定及生物学特性研究

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饲料工业 2024年第10期45卷 113-118页

作者：陈穗莲张伟黄云田永宽王彬吴学祥贵州大学动物科学学院贵州贵阳550025

为了筛选可应用于香猪用饲料添加剂的乳酸菌菌株,试验通过1%碳酸钙的MRS固体培养基从香猪盲肠内容物中分离筛选出1株产酸能力强、抗逆性好、抗生素敏感的乳酸菌。经革兰氏染色鉴定、生理生化鉴定、16S rRNA测序,鉴定该乳酸菌为植物乳杆... 详细信息

为了筛选可应用于香猪用饲料添加剂的乳酸菌菌株,试验通过1%碳酸钙的MRS固体培养基从香猪盲肠内容物中分离筛选出1株产酸能力强、抗逆性好、抗生素敏感的乳酸菌。经革兰氏染色鉴定、生理生化鉴定、16S rRNA测序,鉴定该乳酸菌为植物乳杆菌(L.plantarum)。进一步从产酸性能、耐酸试验、耐热试验、耐胆盐试验、抗生素敏感性试验等方面对分离到的L.plantarum进行生物学特性研究。结果表明:L.plantarum生长最适温度为37~45℃;L.plantarum具有优秀的产酸能力,pH最低可达到3.3;L.plantarum可以耐受低pH,在pH为2.0时的存活率为13%;在含0.4%猪胆盐的MRS肉汤中存活率为13%;L.plantarum对红霉素、复方新诺明、氯霉素、青霉素、氨苄西林、头孢唑林高度敏感。由此可见,L.plantarum是一株抗逆性、抗生素敏感性、产酸效果都非常优异的香猪源微生态制剂备用菌株。

关键词：香猪植物乳杆菌分离鉴定生物学特性抗逆性

Structure analysis of ethyl ferulate from Rubus corchorifolius L.f.leaves and its inhibitory effects on HepG2 liver cancer cells

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Food Bioscience 2022年第1期45卷 370-376页

作者： xuexiang chen Xian Wu Guo Liu Qun Wang Sasha A.Itenberg Wen Ouyang Mingyue Song William RDixon Yong Cao Hang Xiao School of Public Health Guangzhou Medical UniversityGuangzhou511436PR China Department of Kinesiology Nutritionand HealthMiami UniversityOxfordOH45056United States College of Food Science South China Agricultural UniversityGuangzhou510642PR China Pharmacy College Hunan University of Traditional Chinese MedicineChangsha410007PR China Department of Food Science University of MassachusettsAmherstMA01003United States

The tender leaves of Rubus corchorifolius L.f.(R.corchorifolius)have been made into herbal tea for relieving coughs in East and Southeast Asia from ancient times.Herein,we obtained an ethyl acetate extract from R.corchorifolius leaves and isolated a major bioactive compound within.Structural analysis of the isolated compound was performed by spectroscopic methods and the compound was identified as ethyl ferulate.Effect of ethyl ferulate on the growth and proliferation of human liver cancer HepG2 cells and normal human liver LO2 cells was determined by MTT assay.We found that ethyl ferulate significantly suppressed the cell proliferation of HepG2 cells(IC_(50)26.4μM),while it did not cause cytotoxicity on LO2 cells.In addition,flow cytometry analysis demonstrated that ethyl ferulate inhibited HepG2 cell growth via inducing cellular apoptosis.Specifically,ethyl ferulate reduced the electrical potential of the mitochondrial membrane and increased the concentration of calcium ions inside cells.Moreover,these changes were accompanied by increases in the expression of the pro-apoptotic proteins,such as cleaved caspase-3 and Bax.In contrast,cell morphology and growth of LO2 cells remained unaffected.In conclusion,for the first time,our observations demonstrated that ethyl ferulate possesses great potential as an effective and safe antitumor agent for cancer chemoprevention in humans.

关键词： Rubus corchorifolius L.f Ethyl ferulate Bioactive compound Functional food Apoptosis

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单方向夹持悬伸薄壁结构件多轴切削工艺优化

机电工程技术 2024年第6期53卷 29-32,55页

作者：陈学翔陈洁训李南华黄志楷佛山高明技师学院广东佛山528500 韶关市技师学院现代制造产业系广东韶关512023 广东省机械研究所有限公司广州510700

以单方向夹持的悬伸薄壁结构零件切削加工为研究对象,通过工艺设计优化有效避免了断裂,振动过切,尺寸变形超差,振纹等加工缺陷。使用Siemens NX12.0和宏程序结合的方式完成零件的四轴加工程序编制。通过降低最小壁厚和伸出长度比值、宏... 详细信息

以单方向夹持的悬伸薄壁结构零件切削加工为研究对象,通过工艺设计优化有效避免了断裂,振动过切,尺寸变形超差,振纹等加工缺陷。使用Siemens NX12.0和宏程序结合的方式完成零件的四轴加工程序编制。通过降低最小壁厚和伸出长度比值、宏程序螺旋铣削切断工艺方案,解决加工过程中切削振动造成曲面与连接底座容易断裂的难题。提出薄壁曲面分段加工和控制走刀方向相结合减少了薄壁曲面振动和过切,减少了表面振纹以及粗糙度超差的影响。严格控制零件圆柱体回转跳动误差,解决不具备RTCP功能数控系统定轴加工精度超差问题。多次实例证明零件达到加工技术要求,为悬伸薄壁复杂结构零件提高切削加工质量提供参考。

