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MiR-107-3p/Atp6v0e1 contributes to protective effects of two selenium-containing peptides,TSeMMM and SeMDPGQQ on lead-induced neurotoxicity

中国微生物学会微生物资源专业委员会成立大会暨第一届学术研讨会

作者： xuesong luo, jian xiong, tiantian ren,jingyu guo,chengxiang fang college of life sciences,wuhan university, wuhan 430072

Radioactive waste contained inorganic and organic contaminants that include radionuclides,heavy metals,acids/bases,and *** links between radioresistance and desiccation tolerance have been ***,radiation resistance bacteria are probable more abundant in the arid desiccation environments than other wet *** the present study,90bacterial strains with the ability to degrade some polyaromaticcompounds were *** Taklamakan *** on

关键词： Taklamakan desert radioresistance bioremediation

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Food Science and Human Wellness 2024年第4期13卷 2060-2067页

作者： Yong fang Tianhang Huang jian Wu Xieqi luo Fengjiao Fan Peng Li jian Ding Xinyang Sun college of Food Science and Engineering Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and SafetyNanjing 210023China Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi School of MedicineJiangnan UniversityWuxi 214122China

Two selenium(Se)-containing peptides from Se-enriched rice,TSeMMM and SeMDPGQQ,possess neuroprotective potency against lead(Pb2+)-induced ***,the crosstalk between mRNA and microRNAs(miRNA)involved in the neuroprotection mechanism remains to be *** this study,RNA-sequencing and miRNA-sequencing were used to independently identify differentially expressed mRNAs and small RNAs profiles in Pb^(2+)-treated primary fetal rat cortical neurons and then the correlated miRNA-mRNA target pairs were *** was found that 34 mRNAs related to oxidative phosphorylation could be reversed by pretreatment of TSeMMM and *** protective effect of TSeMMM and SeMDPGQQ was mediated by upregulation of miR-107-3p,which downregulates the ATPase H+transporting V0 subunit e1(Atp6v0e1)mRNA level.A zebrafish model was applied to verify the relevance between the targeted mRNA and miRNA by real-time quantitative *** results indicated that miR-107-3p was a potential therapeutic target to achieve neuroprotection of Se-containing peptides via stimulation of Atp6v0e1.

关键词： Lead Se-containing peptides Neuroprotection miRNA

Convenient room-temperature synthesis of sulfur and nitrogen co-doped NiCo-LDH coupled with CNTs on NiCo foam as battery-type electrode for high performance hybrid supercapacitor

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Rare Metals 2024年第9期43卷 4286-4301页

作者： Li Song Xiao-Hong Zhong fang-Lin Wang Zhi-Hui Huang Zhe Hong Yun-fang Gao Hai-Dong Wang jian-Wei ren Sheng-Jie Peng Lei Li college of Biological Chemical Sciences and EngineeringJiaxing UniversityJiaxing 314001China college of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China college of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Research and Development Department Jiangxi Ganfeng LiEnergy Technology Co.Ltd.Xinyu 338000China Department of Mechanical Engineering Science University of JohannesburgAuckland ParkJohannesburg 2092South Africa

The convenient synthesis of the composite electrode with high supercapacitance performance plays an important role in practical application but is ***,the carbon nanotubes(CNTs)coupled with lowcrystalline sulfur and nitrogen co-doped Ni Co-LDH(denoted as SN-Ni Co-LDH)nanosheets array are grown on Ni Co foam(NCF)substrate by two convenient steps of metal induced self-assembly and corrosion engineering,which present the advantages of operating at roomtemperature and low preparation *** from the S–N co-doping and low-crystallinity of Ni Co-LDH,the prepared SN-Ni Co-LDH@CNTs@NCF electrode presents a topping charge capacity of 2470 C·g^(-1)(4.94 C·cm^(-2))at 5 m A·cm^(-2).Furthermore,the fabricated asymmetry supercapacitor(ASC)achieves an extraordinary energy density of 77 Wh·kg^(-1)(0.617 m Wh·cm^(-2))at a power density of 438 W·kg^(-1)(3.5 m W·cm^(-2))and outstanding stability(91%capacity retention after 5000 cycles at20 m A·cm^(-2)).Impressively,the structure evolution of Ni Co-LDH during the charge/discharge processes has been thoroughly elucidated by in-situ Raman ***,this work verifies a powerful strategy and practical value for preparing composite electrodes with high supercapacitance performance,and also provides guidance for the rational design of the smart electrodes.

