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GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases

The Innovation 2024年第2期5卷 27-41页

作者： Zheyan Fang Gang Zhao Shuang Zhao xueting yu Runyang Feng You-en Zhang Haomin Li Lei Huang Zhenyang Guo Zhentao Zhang Mukaddas Abdurahman Hangnan Hong Peng Li Bing Wu Jinhang Zhu Xin Zhong Dong Huang Hao Lu Xin Zhao Zhaoyang Chen Wenbin Zhang Junjie Guo Hongchao Zheng yue He Shengying Qin Haojie Lu yun Zhao Xiangdong Wang Junbo Ge Hua Li Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Medical Examination Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology and Institute of Clinical Medicine Renmin HospitalHubei University of MedicineShiyan 442000China Clinical Data Center Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Molecular Celland Cancer BiologyUniversity of Massachusetts Chan Medical SchoolWorcesterMA 01605USA Bio-X Institute Key Laboratory for The Genetics of Developmental and Neuropsychiatric DisordersShanghai Jiao Tong UniversityShanghai 200030China Department of Cardiology Heart Center of Fujian ProvinceFujian Medical University Union HospitalFuzhou 350001China Department of Cardiology Sir Run Run Shaw Hospitalaffiliated with Zhejiang University School of MedicineHangzhou 310020China Department of Cardiology The Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Cardiology Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology Shanghai Eighth People’s HospitalShanghai 200235China Department of Chemistry and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology Shanghai Tech University100 Haike RoadShanghai 201210China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Pulmonary and Critical Care Medicine Zhongshan Hospital

Partial endothelial-to-mesenchymal transition(EndMT)is an intermediate phenotype observed in endothelial cells(ECs)undergoing a transition toward a mesenchymal state to support neovascularization during(patho)physiological angiogenesis.Here,we investigated the occurrence of partial EndMT in ECs under hypoxic/ischemic conditions and identified general transcription factor IIH subunit 4(GTF2H4)as a positive regulator of this process.In addition,we discovered that GTF2H4 collaborates with its target protein excision repair cross-complementation group 3(ERCC3)to co-regulate partial EndMT.Furthermore,by using phosphorylation proteomics and site-directed mutagenesis,we demonstrated that GTF2H4 was involved in the phosphorylation of receptor coactivator 3(NCOA3)at serine 1330,which promoted the interaction between NCOA3 and p65,resulting in the transcriptional activation of NF-κB and the NF-kB/Snail signaling axis during partial EndMT.In vivo experiments confirmed that GTF2H4 significantly promoted partial EndMT and angiogenesis after ischemic injury.Collectively,our findings reveal that targeting GTF2H4 is promising for tissue repair and offers potential opportunities for treating hypoxic/ischemic diseases.

关键词： ischemic activation GTF

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中国通货膨胀持久性特征与货币政策启示

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北方经贸 2024年第4期 103-108页

作者：于学霆重庆工商大学数字与统计学院重庆400067

基于1992Q1至2023Q2中国四类总体价格指标的环比折年率数据,借助于自回归系数和法和多倍未知结构断点检验方法,测度分析了中国通货膨胀持久性特征及其货币政策含义。研究发现:一是在样本区间内四类通货膨胀持久性相对较高,CPI和RPI存在... 详细信息

基于1992Q1至2023Q2中国四类总体价格指标的环比折年率数据,借助于自回归系数和法和多倍未知结构断点检验方法,测度分析了中国通货膨胀持久性特征及其货币政策含义。研究发现:一是在样本区间内四类通货膨胀持久性相对较高,CPI和RPI存在两个显著的均值结构断点,分别在1996Q2和2003Q2,GDP_def存在一个显著的均值结构断点,在1996Q2,三者通货膨胀持久性近期均呈现上升趋势。PPI不存在明显均值结构断点;二是半衰期持久性测度结果显示,当前我国货币政策对CPI和RPI的调控应至少提前1个季度,对PPI的调控应至少提前2个季度,对GDP_def的调控应至少提前3个季度;三是我国CPI和RPI通货膨胀持久性在20世纪90年代呈现出一定程度的下降,这与国际研究实践一致。

