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颈椎前路术后吞咽困难的研究进展

中华骨与关节外科杂志 2018年第3期11卷 227-232页

作者：陆英杰鲍卫国杨惠林朱雪松苏州大学附属第一医院骨科江苏苏州215006

颈椎前路减压椎间融合手术是骨科广泛用于治疗颈椎间盘退变性疾病的经典术式,能够切除突出的椎间盘,解除脊髓和神经根的压迫,术后有较高的融合率。吞咽困难作为该术式最常见的并发症之一,已受到许多临床医师的关注。本文回顾了近年来国... 详细信息

颈椎前路减压椎间融合手术是骨科广泛用于治疗颈椎间盘退变性疾病的经典术式,能够切除突出的椎间盘,解除脊髓和神经根的压迫,术后有较高的融合率。吞咽困难作为该术式最常见的并发症之一,已受到许多临床医师的关注。本文回顾了近年来国内外文献,对颈椎前路术后吞咽困难的评估方法、发生率、病因与发病机制、风险因素、预防和治疗进行综述。

关键词：颈椎脊柱融合术吞咽困难研究进展

丝素蛋白／双相磷酸钙／半水硫酸钙／重组人骨形态发生蛋白-2骨水泥的制备及修复椎体骨缺损的实验研究

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中华创伤骨科杂志 2015年第1期17卷 82-86页

作者：王根林陈广东朱雪松朱志军谢瑞娟卢神州张波夏太宝杨惠林苏州大学附属第一医院骨科 215006 苏州大学高分子科学与工程系

目的研制丝素蛋白（SF）／双相磷酸钙（BCP）／半水硫酸钙（CSH）／重组人骨形态发生蛋白-2（rhBMP-2）骨水泥，并探讨其在绵羊椎体内的成骨作用。方法制备SF／BCP／CSH／rhBMP-2骨水泥，分别在12只绵羊的L2、L3、L4椎体内制作直径为6．... 详细信息

目的研制丝素蛋白（SF）／双相磷酸钙（BCP）／半水硫酸钙（CSH）／重组人骨形态发生蛋白-2（rhBMP-2）骨水泥，并探讨其在绵羊椎体内的成骨作用。方法制备SF／BCP／CSH／rhBMP-2骨水泥，分别在12只绵羊的L2、L3、L4椎体内制作直径为6．0mm、深度为10mm的圆柱型骨缺损模型，在3个缺损处随机植入SF／BCP／CSH／rhBMP-2骨水泥作为实验组，植入聚甲基丙烯酸甲酯（PMMP）作为对照组，另一椎体缺损处不植入任何材料作为空白对照组。术后3、6个月分别随机处死6只绵羊进行CT、组织学和生物力学检查。结果CT和组织学检查显示：术后3个月实验组椎体密度与正常椎体相似，骨缺损修复基本完成，术后6个月骨缺损修复完成；对照组术后3、6个月时PMMP无降解，并与骨之间结合疏松，表面无新骨形成；空白对照组术后3、6个月时骨缺损一直存在。生物力学测试显示：术后3、6个月时实验组椎体抗压强度和刚度与正常椎体相比差异无统计学意义（P〉0．05）。结论SF／BCP／CSH／rhBMP-2骨水泥具有良好的成骨作用，在成骨过程中能维持椎体的力学性能，有望成为经皮椎体强化术的一种可降解、具成骨作用的填充剂。

关键词：丝素蛋白椎体成形术绵羊骨水泥填充剂

RAPID AND NONDESTRUCTIVE MEASUREMENT SYSTEM FOR WELDING RESDlUAL STRESS BY ULTRASONIC METHOD

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Chinese Journal of Mechanical Engineering 2008年第6期21卷 91-93页

作者： LU Hao LIU xuesong zhu Zheng ZHANG Shiping FANG Hongyuan State Key Laboratory of Advanced Welding Production Technology Harbin Institute of Technology Harbin 150001 China School of Electrical Engineering and Automation Harbin Institute of Technology Harbin 150001 China

Traditional methods of residual stress measurement are generally destructive or semi-destructive, as well as expensive, time-consuming and complex to implement. With the new development of welded structure, traditional methods can not satisfy the need of full life task management. So the acoustical theory is introduced, since the ultrasonic technique provides a useful nondestructive tool in the evaluation of stresses. In this study an ultrasonic stress measurement experimental installation is established, which consists of a special transducer, a signal emission unit and a signal recipient processing unit. Longitudinal critically refracted wave is selected as the measurement wave mode. The supporting software is programmed by Labview software. The longitudinal residual stress and transverse residual stress of twin wire welded plate are measured by this installment, in which the measuring process is real-time, quick and nondestructive. The experiment results indicate that the system can satisfy the need of life evaluation for welded structure. The system is light and portable.