关键词： Supercapacitor NiCo-LDH Carbon nanotubes Sulfur and nitrogen co-doped Convenient synthesis

Pd-catalyzed asymmetric carbonyl alkynylation:Synthesis of axial chiral ynones

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Chinese Chemical Letters 2024年第6期35卷 293-297页

作者： Long Jin jian Han Dongmei fang Min Wang jian Liao Natural Products Research Center Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China college of Chemical Engineering Sichuan UniversityChengdu 610065China university of Chinese Academy of sciences Beijing 100049China

Ynones are important skeletons in bioactive molecules and valuable building blocks for organic synthesis,thus great efforts have been devoted to their ***,introducing prochiral substrates to construct ynones bearing a chiral framework is unrealized to ***,we reported the first example of Pd/SOP-catalyzed asymmetric carbonylative alkynylation via a non-classical carbonylative Sonogashiratype approach(acyl-Pd(Ⅱ)species generated from nucleophiles).By using cyclic diaryliodonium salts as prochiral substrates,various axial chiral ynones with good functional group tolerance(39 examples),satisfied yields(71%-96%)and excellent enantioselectivities(generally 94%-99%ee)were *** of bioactive compounds,scale-up experiment and useful transformations were also conducted to demonstrate the utility of this process.

关键词： Pd-catalyzed Axial chiral ynones Cyclic diaryliodonium High-valent palladium catalyzed Asymmetric carbonyl alkynylation

Buckling Properties of Water-Drop-Shaped Pressure Hulls with Various Shape Indices Under Hydrostatic External Pressure

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China Ocean Engineering 2024年第1期38卷 1-17页

作者： DING Xiao-de ZHANG jian WANG fang JIAO Hui-feng WANG Ming-lu School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Shanghai Engineering Research Center of Marine renewable Energy College of Engineering Science and Technol-ogyShanghai Ocean UniversityShanghai 201306China China Ship Scientific Research Center Wuxi 214082China

The water-drop-shaped pressure hull has a good streamline,which has good application prospect in the underwater ***,this study conducted analytical,experimental and numerical investigation of the buckling properties of water-drop-shaped pressure hulls under hydrostatic pressure.A water-drop experiment was conducted to design water-drop-shaped pressure hulls with various shape *** critical loads for the water-drop-shaped pressure hulls were resolved by using Mushtari’s *** numerical simulations including linear buckling analysis and nonlinear buckling analysis including eigenmode imperfections were *** results indicated that the critical loads resolved by Mushtari's formula were in good agreement with the linear buckling loads from the numerical *** formula can be extended to estimate the buckling capacity of water-drop-shaped pressure *** addition,three groups of pressure hulls were fabricated by using stereolithography,a rapid prototyping ***,three groups of the pressure hulls were subjected to ultrasonic measurements,optical scanning,hydrostatic testing and numerical *** experimental results were consistent with the numerical *** results indicate that the sharp end of the water-drop-shaped pressure hulls exhibited instability compared with the blunt *** paper provides a new solution to the limitations of experimental studies on the water-drop-shaped pressure hulls as well as a new configuration and evaluation method for underwater observatories.

关键词： buckling pressure hull water drop underwater observatory

General anesthetic agents induce neurotoxicity through oligodendrocytes in the developing brain

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Zoological Research 2024年第3期45卷 691-703页

作者： Wen-Xin Hang Yan-Chang Yang Yu-Han Hu Fu-Quan fang Lang Wang Xing-Hua Qian Patrick M.McQuillan Hui xiong jian-Hang Leng Zhi-Yong Hu Department of Anesthesiology First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Cell Biology Yale UniversityNew HavenCT 06520USA Department of Neurology of the First Affiliated Hospital Interdisciplinary Institute of Neuroscience and TechnologySchool of Brain Science and Brain MedicineZhejiang University School of MedicineHangzhouZhejiang 310027China Department of Anesthesiology Jiaxing Maternity and Childcare Health HospitalJiaxingZhejiang 314009China Department of Anesthesiology Penn State Hershey Medical CentrePenn State College of MedicineHersheyPA 17033USA Department of Central Laboratory Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang 310006China

