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Irisin-loaded electrospun core-shell nanofibers as calvarial periosteum accelerate vascularized bone regeneration by activating the mitochondrial SIRT3 pathway

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Regenerative Biomaterials 2024年第1期3卷 44-57页

作者： Xi Hua Mingzhuang Hou Lei Deng Nanning Lv Yong Xu xuesong zhu Huilin Yang Qin Shi Hao Liu Fan He Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Orthopaedic Institute Suzhou Medical CollegeSoochow UniversitySuzhou 215000China Department of Orthopedics Suzhou Wuzhong People’s HospitalSuzhouJiangsu Province 215128China Department of Orthopedic Surgery Lianyungang Clinical College of Xuzhou Medical UniversityLianyungang 222003China

The scarcity of native periosteum poses a significant clinical barrier in the repair of critical-sized bone *** challenge of enhancing regenerative potential in bone healing is further compounded by oxidative stress at the fracture ***,the introduction of artificial periosteum has demonstrated its ability to promote bone regeneration through the provision of appropriate mechanical support and controlled release of proosteogenic *** this study,a poly(L-lactic acid)(PLLA)/hyaluronic acid(HA)-based nanofibrous membrane was fabricated using the coaxial electrospinning *** incorporation of irisin into the core-shell structure of PLLA/HA nanofibers(PLLA/HA@Irisin)achieved its sustained *** vitro experiments demonstrated that the PLLA/HA@Irisin membranes exhibited favorable *** osteogenic differentiation of bone marrow mesenchymal stem cells(BMMSCs)was improved by PLLA/HA@Irisin,as evidenced by a significant increase in alkaline phosphatase activity and matrix ***,PLLA/HA@Irisin significantly enhanced the mitochondrial function of BMMSCs via the activation of the sirtuin 3 antioxidant *** assess the therapeutic effectiveness,PLLA/HA@Irisin membranes were implanted in situ into critical-sized calvarial defects in *** results at 4 and 8 weeks post-surgery indicated that the implantation of PLLA/HA@Irisin exhibited superior efficacy in promoting vascularized bone formation,as demonstrated by the enhancement of bone matrix synthesis and the development of new blood *** results of our study indicate that the electrospun PLLA/HA@Irisin nanofibers possess characteristics of a biomimetic periosteum,showing potential for effectively treating critical-sized bone defects by improving the mitochondrial function and maintaining redox homeostasis of BMMSCs.

关键词： periosteum irisin mitochondrial function critical-sized bone defect redox homeostasis

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3D-bioprinted anisotropic bicellular living hydrogels boost osteochondral regeneration via reconstruction of cartilage–bone interface

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The Innovation 2024年第2期5卷 88-97页

作者： Yijian Zhang Duo Li Yang Liu Liuqi Peng Dongdong Lu Pinpin Wang Dongxu Ke Huilin Yang xuesong zhu Changshun Ruan Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Research Center for Human Tissue and Organ Degeneration Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Novaprint Therapeutics Suzhou Co. Ltd.Room 605B1 BuildingBioBayNo.218 Xinghu StreetSuzhou Industrial ParkSuzhou 215000China

Reconstruction of osteochondral(OC)defects represents an immense challenge due to the need for synchronous regeneration of special stratified *** revolutionary innovation of bioprinting provides a robust method for precise fabrication of tissue-engineered OCs with hierarchical structure;however,their spatial living cues for simultaneous fulfilment of osteogenesis and chondrogenesis to reconstruct the cartilage-bone interface of OC are ***,inspired by natural OC bilayer features,anisotropic bicellular living hydrogels(ABLHs)simultaneously embedding articular cartilage progenitor cells(ACPCs)and bone mesenchymal stem cells(BMSCs)in stratified layers were precisely fabricated via two-channel extrusion *** optimum formulation of the 7%GelMA/3%AlgMA hydrogel bioink was demonstrated,with excellent printability at room temperature and maintained high cell ***,the chondrogenic ability of ACPCs and the osteogenic ability of BMSCs were demonstrated in vitro,confirming the inherent differential spatial regulation of ABLHs.

