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Evolved differential model for sporadic graph time-series prediction

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Intelligent and Converged Networks 2024年第3期5卷 237-247页

作者： Yucheng Xing Jacqueline Wu Yingru Liu xuewen yang Xin Wang Department of Electrical and Computer Engineering Stony Brook UniversityStony BrookNY 11794USA New York University New YorkNY 10012USA

Sensing signals of many real-world network systems,such as traffic network or microgrid,could be sparse and irregular in both spatial and temporal domains due to reasons such as cost reduction,noise corruption,or device *** is a fundamental but challenging problem to model the continuous dynamics of a system from the sporadic observations on the network of nodes,which is generally represented as a *** this paper,we propose a deep learning model called Evolved Differential Model(EDM)to model the continuous-time stochastic process from partial observations on *** model incorporates diffusion convolutional network to parameterize continuous-time system dynamics by graph Ordinary Differential Equation(ODE)and graph Stochastic Differential Equation(SDE).The graph ODE is applied to accurately capture the spatial-temporal relation and extract hidden features from the *** graph SDE can efficiently capture the underlying uncertainty of the network *** the recurrent ODE-SDE scheme,EDM can serve as an accurate online predictive model that is effective for either monitoring or analyzing the real-world networked *** extensive experiments on several datasets,we demonstrate that EDM outperforms existing methods in online prediction tasks.

关键词： graph sequence prediction sporadic time series continuous model stochastic model differential equation

Serum microRNA-155 as a potential biomarker for breast cancer screening

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Chinese Science Bulletin 2012年第26期57卷 3466-3468页

作者： ZHAO SuYing WU Qian GAO Fen ZHANG ChunBing yang xuewen Department of Laboratory Medicine Jiangsu Provincial Hospital of TCMNanjing 210029China School of Public Health Nanjing Medical UniversityNanjing 210029China

MicroRNAs(miRs) have been shown to be differentially expressed in the serum of cancer patients and controls,and can thus be used as biomarkers for cancer *** detected the expression level of miR-155 in the serum of female breast cancer patients and healthy controls to investigate whether serum miR-155 could discriminate patients with early-stage breast *** samples were collected from 20 female patients with newly diagnosed breast cancer and 10 healthy ***-time quantitative PCR was used to detect the expression level of *** expression level of miR-155 was significantly increased in the serum of breast cancer patients compared with in the serum of normal ***-155 may be useful as a blood-based biomarker for breast cancer screening.

关键词：血清样品生物标志物乳腺癌筛查癌症患者小分子RNA PCR方法对照组

Association among lifestyle, clinical examination, polymorphisms in CDH1 gene and Traditional Chinese Medicine syndrome differentiation of gastric cancer

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Journal of Traditional Chinese Medicine 2013年第5期33卷 572-579页

作者： Junfeng Zhang Zhen Zhan Juan Wu Chunbing Zhang Yaping yang Shujuan Tong Ruiping Wang xuewen yang Wei Dong Department of Pathogen and Immunology Discipline of Chinese and Western Integrative Medicine College of Basic Medicine Nanjing University of Chinese Medicine Department of Statistics and Preventive Medicine Discipline of Chinese and Western Integrative Medicine College of Basic Medicine Nanjing University of Chinese Medicine Department of Clinical Laboratory First Affiliated Hospital of Nanjing University of Chinese Medicine Department of Traditional Chinese Medicine Diagnostics College of Basic Medicine Nanjing University of Chinese Medicine Department of Traditional Chinese Medicine Oncology First Affiliated Hospital of Nanjing University of Chinese Medicine

OBJECTIVE:To explore the association among lifestyle,clinical examination,polymorphisms in CDH1 gene and Traditional Chinese Medicine(TCM)syndrome differentiation of gastric cancer(GC). METHODS:A hospital-based population of 387 GC patients was investigated in Jiangsu *** information regarding lifestyle and clinical examination were collected by a standard *** known single nucleotide polymorphisms(SNPs)in CDH1 were investigated by polymerase chain reaction-ligation detection reaction *** analysis was conducted by SPSS 16.0 ***:The results showed that meal duration and the status of glutamic pyruvic transaminase were significantly associated with TCM syndrome differentiation of GC(both P0.05).However,significant differences were observed in rs13689 genotype distributions between several pairs of syndrome types of GC,suggesting that rs13689 is correlated with the syndrome differentiation of ***:Integrated analysis of lifestyle,clinical examination and CDH1 gene polymorphisms can contribute to a better understanding of the GC syndrome types and may improve the efficacy of interventions by stratifying disease according to TCM criteria.

