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中枢性性早熟女童血清神经肽吻素和网膜素-1的表达与骨龄指数和卵巢体积的相关性分析

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中国医药 2024年第6期19卷 888-892页

作者：郑新月焦娇张雪松河北省唐山市妇幼保健院小儿内分泌科唐山063000 河北省唐山市路北区妇幼保健院儿童保健科唐山063001

目的探讨中枢性性早熟女童血清神经肽吻素、网膜素-1的表达与骨龄指数、卵巢体积的相关性。方法选取2022年7月至2023年6月于河北省唐山市妇幼保健院进行治疗的中枢性性早熟女童85例作为观察组。另选取70例同期体检正常女童作为对照组。... 详细信息

目的探讨中枢性性早熟女童血清神经肽吻素、网膜素-1的表达与骨龄指数、卵巢体积的相关性。方法选取2022年7月至2023年6月于河北省唐山市妇幼保健院进行治疗的中枢性性早熟女童85例作为观察组。另选取70例同期体检正常女童作为对照组。比较2组相关临床指标、神经肽吻素、网膜素-1水平。采用Logistic回归分析法分析骨龄指数、卵巢体积的影响因素。采用Pearson相关性分析法分析中枢性性早熟女童神经肽吻素、网膜素-1表达与骨龄指数、卵巢体积的相关性。结果观察组神经肽吻素、骨龄指数、卵巢体积高于/大于对照组[(2.68±1.05)μg/L比(0.60±0.20)μg/L、(1.67±0.25)比(1.02±0.06)、(3.68±0.58)cm^(3)比(2.70±0.29)cm^(3)],网膜素-1水平低于对照组[(27±4)μg/L比(70±8)μg/L],差异均有统计学意义(均P<0.001)。多因素Logistic回归分析结果显示,预测成年身高、雌二醇、黄体生成素(LH)、卵泡刺激素(FSH)、骨源性碱性磷酸酶、骨钙素、胰岛素样生长因子1、神经肽吻素、网膜素-1为骨龄指数的影响因素(均P<0.001),子宫体积、雌二醇、LH、FSH、神经肽吻素、网膜素-1为卵巢体积的影响因素(均P<0.001)。中枢性性早熟女童神经肽吻素与骨龄指数(r=0.634,P=0.001)、卵巢体积(r=0.533,P=0.001)呈正相关;网膜素-1与骨龄指数(r=-0.569,P=0.001)、卵巢体积(r=-0.459,P=0.001)呈负相关。结论中枢性性早熟女童神经肽吻素表达升高,网膜素-1表达降低,神经肽吻素与患儿骨龄指数、卵巢体积呈正相关,网膜素-1与患儿骨龄指数、卵巢体积呈负相关。

关键词：中枢性性早熟女童神经肽吻素网膜素-1 骨龄指数卵巢体积

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配电网与分布式电氢耦合系统的交互策略研究

浙江电力 2024年第2期43卷 115-125页

作者：吴启亮谭彩霞章雷其刘敏赵波张雪松谭忠富国网浙江省电力有限公司电力科学研究院杭州310014 华北电力大学经济与管理学院北京102206

针对新能源大规模接入给配电网安全运行带来的影响,开展了含混合储能的分布式电氢耦合系统与配电网间的多时间尺度交互策略研究。首先,提出分布式电氢耦合系统与配电网之间的平衡服务机制、需求响应机制等多元交互机制;其次,基于博弈理... 详细信息

针对新能源大规模接入给配电网安全运行带来的影响,开展了含混合储能的分布式电氢耦合系统与配电网间的多时间尺度交互策略研究。首先,提出分布式电氢耦合系统与配电网之间的平衡服务机制、需求响应机制等多元交互机制;其次,基于博弈理论,制定了电氢耦合系统与配电网之间的中长期与短期交互策略;最后,以某一典型区域的配电网与分布式电氢耦合系统为例进行仿真分析。算例结果表明:氢储能因其跨周期特性在中长期交互中具有优势;电化学储能响应迅速更适合短期交互;相较于单一形式储能系统,电氢混合储能系统能够有效降低峰谷差,提高系统收益,更契合现有配电网体系。

关键词：电氢耦合配电网多时间尺度交互策略

Optimal Scheduling for Flexible Regional Integrated Energy Systemwith Soft Open Point

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Computer Modeling in Engineering & Sciences 2022年第5期131卷 1101-1123页