关键词： printing stratified boost

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永磁同步电机宽转速的高阶滑模MRAS控制

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实验技术与管理 2024年第6期41卷 70-80页

作者：韩琨张长征袁雷朱雪松湖北工业大学太阳能高效利用及储能运行控制湖北省重点实验室湖北武汉430068

为抑制基于滑模控制的永磁同步电机系统的抖振现象,提出一种通过高阶滑模控制设计的MRAS无传感器控制策略。通过设置滑模积分环节达到了抑制抖振的目的,表明了高阶滑模控制过程中积分环节的重要性,阐述了非线性滑模控制参数设置思路,相... 详细信息

为抑制基于滑模控制的永磁同步电机系统的抖振现象,提出一种通过高阶滑模控制设计的MRAS无传感器控制策略。通过设置滑模积分环节达到了抑制抖振的目的,表明了高阶滑模控制过程中积分环节的重要性,阐述了非线性滑模控制参数设置思路,相较于MRAS与SMCMRAS提高了SPMSM在中低速的表现性能。最后,基于MATLAB/Simulink代码自动生成的电机算法测试平台,验证了所设计观测器的有效性。实验结果表明,SPMSM在低速的表现效果良好,零速启动表现良好,高阶滑模控制策略较一阶SMC有效降低了抖振,提高了PI控制的鲁棒性,实现了PMSM的宽速域控制。

关键词： MRAS 自动代码生成抖振高阶滑模控制低速控制

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基于熵权-TOPSIS法的货运航线网络设计研究

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中国民航飞行学院学报 2024年第1期35卷 5-8,24页

作者：朱学松陈肯中国民用航空飞行学院四川广汉618307

本文提出了一种轴辐式货运航线网络设计的方法。运用聚类分析(K-Means)进行枢纽机场选址,以枢纽机场间多重连接的方式,建立无机场容量限制的轴辐式货运航线网络优化模型,运用枚举法求解最终得到一个较为合理的货运航线网络。其中为提高... 详细信息

本文提出了一种轴辐式货运航线网络设计的方法。运用聚类分析(K-Means)进行枢纽机场选址,以枢纽机场间多重连接的方式,建立无机场容量限制的轴辐式货运航线网络优化模型,运用枚举法求解最终得到一个较为合理的货运航线网络。其中为提高聚类精度,引入熵权-TOPSIS法对数据进行处理,通过对TOPSIS评价数据进行聚类得到精度较高的聚类结果,实验表明基于熵权-TOPSIS的聚类分析较传统的聚类分析降低了运输成本。

关键词：交通运输工程航线网络设计熵权-TOPSIS K-Means聚类分析

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基于灰靶理论的竞争航线货运机队规划研究

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舰船电子工程 2024年第3期44卷 22-27页

作者：朱学松陈肯陈洪浩李梁昆中国民用航空飞行学院空中交通管理学院广汉618307

随着航空事业的发展,航空公司间的竞争关系不断加剧。为解决竞争环境下的航空公司的机队规划问题,建立了灰靶-PSO模型,并以航空公司货运航线机队规划为研究对象,验证模型的科学性。该模型引入灰靶理论,通过靶心度量化航空公司航线竞争力... 详细信息

随着航空事业的发展,航空公司间的竞争关系不断加剧。为解决竞争环境下的航空公司的机队规划问题,建立了灰靶-PSO模型,并以航空公司货运航线机队规划为研究对象,验证模型的科学性。该模型引入灰靶理论,通过靶心度量化航空公司航线竞争力,其中为降低主观因素对结果的影响,引入C-OWA算子赋权法计算指标权重,将量化后的竞争力转换为航空公司在货运航线上的初始市场份额,并基于初始市场份额,运用粒子群算法对模型进行求解。通过数据仿真实验表明:建立的灰靶-PSO模型对于解决竞争环境下航空公司机队规划问题具有一定的科学性,可为航空公司在进行航线运营和机队规划前期提供决策参考。

关键词：交通运输工程竞争环境运力分配灰靶理论粒子群算法

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High-resolution sea surface wind speeds of Super Typhoon Lekima (2019) retrieved by Gaofen-3 SAR

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Frontiers of Earth Science 2022年第1期16卷 90-98页