关键词： Cadherins Stomach neoplasms Polymorphism single nucleotide Syndrome differentiation Clinical examination

Promoting osteogenic differentiation in pre-osteoblasts and reducing tibial fracture healing time using functional nanofibers

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Nano Research 2018年第7期11卷 3658-3677页

作者： Gu Cheng Jiajia Chen Qun Wang xuewen yang Yuet Cheng Zhi Li Hu Tu Hongbing Deng Zubing Li The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology & Department of Oral and Maxillofacial Trauma and Plastic Surgery Wuhan University Stomatological Hospital Wuhan University Wuhan 430079 China Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy Hubei Key Lab of Biomass Resource Chemistry and Environmental Biotechnology School of Resource and Environmental Science Wuhan University Wuhan 430079 China Department of Chemical and Biological Engineering Iowa State University Ames IA 50014 USA

Various composite materials are now used as artificial tissue substitutes, and are defining new frontiers in tissue engineering. In the present study, composite membranes based on silk fibroin （SF） were fabricated to form a synthetic periosteum. The fabricated membranes were physicochemically characterized by their morphology, porosity, biocompatibility, biodegradability, chemical structure, and mechanical properties. Following the addition of polycaprolactone （PCL） to the silk fibers, there was a 3-5-fold increase in the elongation at break compared with the pure silk membranes, and surface wettability was retained. The degradation time of the SF within the membranes was also prolonged by adding PCL. Compared with pure PCL membranes or plastic culture plates, the SF-based membranes significantly enhanced the cellular viability and osteogenic differentiation capability of MC3T3-E1 cells. Higher expression levels of osteogenic differentiation markers （runt-related transcription factor 2 （RUNX2）, alkaline phosphatase （ALP）, and osteopontin （OP）） further supported the use of the SF component in bone-related applications. A non-rigid internal fixation （non-RIF） fracture model that healed via endochondral bone formation was created, and fracture callus samples were collected to perform micro-computed tomography, histolog~ and immunohistochemistry analyses at 8 weeks after surgery. A smaller bone volume accompanied by a mineralized bony callus was observed in SF/PCL membrane-treated rats. Immunohistochemistry also indicated that the SF/PCL membrane-treated rats exhibited increased osteocalcin expression but reduced collagen type X expression. These findings could lead to an alternative strategy for treating comminuted fractures with enhanced intramembranous ossification and reduced endochondral ossification.

关键词： silk fibroin polycaprolactone scaffold bone tissue engineering

Apparent diffusion coefficient in normal and abnormal pattern of intervertebral lumbar discs: initial experience

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The Journal of Biomedical Research 2011年第3期25卷 197-203页

作者： Gang Niu xuewen Yu Jian yang Rong Wang Shaojuan Zhang Youmin Guo Department of Diagnostic Radiology the First Hospital of Medical School Xi'an Jiaotong University Xi'an Shaanxi 710061 China

The aim of the present study was to compare the relationship of morphologically defined non-bulging/herni-ated, bulging and herniated intervertebral lumbar discs with quantitative apparent diffusion coefficient （ADC）. Thirty-two healthy volunteers and 28 patients with back pain or sciatica were examined by MRI. All intervertebral lumbar discs from L1 to S1 were classified according to morphological abnormality and degenerated grades. The ADC values of nucleus pulposus （NP） were measured and recorded. The significant differences about mean ADC values of NP were found between non-bulging/herniated discs and bulging discs as well as herniated discs （P 0.05）, whereas there were no significant differences in ADC values between bulging and herniated discs （P 0.05）. Moreover, statistically significant relationship was found in the mean ADC values of NP between ＂non-bulging/herniated and non-degenerated discs＂ and ＂non-bulging/herniated degenerated discs＂ as well as herniated discs （P 0.05）. Linear regression analysis between ADC value and disc level revealed an inverse correlation （r = -0.18）. The ADC map of the NP is a potentially useful tool for the quantitative assessment of componential and molecular alterations accompanied with lumbar disc abnormalities.