作者： Wen Xu Dongdong Ren Biyi Yi Haoqing Zhen Youbing zhang xuesong zhang Zhejiang Huayun Electric Power Engineering Design&Consulting Co. Ltd.Hangzhou310026China College of Information Engineering Zhejiang University of TechnologyHangzhou310023China Electric Power Research Institute of State Grid Zhejiang Electric Power Company Hangzhou310014China

The Regional Integrated Energy System(RIES)has brought new modes of development,utilization,conversion,storage of *** introduction of Soft Open Point(SOP)and the application of Power to Gas(P2G)technology will greatly deepen the coupling of the electricity-gas integrated energy system,improve the flexibility and safety of the operation of the power system,and bring a deal of benefits to the power *** this background,an optimal dispatch model of RIES combined cold,heat,gas and electricity with SOP is ***,RIES architecture with SOP and P2G is designed and its mathematical model also is ***,on the basis of considering the optimal scheduling of combined cold,heat,gas and electricity,the optimal scheduling model for RIES was *** that,the original model is transformed into a mixed-integer second-order cone programming model by using linearization and second-order cone relaxation techniques,and the CPLEX solver is invoked to solve the optimization ***,the modified IEEE 33-bus systemis used to analyze the benefits of SOP,P2G technology and lithium bromide absorption chillers in reducing systemnetwork loss and cost,as well as improving the system’s ability to absorb wind and solar and operating safety.

关键词： Regional integrated energy system power to gas soft open point wind and photovoltaic power permeation lithium bromide chiller operating cost

Potential and limitations of satellite laser altimetry for monitoring water surface dynamics:ICESat for US lakes

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International Journal of Agricultural and Biological Engineering 2017年第5期10卷 154-165页

作者： Liu Shu Jiang Qigang xuesong zhang Kaiguang Zhao Department of Geo-exploration Science and Technology Jilin UniversityChangchun 130021China School of Environment and Natural Resources The Ohio State UniversityColumbusOH 43210USA Joint Global Change Research Institute Pacific Northwest National LaboratoryCollege ParkMD 20740USA Ohio Agricultural and Research Development Center School of Environment and Natural ResourcesThe Ohio State UniversityWoosterOH 44691USA

Elevation measurements from the Ice,Cloud and Land Elevation Satellite(ICESat)have been applied to monitor dynamics of lakes and other surface water *** such potential,the true utility of ICEsat--more generally,satellite laser altimetry--for continuously tracking surface water dynamics over time has not been adequately assessed,especially in the continental or global *** study analyzed elevation derived from ICESat data for the conterminous United States and examined the potential and limitations of satellite laser altimetry in monitoring the water level *** to a lack of spatially-explicit ground-based water-level data,the high-fidelity land elevation data acquired by airborne lidar were firstly resorted to quantify ICESat’s ranging *** and frequency analyses were then performed to evaluate how reliably ICESat could capture water-level dynamics over a range of temporal scales,as compared to in-situ gauge *** analytical results showed that ICESat had a vertical ranging error of 0.16 m at the footprint level-an lower limit on the detectable range of water-level *** sparsity of data over time was identified as a major factor limiting the use of ICESat for water dynamics *** all the US lakes,only 361 had reliable ICESat measurements for more than two flight *** for those lakes with sufficient temporal coverage,ICESat failed to capture the true interannual water-level dynamics in 32%of the *** frequency analysis suggested that even with a repeat cycle of two months,ICESat could capture only 60%of the variations in water-level dynamics for at most 34%of the US *** capture 60%of the water-level variation for most of the US lakes,a weekly repeated cycle(e.g.,less than 5 d)is needed-a requirement difficult to meet in current designs of spaceborne laser ***,the results highlight that current or near-future satellite laser missions,though with high ranging accuracies,are un

关键词： ICESat lidar water resources lake dynamics water level satellite laser altimetry lake surfaces repeat cycle

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对居民自建房安全隐患排查及治理的几点思考

建设监理 2024年第4期 64-66页

作者：张家伦张青松张雪松马群胡晴安徽徽匠全过程工程咨询有限公司安徽阜阳236300

近年来、全国各地频发居民自建、改扩建、住改商等经营性用房质量安全事故,导致严重的人员伤亡和财产损失,对此类建筑进行安全隐患排查及治理十分必要。分析了居民自建房安全隐患的主要表现,包括农村危房改造、乡镇自建房管理的简便化... 详细信息