General anesthetic agents can impact brain function through interactions with neurons and their effects on glial *** perform essential roles in the central nervous system,including myelin sheath formation,axonal metabolism,and neuroplasticity *** are particularly vulnerable to the effects of general anesthetic agents resulting in impaired proliferation,differentiation,and *** are increasingly interested in the effects of general anesthetic agents on *** agents not only act on the surface receptors of oligodendrocytes to elicit neuroinflammation through modulation of signaling pathways,but also disrupt metabolic processes and alter the expression of genes involved in oligodendrocyte development and *** this review,we summarize the effects of general anesthetic agents on *** anticipate that future research will continue to explore these effects and develop strategies to decrease the incidence of adverse reactions associated with the use of general anesthetic agents.

关键词： Oligodendrocytes General anesthetic agents Neurotoxicity Central nervous system Perioperative neurocognitive disorders

On implications of somatostatin in diabetic retinopathy

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Neural Regeneration Research 2024年第9期19卷 1984-1990页

作者： Yanhong fang Qionghua Wang Youjian Li Li Zeng jian Liu Kepeng Ou Department of Ophthalmology Chongqing University Jiangjin HospitalChongqingChina college of Pharmacy National&Local Joint Engineering Research Center of Targeted and Innovative TherapeuticsIATTIChongqing University of Arts and SciencesChongqingChina Shandong Provincial Hospital Shandong Laboratory Animal CenterScience and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinanShandong ProvinceChina Academic Unit of Ophthalmology Bristol Medical SchoolUniversity of BristolBristolUK

Somatostatin,a naturally produced neuroprotective peptide,depresses excitatory neurotransmission and exerts anti-proliferative and anti-inflammatory effects on the *** this review,we summarize the progress of somatostatin treatment of diabetic retinopathy through analysis of relevant studies published from February 2019 to February 2023 extracted from the PubMed and Google Scholar *** neuroprotection,which occurs as a consequence of declined expression or dysregulation of retinal somatostatin in the very early stages of diabetic retinopathy,triggers retinal neurovascular unit impairment and microvascular *** replacement is a promising treatment for retinal neurodegeneration in diabetic *** pre-clinical and clinical trials of somatostatin analog treatment for early diabetic retinopathy have been *** one such trial(EUROCONDOR),topical administration of somatostatin was found to exert neuroprotective effects in patients with pre-existing retinal neurodysfunction,but had no impact on the onset of diabetic ***,we concluded that somatostatin restoration may be especially beneficial for the growing population of patients with early-stage *** order to achieve early prevention of diabetic retinopathy initiation,and thereby salvage visual function before the appearance of moderate non-proliferative diabetic retinopathy,several issues need to be *** include the needs to:a)update and standardize the retinal screening scheme to incorporate the detection of early neurodegeneration,b)identify patient subgroups who would benefit from somatostatin analog supplementation,c)elucidate the interactions of somatostatin,particularly exogenously-delivered somatostatin analogs,with other retinal peptides in the context of hyperglycemia,and d)design safe,feasible,low cost,and effective administration routes.

关键词： diabetes retinopathy excitotoxicity growth hormone insulin like growth factor irisin neurodegeneration neuroinflammation neuroprotection neurovascular unit octreotide oxidative stress somatostatin

High-efficiency preparation of multifunctional conjugated electrospun graphene doped PVDF/CF yarns for energy harvesting and human movement monitoring in TENG textile

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Nano Research 2024年第5期17卷 4478-4488页

作者： Ting Yang Chengwei Wan Xiaoyu Zhang Tong Liu Li Niu jian fang Yuqing Liu college of Textile and Clothing Engineering Soochow UniversitySuzhou 215123China