关键词： intervertebral lumbar disc apparent diffusion coefficient disc bulging disc herniation

Theoretical exploration of water injection gravity flooding oil in ultra-deep fault-controlled fractured-cavity carbonate reservoirs

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Petroleum Exploration and Development 2022年第1期49卷 133-143页

作者： yang xuewen WANG Rujun DENG Xingliang LI Shiyin ZHANG Hui YAO Chao PetroChina Tarim Oilfield Company Korla 841000China

Based on the analysis of geological characteristics of ultra-deep fault-controlled fracture-cavity carbonate reservoirs and division of reservoir units, two physical models were made, and physical simulations of oil displacement by water injection were carried out to find out water flooding mechanism in the fault-controlled fracture-cavity carbonate reservoir under complex flow state. On this basis, a mathematical model of fault-controlled carbonate reservoir with coexisting seepage and free flow has been established. Pilot water injection tests have been carried out to evaluate the effects of enhancing oil recovery by water injection. The results show that: fault-controlled fracture-cavity carbonate reservoir units can be divided into three types:the strong natural energy connected type, the weak natural energy connected type and the weak natural energy isolated type;the fault-fracture activity index of the fault-controlled fractured-cavity body can effectively characterize the connectivity of the reservoir and predict the effective direction of water injection;the mathematical model of fault-controlled carbonate reservoir with coexisting seepage and free flows can quantitatively describe the fluid flow law in the fracture-cavity body;the water injected into the fault-controlled fracture-cavity body is weakly affected by the capillary force of the lithologic body, and the oil-water movement is mainly dominated by gravity. The development modes of single well water injection, unit water injection,and single well high pressure water injection proposed based on the connection structure of fracture-cavity space and well storage space configuration are confirmed effective by pilot tests, with obvious water injection gravity flooding effect.

关键词： Tarim Basin Ordovician fault-controlled carbonate reservoir fractured-cavity carbonate reservoir water flooding gravity flooding EOR

Clinical analysis of neurological system complications in AIDS and HIV positive patients

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Journal of Nanjing Medical University 2007年第5期21卷 345-347页

作者： Yongmei yang Huiyong Su xuewen yang Qinglong Ai Department of Neurology the People＇ s Hospital of Dali Prefecture Dali 671000 Yunnan Province China Department of Neurology the First Affiliated Hospital of Kunming Medical College Kunming 650032 Yunnan Prorince China

Objective：To report the clinical manifestations of AIDS with nervous system complications. Methods：We collected the clinical material of AIDS and HIV positive patients who were admitted to our hospital from January 1998 to July 2006, and retrospectively analyzed the 39 cases having nervous system complications, among 146 cases in total. Results：Among 39 cases, there were 3 cases of HIV dementia, 1 case of vacuolar myelopathy, 3 cases of Gullain-barre syndrome, 3 cases of myopathy and 26 cases of secondary opportunistic infection of CNS,including 9 cases of tuberculosis, 6 cases of cryptococcus, 5 cases of toxoplasma, 3 cases of herpes zoster virus, 2 cases of herpes simples virus, 1 case of cytomegalovirus, 1 case of progressive multifocal leukoencencephalitis. 2 cases with central nervous system *** them 12 patients gave up treatment, other patients received anti-HIV treatment and antimicroorganism treatment. 5 patients died of respiratory failure, 2 patients died of multiple organs failure. Conclusion：Up to now, AIDS still has not very good management. So prevention is very important.

关键词： AIDS HIV nervous system

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化学镀镍对铁基复合材料力学性能的影响

铸造技术 2014年第11期35卷 2617-2619页

作者：阳学文萍乡学院江西萍乡337055 江西师范大学化学化工学院江西南昌330022

研究了化学镀镍对铁基复合材料力学性能的影响。结果表明,铁基复合材料化学镀镍后,可以增强粒子之间的连接强度,从而提高铁基复合材料的抗拉强度和伸长率。而且,铁基复合材料的抗拉强度和伸长率都随着Si

关键词：化学镀镍铁基体抗拉强度伸长率

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TC6钛合金加热和冷却过程中的相转变研究

稀有金属材料与工程 2012年第12期41卷 2123-2126页

作者：陈勋范群波杨学文北京理工大学北京100081

采用迅速水冷保留高温组织状态的方法,研究TC6钛合金在两相区加热和冷却过程中的相转变。结果表明：在加热过程中,次生α相会在700~850℃时优先固溶,初生α相在900℃时才会固溶,能谱分析结果表明,初生α相中Al元素浓度高于次生α相中Al... 详细信息

采用迅速水冷保留高温组织状态的方法,研究TC6钛合金在两相区加热和冷却过程中的相转变。结果表明：在加热过程中,次生α相会在700~850℃时优先固溶,初生α相在900℃时才会固溶,能谱分析结果表明,初生α相中Al元素浓度高于次生α相中Al元素浓度,因此初生α相在高温下更加稳定。在冷却过程中初生α相优先长大,而次生α相由于是通过形核长大,表现为在较低温度段才开始析出,且次生α相析出会降低初生α相的长大速度;进一步研究发现,冷却过程中次生α相析出温度会随着保温温度的降低而逐渐降低。

关键词： TC6钛合金相转变显微组织