作者： He FANG William PERRIE Gaofeng FAN Zhengquan LI Juzhen CAI Yue HE Jingsong YANG Tao XIE xuesong zhu Zhejiang Climate Centre Hangzhou 310017China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Shanghai Typhoon Institute and Key Laboratory of Numerical Modeling for Tropical Cyclone of China Meteorological AdministrationShanghai 200030China Fisheries&Oceans Canada Bedford Institute of OceanographyDartmouth B2Y4A2Canada School of Remote Sensing and Geomatics Engineering Nanjing University of Information Science and TechnologyNanjing 210044China

Gaofen-3(GF-3)is the first Chinese spaceborne multi-polarization synthetic aperture radar(SAR)instrument at C-band(5.43 GHz).In this paper,we use data collected from GF-3 to observe Super Typhoon Lekima(2019)in the East China *** a VH-polarized wide ScanSAR(WSC)image,ocean surface wind speeds at 100m horizontal resolution are obtained at 21:56:59 UTC on 8 August 2019,with the maximum wind speed,38.9 m·s^(-1).Validating the SAR-retrieved winds with buoymeasured wind speeds,we find that the root mean square error(RMSE)is 1.86 m·s^(-1),and correlation coefficient,*** suggests that wind speeds retrieved from GF-3 SAR are *** the European Centre for MediumRange Weather Forecasts(ECMWF)fine grid operational forecast products with spatial resolution,and China Global/Regional Assimilation and Prediction Enhance System(GRAPES)have good performances on surface wind prediction under weak wind speed condition(24m·s^(-1)).With respect to SAR-retrieved wind speeds,the RMSEs are 5.24 m·s^(–1) for ECMWF and 5.17 m·s^(–1) for GRAPES,with biases of 4.16 m·s^(–1) for ECMWF and 3.84 m·s^(-1)for GRAPES during Super Typhoon Lekima(2019).

关键词： synthetic aperture radar wind speed numerical weather predication(NWP) typhoon

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Biomimetic melatonin-loaded silk fibroin/GelMA scaffold strengthens cartilage repair through retrieval of mitochondrial functions

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Journal of Materials Science & Technology 2023年第15期146卷 102-112页

作者： Mingzhuang Hou Yijian Zhang Yang Liu Xiaoyang Ge Xiayu Hu Zhijian Zhao Xin Tian Tao Liu Huilin Yang Xi Chen Fan He xuesong zhu Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Orthopaedic Institute Medical CollegeSoochow UniversitySuzhou 215007China Department of Pathology The Third Affiliated Hospital of Soochow UniversityChangzhou 213003China

Articular cartilage injury induced by collision or trauma is a common sports-related condition that may progress to pain,dysfunction,and secondary osteoarthritis(OA).Limited by self-renewal potential,cartilage regeneration faces a quandary while bio-inspired novel strategies are urgently *** this study,by a soft freezing method and surface modification technique,a multi-functional silk fibroin(SF)plus gelatin methacrylate(GelMA)scaffold laden with melatonin(MT)was ***-GelMA@MT scaffold demonstrated enhanced biomechanical characteristics and long-acting melatonin *** vitro treatment with SF-GelMA@MT induced the synthesis of cartilage extracellular matrix(ECM)***,sustained release of melatonin yielded robust chondroprotective effects via improving mitochondrial polarization and antioxidant ***-GelMA@MT implantation boosted cartilage renascence in a full-thickness cartilage defect model via mitochondria-associated sirtuins 1(SIRT1)-superoxide dismutase 2(SOD2)signaling pathway in *** summary,this research proposed a welldesigned bionic composite scaffold that promotes cartilage regeneration via mitochondrial function enhancement,which is of tremendous potential for cartilage tissue engineering.

关键词： Cartilage injury Silk fibroin Gelatin methacrylate Melatonin Mitochondri

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FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells

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Bone Research 2023年第2期11卷 398-415页

作者： Fei Zhang Lei Wei Lei Wang Tao Wang Zhihong Xie Hong Luo Fanchao Li Jian Zhang Wentao Dong Gang Liu Qinglin Kang xuesong zhu Wuxun Peng Department of Emergency Orthopedics The Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou550004China School of Clinical Medicine Guizhou Medical UniversityGuiyangGuizhou 550004China Department of Orthopedics Rhode Island HospitalBrown UniversityProvidenceRhode Island02903USA Department of Orthopedics Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China Department of Orthopedics The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu215000China