近年来、全国各地频发居民自建、改扩建、住改商等经营性用房质量安全事故,导致严重的人员伤亡和财产损失,对此类建筑进行安全隐患排查及治理十分必要。分析了居民自建房安全隐患的主要表现,包括农村危房改造、乡镇自建房管理的简便化、城镇化发展中的违规建设、早期建筑的违章加层、年久失修的房屋、未经许可的私自加建等。指出自建房安全隐患的主要成因是监管缺失,建议通过建立长效机制、加强宣传教育、严格监管、专业检测鉴定、合理规划和设计等措施来进行排查和治理。强调自建房安全隐患排查工作需要长期坚持,并且要获得群众的支持和理解,以确保人民群众的生命财产安全。

关键词：居民自建房安全隐患排查及治理症结表现监管缺失

The Four Intersection-and-Difference Model for Line-Line Topological Relations

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Geo-Spatial Information Science 2007年第4期10卷 293-298页

作者： DENG Min LI Zhilin LI Guangqiang zhang xuesong Department of Surveying and Geo-informatics Central South University Yuelu Mountain Changsha 410083. China

The description of line-line topological relations is still an unsolved issue although much effort has been done. The problem is involved in many practical applications such as spatial query, spatial analysis and cartographic generalization. To develop a sound and effective approach to describe line-line relations, it is first necessary to define the topology of an individual line, i.e., local topology. The concept of connective degree is used for the identification of topological differences in the geometric structure of a line. The general topological definition of a line is given, i.e., endpoints set and interior point set. This definition can be applied to the embedded spaces of different dimensions, whether co-dimension is equal to or larger than zero. On this basis, a generic model called the 4 intersection-and-difference is set up for the description of basic line-line topological relations, upon which a conceptual neighborhood graph is built with consideration of topological distance, it is concluded that the proposed model can represent the property of topological changes, and basic relations between line segments in IR^1 and IR^2.

关键词： topological relations line object topological distance conceptual neighborhood co-dimension

乳腺癌抑癌基因KRT17过表达通过活化p53信号通路促进癌细胞凋亡并阻滞细胞周期

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现代肿瘤医学 2024年第17期32卷 3180-3189页

作者：陈铎胡明周海瑞张雪松佳木斯大学临床医学院整形外科黑龙江佳木斯154007

目的:探讨乳腺癌中角蛋白17(keratin 17,KRT17)的表达、预后意义及其对癌细胞生长的影响与机制。方法:基于癌症基因组图谱(The Cancer Genome Atlas,TCGA)收录的乳腺癌(breast cancer,BC)数据筛选差异表达基因和预后相关基因,取交集获... 详细信息

目的:探讨乳腺癌中角蛋白17(keratin 17,KRT17)的表达、预后意义及其对癌细胞生长的影响与机制。方法:基于癌症基因组图谱(The Cancer Genome Atlas,TCGA)收录的乳腺癌(breast cancer,BC)数据筛选差异表达基因和预后相关基因,取交集获得靶基因KRT17。分别利用UALCAN、人类蛋白质图谱(Human Protein Mapping,HPA)和TISCH2数据库分析各种癌症中KRT17 mRNA和蛋白水平的表达、BC组织芯片中KRT17的表达与定位以及肿瘤微环境中KRT17的表达,利用bc-GenExMiner v5.0数据库分析不同数据集中KRT17表达与预后的相关性。接下来,检测KRT17过表达对MDA-MB-231和MCF7细胞生长的影响,并用全基因组敲除和敲低文库筛选数据验证KRT17对BC细胞系生长的影响,裸鼠移植瘤实验验证KRT17对裸鼠异种移植瘤生长的调节作用。最后,利用流式细胞术检测过表达KRT17对细胞周期和凋亡的调控,GSEA富集分析KRT17功能,RT-qPCR和Western blotting揭示KRT17促癌生长的分子机制。结果:不同肿瘤中KRT17表达具有异质性;BC中KRT17mRNA和蛋白水平显著下调(P<0.001,P<0.001),KRT17蛋白主要定位于癌细胞的细胞质和细胞膜,且肿瘤微环境中各种细胞均表达KRT17;KRT17低表达是BC预后不良因素(均P<0.01),过表达KRT17可以显著抑制MDA-MB-231和MCF7细胞的生长(P<0.01,P<0.01),敲除或敲低KRT17可促进MDA-MB-231和MCF7等多种BC细胞系的生长,裸鼠异体移植瘤模型证实过表达KRT17可抑制肿瘤体积(P<0.001);过表达KRT17可显著促进细胞凋亡(P <0.001)并阻滞细胞周期G1期(P <0.01);分子实验结果显示p53信号通路部分介导了KRT17过表达对细胞凋亡和周期的调节作用。结论:KRT17在BC中低表达,不利于患者预后,过表达KRT17通过活化p53通路促进细胞凋亡并阻滞细胞周期,KRT17是一种潜在的抑癌基因。