关键词：通货膨胀持久性环比折年率结构断点货币政策

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基于最优碰撞波形的某电动汽车前端结构碰撞性能改进

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汽车技术 2024年第6期 32-36页

作者：唐洪斌张君媛王士彬余雪婷中国第一汽车股份有限公司研发总院长春130013 吉林大学长春130022 高端汽车集成与控制全国重点实验室长春130013

为实现电动汽车正面碰撞时车身结构吸能最大化,通过分析汽车最优碰撞波形构型的特点,结合理论和经验公式对汽车前端结构进行设计,同时引入弯折等变形模式,提出基于理论最优波形构型的车身结构正面碰撞性能改进方法。结果表明,改进后车... 详细信息

为实现电动汽车正面碰撞时车身结构吸能最大化,通过分析汽车最优碰撞波形构型的特点,结合理论和经验公式对汽车前端结构进行设计,同时引入弯折等变形模式,提出基于理论最优波形构型的车身结构正面碰撞性能改进方法。结果表明,改进后车体结构的碰撞波形与最优波形构型基本一致,同时乘员胸部加速度明显下降,提高了整车安全性。

关键词：电动汽车最优碰撞波形结构改进前端结构

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张雅丽运用中药膏剂治疗脂肪肝的经验撷英

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中医药临床杂志 2024年第5期36卷 889-892页

作者：张传举喻学婷张雅丽王涛黑龙江省中医药科学院黑龙江哈尔滨150036

脂肪肝是目前临床最常见的慢性肝病,临床表现为肝脏脂质沉积,严重者可进展为肝硬化、肝癌,给临床患者带来了极大的身心损害。气血是生命活动的基本物质,气血不和则百病生。张雅丽教授从内经“气血”理论的角度探讨中药膏剂治疗脂肪肝,... 详细信息

脂肪肝是目前临床最常见的慢性肝病,临床表现为肝脏脂质沉积,严重者可进展为肝硬化、肝癌,给临床患者带来了极大的身心损害。气血是生命活动的基本物质,气血不和则百病生。张雅丽教授从内经“气血”理论的角度探讨中药膏剂治疗脂肪肝,血气不和是脂肪肝的主要病机,认为调和气血应当贯穿脂肪肝治疗的始终。张雅丽教授从调和气血、投方问路、三因致宜等方面来论治脂肪肝,临床疗效显著。现分享张雅丽教授临床运用中药膏剂治疗脂肪肝的经验,为临床深入研究脂肪肝提供新的诊疗思路。

关键词：脂肪肝中药膏剂气血不和张雅丽名医经验

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Outer-surface Covering of Nanochannels with Hydrogel for Highly Sensitive and Specific Cr(VI)Detection Through Analyte-caused Charge Change in Hydrogel

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Chemical Research in Chinese Universities 2024年第2期40卷 326-332页

作者： LIU Huan SUN xueting DAI yu ZHANG Xiaojin XIA Fan Faculty of Materials Science and Chemistry China University of GeosciencesWuhan430074P.R.China

Nanochannels have made great progress and are a promising platform for detecting a series of targets.However,most nanochannels are modified on the inner wall,while ignoring the outer surface.Here,we modified the outer surface of nanochannels with hydrogel.Different from other reported outer-surface modification methods,we directly cover nanochannels with hydrogel to form heterogeneous membrane.The selected hydrogel hardly adsorbs other ions and shows specific adsorption for Cr(VI).The adsorption sites in hydrogel are homogeneous,and Cr(VI)adsorption onto hydrogel is endothermic and spontaneous.The charge in hydrogel changes after Cr(VI)adsorption,and the resulting current changes can be used for the detection of Cr(VI)with the detection limit of 10−11 mol/L.Our platform is expected to be used for Cr(VI)detection in living organisms,especially within cells.This work provides a new approach for outer-surface modification of nanochannels and offers a new choice for nanochannel detection platforms.