关键词： Ultrasonic Longitudinal critically refracted wave Residual stress

Improvement of part-load performance of gas turbine by adjusting compressor inlet air temperature and IGV opening

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Frontiers in Energy 2022年第6期16卷 1000-1016页

作者： Wei zhu Xiaodong REN xuesong LI Chunwei GU Zhitan LIU Zhiyuan YAN Hongfei zhu Tao ZHANG Department of Energy and Power Engineering Tsinghua UniversityBeijing 100084China Guodian Science and Technology Research Institute Nanjing 210023China

A novel adjusting method for improving gas turbine(GT)efficiency and surge margin(SM)under partload conditions is *** method adopts the inlet air heating technology,which uses the waste heat of lowgrade heat source and the inlet guide vane(IGV)opening ***,the regulation rules of the compressor inlet air temperature and the IGV opening are studied comprehensively to optimize GT performance.A model and calculation method for an equilibrium running line is adopted based on the characteristic curves of the compressor and *** equilibrium running lines calculated through the calculation method involve three part-load conditions and three IGVopenings with different inlet air *** results show that there is an optimal matching relationship between IGV opening and inlet air *** the best GT performance of a given load,the IGV could be adjusted according to inlet air *** addition,inlet air heating has a considerable potential for the improvement of part-load performance of GT due to the increase in compressor efficiency,combustion efficiency,and turbine efficiency as well as turbine inlet temperature,when inlet air temperature is lower than the optimal value with different IGV ***,when the IGV is in a full opening state and an optimal inlet air temperature is achieved by using the inlet air heating technology,GT efficiency and SM can be obviously higher than other *** IGV can be left unadjusted,even when the load is as low as 50%.These findings indicate that inlet air heating has a great potential to replace the IGV to regulate load because GT efficiency and SM can be remarkably improved,which is different from the traditional viewpoints.

关键词： inlet air temperature inlet guide vane(IGV)opening part-load equilibrium running line gas turbine(GT)efficiency surge margin(SM)

Recent movement changes of main fault zones in the Sichuan-Yunnan region and their relevance to seismic activity

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Science China Earth Sciences 2016年第6期59卷 1267-1282页

作者： LIU Xia MA Jin DU xuesong zhu Shuang LI LaYue SUN DongYing First Crustal Monitoring and Application Center China Earthquake Administration State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake Administration

The Wenchuan earthquake occurred near the "triple junction" linking the Bayan Har block, the South China block, and the Sichuan-Yunnan rhombic block, and its influences on the surrounding blocks and the main fault zones in the Sichuan-Yunnan region, i.e., the block boundary zone, cannot be ignored. In this paper, changes of movement and stress of the fault zones before and after a strong earthquake were simulated based on the GPS repetition survey results recently obtained during 1999–2007, 2009–2011, and 2011–2013 with a two-dimensional finite-element contact model and the "block- loading" method. The results show that, before the Wenchuan earthquake, the movement of the Longmenshan fault zone was very slow and its compressive stress accumulated rapidly; after the Wenchuan earthquake, movements toward the E-SSE direction of the Bayan Har, southwestern Yunnan, and rhombic blocks were enhanced, and the dextral and horizontal compressive speeds and annual accumulative compressive stress of the Longmenshan fault zone increased markedly by factors of 4.5, 2.1, and 2.5, respectively. The southern Xianshuihe, Anninghe, Zemuhe, Daliangshan, and Lijiang-Xiaojinhe fault zones accumulated compressive stress rapidly, forming enhanced compressive stress zones along a NE strike crossing the central part of the Sichuan-Yunnan region. The tensional movement of the Xianshuihe fault zone was enhanced and the slip movement in the central part of the zone was reversed in a short time. The changes are tightly related to the medium-intensity earthquakes that occurred during the same period in this region, revealing that the spatial migration of seismic activity is related to changes of movement of the blocks.

关键词： Sichuan-Yunnan region Wenchuan earthquake Tectonic block Finite-element analysis Fault

Service Scheduling Based on Edge Computing for Power Distribution IoT

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Computers, Materials & Continua 2020年第3期62卷 1351-1364页

作者： zhu Liu xuesong Qiu Shuai Zhang Siyang Deng Guangyi Liu State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing100876China State Grid Information&Telecommunication Group Co. Ltd.Beijing102211China Global Energy Interconnection Research Institute North America San JoseCA95134USA

With the growing amounts of multi-micro grids,electric vehicles,smart home,smart cities connected to the Power Distribution Internet of Things(PD-IoT)system,greater computing resource and communication bandwidth are required for power *** probably leads to extreme service delay and data congestion when a large number of data and business occur in *** paper presents a service scheduling method based on edge computing to balance the business load of *** architecture,components and functional requirements of the PD-IoT with edge computing platform are ***,the structure of the service scheduling system is ***,a novel load balancing strategy and ant colony algorithm are investigated in the service scheduling *** validity of the method is evaluated by simulation *** indicate that the mean load balancing ratio is reduced by 99.16%and the optimized offloading links can be acquired within 1.8 *** load of the nodes in edge computing platform can be effectively balanced through the service scheduling.

