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Intranasal administration nanosystems for brain-targeted drug delivery

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Nano Research 2023年第12期16卷 13077-13099页

作者： Yue Jiang xueting pan Tao Yu Hai Wang CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute of Functional Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

The existence of the blood-brain barrier(BBB)restricts the entry of drugs from the circulation into the central nervous system(CNS),which severely affects the treatment of neurological diseases,including glioblastoma,Parkinson’s disease(PD),and Alzheimer’s disease(AD).With the advantage of bypassing the BBB and avoiding systemic distribution,intranasal administration has emerged as an alternative method of delivering drugs to the brain.Drug delivery directly to the brain using intranasal nanosystems represents a new paradigm for neurological disease treatment because of its advantages in improving drug solubility and stability in vivo,enabling targeted drug delivery and controlled release,and reducing non-specific toxicity.And it has shown efficacy in animal models and clinical applications.Herein,this review describes the mechanisms of intranasal delivery of brain-targeted drugs,the properties of nanosystems for intranasal administration(e.g.,liposomes,nanoemulsions,and micelles),and strategies for intranasal drug delivery to enhance brain-targeted drug delivery.Recent applications of nanosystems in intranasal drug delivery and disease treatment have been comprehensively reviewed.Although encouraging results have been reported,significant challenges still need to be overcome to translate these nanosystems into clinics.Therefore,the future prospects of intranasal drug delivery nanosystems are discussed in depth,expecting to provide useful insights and guidance for effective neurological disease treatment.

关键词： intranasal administration nanosystems brain-targeted delivery neurological diseases drug delivery

A reusable SMA actuated non-explosive lockrelease mechanism for space application

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International Journal of Smart and Nano Materials 2020年第1期11卷 65-77页

作者： xueting pan Yuliang Zhang Yifan Lu Fei Yang Honghao Yue State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbinChina Beijing Spacecraft BeijingChina

After the satellite is launched with the carrier rocket,it is necessary to separate the satellite from the rocket at an appropriate time to ensure that the satellite enters the intended orbit.In this process,it is vital to ensure a reliable connection and accurate separation.With the increasing use of microsatellite in orbit,the contradiction between the shock of separation and the requirement of the platform’s dynamic environment is becoming increasingly prominent.Therefore,the traditional pyrotechnic separation device can no longer meet the requirements.This paper presents a reusable non-explosive release actuator using shape memory alloy(SMA)wire for high load and low shock.The system is based on the Fast Acting Shock-less Separation Nut(FASSN)technology.Using the shape memory effect of SMA,a biased SMA wire trigger has been developed,which is used as the driver source of the actuator.At the moment of receiving the electrical signal,the SMA wire generates stress and deformation.The trigger set free the constraints on the mechanical components,and the target is released.Experimental results indicate that the trigger device can unlock successfully and well meet the technical objectives.

关键词： SMA actuator non-explosive lock-release space application

杜甫《杜鹃》“四杜鹃”句式及其内涵研究评议

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杜甫研究学刊 2024年第2期 24-32,119页

作者：潘雪婷安徽大学文学院 230039

杜甫《杜鹃》诗开篇四句句式奇特,对这种“有—无—无—有”参错现象及其内容的解读一直是学者讨论的焦点。从句式上看,这四句属于“复沓句式”,来自前代诗歌经验而又有创变。从内容上看,诗中的“杜鹃”,既是杜甫辗转各地时所见的客观... 详细信息

杜甫《杜鹃》诗开篇四句句式奇特,对这种“有—无—无—有”参错现象及其内容的解读一直是学者讨论的焦点。从句式上看,这四句属于“复沓句式”,来自前代诗歌经验而又有创变。从内容上看,诗中的“杜鹃”,既是杜甫辗转各地时所见的客观存在的杜鹃鸟,也是他尊崇的皇帝的化身或象征。此诗并非仅仅吟咏普通的杜鹃鸟,而是借咏杜鹃寄托对玄宗的怀念,既体现出他的忠君爱国,也体现出他对一个消逝的理想时代的缅怀。

关键词：杜甫《杜鹃》复沓句式纪实政治寄托

Sonodynamic therapy(SDT): a novel strategy for cancer nanotheranostics

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Science China(Life Sciences) 2018年第4期61卷 415-426页

作者： xueting pan Hongyu Wang Shunhao Wang Xiao Sun Lingjuan Wang Weiwei Wang Heyun Shen Huiyu Liu Beijing Key Laboratory of Bioprocess Bionanomaterials & Translational Engineering Laboratory State Key Laboratory of Chemical Resource Engineering Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology

Sonodynamic therapy(SDT) is a promising non-invasive therapeutic modality. Compared to photo-inspired therapy, SDT provides many opportunities and benefits, including deeper tissue penetration, high precision, less side effects, and good patient compliance. Thanks to the facile engineerable nature of nanotechnology, nanoparticles-based sonosensitizers exhibit predominant advantages, such as increased SDT efficacy, binding avidity, and targeting specificity. This review aims to summarize the possible mechanisms of SDT, which can be expected to provide the theoretical basis for SDT development in the future. We also extensively discuss nanoparticle-assisted sonosensitizers to enhance the outcome of SDT. Additionally, we focus on the potential strategy of combinational SDT with other therapeutic modalities and discuss the limitations and challenges of SDT toward clinical applications.