关键词： Nanochannel Hydrogel Heterogeneous membrane Cr(VI)detection

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Understanding livelihood vulnerability:a perspective from Western Sichuan’s ethnic rural settings

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Journal of Mountain Science 2024年第2期21卷 380-396页

作者： yu Yongqian JING Zheng WANG Yan QIU Xiaoping YANG xueting XU yun School of Geography and Resource Science Sichuan Normal UniversityChengdu 610101China Key Laboratory of land Resources Evaluation and Monitoring in Southwest Ministry of EducationSichuan Normal UniversityChengdu 610101China Sichuan County Economic Development Research Center Mianyang Normal UniversityMianyang 621000China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China

To explore the livelihood status and key influencing factors of rural households in the minority areas,we collected flat data from 284 rural households in 32 villages across 12 counties of Western Sichuan from 2021 to 2022.We conducted participatory household survey on the livelihood status of the rural households and try to identify the key factors to influence their livelihood vulnerability using multiple linear regression.The results showed that:the livelihood situation of the rural households is relatively vulnerable.The vulnerability varies significantly with the income levels,education levels,and income sources.The vulnerability of farm households,categorized from low to high livelihood types,follows the sequence:non-agricultural dominant households,non-agricultural households,agricultural dominant households,and pure agricultural households.The degree of damage to the natural environment,education costs,loan opportunities,the proportion of agricultural income to annual household income,and the presence of sick people in the household have significant positive effects on the livelihood vulnerability index(LVI)of rural households;while help from relatives and friends,net income per capita,household size,household education,agricultural land area,participation in industrial organizations,number of livestock,purchase of commercial houses,drinking water source,and self-supply of food have significant negative effects.Based on the findings,we believe that local rural households operate in a complex livelihood system and recommend continuous interventions targeting key influences to provide empirical research support for areas facing similar situations.

关键词： Livelihood Vulnerability Rural households Ethnic areas

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不同中医证型2型糖尿病与外周血巨噬细胞表型的相关性

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中医药导报 2024年第6期30卷 74-78页

作者：张传举喻学婷颉彦鹏李浩经王涛蔡萧君黑龙江省中医药科学院黑龙江哈尔滨150036

目的:探讨2型糖尿病(T2DM)患者中医证型与外周血巨噬细胞M1和M2表型的相关性。方法:选取102例T2DM患者及20名健康者作为健康对照组,检测122名受试者的空腹血糖(FBG)、糖化血红蛋白(HbA1c)、空腹胰岛素、空腹C肽、巨噬细胞表型及血清炎... 详细信息

目的:探讨2型糖尿病(T2DM)患者中医证型与外周血巨噬细胞M1和M2表型的相关性。方法:选取102例T2DM患者及20名健康者作为健康对照组,检测122名受试者的空腹血糖(FBG)、糖化血红蛋白(HbA1c)、空腹胰岛素、空腹C肽、巨噬细胞表型及血清炎症因子(IL-1β、IL-6、IL-4、IL-10)的含量在不同证型患者中的差异。并经Pearson分析各组患者巨噬细胞表型与T2DM中医证型的相关性。结果:T2DM患者外周血M1型巨噬细胞百分比与IL-1β、IL-6呈正相关,与IL-4、IL-10呈负相关;M2型巨噬细胞百分比与IL-1β、IL-6呈负相关,与IL-4、IL-10呈正相关。与健康受试者比较,T2DM患者的FBG、HbA1c、空腹胰岛素、空腹C肽、M1型巨噬细胞百分比、M1/M2比值、IL-1β、IL-6水平均显著升高,M2型巨噬细胞百分比、IL-4、IL-10水平均显著下降(P<0.05)。T2DM各中医证型患者的FBG、HbA1c、空腹胰岛素、空腹C肽、M1型巨噬细胞百分比、M1/M2比值、IL-1β、IL-6含量由高到低排序为痰热互结组、血瘀脉络组、阴阳两虚组、肝肾阴虚组、气阴两虚组,而M2型巨噬细胞百分比、IL-4和IL-10水平由低到高排序为痰热互结组、血瘀脉络组、阴阳两虚组、肝肾阴虚组、气阴两虚组。结论:各中医证型的T2DM中,M1型巨噬细胞百分比含量最高的组是痰热互结组,最低的组是气阴两虚组;M2型巨噬细胞百分比含量最高的是气阴两虚组,含量最低的是痰热互结组。T2DM的病情变化可能与巨噬细胞的极化调控有关。

关键词： 2型糖尿病巨噬细胞中医证型相关性 M1/M2 Pearson分析

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Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function variants in TMEM141,DDHD2,and LHFPL5

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Frontiers of Medicine 2024年第1期18卷 81-97页