关键词： PD-IoT edge computing service scheduling load balancing strategy ant colony algorithm

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酮洛芬缓释片的制备及其体外释放度考察

中国药师 2010年第11期13卷 1630-1632页

作者：李春雷郑芳李志浩李鹏朱雪松湖北医药学院附属东风医院湖北十堰442008

目的:优化筛选酮洛芬缓释片的处方。方法:以体外释放度为指标,采用正交设计法优化酮洛芬缓释片的处方,并考察酮洛芬缓释片体外的释放机制。结果:最佳处方为:酮洛芬110 g,羟丙甲纤维素(HPMC)20 g,乳糖30 g,乙基纤维素(EC)40 g。酮洛芬缓... 详细信息

目的:优化筛选酮洛芬缓释片的处方。方法:以体外释放度为指标,采用正交设计法优化酮洛芬缓释片的处方,并考察酮洛芬缓释片体外的释放机制。结果:最佳处方为:酮洛芬110 g,羟丙甲纤维素(HPMC)20 g,乳糖30 g,乙基纤维素(EC)40 g。酮洛芬缓释片体外释放行为符合Higuchi方程。结论:酮洛芬缓释片处方合理,工艺简单,缓释效果较好。

关键词：酮洛芬正交设计缓释片释放度

武当地区及其他产地茶叶中咖啡因和表没食子儿茶素没食子酸酯的含量测定

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中国药师 2020年第1期23卷 168-171页

作者：郑芳何晓东熊琳林敏周爽朱雪松湖北医药学院附属东风医院药学部武当特色中药研究湖北省重点实验室湖北十堰442000 湖北医药学院药学院

目的:采用HPLC法测定武当地区不同品种茶叶及其他地区茶叶的咖啡因和表没食子儿茶素没食子酸酯的含量。方法:以Luna-C18柱(250 mm×4.6 mm,5μm)为色谱柱,流动相为乙腈-0.2%磷酸水溶液,梯度洗脱,流速为0.75 ml·min^-1,检测波长为272 nm... 详细信息

目的:采用HPLC法测定武当地区不同品种茶叶及其他地区茶叶的咖啡因和表没食子儿茶素没食子酸酯的含量。方法:以Luna-C18柱(250 mm×4.6 mm,5μm)为色谱柱,流动相为乙腈-0.2%磷酸水溶液,梯度洗脱,流速为0.75 ml·min^-1,检测波长为272 nm,柱温为25℃。结果:咖啡因和表没食子儿茶素没食子酸酯的线性范围分别为10.21~102.10μg·ml^-1(r=0.9994)、16.21~162.10μg·ml-1(r=0.9991),平均回收率分别为98.67%(RSD=1.86%,n=6),98.19%(RSD=2.28%,n=6)。结论:该方法用于武当地区及其他地区茶叶的咖啡因及表没食子儿茶素没食子酸酯含量的快速测定,具有简便、稳定性好、准确度高等特点,可以作为茶叶中咖啡因及表没食子儿茶素没食子酸酯含量的测定。

关键词：茶叶咖啡因表没食子儿茶素没食子酸酯高效液相色谱法含量测定

奥曲肽与奥美拉唑联合应用对肝癌H22生长的抑制作用

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中国医药导报 2012年第35期9卷 34-35,40页

作者：李春雷刘菁耿丽李鹏朱雪松郑芳湖北医药学院附属东风医院药学部湖北十堰442008

目的观察奥曲肽与奥美拉唑联合应用对肝癌H22生长的抑制作用。方法建立小鼠肝癌H22肉瘤移植模型后,随机分为阴性对照组、顺铂组、奥曲肽组、奥美拉唑组和奥曲肽+奥美拉唑组(联合用药组),给药后计算肿瘤生长抑制率和肿瘤微血管密度的变... 详细信息

目的观察奥曲肽与奥美拉唑联合应用对肝癌H22生长的抑制作用。方法建立小鼠肝癌H22肉瘤移植模型后,随机分为阴性对照组、顺铂组、奥曲肽组、奥美拉唑组和奥曲肽+奥美拉唑组(联合用药组),给药后计算肿瘤生长抑制率和肿瘤微血管密度的变化。结果奥曲肽组与奥美拉唑组的抑瘤率分别为33.5%、29.6%,联合用药组的抑瘤率为37.1%,差异无统计学意义(P>0.05)。与阴性对照组比较,奥曲肽组与奥美拉唑组能够降低小鼠肝癌H22的微血管密度,差异有统计学意义(P<0.05),联合用药降低更加明显,其中奥曲肽组与奥美拉唑组的微血管密度分别为(29.34±8.78)、(40.95±9.23),联合用药组为(23.89±5.76)。结论奥曲肽联合奥美拉唑能够显著抑制肝癌H22的生长,联合用药可能具有协同效果。

关键词：奥曲肽奥美拉唑肝癌H22 微血管