关键词：治疗学癌症 SDT 纳米技术副作用约束力

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论杜甫参政实践及其文学影响

淮南师范学院学报 2024年第1期26卷 74-81页

作者：吴怀东潘雪婷安徽大学文学院安徽合肥230039

杜甫入仕之路坎坷,疏救房琯失败,表明其实际政治能力不足。儒家“学而优则仕”为杜甫参政提供了社会基础,“致君尧舜”的儒家政治理想促使杜甫一生积极参政,从而具有敏锐的政治眼光。杜甫参政的失败,与盛唐时期“吏治与文学之争”有关,... 详细信息

杜甫入仕之路坎坷,疏救房琯失败,表明其实际政治能力不足。儒家“学而优则仕”为杜甫参政提供了社会基础,“致君尧舜”的儒家政治理想促使杜甫一生积极参政,从而具有敏锐的政治眼光。杜甫参政的失败,与盛唐时期“吏治与文学之争”有关,而文学的浪漫与现实政治的冷峻功利的天然矛盾是杜甫参政失败的根本原因。杜甫的参政理想和政治理想代表着人类伟大而宝贵的良知。参政的经历乃至参政的失败,激发了杜甫文学创作的激情,并形成其独特的文学面貌。

关键词：杜甫参政政治见识文学影响

CRISPR-based genetic screens advance cancer immunology

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Science China Life Sciences 2024年

作者： Yuanfang Cao xueting Li Yumu pan Huahe Wang Siyu Yang Lingjuan Hong Lupeng Ye Institute of Modern Biology Nanjing University

CRISPR technologies have revolutionized research areas ranging from fundamental science to translational medicine. CRISPR-based genetic screens offer a powerful platform for unbiased screening in various fields, such as cancer immunology. Immune checkpoint blockade(ICB)therapy has been shown to strongly affect cancer treatment. However, the currently available ICBs are limited and do not work in all cancer patients. Pooled CRISPR screens enable the identification of previously unknown immune regulators that can regulate T-cell activation,cytotoxicity, persistence, infiltration into tumors, cytokine secretion, memory formation, T-cell metabolism, and CD4+T-cell differentiation.These novel targets can be developed as new immunotherapies or used with the current ICBs as new combination therapies that may yield synergistic efficacy. Here, we review the progress made in the development of CRISPR technologies, particularly technological advances in CRISPR screens and their application in novel target identification for immunotherapy.

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国际关系对中国大豆进口来源的影响

世界农业 2022年第7期 57-66页

作者：潘雪婷穆月英中国农业大学经济管理学院北京100083 上海财经大学城市与区域科学学院上海200433

本文基于2010年1月至2021年10月的月度贸易数据,通过运用Rotterdam改进模型分析了中国对不同来源国的大豆进口需求及影响因素。结果显示,国际关系对于本国和其他进口来源国的大豆出口均有影响,且市场份额较小的国家更易受到他国影响。其... 详细信息

本文基于2010年1月至2021年10月的月度贸易数据,通过运用Rotterdam改进模型分析了中国对不同来源国的大豆进口需求及影响因素。结果显示,国际关系对于本国和其他进口来源国的大豆出口均有影响,且市场份额较小的国家更易受到他国影响。其中,加拿大作为美国的利益相关方,其国际关系变化更能反映到贸易上;巴西和阿根廷之间存在政策的溢出效应;乌拉圭大豆受到美国和巴西大豆挤出,享受阿根廷大豆出口的溢出;俄罗斯更多受到国际大豆市场波动的影响。弹性方面,中国对美国和巴西进口需求的支出弹性和价格弹性均不敏感,阿根廷和乌拉圭则更加有弹性;进口占比份额小的来源国之间的交叉价格弹性更多表现出替代效应。结论表明,通过积极推进国际关系在中国大豆进口中的作用可以多样化进口来源,确保中国大豆进口安全。

关键词：国际关系 Rotterdam改进模型大豆进口安全进口来源国

Taming heat with tiny pressure

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The Innovation 2024年第2期5卷 70-78页

作者： Kun Zhang Zhe Zhang Hailong pan Haoyu Wang xueting Zhao Ji Qi Zhao Zhang Ruiqi Song Chenyang Yu Biaohong Huang Xujing Li Huaican Chen Wen Yin Changlong Tan Weijin Hu Michael Wüubbenhorst Jiangshui Luo Dehong Yu Zhidong Zhang Bing Li Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Laboratory for Soft Matter and Biophysics Department of Physics and AstronomyKU Leuven3001 LeuvenBelgium Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150080China Australian Nuclear Science and Technology Organisation Lucas HeightsNSW 2234Australia

Heat is almost everywhere.Unlike electricity,which can be easily manipulated,the current ability to control heat is still highly limited owing to spontaneous thermal dissipation imposed by the second law of thermodynamics.Optical illumination and pressure have been used to switch endothermic/exothermic responses of materials via phase transitions;however,these strategies are less cost-effective and unscalable.Here,we spectroscopically demonstrate the glassy crystal state of 2-amino-2-methyl-1,3-propanediol(AMP)to realize an affordable,easily manageable approach for thermal energy recycling.The supercooled state of AMP is so sensitive to pressure that even several megapascals can induce crystallization to the ordered crystal,resulting in a substantial temperature increase of 48 K within 20 s.Furthermore,we demonstrate a proof-of-concept device capable of programable heating with an extremely high work-to-heat conversion effi-ciency of383.Such delicate and efficient tuning of heat may remarkably facilitate rational utilization of waste heat.

关键词： illumination thermal rational

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国内外志愿服务标准化比对研究

中国质量与标准导报 2022年第6期 33-37页

作者：潘雪婷上海市质量和标准化研究院

本文对国内和国外的志愿服务标准化进行了研究,分析了相关国际标准、国外标准、国内标准,以及国内外有关法律法规和政策文件,总结出我国志愿服务标准化工作的优势及不足,并提出发展建议。

关键词：志愿者志愿服务标准化