作者： Liwei Sun xueting Yang Amjad Khan Xue yu Han Zhang Shirui Han Xiaerbati Habulieti Yang Sun Rongrong Wang Xue Zhang McKusick-Zhang Center for Genetic Medicine State Key Laboratory for Complex Severe and Rare DiseasesInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing100005China Chongqing Key Laboratory of Human Embryo Engineering Center for Reproductive MedicineNational Key Clinical Speciality Construction Project(Obstetrics and Gynecology)Chongqing Health Center for Women and ChildrenChongqing400013China Chongqing Clinical Research Center for Reproductive Medicine Women and Children’s Hospital of Chongqing Medical UniversityChongqing400013China Faculty of Biological Sciences Department of ZoologyUniversity of Lakki MarwatKhyber Pakhtunkhwa28420Pakistan Institute for Medical Genetics and Applied Genomics University of TübingenTübingen72076Germany Alexander von Humboldt fellowship Foundation Berlin10117Germany Department of Pediatrics The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Department of Laboratory Medicine State Key Laboratory for Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing100730China

Highly clinical and genetic heterogeneity of neurodevelopmental disorders presents a major challenge in clinical genetics and medicine.Panoramic variation analysis is imperative to analyze the disease phenotypes resulting from multilocus genomic variation.Here,a Pakistani family with parental consanguinity was presented,characterized with severe intellectual disability(ID),spastic paraplegia,and deafness.Homozygosity mapping,integrated single nucleotide polymorphism(SNP)array,whole-exome sequencing,and whole-genome sequencing were performed,and homozygous variants in TMEM141(c.270G>A,p.Trp90^(*)),DDHD2(c.411+767_c.1249-327del),and LHFPL5(c.250delC,p.Leu84^(*))were identified.A Tmem141^(p.Trp90^(*)/p.Trp90^(*))mouse model was generated.Behavioral studies showed impairments in learning ability and motor coordination.Brain slice electrophysiology and Golgi staining demonstrated deficient synaptic plasticity in hippocampal neurons and abnormal dendritic branching in cerebellar Purkinje cells.Transmission electron microscopy showed abnormal mitochondrial morphology.Furthermore,studies on a human in vitro neuronal model(SH-SY5Y cells)with stable shRNA-mediated knockdown of TMEM141 showed deleterious effect on bioenergetic function,possibly explaining the pathogenesis of replicated phenotypes in the cross-species mouse model.Conclusively,panoramic variation analysis revealed that multilocus genomic variations of TMEM141,DDHD2,and LHFPL5 together caused variable phenotypes in patient.Notably,the biallelic loss-of-function variants of TMEM141 were responsible for syndromic ID.

关键词： neurodevelopmental disorder autosomal recessive intellectual disability consanguinity spastic paraplegia hearing loss TMEM141

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不同中医证型非酒精性脂肪性肝病与外周血巨噬细胞表型的相关性研究

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现代中西医结合杂志 2024年第10期33卷 1315-1321页

作者：张雅丽袁星星高佳炜杨柳欣张传举喻学婷黑龙江省中医药科学院黑龙江哈尔滨150036 张雅丽全国名老中医药专家传承工作室黑龙江哈尔滨150006 黑龙江中医药大学黑龙江哈尔滨150040 铜陵市人民医院东部院区安徽铜陵244099

目的探究非酒精性脂肪性肝病(NAFLD)患者中医证型与外周血巨噬细胞M1和M2表型的相关性。方法选取2021年12月—2022年12月在黑龙江省中医医院肝胆脾胃二科门诊就诊并临床诊断为NAFLD的患者140例,根据中医辨证分型将患者分为湿浊内停组2... 详细信息