Portable power is an effective solution to realize self-powered sensors for wearable devices,promoting future sustainable ***-based triboelectric nanogenerators(M-TENGs)have emerged as a promising technology for harvesting biomechanical energy from human motion owing to their advantages,such as simple structure,lightweight design,and efficient energy ***,the poor durability,low adaptability,and un-washability of two-dimensional membrane materials have largely hindered their application in wearable *** this study,we propose a sheath-core polyvinylidene fluoride(PVDF)/graphene(G)-carbon fiber(CF)yarn fabricated via conjugate electrospinning,comprising a commercial CF core and an electrospun graphene-doped PVDF sheath,which improves the fatigue resistance of electrospun nanofiber films under prolonged friction and keeps a high degree of *** resulting electronic textile,woven with the large-scale electrospun PVDF/G-CF yarn,demonstrates a remarkable power density of 25.5 mW·m^(-2).The tight distribution of PVDF/G nanofibers on the textile surface ensures excellent softness,washability,and ***,the electrospun PVDF/G-CF textile exhibits significant potential in pressure sensing,self-powered operation,and motion detection,making it highly suitable for wearable electronics applications.

关键词： yarn-based triboelectric nanogenerator(TENG) graphene polyvinylidene fluoride(PVDF) conjugated-electrospinning multifunctional

Sequence-Controlled Synthesis of Alternating Poly(ester amide)s using Water as Control Agent in One-Pot

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Chinese Journal of Polymer Science 2024年第8期42卷 1015-1020页

作者： Tao Liu fang-fang Niu Kan Cheng Yu-Min Xia Bo-Mou Ma Xue-Li Wang jian-Yong Yu Yong He State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Innovation Center for Textile Science and Technology Donghua UniversityShanghai 201620China

Poly(ester amide)s(PEAs)attract much attention as a new kind of biodegradable ***,the synthesis of PEAs with sequence-regulated chain structures is still complicated due to the multistep polymerization,high monomer purity,as well as the usage of organic solvents,which greatly inhibits its development and ***,a one-pot strategy without solvent was developed to synthesize the alternating PEA fromα,ω-amino alcohol and dicarboxylic acid by sequential polycondensation,where water was used as the controlling agent for amidation and ***,the amidation and esterification were controlled to proceed in turn by adding or removing water,realizing the one-pot preparation of alternating *** resultant PEA is characterized by^1H-and^(13)C-NMR,and its chain structure is confirmed to be highly quasi-alternating similar to alternating PEAs prepared by classical methods The evaluations from DSC and DMA demonstrate that the properties of quasi-alternating PEA(T_(m)=102℃,ΔH_(m)=30J·g^(-1))are far superior to those of random PEA(T_(m)=72℃,ΔH_(m)<1 J·g^(-1)).

关键词： Biodegradable macromolecules Polymer architectures Sequence-controlled synthesis One-pot polymerization

Influence of cutterhead opening ratio on soil arching effect and face stability during tunnelling through non-uniform soils

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Underground Space 2024年第4期17卷 45-59页

作者： Xue-jian Chen Pei-Pei fang Qiu-Nan Chen Jun Hu Kai Yao Yong Liu State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan 430072China Hubei Technology Innovation Center for Smart Hydropower Wuhan 430000China college of Civil Engineering Anhui Jianzhu UniversityHefei 230601China School of Civil Engineering Hunan University of Science and TechnologyXiangtan 411201China School of Civil and Architectural Engineering Hainan UniversityHaikou 570228China School of Qilu Transportation Shandong UniversityJinan 250002China

Tunnelling has increasingly become an essential tool in the exploration of underground space.A typical construction problem is the face instability during tunnelling,posing a great threat to associated *** face instability often occurs with the soil arching *** study investigates the combined effect of cutterhead opening ratio and soil non-uniformity on soil arching effect and face stability,via conducting random finite-element analysis coupled with Monte–Carlo *** results underscore that the face stability is strongly associated with the evolution of stress *** obtained stability factors in the uniform soils can serve as a reference for the design of support pressure in practical tunnelling *** addition,non-uniform soils exhibit a lower stability factor than uniform soils,which implies that the latter likely yields an underestimated probability of face *** tunnel face is found to have a probability of failure more than 50%if the spatial non-uniformity of soil is *** the end,a practical framework is established to determine factor of safety(FOS)corresponding to different levels of probability of face failure considering various opening ratios in non-uniform *** required FOS is 1.70 to limit the probability of face instability no more than 0.1%.Our findings can facilitate the prediction of probability of instability in the conventionally deterministic design of face pressure.

关键词： Tunnel Face stability Soil arching effect Cutterhead opening ratio Non-uniform soil Random field