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以问题为基础的教学模式在临床医师规范化培训中的应用

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继续医学教育 2018年第3期32卷 89-91页

作者：范垂锋姜贵洋林旭勇李庆昌邱雪杉王恩华中国医科大学基础医学院病理学教研室辽宁沈阳110122

随着1993年原卫生部关于实施《临床住院医师规范化培训试行办法》的通知的出台,临床住院医师规范化培训在全国范围内逐渐开展起来。经过十余年的实践,积累了一些经验。PBL是一种具有先进理念的教学模式,已经为国内医学院校所广泛熟悉。... 详细信息

随着1993年原卫生部关于实施《临床住院医师规范化培训试行办法》的通知的出台,临床住院医师规范化培训在全国范围内逐渐开展起来。经过十余年的实践,积累了一些经验。PBL是一种具有先进理念的教学模式,已经为国内医学院校所广泛熟悉。以中国知网中文文献为基础,就国内住院医师培训中采用PBL教学的现状进行综述。

关键词：以问题为基础的教学规培医学住院医师

以微课为载体移动学习教学模式在病理学教学中的应用

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中华医学教育杂志 2018年第4期38卷 570-574页

作者：孙丽梅邱雪杉张清富李庆昌曲波孙宝志闻德亮中国医科大学基础医学院病理学教研室沈阳110122 中国医科大学基础医学院国际医学教育研究院沈阳110122

目的通过与传统教学模式比较，探讨以微课为载体移动学习教学模式在病理学教学中的应用效果。方法选择中国医科大学2013级～2015级五年制和七年制临床医学专业1班～8班共1458名学生为研究对象，其中1班～4班学生为实验组，5班一8班学生... 详细信息

目的通过与传统教学模式比较，探讨以微课为载体移动学习教学模式在病理学教学中的应用效果。方法选择中国医科大学2013级～2015级五年制和七年制临床医学专业1班～8班共1458名学生为研究对象，其中1班～4班学生为实验组，5班一8班学生为对照组，两组授课教师相同。实验组采用以微课为载体的移动学习教学模式，对照组采用传统教学模式。结果实验组问卷调查结果显示，大多数学生对于以微课为载体的移动学习教学模式给予肯定的评价；实验组学生的理论考核成绩均高于对照组，其中2013级七年制（t=2．23，P=0．0263）、2014级五年制（t=2．46，P=0．0147）和2015级七年制（t=2．05，P=0．0414）学生成绩差异具有统计学意义。结论病理学教学中采用以微课为载体移动学习教学模式教学效果优于传统教学模式，有利于达到教学目标，更好地实现培养优秀人才的目的。

关键词：微课病理学移动学习应用

RNF146真核表达载体的构建及其对非小细胞肺癌细胞系生物学行为的影响

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山西医药杂志 2014年第7期43卷 723-726,I0001页

作者：高英惠林萍宋成洋徐慧慧王睿田大力邱雪杉王恩华中国医科大学附属第四医院病理科沈阳110032 中国医科大学附属第四医院中心实验室沈阳110032 中国医科大学附属第四医院胸外科沈阳110032 中国医科大学基础医学院病理学教研室中国医科大学附属第一医院病理科

目的构建E3泛素连接酶环指蛋白146(RNF146)基因真核表达载体,研究RNF146对非小细胞肺癌细胞系体外生物学行为的影响。方法采用反转录-聚合酶链反应(RT-PCR)和蛋白印迹法筛选RNF146低表达细胞系。构建pEX4-RNF146真核表达载体,经酶切和... 详细信息

目的构建E3泛素连接酶环指蛋白146(RNF146)基因真核表达载体,研究RNF146对非小细胞肺癌细胞系体外生物学行为的影响。方法采用反转录-聚合酶链反应(RT-PCR)和蛋白印迹法筛选RNF146低表达细胞系。构建pEX4-RNF146真核表达载体,经酶切和测序后瞬时转染LTE细胞,荧光显微镜观察、蛋白印迹法检测转染效率。四甲基偶氮唑盐(MTT)比色实验检测肿瘤细胞体外增殖能力,划痕实验评价肿瘤细胞体外迁移能力,Buyden小室实验检测肿瘤细胞体外侵袭能力。结果酶切和基因测序证实重组质粒pEX4构建正确。MTT比色实验显示转染pEX4-RNF146组细胞增殖速度明显高于转染空载体组和未转染组(P<0.05)。划痕实验显示转染组细胞24h迁移率明显高于空载体组和未转染组(P<0.05)。Buyden小室实验结果表明转染组比空载体组和未转染组穿膜数目明显增多(P<0.05)。结论 RNF146基因转染能促进非小细胞肺癌LTE细胞的体外增殖、迁移和侵袭能力,可能是一个潜在的促肿瘤增殖、侵袭和转移的相关基因。