关键词：单方向夹持悬伸薄壁零件多轴切削加工加工缺陷优化策略过切和变形

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基于无人机影像城市建筑物的分类制图与统计

现代信息科技 2024年第2期8卷 141-144页

作者：陈梁余学祥蒲涛汤连盟安徽理工大学空间信息与测绘工程学院安徽淮南232001 安徽理工大学矿山采动灾害空天地协同监测与预警安徽普通高校重点实验室安徽淮南232001 安徽理工大学矿区环境与灾害协同监测煤炭行业工程研究中心安徽淮南232001

建筑物是人类生活的主要场所,对其进行分类与统计可以为城市规划、资源管理、灾害风险评估和环境监测等要事提供所需的基础数据和信息,从而支持正确决策的制定和城市的可持续发展。为解决遥感影像中各建筑物之间间距小的问题,基于机器... 详细信息

建筑物是人类生活的主要场所,对其进行分类与统计可以为城市规划、资源管理、灾害风险评估和环境监测等要事提供所需的基础数据和信息,从而支持正确决策的制定和城市的可持续发展。为解决遥感影像中各建筑物之间间距小的问题,基于机器学习中随机森林算法并结合多尺度分割进行安庆市区无人机影像建筑物的分类制图与统计,结果表明该方法的分类精度为0.873 4,Kappa系数为0.762 7,并通过目视解译法进行对比分析,得出该方法在建筑物分类上具有可行性。

关键词：建筑物无人机影像分类遥感应用

Quantitative assessment of acute kidney injury by noninvasive arterial spin labeling perfusion MRI:a pilot study

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Science China(Life Sciences) 2013年第6期56卷 745-750页

作者： DONG Jian YANG Li SU Tao YANG XueDong chen Bin ZHANG Jue WANG XiaoYing JIANG xuexiang Department of Radiology Peking University First Hospital Department of Nephrology Peking University First Hospital Academy for Advanced Interdisciplinary Studies Peking University College of Engineering Peking University

The kidneys are essential for maintaining homeostasis,are responsible for the reabsorption of water,glucose and amino acids,and filter the blood by removing waste.Acute kidney injury(AKI) is a syndrome characterized by the rapid loss of renal excretory function and the accumulation of end metabolic products of urea and creatinine.AKI is associated with the later development of chronic kidney disease and end-stage kidney disease,and may eventually be fatal.Early diagnosis of AKI and assessments of the effects of treatment,however,are challenging.The pathophysiological mechanism of AKI is thought to be the imbalance between oxygen supply and demand in the kidneys.We have assessed the ability of arterial spin labeling(ASL) perfusion magnetic resonance imaging(MRI),without the administration of contrast media,to quantify renal blood flow(RBF) non-invasively.We found that RBF was significantly lower in AKI patients than in healthy volunteers.These results suggest that ASL perfusion MRI,a noninvasive measurement of RBF,may be useful in the early diagnosis of AKI.

关键词：定量评估自旋标记肾损伤灌注动脉急性磁共振成像早期诊断

Oligomerization of Ethylene with Nickel-based Catalysts

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China Petroleum Processing & Petrochemical Technology 2001年第3期3卷 53-55页

作者： Yi Jianjun Xu xuexiang chen Wei Jing Zhenhua Research Institute of Petroleum Processing Beijing 100083 Research Institute of Petroleum Processing Beijing 100083 Research Institute of Petroleum Processing Beijing 100083 Research Institute of Petroleum Processing Beijing 100083

Since the group of Brookhart produced high molecular weight polyethylene for the first time with á-diimine Ni(II) or Pa (II) complexes in the presence of methylaluminoxane(MAO),the investigation of the late transitio... 详细信息

关键词： molecular weight metal complexes

Tectonic Movement and Global Climate Change

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Global Geology 2000年第2期5卷 121-128页

作者： Yang xuexiang chen Dianyou Jilin University Changchun 130026 P. R. China

Glaciation between northern hemisphere and southern hemisphere were synchronous, the ice age occurred not in high but in low value of the eccentricity of the earth’s orbit. Such facts went against the precession principle of the astronomical theory of ice age. The inhomogeneous distribution of climate consisted with the inhomogeneous distribution of ocean and continent. The north/south antisymmetry may be attributed to southward deviation of the thermal center and northward deviation of the mass center within the mantle demonstrated by seismic tomography. The core - mantle angular momentum makes rotational energy into thermal energy and mantle plumes erupt in the ocean bottom. The earth’s deformation by tidal force makes the eruption of mantle plumes strong. They are the reason that glaciation between the Northern Hemisphere and Southern Hemisphere are synchronotis and the ice age occurred in low value of the eccentricity of the earth’s orbit. The tectonic movement is playing a most important part in global climate change.

关键词： Asymmetry of geodynamic system Southward deviation of the thermal center Ice ages synchronism between the two hemispheres Core- mantle angular momentum Sea bottom boiler effects.

The Characteristics of Sulfur and Lead Isotope Geochemistry of Laozhaiwan Gold Deposit,Yunnan Province

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地球科学进展 2012年第S1期27卷 310-311页

作者： Zhao Dekun chen Cuihua Gu xuexiang Dai HongZhang He Chaoxin College of Earth Sciences Chengdu University of Technology School of Earth Sciences & Resources China University of Geosciences

1 Introduction Laozhaiwan gold deposit,a part of"Golden Triangle"in Yunnan-Guizhou-Guangxi,was located in Jiumo village in Guangnan county,Yunnan province.The main ore-bearing stratum of the deposit was Posongchong Formation（D1 ps）of the lower Devonian.The structure was well-developed in this area,the ore bodies produced which mainly controlled by the faults.There was a diabasic dike in the northwest of this area,where the grade of the ore bodies was higher.2 S isotope geochemistry The composition ofδ34S in pyrites was 5.

关键词： Sulfur stratum geochemistry village northwest Isotope Golden county isotope mantle