The specific pathogenesis of steroid-induced osteonecrosis of the femoral head(SONFH)is still not fully understood,and there is currently no effective early *** the role and mechanism of long noncoding RNAs(lnc RNAs)in the pathogenesis of SONFH will help reveal the pathogenesis of SONFH and provide new targets for its early prevention and *** this study,we first confirmed that glucocorticoid(GC)-induced apoptosis of bone microvascular endothelial cells(BMECs)is a pre-event in the pathogenesis and progression of ***,we identified a new lnc RNA in BMECs via lnc RNA/m RNA microarray,termed Fosassociated linc RNA ENSRNOT00000088059.1(FAR591).FAR591 is highly expressed during GC-induced BMEC apoptosis and femoral head *** of FAR591 effectively blocked the GC-induced apoptosis of BMECs,which then alleviated the damage of GCs to the femoral head microcirculation and inhibited the pathogenesis and progression of *** contrast,overexpression of FAR591 significantly promoted the GC-induced apoptosis of BMECs,which then aggravated the damage of GCs to the femoral head microcirculation and promoted the pathogenesis and progression of ***,GCs activate the glucocorticoid receptor,which translocates to the nucleus and directly acts on the FAR591 gene promoter to induce FAR591 gene ***,FAR591 binds to the Fos gene promoter(–245–51)to form a stable RNA:DNA triplet structure and then recruits TATA-box binding protein associated factor 15 and RNA polymerase II to promote Fos expression through transcriptional *** activates the mitochondrial apoptotic pathway by regulating the expression of Bcl-2 interacting mediator of cell death(Bim)and P53 upregulated modulator of apoptosis(Puma)to mediate GC-induced apoptosis of BMECs,which leads to femoral head microcirculation dysfunction and femoral head *** conclusion,these results confirm the mechanistic link between lnc RNAs and the p

关键词： pathogenesis prevention inhibited

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Breeding exceptionally fragrant soybeans for soy milk with strong aroma

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Journal of Integrative Plant Biology 2024年第4期66卷 642-644页

作者： Hongtao Xie Minglei Song xuesong Cao Qingfeng Niu Jianhua zhu Shasha Li Xin Wang Xiaomu Niu Jian-Kang zhu Bellagen Biotechnology Co.Ltd. Jinan 250000China Institute of Advanced Biotechnology and School of Life Sciences Southern University of Science and TechnologyShenzhen 518055China School of Life Sciences Anhui Agricultural UniversityHefei 230036China Shandong Normal University Jinan 250000China

Soybean(Glycine max(L.)Merr.)is a major source of vegetable protein and oil in human diet and animal *** seeds have been extensively used in various food products and *** quality,particularly the aroma,affects cooking and eating,and ultimately influences consumer *** milk is particularly popular in China and has been gaining popularity in many other countries in the world.

关键词： exceptional soybean cooking

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Simple method for transformation and gene editing in medicinal plants

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Journal of Integrative Plant Biology 2024年第1期66卷 17-19页

作者： xuesong Cao Hongtao Xie Minglei Song Lianghui Zhao Hailiang Liu Guofu Li Jian‐Kang zhu Institute of Advanced Biotechnology and School of Life Sciences Southern University of Science and TechnologyShenzhen 518055China Bellagen Biotechnology Co.Ltd. Jinan 250000China Institute for Regenerative Medicine Shanghai East HospitalTongji University School of MedicineShanghai 200123China Ministry of Agriculture and Rural Affairs Key Laboratory of Gene Editing Technologies Nanfan Research InstituteChinese Academy of Agricultural SciencesSanya 572024China

Gene-editing technologies have ushered in a significant advancement in plant genetics research and molecular ***,a critical challenge hindering the widespread adoption of these technologies is the efficient delivery of gene-editing *** predominant methods for introducing these tools into plants typically involve Agrobacterium tumefaciens-mediated transformation or particle bombardment(Mao et al.,2019).Unfortunately,these traditional gene delivery methods require delicate and timeconsuming tissue culture procedures and show limited success,especially in medicinal and other less studied plants.A recent breakthrough is the development of the Cut-Dip-Budding(CDB)gene delivery *** CDB system is highly effective for plants with root-suckering *** allows the delivery of transgenes and gene-editing tools into plants through hairy root induction followed by shoot regeneration from transformed hairy roots,bypassing the need for tissue culture processes(Cao et al.,2023).

关键词： transformation culture breakthrough

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