目的探究非酒精性脂肪性肝病(NAFLD)患者中医证型与外周血巨噬细胞M1和M2表型的相关性。方法选取2021年12月—2022年12月在黑龙江省中医医院肝胆脾胃二科门诊就诊并临床诊断为NAFLD的患者140例,根据中医辨证分型将患者分为湿浊内停组27例、肝郁脾虚组40例、湿热蕴结组32例、脾肾两虚组13例、痰瘀互结组28例。另从该院健康体检中心招募健康受试者15例作为健康受试组。检测各组受试者肝功能指标[血清谷丙转肽酶(ALT)、谷草转肽酶(AST)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)]、血脂指标[三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、血清炎症因子指标[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)和白细胞介素-4(IL-4)]、巨噬细胞表型、肝脏受控衰减参数(CAP),并经Pearson相关分析各组患者巨噬细胞表型与NAFLD病情的相关性。结果与健康受试组相比,各中医证型组患者血清ALT、AST、GGT、ALP、TC、TG、LDL-C、IL-6、IL-8水平及M1型巨噬细胞百分比、M1/M2比值、CAP均显著增高(P均<0.05),血清HDL-C、IL-10、IL-4水平和M2型巨噬细胞百分比均显著降低(P均<0.05)。不同中医证型患者血清ALT、AST、GGT、ALP、TG、IL-6、IL-8水平及M1型巨噬细胞百分比、CAP由低到高分别为肝郁脾虚组、脾肾两虚组、湿浊内停组、痰瘀互结组、湿热蕴结组,血清HDL-C、IL-10、IL-4水平及M2型巨噬细胞百分比由高到低分别为肝郁脾虚组、脾肾两虚组、湿浊内停组、痰瘀互结组、湿热蕴结组,血清TC和LDL-C水平由低到高依次为肝郁脾虚组、湿浊内停组、湿热蕴结组、脾肾两虚组、痰瘀互结组。相关性分析发现,血清ALT、AST、GGT、ALP、TC、TG、LDL-C、IL-6、IL-8水平及CAP与M1型巨噬细胞百分比呈正相关(P均<0.05),与M2型巨噬细胞百分比呈负相关(P均<0.05);血清HDL-C、IL-10、IL-4水平与M1型巨噬细胞百分比呈负相关(P均<0.05),与M2型巨噬细胞百分比呈正相关(P均<0.05)。结论 NAFLD各中医证型中湿热蕴结型患者M1型巨噬细胞百分比最高,肝郁脾虚型患者M1型巨噬细胞百分比最低,而M2型巨噬细胞百分比规律与此相反,推测巨噬细胞极化参与NAFLD的发生和发展。

关键词：非酒精性脂肪性肝病中医证型巨噬细胞表型相关性分析

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Genome-Wide Exploration of the Grape GLR Gene Family and Differential Responses of VvGLR3.1 and VvGLR3.2 to Low Temperature and Salt Stress

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 533-549页

作者： Honghui Sun Ruichao Liu yueting Qi Hongsheng Gao xueting Wang Ning Jiang Xiaotong Guo Hongxia Zhang Chunyan yu The Engineering Research Institute of Agriculture and Forestry Ludong UniversityYantai264025China College of Agriculture Ludong UniversityYantai264025China

Grapes,one of the oldest tree species globally,are rich in vitamins.However,environmental conditions such as low temperature and soil salinization signiﬁcantly affect grape yield and quality.The glutamate receptor(GLR)family,comprising highly conserved ligand-gated ion channels,regulates plant growth and development in response to stress.In this study,11 members of the VvGLR gene family in grapes were identiﬁed using whole-genome sequence analysis.Bioinformatic methods were employed to analyze the basic physical and chemical properties,phylogenetic trees,conserved domains,motifs,expression patterns,and evolutionary relationships.Phylogenetic and collinear analyses revealed that the VvGLRs were divided into three subgroups,showing the high conservation of the grape GLR family.These members exhibited 2 glutamate receptor binding regions(GABAb and GluR)and 3-4 transmembrane regions(M1,M2,M3,and M4).Real-time quantitative PCR analysis demonstrated the sensitivity of all VvGLRs to low temperature and salt stress.Subsequent localization studies in Nicotiana tabacum veriﬁed that VvGLR3.1 and VvGLR3.2 proteins were located on the cell membrane and cell nucleus.Additionally,yeast transformation experiments conﬁrmed the functionality of VvGLR3.1 and VvGLR3.2 in response to low temperature and salt stress.Theseﬁndings highlight the signiﬁcant role of the GLR family,a highly conserved group of ion channels,in enhancing grape stress resistance.This study offers new insights into the grape GLR gene family,providing fundamental knowledge for further functional analysis and breeding of stress-resistant grapevines.

关键词： Genome-wide identiﬁcation glutamate receptor(GLR)family low temperature stress salt stress grape

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