关键词：乳腺癌角蛋白17 预后 p53信号通路细胞生长

A Superhydrophobic Hydrogel for Self-Healing and Robust Strain Sensor with Liquid Impalement Resistance

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Chinese Journal of Chemistry 2021年第12期39卷 3393-3398页

作者： Peng Wang Tao Chen xuesong zhang Wei Duan Chongyuan zhang Huilong Han Qing Xie School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBaodingHebei 071003China Hebei Key Laboratory of Electric Machinery Health Maintenance&Failure Prevention North China Electric Power UniversityBaodingHebei 071003China School of Electrical and Electronic Engineering North China Electric Power UniversityBaodingHebei 071003China

The superhydrophobic strain sensor is a fantastic direction,which could protect the strain sensor in harsh ***,the self-healing superhydrophobic strain sensor has not been *** this research,we developed a superhydrophobic strain sensor,which demonstrated excellent self-healing,mechanical robustness,and liquid impalement resistance *** key innovation is to partially embed hydrophobic graphene and carbon nanotubes into the hydrogel *** hodrogel substrate endows the sample with self-healing *** graphene,carbon nanotubes and hydrogel together lead to an accurate and real-time monitoring of human ***,the prepared sample demonstrated super-robust superhydrophobicity,which retained superhydrophobicity after many kinds of damage(such as 1000%stretch,10000 stretching-releasing cycles,hand-rub,tape-peeling,and high-speed drop/jet impact).

关键词： Hydrophobic effect Gels Graphene Strain sensor Self-healing

AB分型联合Arima分型对食管表浅鳞状细胞癌浸润深度判定的价值

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中华消化内镜杂志 2024年第5期41卷 372-378页

作者：陆宏娜许丰张学松王瑶王耀辉邓茜郭雯莹翁烃张良舜凌亭生宁波市医疗中心李惠利医院消化内科宁波315041 江苏省中医院消化内镜中心南京230004 江苏省中医院病理科南京230004 宁波市临床病理诊断中心宁波315021

目的探讨AB分型联合Arima分型预测浅表食管鳞状细胞癌(superficial esophageal squamous cell carcinomas,SESCC)浸润深度的临床价值。方法2017年7月至2022年12月期间在宁波市医疗中心李惠利医院及江苏省中医院接受内镜黏膜下剥离术治... 详细信息

目的探讨AB分型联合Arima分型预测浅表食管鳞状细胞癌(superficial esophageal squamous cell carcinomas,SESCC)浸润深度的临床价值。方法2017年7月至2022年12月期间在宁波市医疗中心李惠利医院及江苏省中医院接受内镜黏膜下剥离术治疗且鳞状上皮乳头内毛细血管袢(intra-epithelial papillary capillary loops,IPCL)AB分型为B2型的患者(76处SESCC病变)纳入回顾性研究,根据Arima分型规则对IPCL进行二次分类,以病理判定的浸润深度为金标准,分析B2型联合Arima分型对SESCC浸润深度预测的敏感度、特异度、阳性预测值和阴性预测值。结果76处病变中,31处(40.79%)浸润黏膜肌层(T1a-MM)或黏膜下层浅层(T1b-SM1),B2型IPCL预测T1a-MM/T1b-SM1 SESCC的敏感度、特异度、阳性预测值、阴性预测值、准确率分别为70.45%(31/44)、79.64%(176/221)、40.79%(31/76)、93.12%(176/189)、78.11%(207/265)。对病变的IPCL进行Arima分型后,B2-4ML型、B2-AVA-4M型IPCL预测T1a-MM/T1b-SM1 SESCC的敏感度、特异度、阳性预测值、阴性预测值、准确率分别为61.36%(27/44)、88.24%(195/221)、50.94%(27/53)、91.98%(195/212)、83.77%(222/265)和38.64%(17/44)、94.57%(209/221)、58.62%(17/29)、88.56%(209/236)、85.28%(226/265)。结论B2型IPCL联合Arima分型可以提高对T1a-MM/T1b-SM1 SESCC的诊断准确性。

关键词：食管鳞状细胞癌放大内镜 AB分型 Arima分型 B2型黏膜肌层黏膜下浅层