关键词：癌,非小细胞肺泛素蛋白连接酶类 RNF146 增殖 RNF146

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

Solar trough receiver with V-grooved light traps for efficiency improvement

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Science China Technological Sciences 2025年第1期 146-156页

作者： Bin LIU Qing LI Yu qiu School of Energy Science and Engineering Central South University

Parabolic trough collector is a promising technology for both domestic and industrial heat supplies. To enhance the collector efficiency, a modified trough receiver with dozens of V-grooved light traps incorporated into its lower-half absorber was introduced. For assessing the performance of this receiver, a solar-thermal-stress coupled model was established. Using this model, firstly, the effects of the V-grooved light traps were investigated. The results reveal that, compared to the conventional trough receiver, the modified trough receivers equipped with different traps can reduce their optical losses by 81.9–138.0 Wm-1（i.e., 15.0%–25.2%）, improving their optical efficiencies by 1.60%–2.69%. However, these traps also result in increased thermal loss from the receiver. Therefore, there is no single optimal modified trough receiver that consistently outperforms all other receivers across all possible conditions. Nonetheless, the MTR30-3 and MTR60-3 receivers emerge as the optimized choices due to their better solar-thermal performance. Subsequently, performance evaluation reveals that the two optimized receivers can enhance the receiver efficiencies within the typical solar irradiance range by 0.02%–2.65% and 0.05%–1.70% when the inlet fluid temperatures are below 488 and 523 K, respectively. Consequently, the collector efficiencies can be improved by 0.02%–2.49% and 0.05%–1.60%, respectively. Additionally, thermal stress analysis verifies that the two optimized receivers remain within safe limits under all typical conditions. Given that the heating temperature of a typical solar collector for domestic or industrial heat supply is typically below 523 K, the integration of the two optimized receivers has the capability to effectively enhance the overall collector efficiency.

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Bifunctional bridging capping layer enables 24.5% efficiency of perovskite solar cells with polymer-based hole transport materials

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Science China Chemistry 2025年第1期 350-359页

作者： Can Zhu Yiyang Wang Lei Meng Beibei qiu Jing Li Shucheng Qin Ke Hu Xin Jiang Wenbin Lai Minchao Liu Zhe Liu Chenxing Lu Jinyuan Zhang Yongfang Li Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences School of Chemical Science University of Chinese Academy of Sciences Key Laboratory of Solid State Optoelectronic Devices of Zhejiang Province College of Physics and Electronic Information Engineering Zhejiang Normal University Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences Laboratory of Advanced Optoelectronic Materials College of Chemistry Chemical Engineering and Materials ScienceSoochow University

Developing a bridge capping layer between perovskite and hole transport layer materials（HTMs） in the n-i-p perovskite solar cells（pero-SCs） is an effective approach to modify the morphology of HTMs and passivate the perovskite ***, we select the quinoxaline-based bifunctional passivation agent, quinoxalin-6-yl-methylamine hydrochloride（Qx MACl）,as the bridging layer, and a D-A copolymer PBQ12 containing the same quinoxaline unit as an HTM for the n-i-p pero-SCs. Due to the π-π stacking among the common quinoxaline units in the bridge layer and HTM, Qx MACl induces the π-π stacking of the PBQ12 film and improves the film morphology of HTMs with better conductivity. Additionally, Qx MACl can effectively passivate the perovskite surface, and PBQ12 possesses appropriate energy levels and high hole mobility. The pero-SCs based on FAPbI3with PBQ12/Qx MACl treatment showed a higher power conversion efficiency（PCE） of 24.05% and outstanding stability, maintaining 95.4% and 92.1% of its initial PCE after 750 h of storage and after over 800 h of thermal annealing at 85 °C, respectively. To further enhance the PCE of the PBQ12/Qx MACl-based devices, we developed a non-metal ion dopant for the PBQ12 HTM. Through trace doping of PBQ12 HTM by the non-metal ion dopant, the PCE of the PBQ12/Qx MACl-based devices reached 25.24%（the calibrated PCE of 24.55% by the National Institute of Metrology, China）.

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Microwave-accelerated direct regeneration of LiCoO_(2)cathodes for Li-ion batteries

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Science China Chemistry 2024年第7期67卷 2181-2189页

作者： xueshan Hu Yun-Chao Yin Chao Li Lihui Zhou Lin Yang Yitian Feng Daxian Zuo Chenhui Ning Das Soham Sheng Dai Longbin qiu Lin Zeng Haw Jiunn Woo Jiayu Wan Future Battery Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China Centre for Ionics University of Malaya Department of PhysicsFaculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Natural and Applied Sciences Duke Kunshan UniversityKunshan 215316China

Recycling spent lithium-ion batteries is integral to today's low-carbon environmental protection *** concept of direct regeneration,acknowledged for its environmental sustainability,economic viability,and consistent performance of recycled materials,is gaining *** study presents an efficient and nondestructive approach by utilizing an ultrafast microwave technology to directly regenerate spent lithium cobaltate(LCO)cathode *** contrast to conventional furnacebased processes,this method significantly reduces the regeneration *** subjecting the spent LCO mixed with lithium sources to three microwave heating cycles(at approximately 1,350 K),LCO regeneration is achieved,yielding a specific capacity of 140.8 mAh g^(-1)(0.2 C)with a robust cycle *** further environmental and economic benefits,the ultrafast microwave technology holds scientific promise for directly regenerating cathode materials,while establishing competitiveness for industrial applications.

关键词： battery recycling spent lithium cobaltate microwave directly regeneration cathode materials

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融合注意力机制的YOLOv8-TS交通标志检测网络

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现代电子技术 2025年第1期48卷 179-186页

作者：黄智渊方遒郭星浩厦门理工学院机械与汽车工程学院福建厦门361024 厦门大学航空航天学院福建厦门361005

道路交通标志识别是自动驾驶、车联网的重要组成部分,为进一步提高交通标志检测的精度和速度,提出一种基于YOLOv8s改进的YOLOv8-TS道路交通标志检测网络。首先,对YOLOv8s进行了整体的轻量化设计,并设计了Conv-G7S和CSP-G7S模块,减少了... 详细信息

道路交通标志识别是自动驾驶、车联网的重要组成部分,为进一步提高交通标志检测的精度和速度,提出一种基于YOLOv8s改进的YOLOv8-TS道路交通标志检测网络。首先,对YOLOv8s进行了整体的轻量化设计,并设计了Conv-G7S和CSP-G7S模块,减少了网络的参数量;其次,设计了CSP-SwinTransformer模块,强化了模型利用窗口内的特征信息进行上下文感知和建模的能力;然后,在颈部网络融合了卷积注意力机制(CBAM),强化了模型对不同通道、空间权重信息的学习;最后,对损失函数进行了改进,提升了边界框回归性能。实验结果表明,在中国道路交通标志TT100K数据集上,精确率(Precision)、平均精度(mAP@0.5)分别提高了6.9%、3.7%,而改进后模型的参数量下降了75.4%,模型的大小仅为5.8 MB,平均精度(mAP@0.5)达到96.5%,检测速度由126.58 f/s提升至136.99 f/s。

关键词：交通标志检测 YOLOv8-TS 轻量化注意力机制 Conv-G7S WIoU

Henig Efficiency in Vector Optimization with Nearly Cone-subconvexlike Set-valued Functions

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Acta Mathematicae Applicatae Sinica 2007年第2期23卷 319-328页

作者： qiu-sheng qiu Department of Mathematics Zhejiang Normal University Jinhua 321004 China Department of Mathematics Shanghai University Shanghai 200436 China

In this paper, we study Henig efficiency in vector optimization with nearly cone-subconvexlike set-valued function. The existence of Henig efficient point is proved and characterization of Henig efficiency is established using the method of Lagrangian multiplier. As an interesting application of the results in this paper, we establish a Lagrange multiplier theorem for super efficiency in vector optimization with nearly conesubconvexlike set-valued function.

关键词： Set-valued function vector optimization Lagrangian multiplier theorem Henig efficiency nearly cone-subconvexlikeness